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1Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao 2015Frontiers of Medicine2015,9,4:47
2Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration显示文摘1. Introduction Drug-induced liver injury (DILI), defined as liver injury caused by a drug and/or its metabolites, is a common clinical adverse drug reaction1–4. This type of injury can cause acute liver failure and even death in severe cases5.Xiaohe Xiao Jianyuan Tang Yimin Mao Xiuhui Li Jiabo Wang Chenghai Liu Kewei Sun Yong’an Ye Zhengsheng Zou Cheng Peng Ling Yang Yuming Guo Zhaofang Bai Tingting He Jing Jing Fengyi Li Na An 2019Acta Pharmaceutica Sinica B2019,9,3:22
3A Bayesian Stepwise Discriminant Model for Predicting Risk Factors of Preterm Premature Rupture of Membranes: A Case-control Study显示文摘Li-Xia Zhang Yang Sun Hai Zhao Na Zhu Xing-De Sun Xing Jin Ai-Min Zou Yang Mi Ji-Ru Xu 2017Chinese Medical Journal2017,,20:18
4Robotic anterior resection of rectal cancer: technique and early outcome显示文摘DU Xiao-hui SHEN Di LI Rong LI Song-yan NING Ning ZHAO Yun-shan ZOU Zhen-yu LIU Na 2013Chinese Medical Journal2013,,1:15
5Piglets cloned from induced pluripotent stem cells显示文摘Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai 2013Cell Research2013,23,1:12
6Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event.TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou 2018Science China(Physics,Mechanics & Astronomy)2018,61,3:12
7Lee discrepancy on asymmetrical factorials with two-and three-levels显示文摘Lee discrepancy has been employed to measure the uniformity of fractional factorials.In this paper,we further study the statistical justification of Lee discrepancy on asymmetrical factorials.We will give an expression of the Lee discrepancy of asymmetrical factorials with two-and three-levels in terms of quadric form,present a connection between Lee discrepancy,orthogonality and minimum moment aberration,and obtain a lower bound of Lee discrepancy of asymmetrical factorials with two-and three-levels.CHATTERJEE Kashinath QIN Hong ZOU Na 2012Science China Mathematics2012,55,3:7
8The Production of Organic-Inorganic Compound Film-Coated Urea and the Characteristics of Its Nutrient Release显示文摘The effect of different concentrations of natural macromolecular compound on the characteristics of nutrient release in the membrane materials of organic-inorganic compound film-coated urea was discussed, and the optimal concentrations for better nutrient release was proposed. The characteristics of nutrient release of film-coated urea were evaluated by soil column leaching experiment. Organic-inorganic compound film-coated urea showed good characteristics of nutrient release, which could be well simulated by Logistic curve. The two parameters in this curve, a and r, can be used to present nutrient release of film-coated urea, and followed the order of B > C > A and C < B < A, respectively, indicating that the release was stronger with the increasing concentration of natural macromolecular compound in the membrane, which implied better controllability of nutrient release. The concentration of 5% of natural macromolecular compound showed better characteristic of nutrient release and can be utilized as a membrane material combined with inorganic mineral powders to develop film-coated slow-release fertilizer.ZOU Hong-tao, WANG Yao-sheng, SONG Hao-wen, HAN Yan-yu, YU Na, ZHANG Yu-ling, DANG Xiu-li, HUANG Yi and ZHANG Yu-long College of Land and Environmental Sciences, Shenyang Agricultural University/Liaoning Key Laboratory of Agricultural Resources and Environment/Northeast Key Laboratory of Soil and Environment, Ministry of Agriculture, Shenyang 110161, P.R.China 2009Agricultural Sciences in China2009,8,6:6
9Molecular characterization of three Hsp90 from Pieris and expression patterns in response to cold and thermal stress in summer and winter diapause of Pieris melete显示文摘热吃惊蛋白质(Hsps ) 在昆虫被连接了到压力和冬季 diapause,但是他们是否是夏天 diapause 的部件,仍然是未知的。分别地,在这研究,从 Pieris melete 的 Hsp90 的互补 DNA, Pieris rapae 和 Pieris canidia,命名 PmHsp90, PrHsp90 和 PcHsp90 被克隆并且定序。推出的氨基酸顺序分别地与 82.6, 82.6 和 82.7 kDa 的一个通常认为的分子的团由 718 氨基酸残余组成了。氨基酸序列在 Hsp90 家庭和合拢活动区域的 bHLH 蛋白质五个保存签名主题包含了所有。响应夏天 diapause 和冬季 diapause 的 PmHsp90 的微分表示模式,与热 / 寒冷应力有关,被调查。冷应力在夏天和冬季 diapause 蛹,然而并非在 nondiapause 个人导致了 Hsp90 upregulation。热吃惊 upregulated PmHsp90 逐渐地随在夏天 diapause,和 PmHsp90 的温度的增加是很快在冬季 diapause 的 upregulated。在 39 点在 30 min 热以后震惊牥捡慥????????  ???? ???? 吗??Wu, Yue‐Kun Zou, Chao Fu, Dao‐Meng Zhang, Wan‐Na Xiao, Hai‐Jun 2018Insect Science2018,25,2:5
10Activity, but not Expression, of Soluble and Cell Wall-Bound Acid Invertases Is Induced by Abscisic Acid in Developing Apple Fruit显示文摘现在的实验,两个都包含 abscisic 酸(骆驼毛的织物)的体内注射进苹果( Malus domestics Brohk )水果和水果纸巾 包含inABA 的体内孵化中等,表明那件骆驼毛的织物激活可溶并且房间墙界限酸 invertases.Immunoblotting 和连接酶的免疫吸着剂试金证明这导致骆驼毛的织物的酸转化酶激活独立于数量在场的酶。骆驼毛的织物导致的酸转化酶激活依赖于中等 pH,时间功课,骆驼毛的织物剂量,生活织物和发育阶段。cis-(+)-ABA,(-) 骆驼毛的织物和 trans 骆驼毛的织物的 Twoisomers,没在酸转化酶上有效果,显示出导致 thatABA 的酸转化酶激活对活跃 cis-(+) ABA.Proteinkinase 禁止者 K252a 和 H7 以及酸性磷酸酶增加了的生理的联盟者特定导致骆驼毛的织物的效果。这些数据显示那件骆驼毛的织物明确地激活可溶并且由一张帖子的房间墙界限酸转化酶可能包含可逆蛋白质的翻译机制磷酸化,和这可以是由哪个骆驼毛的织物涉及调整水果开发的机制之一。Qiu-Hong Pan Xiang-Chun Yu Na Zhang Xun Zou Chang-Cao Peng Xiu-Ling Wang Ke-Qin Zou Da-Peng Zhang 2006Journal of Integrative Plant Biology2006,48,5:5
11NAD+metabolism:pathophysiologic mechanisms and therapeutic potential显示文摘Nicotinamide adenine dinucleotide(NAD^(+))and its metabolites function as critical regulators to maintain physiologic processes,enabling the plastic cells to adapt to environmental changes including nutrient perturbation,genotoxic factors,circadian disorder,infection,inflammation and xenobiotics.These effects are mainly achieved by the driving effect of NAD^(+)on metabolic pathways as enzyme cofactors transferring hydrogen in oxidation-reduction reactions.Besides,multiple NAD^(+)-dependent enzymes are involved in physiology either by post-synthesis chemical modification of DNA,RNA and proteins,or releasing second messenger cyclic ADPribose(cADPR)and NAADP^(+).Prolonged disequilibrium of NAD^(+)metabolism disturbs the physiological functions,resulting in diseases including metabolic diseases,cancer,aging and neurodegeneration disorder.In this review,we summarize recent advances in our understanding of the molecular mechanisms of NAD^(+)-regulated physiological responses to stresses,the contribution of NAD^(+)deficiency to various diseases via manipulating cellular communication networks and the potential new avenues for therapeutic intervention.Na Xie Lu Zhang Wei Gao Canhua Huang Peter Ernst Huber Xiaobo Zhou Changlong Li Guobo Shen Bingwen Zou 2020Signal Transduction and Targeted Therapy2020,5,1:5
12Overexpression of AHL20 Negatively Regulates Defenses in Arabidopsis显示文摘Plants are equipped to recognize invading pathogenic microbes and activate innate immune responses by sensing pathogen-associated molecular patterns(PAMPs).PAMP-triggered immunity(PTI) is critical for plant resistance to potential pathogens.Although the mechanism by which PTI is activated has been intensively studied,exactly how plants prevent unregulated immune responses is less well understood.Here we provide evidence that AHL20,an AT-hook containing DNA-binding protein,negatively regulates PTI.Overexpression of AHL20 as a stable transgene suppressed PAMP-induced NHO1 and FRK1 expression in Arabidopsis plants.Similarly,transient expression of the closely related family members AHL19,AHL15,and AHL27 in protoplasts also blocked PAMP-induced gene expression.The AHL20 overexpression plants displayed greater susceptibility to virulent Pseudomonas syringae bacteria.These results indicate that AHL proteins play an important role in plant immunity.Haibin Lu Yan ZOU Na Feng 2010Journal of Integrative Plant Biology2010,52,9:5
13Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome显示文摘To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine.Zhenglin Du Liang Ma Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng 2019Genomics, Proteomics & Bioinformatics2019,17,3:4
14Enantiomer-selective Living Polymerization of rac-Phenyl Isocyanide Using Chiral Palladium Catalyst显示文摘We report the polymerization of phenyl isocyanides with the chiral palladium(II) initiating system. The resulting polymers with optically active properties were obtained by polymerization of the racemic isocyanide monomer(rac-1), and enantiomerically unbalanced polymerization of the monomer was found, providing substantial evidence for the enantiomer-selective polymerization of rac-1 mediated through chiral catalyst. A comparison between the enantiomerically pure monomers, 4-isocyanobenzoyl-L-alanine decyl ester(1 s) and 4-isocyanobenzoyl-D-alanine decyl ester(1 r), revealed a drastic discrepancy in the reactivity ratio of their homopolymerizations.It turned out that the monomer reactivity ratio of 1 s was higher than that of 1 r with chiral ligands. The results clearly demonstrated the inclination for incorporation of the 1 s enantiomer during the polymerization process and thus resulted in the enantiomer-selective polymerization in this system. The effects of the catalyst chirality on the optically active properties of polymerization were investigated,and it was concluded that the formation of higher-ordered conformation with a handed helicity might be attributed to the chiral induction of chiral palladium(II) catalyst. Moreover, the polymers obtained through the enantiomer-selective polymerization of the enantiomerically pure monomer were with a significant improvement of the optical activity if the chirality of the monomer and the catalyst matched with each other.Jian Huang Ling Shen Hui Zou Na Liu 2018Chinese Journal of Polymer Science2018,36,7:4
15A Note on Lower Bound of Centered L_2 -discrepancy on Combined Designs显示文摘This note provides a theoretical justification of optimal foldover plans in terms of uniformity. A new lower bound of the centered L2 -discrepancy values of combined designs is obtained, which can be used as a benchmark for searching optimal foldover plans. Our numerical results show that this lower bound is sharper than existing results when more factors reverse the signs in the initial design.Yi Ju LEI Zu Jun OU Hong QIN Na ZOU 2012Acta Mathematica Sinica,English Series2012,28,4:4
16COPII mitigates ER stress by promoting formation of ER whorls显示文摘Cells mitigate ER stress through the unfolded protein response(UPR).Here,we report formation of ER whorls as an effector mechanism of the ER stress response.We found that strong ER stress induces formation of ER whorls,which contain ER-resident proteins such as the Sec61 complex and PKR-like ER kinase(PERK).ER whorl formation is dependent on PERK kinase activity and is mediated by COPII machinery,which facilitates ER membrane budding to form tubular-vesicular ER whorl precursors.ER whorl precursors then go through Sec22b-mediated fusion to form ER whorls.We further show that ER whorls contribute to ER stressinduced translational inhibition by possibly modulating PERK activity and by sequestering translocons in a ribosome-free environment.We propose that formation of ER whorls reflects a new type of ER stress response that controls inhibition of protein translation.Fang Xu Wanqing Du Qin Zou Yuting Wang Xin Zhang Xudong Xing Ying Li Dachuan Zhang Huimin Wang Wenhao Zhang Xinyao Hu Xin Liu Xiaoling Liu Shaojin Zhang Jinqiang Yu Jianhuo Fang Fajin Li Ying Zhou Tieqiang Yue Na Mi Haiteng Deng Peng Zou Xiaowei Chen Xuerui Yang Li Yu 2021Cell Research2021,31,2:4
17Effect of fructooligosaccharides on the colonization of Lactobacillus rhamnosus AS 1.2466^(T) in the gut of mice显示文摘Lactobacillus rhamnosus and fructooligosaccharides(FOS)have been widely studied so far.However,the effects of L.rhamnosus on the intestinal microecological environment at the species level and the effect of different proportions of FOS on L.rhamnosus colonization in different parts of mice intestine are still unclear.The study results indicated that the specific bands of enterobacterial repetitive intergenic consensus polymerase chain reaction(ERIC-PCR)in the L.rhamnosus(LR)group significantly increased at 7 days.Although the number of bands was similar to the natural recovery(NR)group,the brightness of few bands significantly enhanced in the later stage of recovery.Besides,Southern-blot maps showed strong signals,indicating that the ERIC-PCR fingerprint could accurately reflect the changes in the mouse gut microbiota diversity.Further,the high-throughput results confirmed that the Lactobacillus and Akkermansia had different changes at different periods,but all of them showed an upward trend,while the Klebsiella were inhibited,thereby maintaining the intestinal microecology balance.Moreover,FOS exerted a positive effect on L.rhamnosus colonization in the gut.Zhihua Niu Meijuan Zou Tingting Bei Na Zhang Dongyao Li Miaoshu Wang Chen Li Hongtao Tian 2023Food Science and Human Wellness2023,12,2:3
18Increased miR-222 in H. pylori -associated gastric cancer correlated with tumor progression by promoting cancer cell proliferation and targeting RECK显示文摘Na Li Bin Tang En-Dong Zhu Bo-sheng Li Yuan Zhuang Shu Yu Dong-shui Lu Quan-Ming Zou Bin Xiao Xu-Hu Mao 2012FEBS Letters2012,,6:3
19Two new isospirostanol sapogenins from Reineckia carnea显示文摘说出的二新 isospirostanol sapogenins (25R )-5-spirostane-(1, 3 )-diol (1 ) 并且(25R )-5-spirostane-(1, 2, 3, 4 )-tetrol (2 ) 从 Reineckia carnea (Andr ) 的整个植物被孤立 Kunth。sapogenins 的结构被化学、光谱的方法阐明。Yao Wang Na Han Ling Li Chen Zhi Hui Liu Li Bo Zou Jun Yin 2012Chinese Chemical Letters2012,23,11:3
20A comparative study of autogenous, allograft and artificial bone substitutes on bone regeneration and immunotoxicity in rat femur defect model显示文摘Repair and reconstruction of large bone defect were often difficult,and bone substitute materials,including autogenous bone,allogenic bone and artificial bone,were common treatment strategies.The key to elucidate the clinical effect of these bone repair materials was to study their osteogenic capacity and immunotoxicological compatibility.In this paper,the mechanical properties,micro-CT imaging analysis,digital image analysis and histological slice analysis of the three bone grafts were investigated and compared after different time points of implantation in rat femur defect model.Autogenous bone and biphasic calcium phosphate particular artificial bone containing 61.4% HA and 38.6%β-tricalcium phosphate with 61.64%porosity and 0.8617±0.0068 g/cm^(3) den-sity(d≤2 mm)had similar and strong bone repair ability,but autogenous bone implant materials caused greater secondary damage to experimental animals;allogenic bone exhibited poor bone defect repair ability.At the early stage of implantation,the immunological indexes such as Immunoglobulin G,Immunoglobulin M concentration and CD4 cells'population of allogenic bone significantly increased in compared with those of autologous bone and artificial bone.Although the repair process of artificial bone was relatively inefficient than autologous bone graft,the low immunotoxicological indexes and acceptable therapeutic effects endowed it as an excellent alter-native material to solve the problems with insufficient source and secondary trauma of autogenous bone.Wen Zou Xing Li Na Li Tianwei Guo Yongfu Cai Xiaoqin Yang Jie Liang Yong Sun Yujiang Fan 2021Regenerative Biomaterials2021,8,1:3
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