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| 1 | MicroRNAs as controlled systems and controllers in non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a multi-faceted condition including simple steatosis alone or associated with inflammation and ballooning(non-alcoholic steatohepatitis) and eventually fibrosis.The NAFLD incidence has increased over the last twenty years becoming the most frequent chronic liver disease in industrialized countries.Obesity,visceral adiposity,insulin resistance,and many other disorders that characterize metabolic syndrome are the major predisposing risk factors for NAFLD.Furthermore,different factors,including genetic background,epigenetic mechanisms and environmental factors,such as diet and physical exercise,contribute to NAFLD development and progression.Several lines of evidence demonstrate that specific microRNAs expression profiles are strongly associated with several pathological conditions including NAFLD.In NAFLD,microRNA deregulation in response to intrinsic genetic or epigenetic factors or environmental factors contributes to metabolic dysfunction.In this review we focused on microRNAs role both as controlled and controllers molecules in NAFLD development and/or their eventual value as non-invasive biomarkers of disease. | Nadia Panera Daniela Gnani Annalisa Crudele Sara Ceccarelli Valerio Nobili Anna Alisi | 2014 | World Journal of Gastroenterology2014，20，41： | 9 |
| 2 | Pediatric non-alcoholic fatty liver disease:Preventive and therapeutic value of lifestyle intervention显示文摘Nonalcoholic fatty liver disease(NAFLD),ranging from simple steatosis to nonalcoholic steatohepatitis(NASH),and eventually cirrhosis and liver failure,is seen to be increasing amongst Western children.NAFLD rates are rising in parallel with the epidemic of childhood obesity,and in particular,fatty liver evolves more easily in NASH when poor dietary habits and sedentary lifestyle are combined.In fact,its general prevalence in the child population varies between 2.6% and 10%,but increases up to 80% in obese children.Since NASH is expected to become the most common cause of pediatric chronic liver disease in the near future,there is broad interest amongst clinical researchers to move forward,both in diagnosis and treatment.Unfortunately,to date,the expensive and invasive procedure of liver biopsy is seen as the gold standard for NASH diagnosis and few noninvasive diagnostic methods can be applied successfully.Moreover,there are still no approved pharmacological interventions for NAFLD/NASH.Therefore,current management paradigms are based upon the presence of associated risk factors and aims to improve an individual's quality of life,thus reducing NAFLD-associated morbidity and mortality.Today,lifestyle intervention(diet and exercise) is the treatment of choice for NAFLD/ NASH.Thus far,no study has evaluated the potential preventive effect of lifestyle intervention on children at risk of NAFLD/NASH.Future studies will be required in this area with the perspective of developing a national program to promote nutrition education and increase physical activity as means of preventing the disease in individuals at risk.Here,we outline the clinical course,pathogenesis and management of NAFLD in children,highlighting the preventive and therapeutic value of lifestyle intervention. | Valerio Nobili Anna Alisi Massimiliano Raponi | 2009 | World Journal of Gastroenterology2009，15，48： | 5 |
| 3 | Toll-like receptor-mediated signaling cascade as a regulator of the inflammation network during alcoholic liver disease显示文摘Chronic abuse of alcohol leads to various histological abnormalities in the liver. These are conditions collectively known as alcoholic liver disease(ALD). Currently, ALD is considered to be one of the major causes of death worldwide. An impaired intestinal barrier with related endotoxemia is among the various pathogenetic factors. This is mainly characterized by circulating levels of lipopolysaccharide(LPS), considered critical for the onset of intra-hepatic inflammation. This in turn promotes hepatocellular damage and fibrosis in ALD. Elevated levels of LPS exert their effects by binding to Toll-like receptors(TLRs) which are expressed by all liver-resident cells. The activation of TLR signaling triggers an overproduction and release of some cytokines, which promote an autocatalytic cascade of other proinflammatory signals. In this review, we provide an overview of the mechanisms that sustain LPS-mediated activation of TLR signaling, reporting current experimental and clinical evidence of its role during inflammation in ALD. | Sara Ceccarelli Valerio Nobili Anna Alisi | 2014 | World Journal of Gastroenterology2014，20，44： | 4 |
| 4 | A 360-Degree Overview Of Paediatric Nafld: Recent Insights显示文摘 | Valerio Nobili Gianluca Svegliati-Baroni Anna Alisi Luca Miele Luca Valenti Pietro Vajro | 2012 | Journal of Hepatology2012，，： | 3 |
| 5 | Pathogen- or damage- associated molecular patterns during nonalcoholic fatty liver disease development 显示文摘 | Alisi A Carsetti R Nobili V | 2011 | Hepatology2011，54，5： | 1 |
| 6 | Retinol-binding protein 4: A promising circulat- ing marker of liver damage in pediatric nonalco- holic fatty liver disease显示文摘 | NOBILI V ALKHOURI N ALISI A | 2009 | Clin Gastroenterol Hepatol2009，7，5： | 1 |
| 7 | I148M patatin-like phospholipase domain-containing3gene variant and severi-ty of pediatric nonalcoholic fatty liver disease显示文摘 | Valenti L Alisi A Galmozzi E | 2010 | Hepatolo-gy2010，52，4： | 1 |
| 8 | Thr 446 phosphorylation of PKR by HCV core protein deregulates G2/M phase in HCC cells显示文摘 | Alisi A Mele R Spaziani A | 2005 | J Cell Physiol2005，205，： | 1 |
| 9 | A study of low-en- ergy ion beam effects on outer plant cell structure for exoge- nous macromolecule transferring显示文摘 | VILAITHONG T YU L D ALISI C eta/ | 2000 | Surface and Coatings Tech- nology2000，，7： | 1 |
| 10 | Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease:Double-blind ran- domized controlled clinical trial显示文摘 | Nobili V Bedogni G Alisi A | 2011 | Arch Dis Child2011，96，4： | 1 |
| 11 | Pathogen‐ or damage‐associated molecular patterns during nonalcoholic fatty liver disease development显示文摘 | Anna Alisi Rita Carsetti Valerio Nobili | 2011 | Hepatology2011，，5： | 1 |
| 12 | Pediatric nonalcoholic fatty liver disease: a multidisciplinary approach 显示文摘 | Alisi A Feldstein AE Villani A | 2012 | Nat Rev Gastroenterol Hepatol2012，179，3： | 1 |
| 13 | Thyroid hormones regulate DNA-synthesis and cell-cycle proteins by activation of PKC alpha and p42/44 MAPK in chick embryo hepatocytes 显示文摘 | Alisi A Spagnuolo S Napoletano S | 2004 | J Cell Physiol2004，201，2： | 1 |
| 14 | Thyroid status affects rat liver regeneration after partial hepatectomy by regulating cell cycle and apoptosis 显示文摘 | Alisi A Demori I Spagnuolo S | 2005 | Cell Physiol Biochem2005，15，14： | 1 |
| 15 | Non-alcoholic fatty liver disease in children now:lifestyle changes and pharmacologic treatments显示文摘 | Alisi A Nobili V | | 0，，7： | 1 |
| 16 | A protective effect of breastfeeding on the progression of non-alcoholic fatty liver disease显示文摘 | Nobili V Bedogni G Alisi A | 2009 | Arch Dis Child2009，94，10： | 1 |
| 17 | Retinoic acid modulates the cell-cycle in fetal rat hepatocytes and HepG2 cells by regulating cyclin-cdk activities显示文摘 | Alisi A Leoni S Piacentani A | 2003 | Liver2003，23，3： | 1 |
| 18 | Low birth weight and catch-up-growth associated with metabolic syndrome: a ten year systematic review 显示文摘 | Nobili V Alisi A Panera N Agostoni C | 2008 | Pediatr Endocrinol Rev2008，6，2： | 1 |
| 19 | Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease:double-blind randomised controlled clinical trial显示文摘 | Nobili V Bedogni G Alisi A | | 0，，04： | 1 |
| 20 | A study of low-energy ion beam effect on outer plant cell structure for exogenous macromolecule transferring显示文摘 | Vilaithong T Yu L D Alisi C | 2000 | Surface and Coatings Technology2000，，128129： | 1 |
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