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| 1 | 中国居民膳食的变迁显示文摘为探讨建国 5 0年来我国膳食的变化趋势及其意义 ,分析了来自中国健康与营养调查 (1989~ 1997年 )、全国营养调查 (1982、1992年 )、统计局家庭膳食消费资料和卫生部死亡统计年报。结果表明 ,1985年经济转轨前我国谷类的摄入量一直在上升 ,以后开始下降 ;蔬菜的摄入量也呈下降趋势 ,1995年后趋于稳定 ;1979年前动物性食品的摄入量增加缓慢 ,以后增加速度加快。摄入的总能量开始下降 ,能量的来源构成发生了很大变化 ,至 1997年时 ,来自脂肪的能量已占总能量的 2 7 3% ,城市占 32 8% ,平均三分之一的居民 (城市5 8 4% )来自脂肪的能量已超过 30 %。这些变化导致了超重和肥胖的患病率、营养相关性慢性病的死亡率和城市居民的总死亡率上升。中国的膳食变迁已进入一个新的历史时期 ,传统膳食正在向高脂肪、高能量密度、低膳食纤维改变。 | 杜树发 吕冰 王志宏 翟凤英 Barry M Popkin | 2001 | 卫生研究2001，30，4： | 69 |
| 2 | 中国成年人体质指数和腰围与高血压关系的四年随访研究显示文摘目的探讨中国成年人体质指数(BMI)和腰围(WC)的增加与高血压发病危险的关系。方法利用“中国居民健康与营养调查”资料,以4552例18-60岁参加2000年调查、当时无高血压等慢性病并且2004年调查被随访到者为研究对象,考察基线BMI和WC对高血压的预测作用,以及BMI和WC4年间的变化与高血压发病之间的关系。结果男性和女性随访4年高血压发病率分别为20.01%和13.52%。随着基线肥胖程度的增加,高血压的发病危险增加。与BMI和WC均不肥胖者相比,BMI超重/肥胖并且WC肥胖者发生高血压的危险最高(男性,RR=2.840,95%CI:2.139-3.771;女性,RR=2.734,95%CI:2.050-3.647)。调整了其它协变量后,4年中BMI每增加一个单位,男性和女性患高血压的危险分别增加0.141和0.109倍;WC每增加1cm,男性和女性患高血压的危险分别增加0.038和0.035倍。结论体质指数和腰围的增加均能增加高血压发病的危险,体质指数和腰围联合使用可增强对高血压发病的预测作用。 | 李园 翟凤英 王惠君 王志宏 于文涛 Barry M Popkin | 2007 | 卫生研究2007，36，4： | 39 |
| 3 | 黏土中静压沉桩离心模型显示文摘采用西澳大学室内鼓轮式离心机,在预先固结的高岭黏土中开展不同离心力场(50g,125g及250g,g为重力加速度)条件下的模型压桩试验、T-bar试验和静力触探试验,分析了模型桩在贯入过程、静置稳定过程中桩身径向应力(σr)的变化规律,并对后期桩体拉伸载荷阶段的径向应力变化值(Δσr)及桩侧摩阻力变化情况行了探讨,揭示了在不同超固结比(OCRs)黏土中静压桩侧摩阻力的演变特性.在此基础上,通过两种经验公式方法对桩侧摩承载力进行了预测计算和对比分析.研究结果表明:沉桩过程中桩端相对高度(h/B)对桩身径向应力的发展变化有很大的影响,桩身不同位置(h/B)的总径向应力对同一贯入深度而言,存在桩侧径向应力退化现象;基于静力触探试验提出的经验方法,能有效考虑静力触探锥端阻力(qt)和桩端相对高度(h/B)因素的影响,将其应用于黏土沉桩时桩侧摩阻力的预测,可取得与试验实测结果较吻合的结果.研究成果对软土地区静压桩施工与承载力设计具有一定的工程指导意义. | 李雨浓 Barry M Lehane 刘清秉 | 2018 | 工程科学学报2018，40，3： | 23 |
| 4 | Anticoagulation with direct thrombin inhibitors during extracorporeal membrane oxygenation显示文摘Use of extracorporeal membrane oxygenation to support patients with critical cardiorespiratory illness is increasing.Systemic anticoagulation is an essential element in the care of extracorporeal membrane oxygenation patients.While unfractionated heparin is the most commonly used agent,unfractionated heparin is associated with several unique complications that can be catastrophic in critically ill patients,including heparin-induced thrombocytopenia and acquired antithrombin deficiency.These complications can result in thrombotic events and subtherapeutic anticoagulation.Direct thrombin inhibitors(DTIs)are emerging as alternative anticoagulants in patients supported by extracorporeal membrane oxygenation.Increasing evidence supports DTIs use as safe and effective in extracorporeal membrane oxygenation patients with and without heparininduced thrombocytopenia.This review outlines the pharmacology,dosing strategies and available protocols,monitoring parameters,and special use considerations for all available DTIs in extracorporeal membrane oxygenation patients.The advantages and disadvantages of DTIs in extracorporeal membrane oxygenation relative to unfractionated heparin will be described. | Barry Burstein Patrick M Wieruszewski Yan-Jun Zhao Nathan Smischney | 2019 | World Journal of Critical Care Medicine2019，8，6： | 12 |
| 5 | Global secretome analysis identifies novel mediators of bone metastasis显示文摘骨头是稳固的肿瘤的远转移的一个最普通的地点。分泌蛋白质被知道影响在变形癌症房间和骨头基质之间的病理学的相互作用。为了包括地介绍,分泌了与骨头转移联系的蛋白质,我们使用了量、非量的集体 spectrometry 全球性分析改变从多重种类和癌症的变形能力打的骨头的九根细胞线的 secretomes。由比较父母房间和他们的骨头的 secretomes 变形衍生物,我们识别了特别地在这些房间线与骨头转移被联系的分泌蛋白质。我们然后合并了大临床的转移数据集的生物信息的分析获得强烈与临床、试验性的骨头转移被联系的几个功能的班的候选人小说骨头转移蛋白质的一张表。选择蛋白质的功能的确认显示在 vivo,骨头转移能被高表示支持(1 ) 唾液的 cystatins CST1, CST2,和 CST4;(2 ) plasminogen 使活跃之物小块地和 PLAU;或(3 ) 骨胶原功能蛋白质 PLOD2 和 COL6A1。总的来说,我们的学习揭开了骨头转移并且因此的几个新分泌调停人证明 secretome 分析是为新奇 biomarkers 和候选人的鉴定的一个强大的方法治疗学的目标。 | Maria Andres Blanco Gary LeRoy Zia Khan Ma a Ale kovi Barry M Zee Benjamin A Garcia Yibin Kang | 2012 | Cell Research2012，22，9： | 12 |
| 6 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 7 | BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection显示文摘Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy(BKN) of the native kidneys has being increasingly recognized as a cause of chronic kidney disease in patients with solid organ transplants, bone marrow transplants and in patients with other clinical entities associated with immunosuppression. In such patients renal dysfunction is often attributed to other factors including nephrotoxicity of medications used to prevent rejection of the transplanted organs. Renal biopsy is required for the diagnosis of BKN. Quantitation of the BK viral load in blood and urine are surrogate diagnostic methods. The treatment of BKN is based on reduction of the immunosuppressive medications. Several compounds have shown antiviral activity, but have not consistently shown to have beneficial effects in BKN. In addition to BKN, BK viral infection can cause severe urinary bladder cystitis, ureteritis and urinary tract obstruction as well as manifestations in other organ systems including the central nervous system, the respiratory system, the gastrointestinal system and the hematopoietic system. BK viral infection has also been implicated in tumorigenesis. The spectrum of clinical manifestations from BK infection and infection from other members of the Papoviridae family is widening. Prevention and treatment of BK infection and infections from other Papovaviruses are subjects of intense research. | Darlene Vigil Nikifor K Konstantinov Marc Barry Antonia M Harford Karen S Servilla Young Ho Kim Yijuan Sun Kavitha Ganta Antonios H Tzamaloukas | 2016 | World Journal of Transplantation2016，6，3： | 4 |
| 8 | β-defensins and the epididymis: contrasting influences of prenatal, postnatal, and adult scenarios显示文摘β -defensins 是主人防卫的部件,与抗菌剂和多种的免疫调节的性质。在最后 15 年的研究表明了许多 β 的丰富的表示;在不同种类的出生后的 epididymis 的 -defensins。这些蛋白质的区域特定、房间特定的表示的一个坡度在出生后的 epididymis 的上皮被观察。他们进到他们沿着 epididymis 旅行的精子的钠液体和绑定的分泌物在繁殖特定的任务建议了他们的参与。因此,连续注意被给了各种各样的 β为他们在精子功能和富饶的角色的 -defensins。尽管 β -defensins 大部分依赖于雄激素,在 epididymis 调整他们的表达式和函数的内在的机制很好没被理解。最近的调查指出了到在哪儿的一种新、有趣的情形 β ; -defensins 在 Wolffian 管与一个不同表示模式出现, epididymis 的胚胎的先锋与成年 epididymis 对比,从而有关 β 的多功能的角色重新定义这个概念;在发展中的 epididymis 的 -defensins 。在这评论,我们总结 β 的一些当前的看法;在在 prenatal-to-postnatal 转变期间在发展中的 epididymis 在他们的角色上加亮我们的最近的数据和推测的 epididymis 的 -defensins ,在可以贡献 epididymal 生物学和男富饶的更好的理解的这个研究区域把注意带到许多未答复的问题。 | Camilla M Ribeiro Erick JR Silva Barry T Hinton Maria Christina W Avellar | 2016 | Asian Journal of Andrology2016，18，2： | 4 |
| 9 | Functional oesophago-gastric junction imaging显示文摘尽管有它在疾病的角色,仍然没有权威的方法估计 oesophago 胃的连接胜任(OGJ ) 。传统地, OGJ 作为指示物与更低的食道的括约肌压力用测压法被估计了。更最近,这被显示了不对倒流是括约肌功能和胜任的一个很可靠的标记。混乱象胃食道的倒流疾病那样并且到更小的 extend 弛缓不能仍然完成病人的一个重要数字。这评论看使用作为阻抗测面积池知道在一只袋子的扩张期间在 OGJ 介绍几何学和压力的一种新技术。收集的数据能被重建进 OGJ 行动的一个动态代表。这被显示了提供 OGJ 的一个有用代表并且由于 endoluminal 治疗以依从和膨胀性显示出变化到 OGJ 的胜任。 | Barry P McMahon Asbjφrn M Drewes Hans Gregersen | 2006 | World Journal of Gastroenterology2006，12，18： | 3 |
| 10 | Haemoxygenase modulates cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury显示文摘AIM To investigate the hepatic microcirculatory changes due to Haemoxygenase(HO),effect of HO inhibition on remote ischemic preconditioning(RIPC) and modulation of CINC.METHODS Eight groups of animals were studied- Sham,ischemia reperfusion injury(IRI) the animals were subjected to 45 min of hepatic ischemia followed by three hours of reperfusion,RIPC(remote ischemic preconditioning) + IRI group,remote ischemic preconditioning in sham(RIPC + Sham),PDTC + IR(Pyridodithiocarbamate,HO donor),Zn PP + RIPC + IRI(Zinc protoporphyrin prior to preconditioning),IR-24(45 min of ischemia followed by 24 h of reperfusion),RIPC+IR-24(preconditioning prior to. After 3 and 24 h of reperfusion the animals were killed by exsanguination and samples were taken. RESULTS Velocity of flow(160.83 ± 12.24 μm/s),sinusoidal flow(8.42 ± 1.19) and sinusoidal perfusion index(42.12 ± 7.28) in hepatic IR were lower(P < 0.05) in comparison to RIPC and PDTC(HO inducer). RIPC increased velocity of flow(328.04 ± 19.13 μm/s),sinusoidal flow(17.75 ± 2.59) and the sinusoidal perfusion index(67.28 ± 1.82)(P < 0.05). PDTC(HO induction) reproduced the effects of RIPC in hepatic IR. PDTC restored RBC velocity(300.88 ± 22.109 μm/s),sinusoidal flow(17.66 ± 3.71) and sinusoidal perfusion(82.33 ± 3.5) to near sham levels. Zn PP(HO inhibition) reduced velocity of flow of RBC in the RIPC group(170.74 ± 13.43 μm/s and sinusoidal flow in the RIPC group(9.46 ± 1.34). Zn PP in RIPC(60.29 ± 1.82) showed a fall in perfusion only at 180 min of reperfusion. Neutrophil adhesion in IR injury is seen in both postsinusoidal venules(769.05 ± 87.48) and sinusoids(97.4 ± 7.49). Neutrophil adhesion in RIPC + IR injury is reduced in both postsinusoidal venules(219.66 ± 93.79) and sinusoids(25.69 ± 9.08)(P < 0.05). PDTC reduced neutrophil adhesion in both postsinusoidal venules(89.58 ± 58.32) and sinusoids(17.98 ± 11.01)(P < 0.05) reproducing the effects of RIPC. Zn PP(HO inhibition) increased venular(589.04 ± 144.36) and sinusoidal neutrophil adhesion in preconditioned animals(121.39 ± 30.65)(P < 0.05). IR after 24 h of reperfusion increased venular and sinusoidal neutrophil adhesion in comparison to the early phase and was significantly reduced by RIPC. Hepatocellular cell death in IRI(80.83 ± 13.03),RIPC + IR(17.35 ± 2.47),and PTDC+IR(11.66 ± 1.17) Zn PP + RIPC + IR(41.33 ± 3.07) reduced hepatocellular death. Zn PP significantly increased hepatocellular death(P < 0.05 PTDC/RIPC vs Zn PP and IR). The CINC cytokine levels in sham(101.32 ± 6.42). RIPC + sham(412.18 ± 65.24) as compared to sham(P < 0.05). Hepatic IR(644.08 ± 181.24)(P < 0.05). RIPC CINC-1 levels in the early phase(401.62 ± 78.56). And PDTC(HO inducer) CINC-1 levels in hepatic IR(413.36 ± 63.06) were significantly lower. HO inhibition in preconditioned animals with Zinc protoporphyrin increased serum CINC levels(521.81 ± 74.9)(P < 0.05). The serum CINC levels were high in the late phase of hepatic IR(15306 ± 1222.04). RIPC reduced CINC levels in the late phase of IR(467.46 ± 26.06),P < 0.05.CONCLUSION RIPC protects hepatic microcirculation by induction of HO and modulation of CINC in hepatic IR. | Niteen Tapuria Sameer Junnarkar Mahmoud Abu-amara Barry Fuller Alexander M Seifalian Brian R Davidson | 2016 | World Journal of Gastroenterology2016，22，33： | 3 |
| 11 | The European registry of quality outcomes for cataract and refractive surgery(EUREQUO):a database study of trends in volumes,surgical techniques and outcomes of refractive surgery显示文摘Background:A European web-based registry for refractive surgery was established in 2008;The European Registry of Quality Outcomes for Cataract and Refractive Surgery(EUREQUO).The aim of the registry was to improve treatment and standards of care for refractive surgery.Further aims were to offer a tool for benchmarking by establishing a reference database and for surgeons to enter and analyze their own outcomes.The purpose of this study was to characterize the registry and analyze the data collected during its first decade.Methods:The characteristics of the web-based registry are described.Data collected from February 4^(th) 2004 until June 30th 2014 are included in the analysis.The database is analyzed in terms of surgical technique,indications for surgery,complications,and refractive and visual outcomes.Results:Data have been reported from 47 centers in 14 countries until mid-2014.About 4,000 procedures were reported annually.The most frequent procedure was laser-assisted in-situ keratomileusis(LASIK)with 11697 reported surgeries.Over time in the database,LASIK declined(p<0.001)while photorefractive keratectomy(PRK)and refractive lens exchange(RLE)increased(p<0.001 for both procedures).The indications for surgery,in terms of preoperative refraction and age,were stable over time,for all types of procedures.Surgical complications were reported infrequently and with a well-known relationship to the type of surgical procedure.The reported refractive outcomes were good.The visual outcomes indicate a significant increase of visual acuity after high myopia treatment by phakic intraocular lens in the anterior(phakic IOL AC)and the posterior(phakic IOL PC)chamber and a poorer visual outcome,after both myopia and hyperopia treatment,by epithelial LASIK(Epi-LASIK).Conclusions:We describe the establishment of a European registry for refractive surgery.The database increases at a rate of approximately 4000 refractive procedures per year.The most frequent procedure is LASIK,but both PRK and RLE are an increasing part of the reported procedures.The indications for surgery have been stable over time.Surgical complications and visual outcome vary,depending on the type of surgery. | Mats Lundström Sonia Manning Peter Barry Ulf Stenevi Ype Henry Paul Rosen | 2015 | Eye and Vision2015，2，1： | 3 |
| 12 | Multitarget stool DNA for colorectal cancer screening:A review and commentary on the United States Preventive Services Draft Guidelines显示文摘Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).The United States Preventive Services Task Force(USPSTF) October 2015 draft recommendation for CRC screening included mt-s DNA as an 'alternative' screening test that 'may be useful in select clinical circumstances',despite its very high sensitivity for early stage CRC.The evidence supporting mt-s DNA for routine screening use is robust.The clinical efficacy of mt-s DNA as measured by sensitivity,specificity,life-years gained(LYG),and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document,especially those requiring annual testing adherence.In a population with primarily irregular screening participation,tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual adherence.This paper reviews the evidence supporting mt-s DNA for routine screening and demonstrates,using USPSTF's modeling data,that mt-s DNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing,high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening. | Barry M Berger Bernard Levin Robert J Hilsden | 2016 | World Journal of Gastrointestinal Oncology2016，8，5： | 3 |
| 13 | 血管紧张素Ⅱ1型受体基因多态性与心力衰竭预后的相关性研究显示文摘目的评价血管紧张素Ⅱ1型受体(AngiotensinⅡtype 1 receptor,AT1R)基因1166位点A/C基因多态性对心力衰竭预后的影响。方法432例患者来源于美国匹兹堡大学医疗中心的心血管事件基因危险性评价研究组,均有收缩功能障碍性心力衰竭〔射血分数(EF)<0.45〕。入选时间为1996年4月至2001年1月,前瞻性随访患者(26.43±18.19)月,随访终点是死亡或心脏移植。用聚合酶链式反应(PCR)方法鉴定AT1R基因A1166C位点基因型,分析AT1R A1166C基因多态性对心力衰竭患者生存率的影响。结果AT1R纯合子CC型8.6%,纯合子AA型50.0%,杂合子AC型41.4%。三组基因型在年龄、性别、种族、病因、血压和治疗方面无显著性差异,而在NYHA心功能分级的比例有显著性差异,AT1R C等位基因与较低心功能分级密切相关(P=0.04),但随访三组基因型的三年生存率并无显著性差异。结论在本组收缩功能障碍性心力衰竭患者中,AT1R C等位基因仅与较低心功能分级密切相关,并不影响未行心脏移植心力衰竭患者的预后。 | 郑茵 方壮伟 吴智勇 Barry London Dennis M McNamara | 2005 | 中国心血管杂志2005，10，6： | 3 |
| 14 | The effect of chloride and oxygen on the stress corrosion cracking of stainless steels:review of literature显示文摘 | Gordon Barry M | 1980 | Materials Performance1980，19，4： | 2 |
| 15 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 16 | ABT-450, Ritonavir, Ombitasvir, and Dasabuvir Achieves 97% and 100% Sustained Virologic Response With or Without Ribavirin in Treatment-experienced Patients with HCV Genotype 1b Infection显示文摘 | Pietro Andreone Massimo G. Colombo Jeffrey V. Enejosa Iftihar Koksal Peter Ferenci Andreas Maieron Beat Müllhaupt Yves Horsmans Ola Weiland Henk W. Reesink Lino Rodrigues Yiran B. Hu Thomas Podsadecki Barry Bernstein | 2014 | Gastroenterology2014，，： | 2 |
| 17 | Refractive surgery in children显示文摘 | Christopher M Fecarotta Marie Kim Barry N Wasserman | 2010 | Current Opinion in Ophthalmology2010，，： | 2 |
| 18 | Differential expresion of the 1-aminocyclopropane-1-carboxylate oxidase gene family of tomato 显示文摘 | Barry C S Blume B Bouzayen M | 1996 | Plant J1996，9，： | 2 |
| 19 | Dynamic kinetic asymmetric transformation of diene monoepoxides: a practical asymmetric synthesis of vinylglycinol, vigabatrin, and ethambutol 显示文摘 | Richard C B Remy C L | 2000 | J Am Chem Soc2000，122，： | 1 |
| 20 | Surface tension of electrolytes:Specific ion effects explained by dispersion forces显示文摘 | Mathias Bostrom David R M Williams Barry W Ninham | 2001 | Langmuir2001，17，： | 1 |
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