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| 1 | Anti-inflammatory effects of fatty acids isolated from Chromolaena odorata显示文摘Objective:To identify inhibitors of nitric oxide production and NF-κB activity from Chromolaena odorata(C.odorata).Methods:The compounds isolated from the aerial parts of C.odorata by bioassay-guided fractionation were investigated for their inhibitory effects on the NO production and NF-κB activity in LPS-stimulated RAW264.7 cells.Results:Six fatty acids (S)-coriolic acid(1),(S)-coriolic acid methyl ester(2),(5)-15,16-didehydrocoriolic acid(3),(S)- 15,16-didehydrocoriolic acid methyl ester(4),linoleamide(5) and linolenamide(6) were isolated. All compounds inhibited the NO production at concentrations consistent with those required for NF-κB inhibition.Compound 2 was the most active with the IC50 values of 5.22 and 5.73μM. The addition of a double bond in the fatty chain decreased the inhibitory effects while the methyl esterification increased the activities.Conclusions:The fatty acid components in C.odorata with NF-κB inhibitory activity could explain the anti-inflammation property of this plant in traditional medicine.This study could also contribute to the better use of C.odorata for human health care. | Tran Thi Hong Hanh Dan Thi Thuy Hang Chau Van Minh Nguyen Tien Dat | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 3 |
| 2 | Assessing the test–retest repeatability of the V ietnamese version of the N ational E ye I nstitute 25‐item V isual F unction Q uestionnaire among bilateral cataract patients for a V ietnamese population显示文摘 | Kien Gia To Lynn Meuleners Huei‐Yang Chen Andy Lee Dung Van Do Dat Van Duong Tien Duy Phi Hoang Huy Tran Nguyen Do Nguyen | 2014 | Australasian Journal on Ageing2014，，： | 1 |
| 3 | Anti-inflammatory effects of alkaloid enriched extract from roots of Eurycoma longifolia Jack显示文摘Objective: To examine the in vitro and in vivo anti-inflammatory effects of the alkaloid enriched extract(ELA) from the roots of Eurycoma longifolia. Methods: The in vitro antiinflammatory effects of ELA were evaluated by examining its inhibitory activities against nitric oxide(NO) production and inducible nitric oxide synthase(iN OS) and cyclooxygenase2(COX-2) expressions in lipopolysaccharide(LPS)-stimulated RAW264.7 cells. The level of NO produced in the culture media was determined by Griess method. The i NOS and COX-2 protein expressions were analyzed by Western blot. The in vivo effect of ELA was evaluated on LPS-induced septic shock in mice model. Mice mortality was monitored for5 days after injection of LPS. The chemical contents of the ELA were determined by using various chromatographic and spectroscopic techniques. Results: The ELA was found to exhibit a significant anti-inflammatory effect in both in vitro and in vivo models. The results demonstrated that ELA dose-dependently inhibited LPS-induced NO production as well as the protein iN OS and COX-2 expressions. In the septic shock model, ELA dose-dependently protected mice from LPS-induced mortality. Further study on the isolated components of ELA indicated that 9,10-dimethoxycanthin-6-one may contribute significantly to the antiinflammatory effects of the extract. Conclusions: These results suggest that ELA exhibits the anti-inflammatory activity via suppression of pro-inflammatory mediators such as NO, iN OS,and COX-2 and protects mice from LPS-induced mortality in septic shock model. | Dao Thi Thanh Hien Tran Phi Long Tran Phuong Thao Jeong-Hyung Lee Duong Thu Trang Nguyen Thi Thu Minh Pham Van Cuong Do Thi Ngoc Lan Nguyen Hai Dang Nguyen Tien Dat | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，1： | 1 |
| 4 | Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression显示文摘 | DAT NGUYEN TIEN LEE JEONG-HYUNG LEE KYEONG | 2008 | Journal of Natural Products2008，71，10： | 1 |
| 5 | The impact of cataract surgery on depressive symptoms for bilateral cataract patients in Ho Chi Minh City, Vietnam显示文摘 | Kien Gia To Lynn B. Meuleners Michelle L. Fraser Dat Van Duong Dung Van Do Van-Anh Ngoc Huynh Tien Duy Phi Hoang Huy Tran Nguyen Do Nguyen | 2013 | International Psychogeriatrics2013，，： | 1 |
| 6 | Lupane-triterpenes from the leaves ofBrassaiopsis glomerulata显示文摘 | Phan Kiem Nguyen Tien Dat Chau Minh Jung Joon Lee Young Ho Kim | 2003 | Archives of Pharmacal Research2003，，8： | 1 |
| 7 | Cytotoxic prenylated flavonoids from Morus alba显示文摘 | Nguyen Tien Dat Phung Thi Xuan Binh Le Thi Phuong Quynh Chau Van Minh Hoang Thanh Huong Jung Joon Lee | 2010 | Fitoterapia2010，，8： | 1 |
| 8 | Inhibitors of osteoclastogenesis from Lawsonia inermis leaves显示文摘 | Nguyen Xuan Cuong Nguyen Xuan Nhiem Nguyen Phuong Thao Nguyen Hoai Nam Nguyen Tien Dat Hoang Le Tuan Anh Le Mai Huong Phan Van Kiem Chau Van Minh Ji-Hee Won Won-Yoon Chung Young Ho Kim | 2010 | Bioorganic & Medicinal Chemistry Letters2010，，16： | 1 |
| 9 | One-step hydrothermal synthesis of Sn-doped α-Fe_(2)O_(3) nanoparticles for enhanced photocatalytic degradation of Congo red显示文摘We report on the synthesis of Sn-doped hematite nanoparticles(Sn-α-Fe_(2)O_(3) NPs)by the hydrothermal method.The prepared Sn-α-Fe_(2)O_(3) NPs had a highly pure and well crystalline rhombohedral phase with an average particle size of 41.4 nm.The optical properties of as-synthesizedα-Fe_(2)O_(3) NPs show a higher bandgap energy(2.40-2.57 eV)than that of pure bulkα-Fe_(2)O_(3)(2.1 eV).By doping Sn intoα-Fe_(2)O_(3) NPs,the Sn-doped hematite was observed a redshift toward a long wavelength with in-creasing Sn concentration from 0%to 4.0%.The photocatalytic activity of Sn-dopedα-Fe_(2)O_(3) NPs was evaluated by Congo red(CR)dye degradation.The degradation efficiency of CR dye using Sn-α-Fe_(2)O_(3) NPs catalyst is higher than that of pureα-Fe_(2)O_(3) NPs.The highest degradation efficiency of CR dye was 97.8%using 2.5%Sn-dopedα-Fe_(2)O_(3) NPs catalyst under visible-light irradi-ation.These results suggest that the synthesized Sn-dopedα-Fe_(2)O_(3) nanoparticles might be a suitable approach to develop a photocatalytic degradation of toxic inorganic dye in wastewater. | Van Nang Lam Thi Bich Vu Quang Dat Do Thi Thanh Xuan Le Tien Dai Nguyen T-Thanh-Bao Nguyen Hoang Tung Do Thi Tu Oanh Nguyen | 2022 | Journal of Semiconductors2022，43，12： | 0 |
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