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| 1 | The human application of gene therapy to re-program T-cell specificity using chimeric antigen receptors显示文摘The adoptive transfer of T cells is a promising approach to treat cancers. Primary human T cells can be modified using viral and non-viral vectors to promote the specific targeting of cancer cells via the introduction of exogenous T-cell receptors(TCRs) or chimeric antigen receptors(CARs). This gene transfer displays the potential to increase the specificity and potency of the anticancer response while decreasing the systemic adverse effects that arise from conventional treatments that target both cancerous and healthy cells. This review highlights the generation of clinical-grade T cells expressing CARs for immunotherapy, the use of these cells to target B-cell malignancies and, particularly, the first clinical trials deploying the Sleeping Beauty gene transfer system, which engineers T cells to target CD19+ leukemia and non-Hodgkin's lymphoma. | Alan D Guerrero Judy S Moyes Laurence JN Cooper | 2014 | Chinese Journal of Cancer2014，33，9： | 4 |
| 2 | Abscisic acid perception and signaling: structura mechanisms and applications显示文摘不利环境条件是对农业产量的威胁因此在生计,健康和经济上施加全球效果。Abscisic 酸(骆驼毛的织物) 是调整不能生活的压力忍耐的重要植物荷尔蒙,从而允许种应付环境压力。以前,试图开发发信号的内在的骆驼毛的织物被困难在真正的骆驼毛的织物受体的鉴定妨碍了的机制的完全的理解。骆驼毛的织物受体的 PYR/PYL/RCAR 家庭的发现因此在克服这些障碍的努力代表了一个主要里程碑;从那以后,许多结构、功能的研究提供了详细卓见进从骆驼毛的织物感觉到骆驼毛的织物应答的基因抄写的激活的过程。这理解骆驼毛的织物感觉的机制并且发信号在压力抵抗的庄稼的遗传工程以及在新合成骆驼毛的织物收缩筋的设计用作最近的、初步的开发的基础,它为应力公差的农业改进保持大诺言。 | Ley Moy NG Karsten MELCHER Bin Tean TEH H Eric XU | 2014 | Acta Pharmacologica Sinica2014，35，5： | 4 |
| 3 | Relation Between Red Blood Cell Distribution Width and Cardiovascular Event Rate in People With Coronary Disease显示文摘 | Marcello Tonelli Frank Sacks Malcolm Arnold Lemuel Moye Barry Davis Marc Pfeffer | 2008 | Circulation2008，，2： | 3 |
| 4 | Women with a low Framingham risk score and a family history of premature coronary heart disease have a high prevalence of subclinical coronary atherosclerosis显示文摘 | Erin D. Michos Chandrasekhar R. Vasamreddy Diane M. Becker Lisa R. Yanek Taryn F. Moy Elliot K. Fishman Lewis C. Becker Roger S. Blumenthal | 2005 | American Heart Journal2005，，6： | 2 |
| 5 | 菠萝蛋白酶治疗心血管疾病的系统综述(英文)显示文摘背景:在2004年,全球估计有1710万人死于心血管疾病。根据美国心脏病协会的数据,心脏病与中风是2型糖尿病患者的首要致死及致残因素。寻找更多的安全有效的心血管疾病治疗方案对于该疾病的预防和治疗十分必要,营养补充品是可行方案之一。目的:探讨菠萝蛋白酶(一种食品补充品)对心血管疾病的预防和治疗作用。检索策略:2009年9月至2010年3月进行电子与手工检索。检索的数据库包括Ovid MEDLINE;All EBMReviews-Cochrane Database of Systematic Reviews(Cochrane DSR)、American College of Physicians(ACP)Journal Club、Database of Abstracts of Reviews of Effects(DARE)、Cochrane Central Register ofControlled Trials(CCTR)、Cochrane Methodology Register(CMR)、Health Technology Assessment(HTA)和National Health Service Economic Evaluation Database(NHSEED);Allied and ComplementaryMedicine(AMED)、British Nursing Index and Archive、EMBASE、Health Management InformationConsortium(HMIC)、ScienceDirect和Electronic Thesis Online Services(ETHOS)。检索语言限定为英文。纳入标准:有关菠萝蛋白酶用于预防或治疗心脑血管疾病的随机对照试验、人体研究、动物研究与实验性研究。资料提取与分析:3位作者分别对检索到的文章进行文献质量评估并提取文献资料。所收集的资料包括实验种类、用药剂量、治疗周期、测量指标、研究结果、菠萝蛋白酶的特征、结果的意义与研究结论。结果:在搜索到的223篇文章中,只有6篇文章符合纳入标准。包括3项动物实验和3项人体试验。菠萝蛋白酶可用来治疗急性血栓性静脉炎,因为它可减少血液中的纤维蛋白原含量,降低血小板聚集度,有保护心脏的作用,并能够改善动脉壁的结构,避免由凝血酶所诱发的血小板聚集,减少血栓的形成。结论:迄今为止,没有菠萝蛋白酶用于心血管疾病治疗的高质量的人体研究。在1948年至2010年间所发表的有关菠萝蛋白酶与心血管疾病的研究的数量极为有限。在未来的心血管疾病研究中这可能是一个值得探索的领域。 | Chit Moy Ley Amalia Tsiami 倪青 Nicola Robinson | 2011 | 中西医结合学报2011，9，7： | 2 |
| 6 | Immunogenicity of a recombinant yeast de - rived hepatitis B vaccine (Engerix - B) in children显示文摘 | Moyes C Milne A | 1988 | NZ Med J1988，101，： | 1 |
| 7 | Efficacy and safety of a new immunoglobulin G product, Gammaplex, in primary immunodeficiency diseases 显示文摘 | Moy JN Scharenberg AM | 2010 | Clin Exp lmmunol2010，162，3： | 1 |
| 8 | The effect of pravastation on coronary avents after myocardial infarction in patients with average cholesterol levels 显示文摘 | Sacks FM Pfeffer MA Moye L | 1996 | NEJM1996，335，： | 1 |
| 9 | The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels 显示文摘 | Sacks FM Pfeffer MA Moye LA | 1996 | N Engl J Med1996，335，14： | 1 |
| 10 | Regeneration of transgenic rose (Rosa hybrida ) plants from embryogertic tissue显示文摘 | FIROOZABADY E MOY Y COURTNEY-GUTTERSON N | 1994 | Bio/technology1994，12，： | 1 |
| 11 | Sphygmomanometrically determined pulse pressure is a powerful independent predictor of recurrent events after myocardial infarction in patients with impaired left ventricular function显示文摘 | Mitchell GF Moye LA Braunwald BE | 1997 | Circulation1997，96，11： | 1 |
| 12 | Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis 显示文摘 | NAGLIK J R MOYES D MAKWANA J | 2008 | Microbiology2008，154，11： | 1 |
| 13 | High organic loading influences the physical characteristics of aerobic granules显示文摘 | Moy B Y P Tay J H Toh S K | 2002 | Letters in Applied Microbiology2002，34，： | 1 |
| 14 | Dental implant failure rates and associated risk factors显示文摘 | Moy PK Medina D Shetty V | | 0，，： | 1 |
| 15 | Wireless Capsule Endoscopy in the Pediatric Age Group: Experience and Complications显示文摘 | Libia Moy Jeremiah Levine | 2007 | Journal of Pediatric Gastroenterology and Nutrition2007，，4： | 1 |
| 16 | Heart Disease and Stroke Statistics—2008 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Wayne Rosamond Katherine Flegal Karen Furie Alan Go Kurt Greenlund Nancy Haase Susan M. Hailpern Michael Ho Virginia Howard Brett Kissela Steven Kittner Donald Lloyd-Jones Mary McDermott James Meigs Claudia Moy Graham Nichol Christopher O’Donnell Veroniqu | 2008 | Circulation2008，，4： | 1 |
| 17 | Comparison of 3-point Dixon imaging and fuzzy C-meansclustering methods for breast density measurement显示文摘 | Clendenen TV Zeleniuch-Jacquotte A Moy L | 2013 | J MagnReson Imaging2013，38，2： | 1 |
| 18 | Insulin allergy in a patient with type 2 diabetes successfully treated with continuous subcutane- ous insulin infusion显示文摘 | Moyes V Driver R Croom A | 2006 | Diabet Med2006，23，2： | 1 |
| 19 | Ulnar coronoidprocess an anatomy : possible implications for elbow instability显示文摘 | Ablove RH Moy OJ Howard C | 2006 | Clin Orthop Relat Res2006，449，： | 1 |
| 20 | Radical scavenging ability of polyphenolic compounds towards DPPH free radical显示文摘 | D. Villa?o M.S. Fernández-Pachón M.L. Moyá A.M. Troncoso M.C. García-Parrilla | 2006 | Talanta2006，，1： | 1 |
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