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| 1 | SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade显示文摘Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099.Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system.SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8tIFN-γtT cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and antiPD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growthin two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy. | Mingxia Zhao Wenjie Guo Yuanyuan Wu Chenxi Yang Liang Zhong Guoliang Deng Yuyu Zhu Wen Liu Yanhong Gu Yin Lu Lingdong Kong Xiangbao Meng Qiang Xu Yang Sun | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 18 |
| 2 | Effectiveness of Inactivated COVID-19 Vaccines Against Symptomatic,Pneumonia,and Severe Disease Caused by the Delta Variant:Real World Study and Evidence—China,2021显示文摘Summary What is already known about this topic?Effectiveness of China’s 2 inactivated vaccines(BBIBPCorV and CoronaVac)against pre-Delta severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)variants ranged from 47%to over 90%,depending on the clinical endpoint,and with greater effectiveness against more severe coronavirus disease 2019(COVID-19).During an outbreak in Guangdong,inactivated vaccine effectiveness(VE)against the Delta variant was 70%for symptomatic infection and 100%for severe COVID-19.However,separate or combined VE estimates for the two inactivated vaccines against Delta are not available.What is added by this report?In an outbreak that started in a hospital,VEs of completed primary vaccination with inactivated COVID-19 vaccines against symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant were 51%,61%,and 82%.Completed primary vaccination reduced the risk of progressing from mild to moderate or severe COVID-19 by 74%.VE estimates for BBIBP-CorV and CoronaVac or combined vaccination were similar,and partial vaccination was ineffective.What are the implications for public health practice?Completed primary vaccination with either of the 2 inactivated COVID-19 vaccines reduces risk of symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant.Completion of the completed primary vaccination with two doses is necessary for protection from Delta. | Dan Wu Yanyang Zhang Lin Tang Fuzhen Wang Ying Ye Chao Ma Hui Zheng Wenzhou Yu Lei Cao Yifan Song Abuduwaili Reyimu Xiaoxiao Zhang Haifeng Wang Yifei Nie Mingxia Lu Muge Qi Jun Li Ruolin Wang Kaichao Yang Changshuang Wang Lawrence Everett Rodewald Geroge Fu Gao Zhijie An Zundong Yin | 2022 | China CDC weekly2022，4，4： | 7 |
| 3 | A novel extractant bis(2-ethylhexyl)((2-ethylhexylamino)methyl) phosphine oxide for cerium(Ⅳ) extraction and separation from sulfate medium显示文摘By introducing the amine group into phosphorus extractant,a novel aminophosphine compound bis(2-ethylhexyl)((2-ethylhexylamino)methyl) phosphine oxide(DEHAPO,abbreviated as A) was synthesized for the extraction of cerium(Ⅳ)(Ce(Ⅳ)) from sulfate medium(H2 SO4).The influence factors including extractant concentration,H2 SO4 concentration and temperature on the Ce(Ⅳ) extraction were investigated and discussed.It is found that the extraction ability of Ce(Ⅳ),thorium(Ⅳ)(Th(Ⅳ)) and rare earths(REs(Ⅲ))(La,Gd,Yb) decreases in sulphate medium in the following order:Ce(Ⅳ)> Th(Ⅳ)> REs(Ⅲ).The extraction process is an exothermic reaction and the thermodynamic parameters were calculated.The extracted complex of Ce(HSO4)2 SO4·A in loaded organic solution was identified by the slope methods and further proved by FT-IR spectral analysis.Stripping studies indicate that Ce(IV) can be effectively stripped from the organic phase.The results of separation factors(β) and saturation loading capacity demonstrate that DEHAPO could be used to selectively extract Ce(Ⅳ) from sulphate medium with high separation efficiency and good extraction ability. | Mingxia Huang Yongmei Fu Youcai Lu Wuping Liao Zhongjun Li | 2020 | Journal of Rare Earths2020，38，12： | 3 |
| 4 | Optimization of compression formulation and load of food-grade tracers for grain traceability using central composite design显示文摘Food-grade tracers have been developed as an identification technology for grain traceability from original harvest to final destination for transportation.The characteristics of food-grade tracers must be able to satisfy the environmental demands for grain traceability.To optimize the food-grade tracer production process,the effects of direct compression formulation and load on the mechanical characteristics were studied using response surface methodology(RSM)with central composite design(CCD).Among the four tested formulations,Formulations#2(consisting of 35.00%lactose 100 mesh,64.50%microcrystalline cellulose 102 and 0.50%magnesium stearate)and#4(consisting of 38.00%lactose 100 mesh,50.00%microcrystalline cellulose 102,11.00%pregelatinized starch and 1.00%magnesium stearate)were selected for tracer production based on their physical properties as powders.The value of Carr’s flowability index was 68 for both Formulations#2 and#4,which was the highest among all the formulations.Therefore,Formulations#2 and#4 also had the best powder flowability.The magnesium stearate ratio(1.00%-3.00%)and pressure(6.00-16.00 kgf)were used as independent variables to detect changes in the breaking rate,peak shear force and friction coefficient of tracers compressed by the selected formulations.The optimal production parameters could be achieved at a magnesium stearate ratio of 2.25%and pressure of 16.00 kgf for Formulation#2 and at a magnesium stearate ratio of 1.02%and pressure of 16.00 kgf for Formulation#4.Under these optimal conditions,the tracers had good impact characteristics(breaking rate),compression characteristics(peak shear force)and frictional characteristics(friction coefficient).Moreover,Formulation#2 was more suitable for production because compared to Formulation#4,its breaking rate and friction coefficient values were lower,and its peak shear force value was higher. | Liang Kun Zhang Lingling Lu Wei Cedric Sean Okinda Shen Mingxia | 2017 | International Journal of Agricultural and Biological Engineering2017，10，6： | 2 |
| 5 | Identification of a novel HLA-A2-restricted cytotoxic T lymphocyte epitope from cancer-testis antigen PLAC1 in breast cancer显示文摘 | Wei Liu Mingxia Zhai Zongyin Wu Yuanming Qi Yahong Wu Chao Dai Meng Sun Lu Li Yanfeng Gao | 2012 | Amino Acids2012，，： | 1 |
| 6 | Multiple forms of vitamin B_(6) regulate salt tolerance by balancing ROS and abscisic acid levels in maize root显示文摘Salt stress causes osmotic stress,ion toxicity and oxidative stress,inducing the accumulation of abscisic acid(ABA)and excessive reactive oxygen species(ROS)production,which further damage cell structure and inhibit the development of roots in plants.Previous study showed that vitamin B_(6)(VB_(6))plays a role in plant responses to salt stress,however,the regulatory relationship between ROS,VB_(6) and ABA under salt stress remains unclear yet in plants.In our study,we found that salt stress-induced ABA accumulation requires ROS production,in addition,salt stress also promoted VB_(6)(including pyridoxamine(PM),pyridoxal(PL),pyridoxine(PN),and pyridoxal 5′-phosphate(PLP))accumulation,which involved in ROS scavenging and ABA biosynthesis.Furthermore,VB_(6)-deficient maize mutant small kernel2(smk2)heterozygous is more susceptible to salt stress,and which failed to scavenge excessive ROS effectively or induce ABA accumulation in maize root under salt stress,interestingly,which can be restored by exogenous PN and PLP,respec-tively.According to these results,we proposed that PN and PLP play an essential role in balancing ROS and ABA levels under salt stress,respectively,it laid a foundation for VB_(6) to be better applied in crop salt resistance than ABA. | Chongchong Lu Yuan Tian Xuanxuan Hou Xin Hou Zichang Jia Min Li Mingxia Hao Yanke Jiang Qingbin Wang Qiong Pu Ziyi Yin Yang Li Baoyou Liu Xiaojing Kang Guangyi Zhang Xinhua Ding Yinggao Liu | 2022 | Stress Biology2022，2，1： | 1 |
| 7 | Separation of trivalent rare earths from nitrate medium using solvent extraction with a novel extractant 2-ethylhexyl((2-ethylhexylamino)methyl)phosphonic acid显示文摘By introducing the amine group into the structure of P227,a novel extractant 2-ethylhexyl((2-ethylhexylamino)methyl)phosphonic acid(EEAMPA,abbreviated as HA)was synthesized for the extraction and separation of trivalent rare earths(REs)from nitrate medium.The influence factors including extractant concentration,equilibrium time,HNO_(3)concentration,separation factors,cycle regeneration,stripping acidity,and actual leach liquor of metal ions,were studied systematically.The results show that the extraction ability of EEAMPA for REs decreases with increasing acidity.A possible extraction mechanism is proposed and the extracted species as REHA_(3)(NO_(3))are confirmed by the slope analysis method.The extraction equilibrium can reach faster than P227.It shows good chemical stability and cycling regeneration.Stripping studies show that HCl is an excellent stripping agent and REs can be effectively stripped from the organic phase. | Yongmei Fu Mingxia Huang Zhulin Zhou Zhongjun Li Wuping Liao Youcai Lu | 2022 | Journal of Rare Earths2022，40，3： | 1 |
| 8 | In situ growth CNT@MOFs core-shell structures enabling high specific supercapacitances in neutral aqueous electrolyte显示文摘Conductive metal-organic frameworks(c-MOFs)are promising active electrode materials for electrochemical double-layer capacitors with a performance that already exceeds most carbon-based materials.However,their excellent supercapacitance is primarily based on organic or alkaline electrolytes,which largely impede their broad applications and sustainabilities.In this work,we propose a new synthesis approach for fabricating carbon nanotubes and c-MOFs(CNT@MOFs)core–shell structures,which result in high supercapacitance in neutral aqueous electrolytes.We identify that CNTs provide abundant active sites to ensure high capacitance,and Ni3(2,3,6,7,10,11-hexaiminotriphenylene(HITP))2 nanoarrays that in situ grow on the surface of CNTs bundles can significantly improve the conductivity and provide enough ion transport pathways in aqueous electrolytes.Specifically,using CNT@MOFs core-shell structures as an electrode,we obtained a high initial capacitance of 150.7 F·g^(−1) at 0.1 A·g^(−1) in 1 M Na2SO4 solution and good capacity retention of 83.5%after 10,000 cycles at 4 A·g^(−1).We also found that the carboxyl groups on the surface of CNTs provide better anchor sites for the in situ growth of c-MOF,which promotes the uniform growth of c-MOF shells on the CNT surface and improves aqueous electrolyte accessibility.We believe that the high supercapacitance in aqueous electrolytes reported in this work would provide a good prospect for deploying c-MOF based energy storage devices into biomedical and other healthcare electronic applications. | Mingxia Lu Gang Wang Xiping Yang Bo Hou | 2022 | Nano Research2022，15，7： | 0 |
| 9 | Epidemiological survey and genetic characterization of type 3 vaccine-derived poliovirus isolated from a patient with four doses of inactivated polio vaccine in Henan Province,China显示文摘Background:Vaccine-derived poliovirus(VDPV)is a potential threat to polio eradication because they can reintroduce into the general population and cause paralytic polio outbreaks,a phenomenon that has recently emerged as a prominent public health concern at the end of global polio eradication.This study aimed to describe the epidemiology and genetic characteristics of the frst VDPV identifed from a patient with acute faccid paralysis(AFP),with four doses of inactivated polio vaccine immunization in Henan Province,China in 2017.Methods:The patient was diagnosed with type 3 VDPV.Subsequently,a series of epidemiological approaches was implemented,including a retrospective search of AFP cases,rate of vaccination assessment,study of contacts,and supplementary immunization activities.Fecal samples were collected,viral isolation was performed,and the viral isolates were characterized using full-length genomic sequencing and bioinformatic analysis.Results:Phylogenetic analysis showed that the viral isolates from the patient were diferent from other reported genetic clusters of type 3 VDPV worldwide.They were identifed as a Sabin 3/Sabin 1 recombinant VDPV with a crossover site in the P2 region.Nucleotide substitutions,including U→C(472)and C→U(2493),have been identifed,both of which are frequently observed as reversion mutations in neurovirulent type 3 poliovirus.A unique aspect of this case is that the patient had been vaccinated with four doses of inactive polio vaccine,and the serum neutralizing antibody for Sabin types 1 and 3 were 1∶16 and 1∶512,respectively.Thus,the patient was speculated to have been infected with type 3 VDPV,and the virus continued to replicate and be excreted for at least 41 d.Conclusions:The existence of this kind of virus in human population is a serious risk and poses a severe challenge in maintaining a polio-free status in China.To the best of our knowledge,this is the frst report of VDPV identifed in the Henan province of China.Our results highlight the importance of maintaining a high-level vaccination rate and highly sensitive AFP case surveillance system in intercepting VDPV transmission. | Mingyu Zhang Jianhui Yang Yiran Bai Hui Zhu Changshuang Wang Lu Zhang Jin Xu Mingxia Lu Xiaoxiao Zhang Zhanpei Xiao Yating Ma Yan Wang Xiaolei Li Dongyan Wang Shuangli Zhu Dongmei Yan Wenbo Xu Yong Zhang Yanyang Zhang | 2022 | Infectious Diseases of Poverty2022，11，6： | 0 |
| 10 | Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis显示文摘The clinical utilization of doxorubicin(Dox)in various malignancies is restrained by its major adverse effect:irreversible cardiomyopathy.Extensive studies have been done to explore the prevention of Dox cardiomyopathy.Currently,ferroptosis has been shown to participate in the incidence and development of Dox cardiomyopathy.Sorting Nexin 3(SNX3),the retromer-associated cargo binding protein with important physiological functions,was identified as a potent therapeutic target for cardiac hypertrophy in our previous study.However,few study has shown whether SNX3 plays a critical role in Dox-induced cardiomyopathy.In this study,a decreased level of SNX3 in Dox-induced cardiomyopathy was observed.Cardiac-specific Snx3 knockout(Snx3-cKO)significantly alleviated cardiomyopathy by downregulating Dox-induced ferroptosis significantly.SNX3 was further demonstrated to exacerbate Dox-induced cardiomyopathy via induction of ferroptosis in vivo and in vitro,and cardiac-specific Snx3 transgenic(Snx3-cTg)mice were more susceptible to Dox-induced feroptosis and cardiomyopathy.Mechanistically,SNX3 facilitated the recycling of transferrin 1 receptor(TFRC)via direct interaction,disrupting iron homeostasis,increasing the accumulation of iron,triggering ferroptosis,and eventually exacerbating Dox-induced cardiomyopathy.Overall,these findings established a direct SNX3-TFRC-ferroptosis positive regulatory axis in Dox-induced cardiomyopathy and suggested that targeting SNX3 provided a new effective therapeutic strategy for Dox-induced cardiomyopathy through TFRCdependentferroptosis. | Wenjing Yu Yuehuai Hu Zhiping Liu Kaiteng Guo Dinghu Ma Mingxia Peng Yuemei Wang Jing Zhang Xiaolei Zhang Panxia Wang Jiguo Zhang Peiqing Liu Jing Lu | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 11 | Short-term feeding behaviour sound classification method for sheep using LSTM networks显示文摘A deep learning approach using long-short term memory(LSTM)networks was implemented in this study to classify the sound of short-term feeding behaviour of sheep,including biting,chewing,bolus regurgitation,and rumination chewing.The original acoustic signal was split into sound episodes using an endpoint detection method,where the thresholds of short-term energy and average zero-crossing rate were utilized.A discrete wavelet transform(DWT),Mel-frequency cepstral,and principal-component analysis(PCA)were integrated to extract the dimensionally reduced DWT based Mel-frequency cepstral coefficients(denoted by PW_MFCC)for each sound episode.Then,LSTM networks were employed to train classifiers for sound episode category classification.The performances of the LSTM classifiers with original Mel-frequency cepstral coefficients(MFCC),DWT based MFCC(denoted by W_MFCC),and PW_MFCC as the input feature coefficients were compared.Comparison results demonstrated that the introduction of DWT improved the classifier performance effectively,and PCA reduced the computational overhead without degrading classifier performance.The overall accuracy and comprehensive F1-score of the PW_MFCC based LSTM classifier were 94.97%and 97.41%,respectively.The classifier established in this study provided a foundation for an automatic identification system for sick sheep with abnormal feeding and rumination behaviour pattern. | Guanghui Duan Shengfu Zhang Mingzhou Lu Cedric Okinda Mingxia Shen Tomas Norton | 2021 | International Journal of Agricultural and Biological Engineering2021，14，2： | 0 |
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