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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Soil water extraction by dryland crops, annual pastures, and lucerne in south-eastern Australia 显示文摘 | Angus J F Stapper M Van Herwaarden A F | 2001 | Australian Journal of Agricultural Research2001，52，2： | 1 |
| 3 | Assessment of eccentric exercise-induced muscle damage of the elbow flexors by tensiomyography 显示文摘 | Angus M Hunter Stuart D R Galloway Iain J S | 2012 | Journal of Electromyography and Kinesiology2012，22，3： | 1 |
| 4 | The performance of a solar regenerated open cycle desiccant bed grain cooling system显示文摘 | Ismail M Z Angus D E Thorpe G R | 1991 | Solar Energy1991，46，2： | 1 |
| 5 | A randomized, double-blind, 24-week study comparing the efficacy and tolerability of mirtazapine and paroxetine in depressed patients in pri mary care显示文摘 | Wade A Crawford GM Angus M | 2003 | Int Clin Psyehopharmaeol2003，18，3： | 1 |
| 6 | Hospitaliesd community-acquired pneumonia in the elderly:age-and sex-related patterns of care and outcome in the United States显示文摘 | KAPLAN V ANGUS D C GRIFFIN M F | 2002 | Am J Respir Crit Care Med2002，165，6： | 1 |
| 7 | Effects of sleep posture on upper airway stability in patients with obstructive sleep apnea显示文摘 | NEILL A M ANGUS S M SAJKOV D | 1997 | Am J Respir Crit Care Med1997，155，： | 1 |
| 8 | Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial显示文摘 | Edward J Gane Stuart K Roberts Catherine AM Stedman Peter W Angus Brett Ritchie Rob Elston David Ipe Peter N Morcos Linda Baher Isabel Najera Tom Chu Uri Lopatin M Michelle Berrey William Bradford Mark Laughlin Nancy S Shulman Patrick F Smith | 2010 | The Lancet2010，，9751： | 1 |
| 9 | Effect of heat stress on glucose kinetics during exercise显示文摘 | HARGREAVES M ANGUS D HOWLETT K | 1996 | J Appl Physiol1996，81，4： | 1 |
| 10 | 显示文摘 | Angus M Brickman CM | 1995 | Gastroenterology1995，88，： | 1 |
| 11 | In vitro approaches to assess bioavailability and human gastrointestinal mobilization of food-borne polychlorinated biphenyls (PCBs) 显示文摘 | Adeola A A Dena W M Angus J B | 2008 | J Environ Sci Heal ( Part B)2008，43，： | 1 |
| 12 | Raising yield potential in wheat显示文摘 | Reynolds M Foulkes M.J Slafer G.A Berry P Parry M.A.J Snape J.W and Angus W.J | | 0，，07： | 1 |
| 13 | Effect of altering substrate availability on metabolism and performance during intense exercise显示文摘 | Hawleyj A Burke L M Angus D J | 2000 | British Journal of Nutrition2000，84，： | 1 |
| 14 | Prognostic significance of immunohistochemistry-based markers and algorithms in immunochemotherapy-treated diffuse large B cell lymphoma patients显示文摘 | Culpin RE Sieniawski M Angus B | 2013 | Histopathology2013，63，6： | 1 |
| 15 | Cyclin D1 expression in transitional cell carcinoma of the bladder:correlation with p53,waf1,pRb and Ki67显示文摘 | Tut V M Braithwaite K L Angus B | 2001 | Br J Cancer2001，84，8： | 1 |
| 16 | General Patterns of Tag Usage Among University Groups in Flickr 显示文摘 | Angus E Thelwall M Stuart D | 2008 | Online Information Re- view2008，32，1： | 1 |
| 17 | D-Lys3-GHRP-6 ex- hibits pro-autophagic effects on skeletal muscle 显示文摘 | Angus P Xiao M Thomas K | 2014 | Mo- lecular and Cellular Endocrinology2014，15，12： | 1 |
| 18 | Metastable growth of diamond and diamond-like phases显示文摘 | Angus J C Wang Y Sunkara M | 1991 | Annual Review of Materials Science1991，21，： | 1 |
| 19 | Soil water extraction by dryland crops,annual pastures and lucerne in southeastern Australia显示文摘 | Angus J F Stapper M Van Herwaarden A F | 2001 | Australian Journal of Agricultural Research2001，，52： | 1 |
| 20 | No effect of atrial natriuretic factor on cardiac rate,force and transmitter release显示文摘 | Hiwatari M Satoh K Angus JA | 1986 | Clin Exp Pharmacol Physiol1986，13，： | 1 |
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