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| 1 | 藜麦的驯化栽培与遗传育种显示文摘藜麦(Chenopodium quinoa Willd.)起源于南美洲提提喀喀湖区,是苋科(Amaranthaceae)藜属(Chenopodium)一年生作物。因其营养全面且对多种非生物逆境胁迫具有抗性,被认为是尚未被充分开发且具有高应用潜力的作物,深受育种学家的关注。近年来,随着人们对健康的关注和高品质生活的追求,对藜麦的需求量急剧增加,加之藜麦能有效缓解全球粮食安全,对其栽培与育种等研究已成为热点。为了加深对藜麦的认识和推动其产业的发展,本文结合本课题组多年来对源于安第斯山藜麦种质资源的收集、评价与利用的实践,从藜麦营养价值与应用、起源与分布、遗传研究、品种选育进展及发展趋势等方面进行了总结,以期为我国藜麦新品种(系)的培育与栽培、产业可持续发展、贫困地区人群增收及新增我国粮食生产途径等方面提供参考信息。 | 林春 刘正杰 董玉梅 Michel Vales 毛自朝 | 2019 | 遗传2019，41，11： | 30 |
| 2 | Overview of the phytomedicine approaches against Helicobacter pylori显示文摘Helicobacter pylori(H.pylori)successfully colonizes thehuman stomach of the majority of the human popula-tion.This infection always causes chronic gastritis,butmay evolve to serious outcomes,such as peptic ulcer,gastric carcinoma or mucosa-associated lymphoid tis-sue lymphoma.H.pylori first line therapy recommend-ed by the Maastricht-4 Consensus Report comprises theuse of two antibiotics and a proton-pomp inhibitor,butin some regions failure associated with this treatmentis already undesirable high.Indeed,treatment failure isone of the major problems associated with H.pylori in-fection and is mainly associated with bacterial antibioticresistance.In order to counteract this situation,someeffort has been allocated during the last years in theinvestigation of therapeutic alternatives beyond antibi-otics.These include vaccines,probiotics,photodynamic inactivation and phage therapy,which are briefly revis-ited in this review.A particular focus on phytomedicine,also described as herbal therapy and botanical therapy,which consists in the use of plant extracts for medicinal purposes,is specifically addressed,namely considering its history,category of performed studies,tested com-pounds,active principle and mode of action.The herbs already experienced are highly diverse and usually selected from products with a long history of employ-ment against diseases associated with H.pylori infec-tion from each country own folk medicine.The studies demonstrated that many phytomedicine products have an anti-H.pylori activity and gastroprotective action.Al-though the mechanism of action is far from being com-pletely understood,current knowledge correlates the beneficial action of herbs with inhibition of essential H.pylori enzymes,modulation of the host immune system and with attenuation of inflammation. | Filipa F Vale Monica Oleastro | 2014 | World Journal of Gastroenterology2014，20，19： | 13 |
| 3 | Helicobacter pylori infection- recent developments in diagnosis显示文摘Considering the recommended indications for Helicobacter pylori(H.pylori)eradication therapy and the broad spectrum of available diagnostic methods,a reliable diagnosis is mandatory both before and after eradication therapy.Only highly accurate tests should be used in clinical practice,and the sensitivity and specificity of an adequate test should exceed 90%.The choice of tests should take into account clinical circumstances,the likelihood ratio of positive and negative tests,the cost-effectiveness of the testing strategy and the availability of the tests.This review concerns some of the most recent developments in diagnostic methods of H.pylori infection,namely the contribution of novel endoscopic evaluation methodologies for the diagnosis of H.pylori infection,such as magnifying endoscopy techniques and chromoendoscopy.In addition,the diagnostic contribution of histology and the urea breath test was explored recently in specific clinical settings and patient groups.Recent studies recommend enhancing the number of biopsy fragments for the rapid urease test.Bacterial culture from the gastric biopsy is the gold standard technique,and is recommended for antibiotic susceptibility test.Serology is used for initial screening and the stool antigen test is particularly used when the urea breath test is not available,while molecular methods have gained attention mostly for detecting antibiotic resistance. | Ana Isabel Lopes Filipa F Vale Mónica Oleastro | 2014 | World Journal of Gastroenterology2014，20，28： | 12 |
| 4 | Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy:A single center report of 8 cases显示文摘This article describes cases of anti-tumor necrosis factor(TNF)-α-induced autoimmune hepatitis and evaluates the outcome of these patients in relation to their immunosuppressive strategy. A retrospective analysis of medical records was performed in our center, in order to detect cases of autoimmune hepatitis(AIH) associated with anti-TNF biologic agents. We describe and analyze eight cases of AIH following anti-TNF therapy, 7 with infliximab and 1 with adalimumab. A distinction should be made between induction of autoimmunity and clinically evident autoimmune disease. Liver biopsy is useful in detecting the role of the TNF-α antagonist in the development of AIH. The lack of relapse after discontinuing immunosuppressive therapy favors, as in this case series, an immune-mediated drug reaction as most patients with AIH have a relapse after treatment is suspended. Although AIH related to anti-TNF therapy is rare, a baseline immunological panel along with liver function tests should be performed in all patients with autoimmune disease before starting biologics. | Susana Rodrigues Susana Lopes Fernando Magro Hélder Cardoso Ana Maria Horta e Vale Margarida Marques Eva Mariz Miguel Bernardes Joanne Lopes Fátima Carneiro Guilherme Macedo | 2015 | World Journal of Gastroenterology2015，21，24： | 9 |
| 5 | Mercury in sediments and vegetation in a moderately contaminated salt marsh (Tagus Estuary, Portugal)显示文摘Depth variations of total mercury (Hg) and methylmercury (MeHg) concentrations were studied in cores from non-colonized sediments, sediments colonized by Halimione portulacoides, Sarcocornia fruticosa and Spartina maritima and belowground biomass, in a moderately contaminated salt marsh (Tagus Estuary, Portugal). Concentrations in belowground biomass exceeded up to 3 (Hg) and 15 (MeHg) times the levels in sediments, and up to 198 (Hg) and 308 (MeHg) times those found in aboveground parts. Methylmercury in colonized sediments reached 3% of the total Hg, 50 times above the maximum values found in non-colonized sediments. The absence of correlations between total Hg concentrations in sediments and the corresponding MeHg levels suggested that methylation was only dependent on the environmental and microbiological factors. The analysis of belowground biomass at high-depth resolution (2 cm) provided evidence that Hg and MeHg were actively absorbed from sediments, with higher enrichment factors at layers where higher microbial activity was probably occurring. The results obtained in this study indicated that the biotransformation of Hg to the toxic MeHg could increase the toxicity of plant-colonized sediments. | Joao Canário Carlos Vale Laurier Poissant Marta Nogueira Martin Pilote Vasco Branco | 2010 | Journal of Environmental Sciences2010，22，8： | 4 |
| 6 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 7 | Method development for the determination of cadmium in fertilizer samples using high-resolution continuum source graphite furnace atomic absorption spectrometry and slurry sampling显示文摘 | Aline R. Borges Emilene M. Becker Céline Lequeux Maria Goreti R. Vale Sergio L.C. Ferreira Bernhard Welz | 2011 | Spectrochimica Acta Part B: Atomic Spectroscopy2011，，7： | 3 |
| 8 | Urgent tracheostomy: four-year experience in a tertiary hospital显示文摘BACKGROUND: Urgent airway management is one of the most important responsibilities of otolaryngologists, often requiring a multidisciplinary approach. Urgent surgical airway intervention is indicated when an acute airway obstruction occurs or there are intubation difficulties. In these situations, surgical tracheostomy becomes extremely important.METHODS: We retrospectively studied the patients who underwent surgical tracheostomy from 2011 to 2014 by an otolaryngologist team at the operating theater of the emergency department of a tertiary hospital. Indications, complications and clinical evolution of the patients were reviewed.RESULTS: The study included 56 patients(44 men and 12 women) with a median age of 55 years. The procedure was performed under local anesthesia in 21.4% of the patients. Two(3.6%) patients were subjected to conversion from cricothyrostomy to tracheostomy. Head and neck neoplasm was indicated in 44.6% of the patients, deep neck infection in 19.6%, and bilateral vocal fold paralysis in 10.7%. Stridor was the most frequent signal(51.8%). Of the 56 patients, 15 were transferred to another hospital. Among the other 41 patients, 21 were decannulated(average time: 4 months), and none of them were cancer patients. Complications occurred in 5(12.2%) patients: hemorrhage in 3, surgical wound infection in 1, and cervico-thoracic subcutaneous emphysema in 1. No death was related to the procedure.CONCLUSION: Urgent tracheostomy is a life-saving procedure for patients with acute airway obstruction or with diffi cult intubation. It is a safe and effective procedure, with a low complication rate, and should be performed before the patient's clinical status turns into a surgical emergency situation. | Liliana Costa Ricardo Matos Sara Julio Fernando Vales Margarida Santos | 2016 | World Journal of Emergency Medicine2016，7，3： | 3 |
| 9 | Management of autoimmune hepatitis:Focus on pharmacologic treatments beyond corticosteroids显示文摘In autoimmune hepatitis, patients who are intolerant or with toxicity experience, non-responders, relapsers or refractory are challenging. Non-standard drugs are being tried to preemptively avoid corticosteroid-related side effects. Prognosis and quality of life of life rely on treatment optimization. Recently, emergence of powerful immunosuppressive agents, mainly from liver transplantation, challenged the supremacy of the corticosteroid regime and promise greater immunosuppression than conventional medications, offer site-specific actions and satisfactory patient tolerance. Successes in experimental models of related diseases have primed these molecular interventions. We performed a literature review on alternative treatments. Azatioprine intolerance is the principal indication for mycophenolate use butit can be used as a front-line therapy. Cyclosporine A and tacrolimus have been tested for non-responders or relapsers. Rituximab may be used as salvage therapy. Anti-tumor necrosis factor-alpha agents may be used for incomplete responses or non-responders. Methotrexate is possibly an alternative for induction of remission and maintenance in refractory patients. Cyclophosphamide has been included in the induction regimen with corticosteroids. Ursodeoxycholic acid action is mainly immunomodulatory. Non-standard treatments are coming slowly to the attention, but its use should be cautious performed by experienced centers. | Marta Casal Moura Rodrigo Liberal Hélder Cardoso Ana Maria Horta e Vale Guilherme Macedo | 2014 | World Journal of Hepatology2014，6，6： | 2 |
| 10 | Mycoplasma pneumoniae in children with acute and refractory asthma显示文摘 | Pamela R. Wood Vanessa L. Hill Margaret L. Burks Jay I. Peters Harjinder Singh Thirumalai R. Kannan Shruthi Vale Marianna P. Cagle Molly F.R. Principe Joel B. Baseman Edward G. Brooks | 2013 | Annals of Allergy Asthma & Immunology2013，，5： | 2 |
| 11 | Transmission pathway of Helicobacter pylori : Does food play a role in rural and urban areas?显示文摘 | F.F. Vale J.M.B. Vítor | 2010 | International Journal of Food Microbiology2010，，1： | 2 |
| 12 | The influence of innate and adaptative immune responses on the differential clinical outcomes of leprosy显示文摘Leprosy is a chronic infectious disease caused by Mycobacterium leprae.According to official reports from 121 countries across five WHO regions,there were 213899 newly diagnosed cases in 2014.Although leprosy affects the skin and peripheral nerves,it can present across a spectrum of clinical and histopathological forms that are strongly influenced by the immune response of the infected individuals.These forms comprise the extremes of tuberculoid leprosy(TT),with a M.leprae-specific Th1,but also a Th17,response that limits M.leprae multiplication,through to lepromatous leprosy(LL),with M.leprae-specific Th2 and T regulatory responses that do not control M.leprae replication but rather allow bacterial dissemination.The interpolar borderline clinical forms present with similar,but less extreme,immune biases.Acute inflammatory episodes,known as leprosy reactions,are complications that may occur before,during or after treatment,and cause further neurological damages that can cause irreversible chronic disabilities.This review discusses the innate and adaptive immune responses,and their interactions,that are known to affect pathogenesis and influence the clinical outcome of leprosy. | Adriana Barbosa de Lima Fonseca Marise do Vale Simon Rodrigo Anselmo Cazzaniga Tatiana Rodrigues de Moura Roque Pacheco de Almeida Malcolm S.Duthie Steven G.Reed Amelia Ribeiro de Jesus | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 13 | Cyclosporin A inhibits hypoxia-induced pulmonary hypertension and right ventricle hypertrophy 显示文摘 | NATHALIE VALE'RIE N C ANDRE P | 2006 | Am d Respir Crit Care Med2006，174，6： | 1 |
| 14 | Gene therapy for myocardial angiogenesis initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia显示文摘 | Losordo DW Vale PR Symes JF | 1998 | Circulation1998，98，25： | 1 |
| 15 | Phase 1/2 placebo-controlled, dou-ble- blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia显示文摘 | Losordo DW Vale PR Hendel RC | | Circulation0，2，： | 1 |
| 16 | Gene therapy with vascular endothelial growth factor for inoperble coronary显示文摘 | Symes JF Losordo DW Vale PR | 1999 | Ann Thorac surg1999，68，3： | 1 |
| 17 | Monodispersed Glucose-Responsive Microgels Operating at Physiological Salinity显示文摘 | Ve'ronique Lapeyre Isabelle Gosse Sylviane Chevreux Vale'rie Ravaine | 2006 | Biomacromolecules2006，7，： | 1 |
| 18 | Stress-induced inhibition of reproductive function: Role of endogenous corticotropic releasing factor显示文摘 | Rivier C Rivier J Vale W | 1986 | Science1986，231，4738： | 1 |
| 19 | Geng therapy for myocardial angiogenesis 显示文摘 | Losord D W Vale P R Isner J M | 1998 | Am Heart J1998，98，25： | 1 |
| 20 | Stabilization/solidification of a municipal solid waste incineration residue using fly ash-based geopolymers 显示文摘 | Luna Galiano Y Ferndndez Pereira C Vale J | 2011 | Journal of Hazardous Materials2011，185，1： | 1 |
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