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| 1 | Effectiveness of probiotic therapy for the prevention of relapse in patients with inactive ulcerative colitis显示文摘AIM: to evaluate the effectiveness of probiotic therapy for suppressing relapse in patients with inactive ulcerative colitis(UC).METHODS: Bio-Three tablets, each containing 2 mg of lactomin(Streptococcus faecalis T-110), 10 mg of Clostridium butyricum TO-A, and 10 mg of Bacillus mesentericus TO-A, were used as probiotic therapy.Sixty outpatients with UC in remission were randomly assigned to receive 9 Bio-Three tablets/day(BioThree group) or 9 placebo tablets/day(placebo group)for 12 mo in addition to their ongoing medications.Clinical symptoms were evaluated monthly or on the exacerbation of symptoms or need for additional medication. Fecal samples were collected to analyze bacterial DNA at baseline and 3-mo intervals. Terminal restriction fragment length polymorphism and cluster analyses were done to examine bacterial components of the fecal microflora.RESULTS: Forty-six patients, 23 in each group,completed the study, and 14 were excluded. The relapse rates in the Bio-Three and placebo groups were respectively 0.0% vs 17.4% at 3 mo(P = 0.036), 8.7%vs 26.1% at 6 mo(P = 0.119), and 21.7% vs 34.8%(P = 0.326) at 9 mo. At 12 mo, the remission rate was 69.5% in the Bio-Three group and 56.6% in the placebo group(P = 0.248). On cluster analysis of fecal flora, 7 patients belonged to cluster Ⅰ, 32 to cluster Ⅱ,and 7 to cluster Ⅲ.CONCLUSION: Probiotics may be effective formaintaining clinical remission in patients with quiescent UC, especially those who belong to cluster Ⅰ on fecal bacterial analysis. | Yasushi Yoshimatsu Akihiro Yamada Ryuichi Furukawa Koji Sono Aisaku Osamura Kentaro Nakamura Hiroshi Aoki Yukiko Tsuda Nobuo Hosoe Nobuo Takada Yasuo Suzuki | 2015 | World Journal of Gastroenterology2015，21，19： | 21 |
| 2 | Sentinel lymph node navigation surgery for early stage gastric cancer显示文摘We attempted to evaluate the history of sentinel node navigation surgery(SNNS),technical aspects,tracers,and clinical applications of SNNS using Infrared Ray Electronic Endoscopes(IREE)combined with Indocyanine Green(ICG).The sentinel lymph node(SLN)is defined as a first lymph node(LN)which receives cancer cells from a primary tumor.Reports on clinical application of SNNS for gastric cancers started to appear since early 2000s.Two prospective multicenter trials of SNNS for gastric cancer have also been accomplished in Japan.Kitagawa et al reported that the endoscopic dual(dye and radioisotope)tracer method for SN biopsy was confirmed acceptable and effective when applied to the early-stage gastric cancer(EGC).We have previously reported the usefulness of SNNS in gastrointestinal cancer using ICG as a tracer,combined with IREE(Olympus Optical,Tokyo,Japan)to detect SLN.LN metastasis rate of EGC is low.Hence,clinical application of SNNS for EGC might lead us to avoid unnecessary LN dissection,which could preserve the patient’s quality of life after operation.The most ideal method of SNNS should allow secure and accurate detection of SLN,and real time observation of lymphatic flow during operation. | Norio Mitsumori Hiroshi Nimura Naoto Takahashi Masahiko Kawamura Hiroaki Aoki Atsuo Shida Nobuo Omura Katsuhiko Yanaga | 2014 | World Journal of Gastroenterology2014，20，19： | 15 |
| 3 | 自发性突发性耳聋危险因素分析显示文摘 | 施海龙 Mieko Nakamura Satoshi Iwasaki Nobuo Aoki 王亚奇 金鑫 俞佳 | 2007 | 中国卫生统计2007，24，5： | 7 |
| 4 | Novel Radio on Fiber Access Eliminating External Electric Power Supply at Base Station显示文摘A novel Radio On Fiber(ROF) access is proposed and demonstrated which enables the pico-cell Base Station (BS) for high-speed wireless communications to eliminate external electric power supply facilities. We demonstrated 2.4-GHz band radio signal transmission through the BS without external electric power supply. The electrical power used for BS circuit is feeded by optical power over optical fiber from central station. | Tetsuya Miki Katsuyasu Kawano Nobuo Nakajima Naoto Kishi Masaru Miyamoto Tetsu Aoki | 2003 | 光学学报2003，23，S1： | 3 |
| 5 | Introduction to a Major Project of the National Social Science Fund:Research on China's Industrial Heritage Conservation System显示文摘Since the 1980s,China has undergone a series of important changes including industrial restructuring,land transfer,and urbanisation.These have given rise to the issue of how to address industrial heritage within many cities.The author’s research team has undertaken a National Social Science’s Major Project(the highest level of Chinese national social science research)titled‘Systematic Research on the Protection of Urban Industrial Heritage in Modern China’.This is the first nationwide and systematic study of industrial heritage in China.This paper provides a brief introduction to the study’s framework and current research achievements,including:(1)the study of industrial modernisation processes,including international perspectives;(2)industrial heritage information acquisition and database setup;(3)estimation of industrial heritage value;(4)studies of the planning and design strategy of industrial heritage reutilisation;and(5)the transition from industrial heritage conservation to the development of a cultural industry. | Subin Xu Nobuo Aoki | 2018 | Built Heritage2018，2，1： | 1 |
| 6 | THROMBOMODULIN ALFA IN THE TREATMENT OF INFECTIOUS PATIENTS COMPLICATED BY DISSEMINATED INTRAVASCULAR COAGULATION: SUBANALYSIS FROM THE PHASE 3 TRIAL显示文摘 | Naoki Aikawa Shuji Shimazaki Yasuhiro Yamamoto Hidehiko Saito Ikuro Maruyama Ryuzo Ohno Akio Hirayama Yoshikazu Aoki Nobuo Aoki | 2011 | Shock2011，，4： | 1 |
| 7 | Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat显示文摘 | Philip S Tsao BS Nobuo Aoki | 1990 | Circulation1990，82，4： | 1 |
| 8 | Effects of ecabet sodium on experimentally induced reflux esophagitis显示文摘 | Nobuo Omura Hideyuki Kashiwagi Ganz Chen Fumiaki Yano Yutaka Suzuki Teruaki Aoki | 2000 | Journal of Gastroenterology2000，，7： | 1 |
| 9 | Clinical effectiveness of probiotics therapy (BIO-THREE) in patients with ulcerative colitis refractory to conventional therapy显示文摘 | Yukiko Tsuda Yasushi Yoshimatsu Hiroshi Aoki Kentaro Nakamura Masaki Irie Katsuyuki Fukuda Nobuo Hosoe Nobuo Takada Koji Shirai Yasuo Suzuki | 2007 | Scandinavian Journal of Gastroenterology2007，，11： | 1 |
| 10 | Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat 显示文摘 | Philip S Tsao BS Nobuo Aoki | 1991 | Circulation1991，82，4： | 1 |
| 11 | The set of axiom A diffeomorphisms with no cycles显示文摘 | Nobuo Aoki | 1992 | Boletim da Sociedade Brasileira de Matemática1992，，1： | 1 |
| 12 | Clinical effectiveness of probiotics therapy (BIO-THREE) in patients with ulcerative colitis refractory to conventional therapy显示文摘 | Yukiko Tsuda Yasushi Yoshimatsu Hiroshi Aoki Kentaro Nakamura Masaki Irie Katsuyuki Fukuda Nobuo Hosoe Nobuo Takada Koji Shirai Yasuo Suzuki | 2007 | Scandinavian Journal of Gastroenterology2007，，11： | 1 |
| 13 | Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat 显示文摘 | Philip S Tsao B S Nobuo Aoki | 1990 | Circulation1990，82，4： | 1 |
| 14 | Crossability of American tree peony ‘High Noon’ as seed parent with Japanese cultivars to breed superior cultivars显示文摘 | Qing Hao Noriaki Aoki Jyunko Katayama Tetsuya Kako Kyeong-Seong Cheon Yusuke Akazawa Nobuo Kobayashi | 2013 | Euphytica2013，，1： | 1 |
| 15 | Ciliogenesis and ciliary abnormalities显示文摘 | H. Hagiwara Nobuo Ohwada Takeo Aoki Kuniaki Takata | 2000 | Medical Electron Microscopy2000，，3： | 1 |
| 16 | A new approach to cutting state monitoring in end-mill machining显示文摘 | Dong Yeulsong Nobuo Otani Takayuki Aoki | 2005 | International Journal of Machine Tools & Manufacture2005，45，78： | 1 |
| 17 | Industrial Heritage Protection in the Period of Inventory Planning显示文摘After entering the 21 st century,under the influence of urbanization and industrial transformation,China's industrial heritage protection is faced with enormous challenges.In the next 10 years,China's urban planning will enter a turning period from increment planning to inventory planning.Among objects of effective land use,industrial use will stand in the breach,which pushes the industrial heritage to the crossroad of protection or non-protection.Therefore,it is essential to study how to effectively use industrial land under the premise of protecting industrial heritage value.In view of these issues,this paper presents some thoughts about how to protect cultural value of industrial heritage in the period of inventory planning. | XU Subin AOKI Nobuo | 2016 | Journal of Landscape Research2016，8，6： | 0 |
| 18 | 四氢生物蝶呤反应性苯丙氨酸羟化酶缺乏症显示文摘目的四氢生物蝶呤(BH4)可以使BH4缺乏症病人的血液苯丙氨酸水平正常化,但是对苯丙酮酸尿症(PKU)病人无效。最近在新生儿PKU筛查中发现了对BH4有反应的轻度PKU患者。本研究将探讨BH4和苯丙氨酸羟化酶(PAH)基因突变在对BH4有反应的轻度PKU和轻度高苯丙酸血症(HPA)患者中的作用。方法对经新生儿PKU筛查中发现的生物蝶呤代谢正常的轻度HPA患者,进行单次(10mg/kg)、4次、1周[20 mg/(kg·d)]的BH4口服负荷试验及长期BH4治疗,评估其对BH4口服负荷试验的反应性。结果在单剂量BH4口服负荷试验中,典型PKU患者的血苯丙氨酸水平没有降低。在单剂量BH4口服负荷试验中血苯丙氨酸水平下降超过20%的患者,在4次BH4口服负荷试验中下降亦超过20%。1周BH4负荷试验确认在单剂量和4次BH4负荷试验中表现出弱反应性的病人对BH4有反应。许多患轻度PKU和轻度HPA且有R241C基因位点的病人,都对BH4治疗有反应。在无BH4反应性的典型PKU病人中未发现R241C、P407S和A373T基因突变。结论1周BH4负荷试验用于诊断BH4反应性PAH缺乏症最为有效。等位基因R241C、P407S和A373T与轻度HPA和轻度PKU病人具有H4反应性有关。BH4治疗是针对轻度HPA和轻度PKU的一种新颖、有效的药物治疗,有望代替限制苯丙氨酸饮食的方法。 | Haruo SHINTAKU Shigeo KURE Toshihiro OHURA Yoshiyuki OKANO Misao OHWADA Naruji SUGIYAMA Nobuo SAKURA Ichiro YOSHIDA Makoto YOSHINO Yohichi MATSUBARA Ken SUZUKI Kikumaro AOKI Teruo KITAGAWA | 2005 | 中国当代儿科杂志2005，7，4： | 0 |
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