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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 3 | 重组卡介苗表达的MalE蛋白T细胞表位的鉴定显示文摘目的 鉴定重组卡介苗表达的MalE蛋白T细胞表位。方法 用抗原提呈试验、T细胞增殖试验、ELISPOT试验和表位作图测试重组MalE蛋白的T细胞表位。结果 重组BCG MalE功能性表达了MalE蛋白的 4种H 2 d 限制性T细胞表位。结论 在 4种表位中 ,p6 8~ 82是重组MalE蛋白的主要T细胞表位 ,而其余 | 焦新安 Richard Lo-man Edith Driaud Sophie Burgaud Brigitte Gicquel Nathalie Winter Claude Leclerc 刘秀梵 | 2002 | 中华微生物学和免疫学杂志2002，22，1： | 3 |
| 4 | Gut microflora as a target for energy and metabolic homeostasis显示文摘 | Patrice D Cani Nathalie M Delzenne | 2007 | Current Opinion in Clinical Nutrition and Metabolic Care2007，，6： | 2 |
| 5 | 重组卡介苗感染树突细胞的研究显示文摘在体内外试验中 ,树突细胞 (DC)均能摄取表达大肠杆菌麦芽糖结合蛋白 (MalE)的重组卡介苗 (rBCG·MalE)。应用流式细胞术测得荧光标记的rBCG·MalE在体内感染DC的水平在 1 % 2 % ,与感染巨噬细胞 (MΦ)的水平相当。体外抗原提呈试验结果显示 ,DC和MΦ能吞噬、加工rBCG·MalE并向T细胞杂交瘤FBU·B1 1提呈MalE蛋白抗原表位 ,而在体内试验中 ,从rBCG·MalE免疫小鼠脾脏中纯化的DC ,可检测到MalE表位MHCⅡ复合物 ,而纯化的MΦs却测不到。这表明DC在起始抗分枝杆菌的免疫保护中发挥关键作用。 | 焦新安 Richard Lo-Man Pierre Guermonprez Edith Dériaud Brigitte Gicquel Nathalie Winter Claude Leclerc 刘秀梵 | 2002 | 扬州大学学报(农业与生命科学版)2002，23，1： | 2 |
| 6 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 7 | Activity of phenylalanine ammonialyase, peroxidase and polyphenol oxidase in roots of banana(Musa acuminata AAA, cvs Grande Naine and Yangambi km5) before and after infection with Radophotus similes显示文摘 | Nathalie W Dirk D Rony S | 2006 | Nematology2006，8，2： | 1 |
| 8 | Evidence for glutamate-mediated excitotoxic mechanisms during photoreceptor degeneration in the rd1 mouse retina显示文摘 | Marie-Noelle D Valérie F Nathalie N | 2005 | Mol Vis2005，11，： | 1 |
| 9 | The role of HLA-G in immunity and hematopoiesis 显示文摘 | EDGARDO D CAROSELLA SILVIA GREGORI NATHALIE ROUAS-FREISS | 2011 | Cellular and Molecular Life Sciences2011，68，3： | 1 |
| 10 | Expression of the bovine viral diarrhoea virus Osloss p80 protein:its use as ELISA antigen for cattle serum antibody detection显示文摘 | Nathalie V de Moerlooze L Vandenbergh D | 1993 | Journal of General Virology1993，74，： | 1 |
| 11 | Balance and sequence in online reviews: the wrap effect显示文摘 | Nathalia P Patrick D P Nathalie D | 2012 | International Journal of Electronic Commerce2012，17，2： | 1 |
| 12 | Comparison between electrocoagulation and chemical precipitation for metals removal from acidic soil leachate 显示文摘 | Nathalie M Patrick D Camille M | 2006 | Hazardous Materials2006，137，1： | 1 |
| 13 | Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae显示文摘 | Chassaing Benoit Rolhion Nathalie de Vallée Amélie Salim Sa’ad Y Prorok-Hamon Maelle Neut Christel Campbell Batty J S?derholm Johan D Hugot Jean-Pierre Colombel Jean-Frédéric Darfeuille-Michaud Arlette | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 14 | Preparation and characterization of poly (amidoaminc) dendrimers functionalized with a rhenium carbonyl complex and PEG as new IR probes for carbonyl metallo immunoassay 显示文摘 | Jan M H Nathalie F D Michele S | 2004 | J Organometallic Chemistry2004，689，25： | 1 |
| 15 | Varicella-zoster virus does not signicantly induce the cell defence mechanism mediated by the 2- 5A/RNase L pathway during显示文摘 | Nathalie D Markus R Manfred H | 2005 | Med Microbiol Immunol2005，194，6： | 1 |
| 16 | The transparent testa 16 locus encodes the Arabidopsis bsister MADS domain protein and is required for proper development and pigmentation of the seed coat显示文摘 | Nathalie N Isabelle D Clarisse J | 2002 | The Plant Cell2002，14，： | 1 |
| 17 | Implementing a Writing Course in an Online RN-BSN Pro- gram 显示文摘 | Stevens Carol J D' Angelo Barbara Rennell Nathalie | 2014 | NurseEduc2014，39，1： | 1 |
| 18 | Biosynthesis and action of neurosteroids显示文摘 | Synthia H Mellon Lisa D Griffin Nathalie A Compagnone | 2001 | Brain Research Reviews2001，，1： | 1 |
| 19 | NOD2/CARD15 gene polymorphisms in Crohn’s disease: a genotype–phenotype analysis显示文摘 | Denis Heresbach Véronique Gicquel-Douabin Brigitte Birebent Pierre-Nicolas D’halluin Nathalie Heresbach-Le Berre Stéphane Dreano Laurent Siproudhis Alain Dabadie Michel Gosselin Jean Mosser Gilbert Semana Jean-Fran?ois Bretagne Jacqueline Yaouanq | 2004 | European Journal of Gastroenterology & Hepatology2004，，1： | 1 |
| 20 | Caseinomacropeptides specifically stimulates exocrine pancreatic secretion in the anesthetized rat显示文摘 | Nathalie L R Claire N D Sylvain M | 2000 | Science Direct-Peptides2000，21，10： | 1 |
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