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您的检索式：作者名="Minjun Tang"
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| 1 | Non-destructive Measurement of Magnetic Properties of Claw Pole显示文摘The magnetic properties of the claw pole have a direct effect on the output power of a generator Many methods can be used to measure these magnetic properties,each with its own advantages,but an important shortcoming is that all are destructive.In this study,a new non-destructive method to measure the magnetic properties of claw pole was proposed and a corresponding testing set-up was designed.A finite-element model was constructed to simulate the measurement process.Results proved that the measured magnetization-like curves had good agreement with the trend of the input magnetic curves and the effect of the positioning error in the measuring process could be neglected.To further validate the new method,seven types of claw poles of different materials subjected to different heat-treatment processes were forged and tested by both the new method and the conventional ring-sample method.Compared with the latter,the new method showed better consistency,relatively higher accuracy,and much stronger stability of measurement results;however,its sensitivity needs to be improved.The effects of material compositions and heat-treatment parameters on the magnetic properties of the claw pole were briefly analyzed. | Chengliang Hu Xuejiao Bai Minjun Tang Xiaofeng Tang Zhen Zhao | 2019 | Chinese Journal of Mechanical Engineering2019，32，5： | 2 |
| 2 | Nanopolyphenol rejuvenates microglial surveillance of multiple misfolded proteins through metabolic reprogramming显示文摘Microglial surveillance plays an essential role in clearing misfolded proteins such as amyloid-beta,tau,andα-synuclein aggregates in neurodegenerative diseases.However,due to the complex structure and ambiguous pathogenic species of the misfolded proteins,a universal approach to remove the misfolded proteins remains unavailable.Here,we found that a polyphenol,α-mangostin,reprogrammed metabolism in the disease-associated microglia through shifting glycolysis to oxidative phosphorylation,which holistically rejuvenated microglial surveillance capacity to enhance microglial phagocytosis and autophagy-mediated degradation of multiple misfolded proteins.Nanoformulation ofα-mangostin efficiently deliveredα-mangostin to microglia,relieved the reactive status and rejuvenated the misfolded-proteins clearance capacity of microglia,which thus impressively relieved the neuropathological changes in both Alzheimer’s disease and Parkinson’s disease model mice.These findings provide direct evidences for the concept of rejuvenating microglial surveillance of multiple misfolded proteins through metabolic reprogramming,and demonstrate nanoformulatedα-mangostin as a potential and universal therapy against neurodegenerative diseases. | Dayuan Wang Xiao Gu Xinyi Ma Jun Chen Qizhi Zhang Zhihua Yu Juan Li Meng Hu Xiaofang Tan Yuyun Tang Jianrong Xu Minjun Xu Qingxiang Song Huahua Song Gan Jiang Zaiming Tang Xiaoling Gao Hongzhuan Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 3 | Antigen presenting cells may be able to distinguish between normal and radiatedSchistosoma japonicum cercaria:anin vitro observation显示文摘Objective:To observe the discrepancies of responses induced by Schistosoma japonicum(S.japonicum)normal cercaria antigen(NCA)and ultraviolet(UV)-radiation-attenuated cercaria antigen(UVACA)in an in vitro system.Methods:S.japonicum cercariae were collected and UVACA and NCA were prepared.Mouse macro- phage model cells(RAW 264.7)were treated with medium,NCA(40μg/mL)or UVACA(40μg/mL)in the presence or absence of recombinant mouse interferon gamma(rmIFN-γ;4 ng/mL)for 48 h.Cell surface staining and flow cytometry were used to assess the major histocompatibility complex(MHC)Ⅱexpression,and data were expressed as mean fluorescence intensities(MFI).Interleukin(IL)-10,IL-6 and prostaglandin E2(PGE 2 ) in cell culture supernatant were evaluated by commercial enzyme-linked immunosorbent assays.Results:NCA significantly suppressed IFN-γ-induced MHCⅡexpression on RAW 264.7 cells.In the presence of IFN-γ,NCA significantly promoted IL-6,IL-10 and PGE 2 secretion from RAW 264.7 cells.In the presence of IFN-γ,UVACA significantly promoted IL-10 but not IL-6 and PGE 2 secretion from RAW 264.7 cells and showed no effect on IFN-γ-induced MHCⅡexpression.Compared with UVACA,NCA significantly suppressed IFN-γ-induced MHC Ⅱexpression and significantly promoted IL-6,PGE 2 and IL-10 secretion from RAW 264.7 cells.Conclusion: RAW 264.7 cells respond differently to NCA and UVACA.NCA can significantly suppress IFN-γ-induced MHC Ⅱexpression and significantly promote IL-6,IL-10 and PGE 2 secretion from RAW 264.7 cells compared with UVACA. | Guixia Tang Minjun Ji HaiweiWu Guanling Wu | 2010 | The Journal of Biomedical Research2010，24，4： | 0 |
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