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| 1 | Effect of burden and origin sites of premature ventricular contractions on left ventricular function by 7-day Holter monitor显示文摘Recent studies have shown that premature ventricular contractions(PVCs) could enlarge the heart,but its risk factors are incompletely understood as a single 24-hour recording cannot reflect the true PVC burden due to day-to-day variability.Our purpose was to investigate the effect of burden and origin sites on left ventricular(LV) function in patients with PVCs by 7-day Holter electrocardiography(ECG).From May 2012 to August2013,112 consecutive patients with PVCs were recruited from the authors' affiliated hospital.All patients received2-dimensional transthoracic echocardiography,12-lead routing ECG and 7-days Holter ECG.Serum N-terminal probrain natriuretic peptide(NT-proBNP) levels were measured.A total of 102 participants with PVCs were included in the final analysis.Origin of PVCs from the tricuspid annulus had the highest burden and NT-proBNP level.LV papillary muscle had a higher LV ejection fraction(EF) level and a lower LV end-systolic dimension(ESD) than other PVC foci(P<0.05).The high burden group had a higher LV end-diastolic dimension(EDD) and LVESD but lower LVEF than the other two groups(P<0.05).Female,older age,physical work,and history of PVCs had a significantly positive correlation with symptoms.Male,older age,physical work,and high burden were positive predictors of enlarged LVEDD,LVESD and higher serum NT-proBNP level,but lower LVEF.Seven-day dynamic ECG Holter monitor showed the true PVC burden on patients with PVCs.PVCs with a lower burden or origin from the LV papillary muscle and the fascicle were relatively benign,while PVCs with a higher burden or origin from the tricuspid annulus may lead to cardiac dysfunction. | Wenhua Xu Mingfang Li Minglong Chen Bing Yang Daowu Wang Xiangqing Kong Hongwu Chen Weizhu Ju Kai Gu Kejiang Cao Hailei Liu Qi Jiang Jiaojiao Shi Yan Cui Hong Wang | 2015 | The Journal of Biomedical Research2015，29，6： | 4 |
| 2 | Epidemiological characteristics and temporal-spatial analysis of overseas imported dengue fever cases in outbreak provinces of China, 2005–2019显示文摘Background Overseas imported dengue fever is an important factor in local outbreaks of this disease in the mainland of China.To better prevent and control such local outbreaks,the epidemiological characteristics and temporal-spatial distribution of overseas imported dengue fever cases in provincial-level administrative divisions(PLADs)where dengue fever is outbreak in the mainland of China were explored.Methods Using the Chinese National Notifiable Infectious Disease Reporting Information System(CNNDS),we identified overseas imported dengue fever cases in dengue fever outbreak areas in the mainland of China from 2005 to 2019 to draw the epidemic curve and population characteristic distribution of overseas imported cases in each PLAD.Based on spatial autocorrelation analysis of ArcGIS 10.5 and temporal-spatial scanning analysis of SaTScan 9.5,we analyzed the temporal-spatial distribution of overseas imported dengue fever in dengue fever outbreak areas in the mainland of China.Results A total of 11,407 imported cases,mainly from Southeast Asia,were recorded from 2005 to 2019 in these 13 PLADs.Of which 62.1%were imported into Yunnan and Guangdong Provinces.Among the imported cases,there were more males than females,mainly from the 21–50 age group.The hot spots were concentrated in parts of Yunnan,Guangdong and Fujian Provinces.We found the cluster of infected areas were expanding northward.Conclusions Based on the analysis of overseas imported dengue cases in 13 PLADs of the mainland of China from 2005 to 2019,we obtained the epidemiological characteristics and spatial distribution of imported dengue cases.Border controls need to pay attention to key population sectors,such as 21–50 years old men and education of key populations on dengue prevention.There is a need to improve the awareness of the prevention and control of imported cases in border areas.At the same time,northern regions cannot relax their vigilance. | Xinchang Lun Yiguan Wang Chunchun Zhao Haixia Wu Caiying Zhu Delong Ma Mingfang Xu Jun Wang Qiyong Liu Lei Xu Fengxia Meng | 2022 | Infectious Diseases of Poverty2022，11，1： | 3 |
| 3 | Gaussian process regression-based quaternion unscented Kalman robust filter for integrated SINS/GNSS显示文摘High-precision filtering estimation is one of the key techniques for strapdown inertial navigation system/global navigation satellite system(SINS/GNSS)integrated navigation system,and its estimation plays an important role in the performance evaluation of the navigation system.Traditional filter estimation methods usually assume that the measurement noise conforms to the Gaussian distribution,without considering the influence of the pollution introduced by the GNSS signal,which is susceptible to external interference.To address this problem,a high-precision filter estimation method using Gaussian process regression(GPR)is proposed to enhance the prediction and estimation capability of the unscented quaternion estimator(USQUE)to improve the navigation accuracy.Based on the advantage of the GPR machine learning function,the estimation performance of the sliding window for model training is measured.This method estimates the output of the observation information source through the measurement window and realizes the robust measurement update of the filter.The combination of GPR and the USQUE algorithm establishes a robust mechanism framework,which enhances the robustness and stability of traditional methods.The results of the trajectory simulation experiment and SINS/GNSS car-mounted tests indicate that the strategy has strong robustness and high estimation accuracy,which demonstrates the effectiveness of the proposed method. | LYU Xu HU Baiqing DAI Yongbin SUN Mingfang LIU Yi GAO Duanyang | 2022 | Journal of Systems Engineering and Electronics2022，33，5： | 2 |
| 4 | Synergistic antitumor effect of β-elemene and etoposide is mediatedvia induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinomacells显示文摘 | Fan Zhang Ling Xu Xiujuan Qu Mingfang Zhao Bo Jin Jian Kang Yunpeng Liu Xuejun Hu | 2011 | Molecular Medicine Reports2011，，6： | 1 |
| 5 | Temporal and Spatial Distribution of Auxin Response Factor Genes During Tomato Flower Abscission显示文摘 | Xiaoxi Guan Tao Xu Song Gao Mingfang Qi Yanling Wang Xin Liu Tianlai Li | 2014 | Journal of Plant Growth Regulation2014，，2： | 1 |
| 6 | Calcium Requirement for Ethylene-Induced Abscission显示文摘 | Tao Xu Tianlai Li Mingfang Qi | 2009 | Journal of Plant Nutrition2009，，3： | 1 |
| 7 | Nedaplatin? versus cisplatin?based chemotherapy in the survival timeof patients with non?small cell lung cancer显示文摘 | Jinlu Shan Yanli Xiong Dong Wang Mingfang Xu Yi Yang Kan Gong Zhenzhou Yang Ge Wang Xueqin Yang | 2015 | Molecular and Clinical Oncology2015，，3： | 1 |
| 8 | Preparation and characterization of CuO/SiO2 and NiO/SiO2 with bimodal pore structure by sol-gel method显示文摘 | Zheng Mingfang Zhao Tianbo Xu Wenguo | 2006 | J Sol-Gel Sci Techn2006，39，： | 1 |
| 9 | Ambient Temperature and Years of Life Lost:A National Study in China显示文摘Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and quantified the YLL per death caused by temperature in China.We collected daily meteorological and mortality data,and calculated the daily YLL values for 364 locations(2013–2017 in Yunnan,Guangdong,Hunan,Zhejiang,and Jilin provinces,and 2006–2011 in other locations)in China.A time-series design with a distributed lag nonlinear model was first employed to estimate the location-specific associations between temperature and YLL rates(YLL/100,000 population),and a multivariate meta-analysis model was used to pool location-specific associations.Then,YLL per death caused by temperatures was calculated.The temperature and YLL rates consistently showed U-shaped associations.A mean of 1.02(95%confidence interval:0.67,1.37)YLL per death was attributable to temperature.Cold temperature caused 0.98 YLL per death with most from moderate cold(0.84).The mean YLL per death was higher in those with cardiovascular diseases(1.14),males(1.15),younger age categories(1.31 in people aged 65–74 years),and in central China(1.34)than in those with respiratory diseases(0.47),females(0.87),older people(0.85 in people R75 years old),and northern China(0.64)or southern China(1.19).The mortality burden was modified by annual temperature and temperature variability,relative humidity,latitude,longitude,altitude,education attainment,and central heating use.Temperatures caused substantial YLL per death in China,which was modified by demographic and regional characteristics. | Tao Liu Chunliang Zhou Haoming Zhang Biao Huang Yanjun Xu Lifeng Lin Lijun Wang Ruying Hu Zhulin Hou Yize Xiao Junhua Li Xiaojun Xu Donghui Jin Mingfang Qin Qinglong Zhao Weiwei Gong Peng Yin Yiqing Xu Jianxiong Hu Jianpeng Xiao Weilin Zeng Xing Li Siqi Chen Lingchuan Guo Zuhua Rong Yonghui Zhang Cunrui Huang Yaodong Du Yuming Guo Shannon Rutherford Min Yu Maigeng Zhou Wenjun Ma | 2021 | The Innovation2021，2，1： | 1 |
| 10 | Optimal ordering policy for platelets:Data-driven method vs model-driven method显示文摘Platelets,one of the most significant materials in treating leukemia,have a limited shelf life of approximately five days.Because platelets cannot be manufactured and can only be centrifuged from whole or donated blood directly,an accurate ordering policy is necessary for the efficient use of this limited blood resource.Given this motivation,the present study examines an ordering policy for platelets to minimize the expected shortage and overage.Rather than using the two-step model-driven method that first fits a demand distribution and then optimizes the order quantity,we solve the issue using an integrated datadriven method.Specifically,the data-driven method works directly with demand data and does not rely on the assumption of demand distribution.Consequently,we derive theoretical insights into the optimal solutions.Through a comparative analysis,we find that the data-driven method has a mean anchoring effect,and the amounts of shortage and overage reduced by this method are greater than those reduced by the model-driven method.Finally,we present an extended model with the service level requirement and conclude that the order decided by the data-driven method can precisely satisfy the service level requirement;however,the order decided by the model-driven method may be either higher or lower than the service level requirement and can lead to a higher cost. | Mingfang Yang Xu Chen Zheng Luo | 2021 | Fundamental Research2021，1，5： | 0 |
| 11 | Study on the Variation Characteristics of Haze Weather in Hubei Province during 1980-2012显示文摘This paper, using the method of 'the combination of 14 o'clock relative humidity, visibility and weather phenomena', selected haze days during 1980-2012 from 13 stations of Hubei Province, and studied years of variation characteristics of haze weather in Hubei Province. The results showed that the average annual haze days showed a fluctuant rising trend in whole from 1980 to 2012, but there were many peak value and valley value during the whole changing process; haze days of most stations showed an increasing trend, among which the stations with less than50 d haze days had a more obvious increasing trend, and the spatial distribution of annual mean haze days had distinct inhomogeneity. Haze days of Hubei Province presented the distribution characteristics of more in autumn and winter, and less in spring and summer, in which haze days during December-January were the most,and haze days during July-August were the least. Terrain had a big impact on local haze days, piedmont leeward zones were prone to haze days, mountainous regions were just the opposite. The research suggested that we should combine different situations with different stations instead of exclusively from the mean value of multiple stations when we analyze the mean change of haze days in a broader area, to investigate the overall changing trend and the reasons. | Tianxing SU Mingfang XU Xiang ZHOU Zaiqiang YANG Jijian YUAN Haiyan ZHANG | 2015 | Agricultural Science & Technology2015，16，1： | 0 |
| 12 | Functional Analysis of Dunaliella salina Calmodulin Kinase Gene显示文摘[Objectives] This study was conducted to investigate the function of Dunaliella salina calmodulin kinase(CaM K) gene.[Methods] The sense and antisense gene fragments(223 bp) and spacer sequence(129 bp) of D.salina calmodulin kinase gene were cloned and inserted into the downstream part of the35 S promoter of the eukaryotic expression vector pM DCMGN-Cat.The siRNA expression system of CaM K gene was successfully constructed.The p CaM K-RNAi expression vector was transformed into D.salina cells by the LiA c/PEG-mediated method,giving transgenic D.salina.The expression of CaM K gene was then analyzed by real-time fluorescence quantitative PCR.[Results]The expression of CaM K gene in the transgenic D.salina was significantly reduced,by 70% compared with the control group,suggesting that the expression of CaM K gene was significantly inhibited.The examination of the growth status of D.salina showed that D.salina cell division and proliferation were also affected.It is proved that CaM K gene has a positive regulation effect on the division and proliferation of D.salina cells.[Conclusions] The study provides important information for further elucidating the function and action mechanism of D.salina calmodulin kinase gene. | Zhenyu XING Mingfang WANG Xiangnan GAO Weiwei XU Yuting CONG Xiaojie CHAI | 2020 | Agricultural Biotechnology2020，9，2： | 0 |
| 13 | Solvent-dependence of KI Mediated Electrosynthesis of Imidazo[1,2-a]pyridines显示文摘Iodized salts are widely used as mediators to promote C-H functionalization.Solvents and additives have been described as significant roles in these reactions.However,the further electrochemical investigations have rarely been reported.Herein,a KI mediated electrochemical annulation between acetophenones and 2-amniopyridines was developed.We revealed the effect of acids and solvents by cyclic voltammetry(CV),differential pulse voltammetry(DPV),and square wave voltammetry(SWV).The oxidation of 2-aminopyridine is inhibited at the potential window with the addition of strong acids,and the lowest oxidation potential difference of KI was obtained by utilizing EtOH as solvent.The experimental studies also show that the mixture solvent of EtOH/DMSO(9/1,volume ratio)facilitates the electrochemical cyclization due to the solubility improvement of KI.CF3SO3H has been screened as the optimal acid.A range of Imidazo[1,2-a]-pyridines have been synthesized in yields of 42%to 96%.Electrochemical investigations present that the KI mediated electrochemical reaction is probably solvent-dependence. | YI Yangjie XU Leitao LIU Yuyang LI Mingfang ZHANG Lijuan YE Jiao HU Aixi | 2023 | Chemical Research in Chinese Universities2023，39，2： | 0 |
| 14 | Epicardial adipose tissue around the superior vena cava: A single center study of factors related to atrial fibrillation显示文摘The superior vena cava(SVC)is the main component of non-pulmonary vein(PV)ectopy in patients with atrial fibrillation(AF).Researchers have found that epicardial adipose tissue(EAT)volume is related to the AF substrate,which can be defined by the low voltage area(LVA).This study aimed to investigate the relationship between SVC-EAT and SVC-AF.Twenty-six patients with SVC-AF triggers were identified as the SVC-AF group.Other three groups were defined and included as the LVA-AF group(LVA>5%),non-LVA-AF group(LVA<5%),and physical examination(PE)group.EAT around left atrium(LA-EAT)and SVC-EAT volumes were obtained using a cardiac risk assessment module.According to the SVC/LA-EAT ratio,there are significant differences between the SVC-AF group and the three control groups(the SVC-AF group 0.092±0.041 vs.the LVA-AF group 0.054±0.026,the non-LVA-AF group 0.052±0.022,and the PE group 0.052±0.019,all P<0.001).Receiver operating characteristic curve analysis suggests the optimal cut-off point of SVC/LA-EAT ratio is 6.8%for detecting SVC-AF patients,with 81.1%sensitivity,73.1%specificity,and an area under the curve of 0.83(95%confidence interval,0.75-0.91).Those with SVC-AF have a higher SVC/LA-EAT ratio and empirical SVC isolation could be considered if the SVC/LA-EAT ratio was over 6.8%. | Xingxing Sun Jun Wang Qing Yan Weizhu Ju Fengxiang Zhang Gang Yang Kai Gu Hailei Liu Zidun wang Xiaohong Jiang Mingfang Li Di Xu Yi Xu Hongwu Chen Minglong Chen | 2022 | The Journal of Biomedical Research2022，36，6： | 0 |
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