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| 1 | Pediatric nonalcoholic fatty liver disease,metabolic syndrome and cardiovascular risk显示文摘Nonalcoholic fatty liver disease(NAFLD) encompasses a range of liver histology severity and outcomes in the absence of chronic alcohol use.The mildest form is simple steatosis in which triglycerides accumulate within hepatocytes.A more advanced form of NAFLD,nonalcoholic steatohepatitis,includes inflammation and liver cell injury,progressive to cryptogenic cirrhosis.NAFLD has become the most common cause of chronic liver disease in children and adolescents.The recent rise in the prevalence rates of overweight and obesity likely explains the NAFLD epidemic worldwide.NAFLD is strongly associated with abdominal obesity,type 2 diabetes,and dyslipidemia,and most patients have evidence of insulin resistance.Thus,NAFLD shares many features of the metabolic syndrome(MetS),a highly atherogenic condition,and this has stimulated interest in the possible role of NAFLD in the development of atherosclerosis.Accumulating evidence suggests thatNAFLD is associated with a significantly greater overall mortality than in the general population,as well as with increased prevalence of cardiovascular disease(CVD),independently of classical atherosclerotic risk factors.Yet,several studies including the pediatric population have reported independent associations between NAFLD and impaired flow-mediated vasodilatation and increased carotid artery intimal medial thickness-two reliable markers of subclinical atherosclerosis-after adjusting for cardiovascular risk factors and MetS.Therefore,the rising prevalence of obesity-related MetS and NAFLD in childhood may lead to a parallel increase in adverse cardiovascular outcomes.In children,the cardiovascular system remains plastic and damage-reversible if early and appropriate interventions are established effectively.Therapeutic goals for NAFLD should address nutrition,physical activity,and avoidance of smoking to prevent not only end-stage liver disease but also CVD. | Lucia Pacifico Valerio Nobili Caterina Anania Paola Verdecchia Claudio Chiesa | 2011 | World Journal of Gastroenterology2011，17，26： | 24 |
| 2 | Genomic and genetic alterations influence the progression of gastric cancer显示文摘Gastric cancer is one of the leading causes of cancerrelated deaths worldwide, although the incidence has gradually decreased in many Western countries. Two main gastric cancer histotypes, intestinal and diffuse, are recognised. Although most of the described genetic alterations have been observed in both types, different genetic pathways have been hypothesized. Genetic and epigenetic events, including 1q loss of heterozygosity (LOH), microsatellite instability and hypermethylation, have mostly been reported in intestinal-type gastric carcinoma and its precursor lesions, whereas 17p LOH, mutation or loss of E-cadherin are more often implicated in the development of diffuse-type gastric cancer.In this review, we summarize the sometimes contradictory findings regarding those markers which influence the progression of gastric adenocarcinoma. | Stefania Nobili Lorenzo Bruno Ida Landini Cristina Napoli Paolo Bechi Francesco Tonelli Carlos A Rubio Enrico Mini Gabriella Nesi | 2011 | World Journal of Gastroenterology2011，17，3： | 17 |
| 3 | 绿肥分解产物中水溶性有机物质的伏安行为及其影响因素显示文摘绿肥分解产物中的水溶性有机物质的峰数和电流值随绿肥培养时间和种类而异。分子量为120—130和140—160的水溶性有机物质具有明显的伏安行为,大于160者则贡献较小或无贡献。pH、亚铁和土壤类型对水溶性有机物质的伏安行为有显著影响。 | 丁昌璞 M.De Nobili B.Ceccanti | 1989 | 土壤学报1989，26，4： | 11 |
| 4 | MicroRNAs as controlled systems and controllers in non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a multi-faceted condition including simple steatosis alone or associated with inflammation and ballooning(non-alcoholic steatohepatitis) and eventually fibrosis.The NAFLD incidence has increased over the last twenty years becoming the most frequent chronic liver disease in industrialized countries.Obesity,visceral adiposity,insulin resistance,and many other disorders that characterize metabolic syndrome are the major predisposing risk factors for NAFLD.Furthermore,different factors,including genetic background,epigenetic mechanisms and environmental factors,such as diet and physical exercise,contribute to NAFLD development and progression.Several lines of evidence demonstrate that specific microRNAs expression profiles are strongly associated with several pathological conditions including NAFLD.In NAFLD,microRNA deregulation in response to intrinsic genetic or epigenetic factors or environmental factors contributes to metabolic dysfunction.In this review we focused on microRNAs role both as controlled and controllers molecules in NAFLD development and/or their eventual value as non-invasive biomarkers of disease. | Nadia Panera Daniela Gnani Annalisa Crudele Sara Ceccarelli Valerio Nobili Anna Alisi | 2014 | World Journal of Gastroenterology2014，20，41： | 9 |
| 5 | Epidemiology of fatty liver: An update显示文摘We provide a concise review of the main epidemiological literature on fatty liver(FL) published between January 2011 and October 2013. The findings from the literature will be considered in light of the already available knowledge. We discuss the limitations inherent in the categorization of FL into non-alcoholic and alcoholic FL, the potential relevance of FL as an independent predictor of cardiometabolic disease, and recent research addressing the role of FL as an independent predictor of mortality. This review is organized as a series of answers to relevant questions about the epidemiology of FL. | Giorgio Bedogni Valerio Nobili Claudio Tiribelli | 2014 | World Journal of Gastroenterology2014，20，27： | 7 |
| 6 | 紫云英和稻草在分解过程中水溶性有机物质的变化显示文摘借助气相色谱、阴极溶出伏安法、循环伏安法及凝胶分离等手段,研究了紫云英和稻草在培养分解过程中水溶性有机物质的变化。结果表明,挥发性有机酸及水溶性有机物质中的碳、氮、二价硫、酚类物质的数量、种类及其变化因植物的种类及分解阶段而异。 | 丁昌璞 B.Ceccanti Maria De Nobili R.Tarsitano | 1991 | 土壤1991，23，1： | 6 |
| 7 | Non invasive evaluation of liver fibrosis in paediatric patients with nonalcoholic steatohepatitis显示文摘AIM: To identify the independent predictors of hepatic fibrosis in 69 children with nonalcoholic steatohepatitis (NASH) due to nonalcoholic fatty liver disease (NAFLD). METHODS: All patients with clinically suspected NASH underwent liver biopsy as a confirmatory test. The following clinical and biochemical variables at baseline were examined as likely predictors of fibrosis at histology: age, body mass index (BMI), systolic blood pressure (SBP), dyastolic blood pressure (DBP), fasting glucose, fasting insulin, homeostatic model assessment for insulin resistence (HOMA-IR), cholesterol, tryglicerides, alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST/ALT ratio, gamma glutamil transferase (GT), platelet count, prothrombin time (PT). RESULTS: At histology 28 (40.6%) patients had no fibrosis and 41 (59.4%) had mild to bridging fibrosis. At multivariate analysis, BMI > 26.3 was the only independent predictor of fibrosis (OR = 5.85, 95% CI = 1.6-21). CONCLUSION: BMI helps identify children with NASH who might have fibrotic deposition in the liver. | Angelo Iacobellis Matilde Marcellini Angelo Andriulli Francesco Perri Gioacchino Leandro Rita Devito Valerio Nobili | 2006 | World Journal of Gastroenterology2006，12，48： | 5 |
| 8 | Pediatric non-alcoholic fatty liver disease:Preventive and therapeutic value of lifestyle intervention显示文摘Nonalcoholic fatty liver disease(NAFLD),ranging from simple steatosis to nonalcoholic steatohepatitis(NASH),and eventually cirrhosis and liver failure,is seen to be increasing amongst Western children.NAFLD rates are rising in parallel with the epidemic of childhood obesity,and in particular,fatty liver evolves more easily in NASH when poor dietary habits and sedentary lifestyle are combined.In fact,its general prevalence in the child population varies between 2.6% and 10%,but increases up to 80% in obese children.Since NASH is expected to become the most common cause of pediatric chronic liver disease in the near future,there is broad interest amongst clinical researchers to move forward,both in diagnosis and treatment.Unfortunately,to date,the expensive and invasive procedure of liver biopsy is seen as the gold standard for NASH diagnosis and few noninvasive diagnostic methods can be applied successfully.Moreover,there are still no approved pharmacological interventions for NAFLD/NASH.Therefore,current management paradigms are based upon the presence of associated risk factors and aims to improve an individual's quality of life,thus reducing NAFLD-associated morbidity and mortality.Today,lifestyle intervention(diet and exercise) is the treatment of choice for NAFLD/ NASH.Thus far,no study has evaluated the potential preventive effect of lifestyle intervention on children at risk of NAFLD/NASH.Future studies will be required in this area with the perspective of developing a national program to promote nutrition education and increase physical activity as means of preventing the disease in individuals at risk.Here,we outline the clinical course,pathogenesis and management of NAFLD in children,highlighting the preventive and therapeutic value of lifestyle intervention. | Valerio Nobili Anna Alisi Massimiliano Raponi | 2009 | World Journal of Gastroenterology2009，15，48： | 5 |
| 9 | Toll-like receptor-mediated signaling cascade as a regulator of the inflammation network during alcoholic liver disease显示文摘Chronic abuse of alcohol leads to various histological abnormalities in the liver. These are conditions collectively known as alcoholic liver disease(ALD). Currently, ALD is considered to be one of the major causes of death worldwide. An impaired intestinal barrier with related endotoxemia is among the various pathogenetic factors. This is mainly characterized by circulating levels of lipopolysaccharide(LPS), considered critical for the onset of intra-hepatic inflammation. This in turn promotes hepatocellular damage and fibrosis in ALD. Elevated levels of LPS exert their effects by binding to Toll-like receptors(TLRs) which are expressed by all liver-resident cells. The activation of TLR signaling triggers an overproduction and release of some cytokines, which promote an autocatalytic cascade of other proinflammatory signals. In this review, we provide an overview of the mechanisms that sustain LPS-mediated activation of TLR signaling, reporting current experimental and clinical evidence of its role during inflammation in ALD. | Sara Ceccarelli Valerio Nobili Anna Alisi | 2014 | World Journal of Gastroenterology2014，20，44： | 4 |
| 10 | Short term soil priming effects and the mineralisation of biochar following its incorporation to soils of different pH显示文摘 | Y. Luo M. Durenkamp M. De Nobili Q. Lin P.C. Brookes | 2011 | Soil Biology and Biochemistry2011，，11： | 3 |
| 11 | A 360-Degree Overview Of Paediatric Nafld: Recent Insights显示文摘 | Valerio Nobili Gianluca Svegliati-Baroni Anna Alisi Luca Miele Luca Valenti Pietro Vajro | 2012 | Journal of Hepatology2012，，： | 3 |
| 12 | Amyloid positron emission tomography and cognitive reserve显示文摘Alzheimer's disease(AD) is characterized by a nonlinear progressive course and several aspects influence the relationship between cerebral amount of AD pathology and the clinical expression of the disease. Brain cognitive reserve(CR) refers to the hypothesized capacity of an adult brain to cope with brain damage in order to minimize symptomatology. CR phenomenon contributed to explain the disjunction between the degree of neurodegeneration and the clinical phenotype of AD. The possibility to track brain amyloidosis(Aβ) in vivo has huge relevance for AD diagnosis and new therapeutic approaches. The clinical repercussions of positron emission tomography(PET)-assessed Aβ load are certainly mediated by CR thus potentially hampering the prognostic meaning of amyloid PET in selected groups of patients. Similarly, amyloid PET and cerebrospinal fluid amyloidosis biomarkers have recently provided new evidence for CR. The present review discusses the concept of CR in the framework of available neuroimaging studies and specifically deals with the reciprocal influences between amyloid PET and CR in AD patients and with the potential consequent interventional strategies for AD. | Matteo Bauckneht Agnese Picco Flavio Nobili Silvia Morbelli | 2015 | World Journal of Radiology2015，7，12： | 3 |
| 13 | Ultrasonographic Quantitative Estimation of Hepatic Steatosis in Children With NAFLD显示文摘 | Angela Shannon Naim Alkhouri Christine Carter-Kent Lidia Monti Rita Devito Rocio Lopez Ariel E. Feldstein Valerio Nobili | 2011 | Journal of Pediatric Gastroenterology and Nutrition2011，，2： | 3 |
| 14 | DLC coatings for hydraulic applications显示文摘与水或低粘性的液体润滑油的代替在许多工业领域里是高度合乎需要的,由于环境、节俭的优点。水的低润滑可能为水力的部件的合适的操作是不够的,并且像钻石的碳(DLC ) 涂层作为稳固的润滑剂电影很吸引人。一个遥远血浆的 PACVD 过程被利用扔 hydrogenated DLC 涂层(交流: H ) 在不同底层上。Microindentation 大小证明涂层坚硬在 35 GPa 附近。Tribological 行为被测试与氧化铝在水和水里执行了的 block-on-ring 评估。wear 率在由激光 profilemeter 测量 wear 体积以后被计算。wear 轨道的词法、组合的分析表明那涂层失败可以由磨料发生穿或分层,取决于底层性质。难、光滑的底层给最好的结果,驱散的氧化铝粒子增加 wear 率。 | Luca NOBILI Luca MAGAGNIN | 2009 | 中国有色金属学会会刊:英文版2009，19，4： | 2 |
| 15 | Management of chronic hepatitis B in children: An unresolved issue显示文摘 | Claudia Della Corte Valerio Nobili Donatella Comparcola Francesca Cainelli Sandro Vento | 2014 | J Gastroenterol Hepatol2014，，5： | 2 |
| 16 | Association Between a Polymorphism in Cannabinoid Receptor 2 and Severe Necroinflammation in Patients With Chronic Hepatitis C显示文摘 | Nicola Coppola Rosa Zampino Giulia Bellini Margherita Macera Aldo Marrone Mariantonietta Pisaturo Adriana Boemio Bruno Nobili Giuseppe Pasquale Sabatino Maione Luigi Elio Adinolfi Laura Perrone Evangelista Sagnelli Emanuele Miraglia Del Giudice Francesca | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 17 | Ultrasonographic Quantitative Estimation of Hepatic Steatosis in Children With NAFLD显示文摘 | Angela Shannon Naim Alkhouri Christine Carter-Kent Lidia Monti Rita Devito Rocio Lopez Ariel E. Feldstein Valerio Nobili | 2011 | Journal of Pediatric Gastroenterology and Nutrition2011，，2： | 2 |
| 18 | The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies显示文摘 | Ahmad Al-Serri Quentin M. Anstee Luca Valenti Valerio Nobili Julian B.S. Leathart Paola Dongiovanni Julia Patch Anna Fracanzani Silvia Fargion Christopher P. Day Ann K. Daly | 2011 | Journal of Hepatology2011，，2： | 2 |
| 19 | Statin use and non-alcoholic steatohepatitis in at risk individuals显示文摘 | Paola Dongiovanni Salvatore Petta Ville Mannisto Rosellina Margherita Mancina Rosaria Pipitone Vesa Karja Marco Maggioni Pirjo Kakela Olov Wiklund Enrico Mozzi Stefania Grimaudo Dorota Kaminska Raffaela Rametta Antonio Craxi Silvia Fargion Valerio Nobili | 2015 | Journal of Hepatology2015，，3： | 2 |
| 20 | Effects of long-term Donepezil therapy on rCBF of Alzheimer's patients显示文摘 | Nobili F Vitali P Canfora M | 2002 | Clin Neuro physiol2002，113，8： | 2 |
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