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| 1 | Hepatitis C virus infection and thyroid autoimmunedisorders:A model of interactions between the host and theenvironment显示文摘The hepatitis C virus(HCV) infection is an important public health problem and it is associated with hepatic and extrahepatic manifestations. Autoimmune thyroid diseases are common in HCV infected patients and the standard interferon-based treatment is associated with an increase of the immune-mediated thyroid damage. Recent evidence in the literature analyzed critical points of the mechanisms of thyroid damage, focusing on the balance between the two sides of the interaction: The environment(virus infection with potential crossreaction) and the host(susceptibility genes with consistent immune response). The spectrum of antiviral treatment for chronic HCV infection is rapidly expanding for the development of dual o triple therapy. The availability of interferon-free combined treatment with direct antiviral agents for HCV is very promising, in order to ameliorate the patient compliance and to reduce the development of thyroid autoimmunity. | francesca pastore antonio martocchia manuela stefanelli pietro prunas stefania giordano lavinia toussan antonio devito paolo falaschi | 2016 | World Journal of Hepatology2016，8，2： | 12 |
| 2 | Non invasive evaluation of liver fibrosis in paediatric patients with nonalcoholic steatohepatitis显示文摘AIM: To identify the independent predictors of hepatic fibrosis in 69 children with nonalcoholic steatohepatitis (NASH) due to nonalcoholic fatty liver disease (NAFLD). METHODS: All patients with clinically suspected NASH underwent liver biopsy as a confirmatory test. The following clinical and biochemical variables at baseline were examined as likely predictors of fibrosis at histology: age, body mass index (BMI), systolic blood pressure (SBP), dyastolic blood pressure (DBP), fasting glucose, fasting insulin, homeostatic model assessment for insulin resistence (HOMA-IR), cholesterol, tryglicerides, alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST/ALT ratio, gamma glutamil transferase (GT), platelet count, prothrombin time (PT). RESULTS: At histology 28 (40.6%) patients had no fibrosis and 41 (59.4%) had mild to bridging fibrosis. At multivariate analysis, BMI > 26.3 was the only independent predictor of fibrosis (OR = 5.85, 95% CI = 1.6-21). CONCLUSION: BMI helps identify children with NASH who might have fibrotic deposition in the liver. | Angelo Iacobellis Matilde Marcellini Angelo Andriulli Francesco Perri Gioacchino Leandro Rita Devito Valerio Nobili | 2006 | World Journal of Gastroenterology2006，12，48： | 5 |
| 3 | High efficiency, high power 808nm laser array and stacked arrays optimized for elevated temperature operation显示文摘Operation of 808-nm laser diode pumping at elevated temperature is crucial to many applications. Reliable operation at high power is limited by high thermal load and low catastrophic optical mirror damage (COMD) threshold at elevated temperature range. We demonstrated high efficiency and high power operation at elevated temperature with high COMD power. These results were achieved through device design optimization such as growth conditions, doping profile, and materials composition of the quantum-well and other layers. Electrical-to-optical efficiency as high as 62% was obtained through lowered threshold current, lowered series resistance and increased slope efficiency. The performance of single broad-area laser diodes scales to that of high power single bars on water-cooled copper micro-channel heatsinks or conductively-cooled CS heatsinks. No reduction in bar performance or significant spectral broadening is seen when these micro-channel coolers are assembled into 6-bar and 18-bar CW stacks for the highest power levels. | Crump P A Crum T R DeVito M Farmer J Grimshaw M Huang Z Igl S A Macomber S Thiagarajan P Wise D | 2004 | 光机电信息2004，21，6： | 4 |
| 4 | Ultrasonographic Quantitative Estimation of Hepatic Steatosis in Children With NAFLD显示文摘 | Angela Shannon Naim Alkhouri Christine Carter-Kent Lidia Monti Rita Devito Rocio Lopez Ariel E. Feldstein Valerio Nobili | 2011 | Journal of Pediatric Gastroenterology and Nutrition2011，，2： | 3 |
| 5 | CT enterography vs. capsule endoscopy显示文摘 | Howard S. Boriskin Bethany S. Devito John J. Hines Victor J. Scarmato Barak Friedman | 2009 | Abdominal Imaging2009，，2： | 2 |
| 6 | Ultrasonographic Quantitative Estimation of Hepatic Steatosis in Children With NAFLD显示文摘 | Angela Shannon Naim Alkhouri Christine Carter-Kent Lidia Monti Rita Devito Rocio Lopez Ariel E. Feldstein Valerio Nobili | 2011 | Journal of Pediatric Gastroenterology and Nutrition2011，，2： | 2 |
| 7 | R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance 显示文摘 | Skripkin E McConnell T S DeVito J | 2008 | Antimicrob Agents Chemother2008，52，10： | 1 |
| 8 | Nurse-administered propofol sedation: feasibility and safety in bronchoscopy 显示文摘 | Bosslet GT Devito ML Lahm T | 2010 | Respiration2010，79，4： | 1 |
| 9 | Methamphetamine induced neuronal damage : Apossible role for free radicals 显示文摘 | Devito M J Wagner G C | 1989 | Neuropharmacol1989，28，10： | 1 |
| 10 | hippocampus and medial 'what-where-when' components Distinct contributions of the prefrontal cortex to the of episodic-like memory in mice 显示文摘 | Devito LM Eichenbaum H | 2010 | Behav Brain Res2010，215，2： | 1 |
| 11 | Serine racemase deletion disrupts memory for order and alters cortical dendritic morpholo- gy显示文摘 | DeVito LM Balu DT Kanter BR | 2011 | Genes Brain Behav2011，10，2： | 1 |
| 12 | Developmental exposureto brominated diphenyl ethers reaults in thyroid hormone disruption显示文摘 | ZHOU T TAYLOR M M DEVITO M J | 2002 | ToxicolSci2002，66，1： | 1 |
| 13 | Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: A randomized, controlled trial显示文摘 | Nobili V Manco M Devito R | 2008 | Hepatology2008，48，1： | 1 |
| 14 | Acute administration of 2,4,7,8-tetrachlorodibenzo-p-dioxin(TCDD)in pregnant Long Evans rats:association of measured tissue concentrations with developmental effects显示文摘 | Hurst CH Devito MJ Setzer RW | 2000 | Toxicol Sci2000，53，2： | 1 |
| 15 | Nitrate dynamics in relation to lithology and hydrologic flow path in a river riparian zone显示文摘 | Devito K J Fritzgerald D Hill A R | 2000 | Journal of Environmental Quality2000，29，： | 1 |
| 16 | Predictive modeling of a mixture of thyroid hormone disrupting chemicals that affect production and clearance of thyroxine显示文摘 | Flippin J L Hedge J M DeVito M J | 2009 | International Journal of Toxicology2009，28，5： | 1 |
| 17 | Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption显示文摘 | Zhou T Taylor M M DeVito M J | 2002 | Toxicological Sciences2002，66，1： | 1 |
| 18 | Nitrate dynamics in relation to lithology and hydrologic flow path in a river riparian zone 显示文摘 | Devito K J Fitzgerald D Hill A R | 2000 | Journal of Environmental Quality2000，29，： | 1 |
| 19 | Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation显示文摘 | Wang J Gallagher D DeVito LM | 2012 | Cell Stem Ce112012，11，1： | 1 |
| 20 | Soil N cy- cling in harvested and pristine Boreal forests and peatlands 显示文摘 | WESTBROOK C J DEVITO K J ALLAN C J | 2006 | Forest Ecology and Managemen2006，234，13： | 1 |
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