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| 1 | Mitochondria-targeted agents: Future perspectives of mitochondrial pharmaceutics in cardiovascular diseases显示文摘Mitochondria are one of the major sites for the genera-tion of reactive oxygen species(ROS) as an undesirable side product of oxidative energy metabolism. Damaged mitochondria can augment the generation of ROS. Dys-function of mitochondria increase the risk for a large number of human diseases, including cardiovascular diseases(CVDs). Heart failure(HF) following ischemic heart disease, infantile cardiomyopathy and cardiac hypertrophy associated with left ventricular dilations are some of the CVDs in which the role of mitochon-drial oxidative stress has been reported. Advances in mitochondrial research during the last decade focused on the preservation of its function in the myocardium, which is vital for the cellular energy production. Expe-rimental and clinical trials have been conducted using mitochondria-targeted molecules like: MnSOD mimetics, such as EUK-8, EUK-134 and MitoSOD; choline esters of glutathione and N-acetyl-L-cysteine; triphenylphospho-nium ligated vitamin E, lipoic acid, plastoquinone andmitoCoQ10; and Szeto-Schiller(SS)- peptides(SS-02 and SS-31). Although many results are inconclusive, some of the findings, especially on CoQ10, are worthwhile. This review summarizes the role of mitochondria-tar-geted delivery of agents and their consequences in the control of HF. | Thekkuttuparambil Ananthanarayanan Ajith Thankamani Gopinathan Jayakumar | 2014 | World Journal of Cardiology2014，6，10： | 7 |
| 2 | Rapid adsorption of toxic Pb(Ⅱ) ions from aqueous solution using multiwall carbon nanotubes synthesized by microwave chemical vapor deposition technique显示文摘Multiwall carbon nanotubes(MWCNTs) were synthesized using a tubular microwave chemical vapor deposition technique, using acetylene and hydrogen as the precursor gases and ferrocene as catalyst. The novel MWCNT samples were tested for their performance in terms of Pb(Ⅱ)binding. The synthesized MWCNT samples were characterized using Fourier Transform Infrared(FT-IR), Brunauer, Emmett and Teller(BET), Field Emission Scanning Electron Microscopy(FESEM) analysis, and the adsorption of Pb(Ⅱ) was studied as a function of p H,initial Pb(Ⅱ) concentration, MWCNT dosage, agitation speed, and adsorption time, and process parameters were optimized. The adsorption data followed both Freundlich and Langmuir isotherms. On the basis of the Langmuir model, Qmaxwas calculated to be 104.2 mg/g for the microwave-synthesized MWCNTs. In order to investigate the dynamic behavior of MWCNTs as an adsorbent, the kinetic data were modeled using pseudo first-order and pseudo second-order equations. Different thermodynamic parameters, viz., ΔH0, ΔS0and ΔG0were evaluated and it was found that the adsorption was feasible, spontaneous and endothermic in nature. The statistical analysis revealed that the optimum conditions for the highest removal(99.9%) of Pb(Ⅱ) are at p H 5, MWCNT dosage 0.1 g, agitation speed 160 r/min and time of 22.5 min with the initial concentration of 10 mg/L. Our results proved that microwave-synthesized MWCNTs can be used as an effective Pb(Ⅱ) adsorbent due to their high adsorption capacity as well as the short adsorption time needed to achieve equilibrium. | Nabisab Mujawar Mubarak Jaya Narayan Sahu Ezzat Chan Abdullah Natesan Subramanian Jayakumar | 2016 | Journal of Environmental Sciences2016，28，7： | 5 |
| 3 | Analysis of chemical composition and bioactive property evaluation of Indian propolis显示文摘Objective:To analyze the chemical composition and to evaluate the bioactive potential of hydroalocoholic extract of propolis.Methods:Ethanol extract of propolis was analyzed by GCMS,HPTLC and HPLC methods and in vitro antioxidant,anticholinesterase and cytotoxicity assay were performed.Remits:GC-MS analysis revealed the presence of fatty acids,alcohols, and quercetin.Quercetin was identified and quantified by HPTLC and HPLC methods.Dose dependent DPPH and hydroxyl radical scavenging activity of hydroalcoholic extract of propolis was calculated as 16.20 and 34.33 μg/mL respectively.Inhibition of lipid peroxidation was significant and the IC_(50) value was calculated as 55.56 μg/mL.Anticholinesterase activity was less observed.The cytotoxic activity against both breast(MCF-7) and lung cancer(A543) cell lines were significant and the IC_(50)value was calculated as 10 and 13 μg/mL respectively.Conclusions: These findings showed that bioactive compounds present in propolis will alleviate many diseases and can be used for better human health. | R Thirugnanasampandan Sayana Beena Raveendran R Jayakumar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，8： | 5 |
| 4 | Hesperetin conjugated PEGylated gold nanoparticles exploring the potential role in anti-inflammation and anti-proliferation during diethylnitrosamine-induced hepatocarcinogenesis in rats显示文摘Liver cancer is the fifth most common cancer and one of the leading causes of death in the world, and second most common cause of death in men. Natural products emerge as the most enduring approaches in the development of anticancer targeting drug. Hesperetin(HP), one of the abundant flavonoids found naturally in citrus fruits, has received considerable attention in anti-cancer promotion and progression. The present study was conducted to decipher the role of 0.5 ml hesperetin conjugated gold nanoparticles(Au-m PEG(5000)-S-HP NPs) during diethylnitrosamine(DEN)-induced hepatocarcinogenesis in male Wistar albino rats and shows the better antioxidant that possesses anti-inflammatory,anti-proliferation and anticarcinogenic properties and may modulate signaling pathways.The confirmation of polymer functionalized gold nanoparticles and drug loaded polymer gold nanoparticles were characterized by HR-TEM with EDAX, and DLS with Zeta potential techniques. The drug encapsulation efficiency and release properties were carried out in PBS at pH 7.4 for Au-mPEG(5000)-S-HP and compared with the control pure hesperetin(HP).Here, we review the role of mast cell counts, tumor necrosis factor alpha(TNF-α), transcription factor nuclear factor-κB(NF-κB), levels of glycoconjugates, proliferating cell nuclear antigen(PCNA) and argyrophilic nucleolar organizing regions, are the master regulator of inflammation and proliferation, in the development of hepatocellular injury, liver fibrosis and HCC. DEN-administered animals showed increased mast cell counts, tumor necrosis factor alpha, transcription factor nuclear factor-κB, glycoconjugates, proliferating cell nuclear antigen, and argyrophilic nucleolar organizing regions. Whereas Au-mPEG(5000)-S-HP NPs supplementation considerably suppressed all the above abnormalities. These results suggest that the Au-m PEG(5000)-S-HP NPs exhibited the better potential anticancer activity by inhibiting cell inflammation and proliferation in DEN-induced hepatocellular carcinogenesis. | Gokuladhas Krishnan Jayakumar Subramaniyan Pramila Chengalvarayan Subramani Barath Muralidharan Devaki Thiruvengadam | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，5： | 4 |
| 5 | Recrystallisation and bonding behaviour of ultra fine grained copper and Cu–Cr–Zr alloy using ECAP显示文摘 | P.K. Jayakumar K. Balasubramanian G. Rabindranath Tagore | 2011 | Materials Science & Engineering A2011，，： | 3 |
| 6 | Oxidative Stress in the Pathogenesis of Hepatic Encephalopathy显示文摘 | M. D. Norenberg A. R. Jayakumar K. V. Rama Rao | 2004 | Metabolic Brain Disease (-)2004，，3： | 2 |
| 7 | Biomaterials based on chitin and chitosan in wound dressing applications显示文摘 | R. Jayakumar M. Prabaharan P.T. Sudheesh Kumar S.V. Nair H. Tamura | 2011 | Biotechnology Advances2011，，3： | 2 |
| 8 | Integrated hydrologic modeling in the inland Heihe River Basin, Northwest China显示文摘As a typical inland river basin in arid Northwest China, having distinct hydrological characteristics and severe and representative water problems, the Heihe River Basin (HRB) has attracted considerable research interest worldwide and in 2007 became a pilot basin of the G-WADI network of UNESCO/IHP. Many research programs have been conducted in the HRB since the 1980s, producing rich knowledge and data about the basin, which will be very helpful to further studies. This paper reviews research efforts related to hydrologic modeling and ongoing model integration studies performed in the HRB in recent years. Recently, an observation network covering the whole area and a Web-based data-sharing system have been established which can greatly improve data acquisition. This paper tabulates modeling activities in past years, including model ap- plications, model modifications and enhancements, and model coupling efforts. Also described is a preliminary modeling integration tool designed to quickly build new models, which has been developed for hydrologic modeling purposes. Challeng- es and issues confronted in current studies are discussed, pointing toward key research directions in the future. | YanBo Zhao ZhuoTong Nan Hao Chen Xin Li Ramasamy Jayakumar WenJun Yu | 2013 | Research in Cold and Arid Regions2013，5，1： | 2 |
| 9 | A model formative assessment strategy to promote student-centered self-regulated learning in higher education显示文摘 | Jayakumar Bose Zed Rengel | 2009 | 美中教育评论2009，6，12： | 2 |
| 10 | New concepts in the mechanism of ammonia-induced astrocyte swelling显示文摘 | M. D. Norenberg A. R. Jayakumar K. V. Rama Rao K. S. Panickar | 2007 | Metabolic Brain Disease (-)2007，，3： | 2 |
| 11 | Gene therapy for myocardial protection: transfection of donor hearts with heat shock protein 70 gene protects cardiac function against ischemia-repeffusion injury 显示文摘 | Jayakumar J Suzuki K Khan M | 2000 | Circulation2000，102，193： | 1 |
| 12 | New concepts in the mechanisms of ammonia-induced astrocytc swelling显示文摘 | Norenberg MD Jayakumar AR Rama Rao KV | 2007 | Metab Brain Dis2007，22，34： | 1 |
| 13 | Folate-receptor-mediated delivery of InP quantum dots for bioimaging using confocal and two-photon microscopy 显示文摘 | Bharali D J Lueey D W Jayakumar H | 2005 | J Am Chem Soc2005，127，11： | 1 |
| 14 | Signaling factors in the mechanism of ammonia neurotoxicity显示文摘 | Norenberg MD Rama RV Jayakumar A | 2009 | Metab Brain Dis2009，24，1： | 1 |
| 15 | Aquaporin-4 in manganese-treated cultured astrocytes显示文摘 | Rao KV Jayakumar AR Reddy PV | 2010 | Glia2010，58，12： | 1 |
| 16 | Heat shock treatment enhances graft cell survival in skeletal myoblast transplantation to the heart显示文摘 | Suzuki K Smolenskl BT Jayakumar J | 2000 | Circulation2000，102，193： | 1 |
| 17 | 查看详情显示文摘 | Gohil P Evans T E Ferron J R Moyer R A Petty C C Burrell K H Casper T A Garofalo A M Hyatt A W Jayakumar R J Kessel C Kim J Y La Haye R J Lohr J Luce T C Makowski M A Mazon D Menard J Murakami M Politzer P A Prater R Wade M R | | 0，，： | 1 |
| 18 | High Density Mapping of Atrial Fibrillation During Vagal Nerve Stimulation in the Canine Heart: Restudying the Moe Hypothesis显示文摘 | SEUNGYUP LEE JAYAKUMAR SAHADEVAN CELEEN M. KHRESTIAN DOMINIQUE M. DURAND ALBERT L. WALDO | 2012 | Journal of Cardiovascular Electrophysiology2012，，3： | 1 |
| 19 | Comparison of central corneal thickness of primary open angle glaucoma patients with normal controls in South India显示文摘 | Maya Natarajan Krishna Das Jayakumar Jeganathan | 2013 | Oman Journal of Ophthalmology2013，，1： | 1 |
| 20 | Graft copolymerized ch itosan-present status and applications 显示文摘 | Jayakumar R Prabaharan M Mano J F | 2005 | Carbohydrate Poly- mers2005，62，2： | 1 |
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