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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | A comparison of survival and pathologic features of non-alcoholic steatohepatitis and hepatitis C virus patients with hepatocellular carcinoma显示文摘AIM:To compare the clinical outcome and pathologic features of non-alcoholic steatohepatitis(NASH) patients with hepatocellular carcinoma(HCC) and hepatitic C virus(HCV) patients with HCC(another group in which HCC is commonly seen) undergoing liver transplantation.METHODS:Patients transplanted for HCV and NASH at our institution from January 2000 to April 2011 were analyzed.All explanted liver histology and pre-transplant liver biopsies were examined by two specialist liver histopathologists.Patient demographics,disease free survival,explant liver characteristics and HCC features(tumour number,cumulative tumour size,vascular invasion and differentiation) were compared between HCV and NASH liver transplant recipients.RESULTS:A total of 102 patients with NASH and 283 patients with HCV were transplanted.The incidence of HCC in NASH transplant recipients was 16.7%(17/102).The incidence of HCC in HCV transplant recipients was 22.6%(64/283).Patients with NASH-HCC were statistically older than HCV-HCC patients(P < 0.001).A significantly higher proportion of HCV-HCC patients had vascular invasion(23.4% vs 6.4%,P = 0.002) and poorly differentiated HCC(4.7% vs 0%,P < 0.001) compared to the NASH-HCC group.A trend of poorer recurrence free survival at 5 years was seen in HCV-HCC patients compared to NASH-HCC who underwent a Liver transplantation(P = 0.11).CONCLUSION:Patients transplanted for NASH-HCC appear to have less aggressive tumour features compared to those with HCV-HCC,which likely in part accounts for their improved recurrence free survival. | Roberto Hernandez-Alejandro Kris P Croome Martin Drage Nathalie Sela Jeremy Parfitt Natasha Chandok Paul Marotta Cheryl Dale William Wall Douglas Quan | 2012 | World Journal of Gastroenterology2012，18，31： | 5 |
| 3 | Cyclosporin A inhibits hypoxia-induced pulmonary hypertension and right ventricle hypertrophy 显示文摘 | NATHALIE VALE'RIE N C ANDRE P | 2006 | Am d Respir Crit Care Med2006，174，6： | 1 |
| 4 | Cell - cycle - dependent expression of transforming growth factor β type Ⅰ receptor correlates with differential proliferative effects if TGF - β1 in articular chondrocytes显示文摘 | Nathalie F Jean - Pierre P | 1998 | Experimental cell research1998，243，： | 1 |
| 5 | Selective proges terone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications显示文摘 | Nathalie C B Meduri G Bo'uchard P | 2005 | Hum Re prod Update2005，11，： | 1 |
| 6 | Determining Robust Impacts of Land-Use-Induced Land Cover Changes on Surface Climate over North America and Eurasia: Results from the First Set of LUCID Experiments显示文摘 | de Noblet-Ducoudré Nathalie Boisier Juan-Pablo Pitman Andy Bonan G B Brovkin V Cruz Faye Delire C Gayler V van den Hurk B J J M Lawrence P J van der Molen M K Müller C Reick C H Strengers B J Voldoire A | 2012 | EN2012，，9： | 1 |
| 7 | Balance and sequence in online reviews: the wrap effect显示文摘 | Nathalia P Patrick D P Nathalie D | 2012 | International Journal of Electronic Commerce2012，17，2： | 1 |
| 8 | 16S rRNA and 16S to 23S internal transcribed spacer sequence analysisreveal inter and intraspecific Bifidobacteriumphylogeny显示文摘 | Nathalie L B Herve P Irene M | 1996 | lntem J Syst Bacteriology1996，46，： | 1 |
| 9 | Using the satellite-derived ndvi to assess ecological responses to environment change显示文摘 | Nathalie P | 2005 | Trends in Ecology and Evolution2005，20，9： | 1 |
| 10 | Determining Robust Impacts of Land-Use-Induced Land Cover Changes on Surface Climate over North America and Eurasia: Results from the First Set of LUCID Experiments显示文摘 | de Noblet-Ducoudré Nathalie Boisier Juan-Pablo Pitman Andy Bonan G B Brovkin V Cruz Faye Delire C Gayler V van den Hurk B J J M Lawrence P J van der Molen M K Müller C Reick C H Strengers B J Voldoire A | 2012 | EN2012，，9： | 1 |
| 11 | Sucrose Metabolism in Plastids 显示文摘 | Nathalie Gerrits Stefan C H J Turk Kees P M van Dun | 2001 | Plant Physiology2001，125，2： | 1 |
| 12 | Outbreak of extended-spectrum ~-lactamase VEB- 1-producing isolates of Acinetobacter baumannii in a French hospital 显示文摘 | Laurent P Olivier M Nathalie A | 2003 | J Clin Microbiol2003，41，8： | 1 |
| 13 | Microgravity self-organization is gravity-dependent显示文摘 | Cyril P Nathalie P James T | 2000 | PNAS2000，97，： | 1 |
| 14 | Carbon areogels, cryogels and xerogels: Influence of the drying method on the textural properties of porous carbon materials 显示文摘 | Nathalie J Alexandre T Rene P | 2005 | Carbon2005，43，12： | 1 |
| 15 | 16S rRNA and 16S to 23 S internal transcribed spacer sequence analysis reveal inter and intraspecific Bifidobacterium phylogeny显示文摘 | Nathalie L B Helve P Irene M | 1996 | Intern J Syst Bacteriology1996，46，： | 1 |
| 16 | Regulation of acp 1, encoding a non-aspartyl acid protease expressed during pathogenesis of Sclerotinia sclerotiorum 显示文摘 | Nathalie P Sandrine C Genevieve B G | 2001 | Microbiology2001，147，： | 1 |
| 17 | Trace protein,cystain C,2microglobulin,and creatinine compared for detecting impaired glomemlar filtration rates in children显示文摘 | Guido F Friedrich P Nathalie L | 2002 | Clin Chem2002，48，： | 1 |
| 18 | 16S rRNA to 23S internal transcribed spacer sequence analyses reveal inter - and intraspecific Bifidobacterium phylogeny 显示文摘 | Nathalie L B Herve P Irene M | 1996 | International Journal of Systematic and Evolutionary Microbiology1996，46，1： | 1 |
| 19 | β2-Trace protein, cystatin C, β2-Microglobulin, and creatinine compared for detecting impaired glomerular filtration rates in children显示文摘 | Guido F Friedrich P Nathalie L | 2002 | Clin Chem2002，48，5： | 1 |
| 20 | Wewer and pascale guicheney selenoprotein N: an endoplasmic reticulum glycoprotein with an early developmental expression pattern 显示文摘 | NATHALIE P ALAIN L MATHIEU R | 2003 | Hum Mol Gen- et2003，12，9： | 1 |
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