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| 1 | Characterization of biofilms in biliary stents and potential factors involved in occlusion显示文摘AIM To quantify the components in biofilms and analyze the predisposing factors involved in occlusion of biliary stents. METHODS In a prospective study conducted from April 2011 to March 2014 at a tertiary care hospital, all consecutive patients who required endoscopic biliary stent exchange/removal were included. Etiology of the biliary disease was diagnosed by imaging, cytology and on follow-up. Clinical details of patients with biliary stent retrieval were noted. All extracted stents were collected in sterile containers and immediatelyprocessed for quantification of biofilm proteins and polysaccharides. Molecular identification of commonly known and unknown bacteria was performed by polymerase chain reaction and density gradient gel electrophoresis methods. RESULTS Eighty one patients(41 males) with age range of 20-86 years were studied. The underlying causes for stent insertion were bile duct stones(n = 46; 56.8%) benign stricture(n = 29; 35.8%) and malignancy(n = 6; 7.4%) with cholangitis in 50(61.7%) patients. The retrieved stent sizes were 7 Fr(n = 62; 76.5%) and 10 Fr(n = 19; 23.5%) with 65 days median insertion duration. Polybacterial consortia were detected in 90.1% of the stents. The most common bacteria identified by polymerase chain reaction alone and/or sequencing were Pseudomonas(n = 38), Citrobacter(n = 23), Klebsiella(n = 22), Staphylococcus(n = 20), Serratia(n = 16), Escherichia coli(n = 14), Streptococcus(n = 13), Enterococcus(n = 13), Aeromonas(n = 12), Proteus(n = 10) and Enterobacter(n = 9). Protein concentration according to gender(0.547 ± 0.242 mg/ml vs 0.458 ± 0.259 mg/ml; P = 0.115) as well as age > 60 years and < 60 years(0.468 ± 0.295 mg/ml vs 0.386 ± 0.238 mg/ml; P = 0.205) was non-significant. However, polysaccharide concentration was significant both according to gender(0.052 ± 0.021 mg/ml vs 0.049 ± 0.016 mg/ml; P < 0.0001) and age(0.051 ± 0.026 mg/ml vs 0.038 ± 0.016 mg/ml; P < 0.011). Protein concentration in the biofilm was significantly higher(0.555 ± 0.225 mg/ml vs 0.419 ± 0.276 mg/ml; P = 0.018) in patients with cholangitis, lower(0.356 ± 0.252 mg/ml vs 0.541 ± 0.238 mg/ml; P = 0.005) in the 10 Fr group than the 7 Fr group, and significantly higher(0.609 ± 0.240 mg/ml vs 0.476 ± 0.251 mg/ml; P = 0.060) in stents of ≥ 6 mo of indwelling time. However presence/absence of cholangitis, size of stent, indication of stent insertion and indwelling time did not affect the quantity of polysaccharide concentration.CONCLUSION Plastic stents retrieved from patients with biliary tract disease showed polymicrobial organisms with higher protein content among patients with cholangitis and those with smaller diameter stents. longer indwelling duration had more biofilm formation. | Chetana Vaishnavi Jayanta Samanta Rakesh Kochhar | 2018 | World Journal of Gastroenterology2018，24，1： | 8 |
| 2 | Selective Policy of No Drain after Pancreaticoduodenectomy Is a Valid Option in Patients at Low Risk of Pancreatic Fistula: A Case-Control Analysis显示文摘 | Chetana Lim Safi Dokmak Fran?ois Cauchy Beatrice Aussilhou Jacques Belghiti Alain Sauvanet | 2013 | World Journal of Surgery2013，，5： | 2 |
| 3 | Quality changes in trans and trans free fats/oils and products during frying显示文摘 | Rani A K S Reddy S Y Chetana R | 2010 | European Food Research and Technology2010，230，6： | 1 |
| 4 | Caval Inflow to the Graft for Liver Transplantation in Patients With Diffuse Portal Vein Thrombosis: A 12-Year Experience显示文摘 | Prashant Bhangui Chetana Lim Chady Salloum Paola Andreani Mylene Sebbagh Emir Hoti Philippe Ichai Faouzi Saliba Rene Adam Denis Castaing Daniel Azoulay | 2011 | Annals of Surgery2011，，6： | 1 |
| 5 | Oncocytic adenoma of thyroid with papillary architecture: A diagnostic dilemma显示文摘 | Sanjay Deshmukh Pallavi Patil Siddhi Khandeparker Chetana Naik | 2015 | South Asian Journal of Cancer2015，，1： | 1 |
| 6 | New ternary copper(II) complexes of L-alanine and heterocyclic bases: DNA binding and oxidative DNA cleavage activity 显示文摘 | Chetana P R Rao R Roy M | 2009 | Inorganiea Chimica Acta2009，362，13： | 1 |
| 7 | Synthesis, structure, DNAbinding and cleavage activity of ternary (L-leucine/isolcucine) copper(II) complexes ofheterocyclic bases 显示文摘 | Rao R oxidative PatraA K Chetana P R | 2008 | Polyhedron2008，27，5： | 1 |
| 8 | Centella asiatica treatment during postnatal period enhances learning and memory in mice显示文摘 | Chetana M Uma Devi P | 2005 | Physiol Behav2005，86，4： | 1 |
| 9 | DNA binding and oxidative cleavage activity of ternary (k-proline)copper(ll) complexes of heterocyclic bases 显示文摘 | Rao R Patra A K Chetana P R | 2007 | Polyhedron2007，26，18： | 1 |
| 10 | Quality changes in trans and trans free fats/oils and products during frying显示文摘 | RANI A K S REDDY S Y CHETANA R | 2010 | European Food Research and Technology2010，230，： | 1 |
| 11 | Surgeon-performed point-of-care ultrasound in severe eye trauma: Report of two cases显示文摘The indications of point-of-care ultrasound(POCUS) in the management of multiple trauma patients have been expanding. Although computed tomography(CT) scan of the orbit remains the gold standard for imaging orbital trauma, ultrasound is a quick, safe, and portable tool that can be performed bedside. Here we report two patients who had severe eye injuries with major visual impairment where surgeon-performed POCUS was very useful. One had a foreign body injury while the other had blunt trauma. POCUS was done using a linear probe under sterile conditions with minimum pressure on the eyes. Ultrasound showed a foreign body at the back of the left eye globe touching the eye globe in the first patient, and was normal in the second patient. Workup using CT scan, fundsocopy, optical coherence tomography, and magnetic resonance imaging of the orbits confirmed these findings. The first patient had vitreous and sub retinal haemorrhage and a full thickness macular hole of the left eye, while the second had traumatic optic neuropathy. POCUS gave accurate information concerning severe eye injuries. Trauma surgeons and emergency physicians should be trained in performing ocular ultrasound for eye injuries. | Fikri M Abu-Zidan Korana Balac Chetana Anand Bhatia | 2016 | World Journal of Clinical Cases2016，4，10： | 1 |
| 12 | Enantiomeric separation of propranolol and selected metabolites by using capillary electrophoresis with hydroxypropyl-β-cyclodextrin as chiral selector 显示文摘 | Chetana Pak Philip J Marriott Peter D Carpenter | 1998 | J Chromatogr A1998，793，： | 1 |
| 13 | Search for pulsations in the LMXB EXO 0748-676显示文摘We present here results from our search for X-ray pulsations of the neutron star in the low mass X-ray binary EXO 0748-676 at a frequency near the burstoscillation frequency of 44.7Hz.Using the observations made with the Proportional Counter Array onboard the Rossi X-ray Timing Explorer,we did not find any pulsations in the frequency band of 44.4Hz to 45.0Hz and obtained a 3σ upper limit of 0.47% on the pulsed fraction for any possible underlying pulsation in this frequency band.We also discuss the importance of EXO 0748-676 as a promising source for the detection of Gravitational Waves. | Chetana Jain Biswajit Paul | 2011 | Research in Astronomy and Astrophysics2011，11，5： | 1 |
| 14 | COVID-19 in a liver transplant recipient:Could iatrogenic immunosuppression have prevented severe pneumonia?A case report显示文摘BACKGROUND Coronavirus disease(COVID)is a new and highly contagious infectious disease caused by the coronavirus(COVID-19 or severe acute respiratory syndrome coronavirus 2).There is limited data regarding the incidence and management of COVID-19 in immunocompromised patients’post-transplantation.In the pre-COVID-19 era,these patients were already at an increased risk of developing opportunistic infections.These often manifested with atypical symptoms.CASE SUMMARY We report another case of uneventful COVID-19 pneumonia in a 58-year old male who was 18 mo’post liver transplantation.He received tacrolimus monotherapy since July 2019.The clinical manifestations included only epigastric pain radiating to the right hypochondrium,nausea and vomiting.He had no fevers,cough,shortness of breath,anosmia or dysgeusia even if the chest computed tomography scan revealed an extension of the multiple patchy ground-glass density shadows to the upper lobe of the left lung too.He was hospitalised and received a course of oral chloroquine(200 mg×3 per day)for a period of 10 d.Interestingly,the COVID 19 infection was uneventful though there were no modifications to his tacrolimus dosing.He was successfully discharged.We performed subsequent follow-up via telemedicine.CONCLUSION In light of the current pandemic,it is even more important to identify how the liver recipient’s patients present and are managed,especially for immunosuppression treatment. | Anna Sessa Alessandra Mazzola Chetana Lim Mohammed Atif Juliana Pappatella Valerie Pourcher Olivier Scatton Filomena Conti | 2020 | World Journal of Gastroenterology2020，26，44： | 1 |
| 15 | A transmembrane intracellular estrogen receptor mediatesrapid cell signaling 显示文摘 | Chetana M Revankar Daniel F Cimino Larry A Sklar etal | 2005 | Science2005，307，5715： | 1 |
| 16 | μ-Oxamido bi- nuclear copper ( Ⅱ ) complexes: synthesis, crystal struc- ture, DNA interaction and antibacterial studies 显示文摘 | CHETANA P R RAO R LAHIRI D | 2014 | poly- hedron2014，68，： | 1 |
| 17 | A trans- membrane intracellular estrogen receptor mediates rapid cell signaling显示文摘 | CHETANA M R DANIEL F C LARRY A S | 2005 | Science2005，5715，307： | 1 |
| 18 | New ternary copper( II )complexes of L-alanine and heterocyclic bases: DNA binding and oxidative DNA cleavage activity显示文摘 | Chetana P R Rao R Roy M | 2009 | Inorganica Chimica Acta2009，362，13： | 1 |
| 19 | Synthesis, structure, DNA binding and oxidative cleavage activity of ternary (L-leucine/isoleucine)copper( II )complexes of heterocyclic bases显示文摘 | Rao R Patra A K Chetana P R | 2008 | Polyhedron2008，27，5： | 1 |
| 20 | DNA binding and oxidative cleavage activity of ternary (L-proline) copper ( II ) complexes of heterocyclie bases显示文摘 | Rao R Patra A K Chetana P R | 2007 | Polyhedron2007，26，18： | 1 |
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