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| 1 | Natriuresis and the extracellular volume expansion by hypertonic saline显示文摘 | Svensen CH Waldrop KS Edsberg L | 2003 | J Surg Res2003，113，1： | 1 |
| 2 | A Systems Biology Approach for Studying Heterotopic Ossification: Proteomic Analysis of Clinical Serum and Tissue Samples显示文摘Heterotopic ossification(HO) refers to the abnormal formation of bone in soft tissue.Although some of the underlying processes of HO have been described, there are currently no clinical tests using validated biomarkers for predicting HO formation. As such, the diagnosis is made radiographically after HO has formed. To identify potential and novel biomarkers for HO, we used isobaric tags for relative and absolute quantitation(iTRAQ) and high-throughput antibody arrays to produce a semi-quantitative proteomics survey of serum and tissue from subjects with(HO^+) and without(HO^-) heterotopic ossification. The resulting data were then analyzed using a systems biology approach. We found that serum samples from subjects experiencing traumatic injuries with resulting HO have a different proteomic expression profile compared to those from the matched controls. Subsequent quantitative ELISA identified five blood serum proteins that were differentially regulated between the HO^+ and HO^- groups. Compared to HO^- samples, the amount of insulin-like growth factor I(IGF1) was up-regulated in HO^+ samples, whereas a lower amount of osteopontin(OPN), myeloperoxidase(MPO), runt-related transcription factor 2(RUNX2),and growth differentiation factor 2 or bone morphogenetic protein 9(BMP-9) was found in HO^+ samples(Welch two sample t-test; P < 0.05). These proteins, in combination with potential serum biomarkers previously reported, are key candidates for a serum diagnostic panel that may enable early detection of HO prior to radiographic and clinical manifestations. | Erin L. Crowgey Jennifer T. Wyffels Patrick M. Osborn Thomas T. Wood Laura E. Edsberg | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 1 |
| 3 | National pressure ulcer advisory panel's updated pressure ulcer staging system显示文摘 | Black J Edsberg L Taler G | 2007 | Urol Nurs2007，27，2： | 1 |
| 4 | Pressure ulcer tissue histology:an appraisal of currentknowledge显示文摘 | Edsberg LE | 2007 | Ostomy Wound Manage2007，53，10： | 1 |
| 5 | Pressure ulcers:Avoidable or unavoidable? Results of the national pressure ulcer advisory panel consensus conference显示文摘 | Black JM Edsberg LE Baharestani MM | 2011 | Ostomy Wound Manage2011，57，2： | 1 |
| 6 | National Pressure Ulcer Advisory Panel' s updated pressure ulcer staging system显示文摘 | Black J Edsberg L Taler G | 2007 | Urologic Nursing2007，27，2： | 1 |
| 7 | National PressureUlcerAdvisory Panels updated pressure ulcer staging sys-tem显示文摘 | Black J Edsberg L Taler G | 2007 | Urologic Nursing2007，27，2： | 1 |
| 8 | Maxillary sinus elevation for implant placement using Calcium Sulfate with and without DFDBA:six cases显示文摘 | Andreana S Cornelini R Edsberg L | | 0，，03： | 1 |
| 9 | National Pressure Ulcer Advisory Panel’s Updated Pressure Ulcer Staging System显示文摘 | Joyce Black Mona Mylene Baharestani Janet Cuddigan Becky Dorner Laura Edsberg Diane Langemo Mary Ellen Posthauer Catherine Ratliff George Taler | 2007 | Advances in Skin & Wound Care2007，，5： | 1 |
| 10 | National pressure ulcer advisorypanel's updated pressure ulcer staging system 显示文摘 | Black J Edsberg L Taler G | 2007 | Urologic Nursing2007，27，2： | 1 |
| 11 | National pressure Ulcer Adrisory Panel's updated pressure ulcer staging system显示文摘 | Black J Edsberg L Taler G | 2007 | Urologic Nursing2007，27，2： | 1 |
| 12 | Volume kinetics of glucose solutions given by intravenous infusion显示文摘 | Sjostrand F Edsberg L Hahn R G | 2001 | Br J Anaesth2001，87，6： | 1 |
| 13 | Reducing epibole using topical hyperbaric oxygen and electricalstimulation显示文摘 | EDSBERG L E BROGAN M S JAYNES C D | 2002 | Ostomy Wound Manage2002，48，4： | 1 |
| 14 | National pressure ulcer advisory panel's updated pressure ulcer staging system 显示文摘 | Black J Edsberg L Taler G | 2007 | Urol Nurs2007，7，2： | 1 |
| 15 | Reducing epibole using topical hyperbaric oxygen and electrical stimulation显示文摘 | Edsberg LE Brogan MS Jaynes CD | 2002 | Ostomy Wound Manage2002，48，4： | 1 |
| 16 | Reducing epibole using topical hyperbaric oxygen and electrical stimulation显示文摘 | Edsberg LE Brogan MS Jaynes CD | 2002 | Ostomy Wound Manage2002，48，4： | 1 |
| 17 | National Pressure Ulcer Advi- sory Panel updated pressure ulcer stagingsystem 显示文摘 | Black J Edsberg L Taler G | 2007 | Uro- logic Nursing2007，27，2： | 1 |
| 18 | National pressure ulcer advisory panel's updated pressure ulcer staging system 显示文摘 | Black J Edsberg L Taler G | 2007 | Urologic Nurs2007，27，2： | 1 |
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