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| 1 | Pancreatic cancer and its stroma: A conspiracy theory显示文摘Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction that has received little attention until recent times. Given that treatments focusing on pancreatic cancer cells alone have failed to significantly improve patient outcome over many decades, research efforts have now moved to understanding the pathophysiology of the stromal reaction and its role in cancer progression. In this regard, our Group was the first to identify the cells(pancreatic stellate cells, PSCs) that produced the collagenous stroma of pancreatic cancer and to demonstrate that these cells interacted closely with cancer cells to facilitate local tumour growth and distant metastasis. Evidence is accumulating to indicate that stromal PSCs may also mediate angiogenesis, immune evasion and the well known resistance of pancreatic cancer to chemotherapy and radiotherapy. This review will summarise current knowledge regarding the critical role of pancreatic stellate cells and the stroma in pancreatic cancer biologyand the therapeutic approaches being developed to target the stroma in a bid to improve the outcome of this devastating disease. | Zhihong Xu Srinivasa P Pothula Jeremy S Wilson Minoti V Apte | 2014 | World Journal of Gastroenterology2014，20，32： | 10 |
| 2 | A Starring Role for Stellate Cells in the Pancreatic Cancer Microenvironment显示文摘 | Minoti V. Apte Jeremy S. Wilson Aurelia Lugea Stephen J. Pandol | 2013 | Gastroenterology2013，，6： | 6 |
| 3 | Alcoholic pancreatitis:A tale of spirits and bacteria显示文摘Alcohol is a major cause of chronic pancreatitis.About5%of alcoholics will ever suffer from pancreatitis,suggesting that additional co-factors are required to trigger an overt disease.Experimental work has implicated lipopolysaccharide,from gut-derived bacteria,as a potential co-factor of alcoholic pancreatitis.This review discusses the effects of alcohol on the gut flora,the gut barrier,the liver-and the pancreas and proposes potential interventional strategies.A better understanding of the interaction between the gut,the liver and the pancreas may provide valuable insight into the pathophysiology of alcoholic pancreatitis. | Alain Vonlaufen Laurent Spahr Minoti V Apte Jean-Louis Frossard | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，2： | 3 |
| 4 | Activation of Pancreatic Stellate Cells in Human and Experimental Pancreatic Fibrosis显示文摘 | Paul S. Haber Gregory W. Keogh Minoti V. Apte Corey S. Moran Nancy L. Stewart Darrell H.G. Crawford Romano C. Pirola Geoffrey W. McCaughan Grant A. Ramm Jeremy S. Wilson | 1999 | The American Journal of Pathology1999，，4： | 2 |
| 5 | Role of Pancreatic Stellate Cells in Pancreatic Cancer Metastasis显示文摘 | Zhihong Xu Alain Vonlaufen Phoebe A. Phillips Eva Fiala-Beer Xuguo Zhang Lu Yang Andrew V. Biankin David Goldstein Romano C. Pirola Jeremy S. Wilson Minoti V. Apte | 2010 | The American Journal of Pathology2010，，5： | 2 |
| 6 | Molecular mecha- nisms of pancreatitis : Current opinion 显示文摘 | Alain V Jeremy S W Minoti V A | 2008 | 2I Gastroen- terol Hepatol2008，23，9： | 1 |
| 7 | Activation of Pancreatic Stellate Cells in Human and Experimental Pancreatic Fibrosis显示文摘 | Paul S. Haber Gregory W. Keogh Minoti V. Apte Corey S. Moran Nancy L. Stewart Darrell H.G. Crawford Romano C. Pirola Geoffrey W. McCaughan Grant A. Ramm Jeremy S. Wilson | 1999 | The American Journal of Pathology1999，，4： | 1 |
| 8 | Analysis of tamoxifen-DNA adducts by high-performance liquid chromatography using postcolumn online photochemical activation显示文摘 | Minoti S | 2000 | Biochem Biophys Res Commun2000，273，1： | 1 |
| 9 | Bacterial Endotoxin: A Trigger Factor for Alcoholic Pancreatitis? Evidence From a Novel, Physiologically Relevant Animal Model显示文摘 | Alain Vonlaufen Zhihong Xu Balu Daniel Rakesh K. Kumar Romano Pirola Jeremy Wilson Minoti V. Apte | 2007 | Gastroenterology2007，，4： | 1 |
| 10 | Redox cycling of iron an lipid peroxidation显示文摘 | Minoti G Aust S D | 1992 | Lipids1992，27，： | 1 |
| 11 | Redox cycling of iron an lipid peroxidation显示文摘 | Minoti G Aust S D | 1992 | Lipids1992，27，： | 1 |
| 12 | Chronic Pancreatitis: Challenges and Advances in Pathogenesis, Genetics, Diagnosis, and Therapy显示文摘 | Heiko Witt Minoti V. Apte Volker Keim Jeremy S. Wilson | 2007 | Gastroenterology2007，，4： | 1 |
| 13 | Bacterial Endotoxin: A Trigger Factor for Alcoholic Pancreatitis? Evidence From a Novel, Physiologically Relevant Animal Model显示文摘 | Alain Vonlaufen Zhihong Xu Balu Daniel Rakesh K. Kumar Romano Pirola Jeremy Wilson Minoti V. Apte | 2007 | Gastroenterology2007，，4： | 1 |
| 14 | Analysis of tamoxifen-DNA adducts by high-performance liquid chromatography using postcolumn online photochemical activation显示文摘 | Minoti S | 2000 | Biochem Biophys Res Commun2000，273，1： | 1 |
| 15 | β-Catenin and Tcfs in Mammary Development and Cancer显示文摘 | Sarah Hatsell Tracey Rowlands Minoti Hiremath Pamela Cowin | 2003 | Journal of Mammary Gland Biology and Neoplasia2003，，2： | 1 |
| 16 | Chronic Pancreatitis: Challenges and Advances in Pathogenesis, Genetics, Diagnosis, and Therapy显示文摘 | Heiko Witt Minoti V. Apte Volker Keim Jeremy S. Wilson | 2007 | Gastroenterology2007，，4： | 1 |
| 17 | Redox cycling of iron an lipid peroxidation 显示文摘 | Minoti G Aust S D | 1992 | Lipids1992，271，219： | 1 |
| 18 | Isolation of Quiescent Human Pancreatic Stellate Cells: A Promising in vitro Tool for Studies of Human Pancreatic Stellate Cell Biology显示文摘 | Alain Vonlaufena Phoebe A. Phillipsa Lu Yanga Zhihong Xua Eva Fiala-Beera Xuguo Zhanga Romano C. Pirola Jeremy S. Wilson Minoti V. Apte | 2010 | Pancreatology2010，，4： | 1 |
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