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| 1 | Molecular mechanisms of liver preconditioning显示文摘Ischemia/reperfusion (I/R) injury still represents an important cause of morbidity following hepatic surgery and limits the use of marginal livers in hepatic transplantation. Transient blood flow interruption followed by reperfusion protects tissues against damage induced by subsequent I/R. This process known as ischemic pre-conditioning (IP) depends upon intrinsic cytoprotective systems whose activation can inhibit the progression of irreversible tissue damage. Compared to other organs,liver IP has additional features as it reduces inflammation and promotes hepatic regeneration. Our present understanding of the molecular mechanisms involved in liver IP is still largely incomplete. Experimental studies have shown that the protective effects of liver IP are triggered by the release of adenosine and nitric oxide and the subsequent activation of signal networks involving protein kinases such as phosphatidylinositol 3-kinase,protein kinase C δ/ε and p38 MAP kinase,and transcription factors such as signal transducer and activator of transcription 3,nuclear factor-κB and hypoxia-inducible factor 1. This article offers an overview of the molecular events underlying the preconditioning effects in the liver and points to the possibility of developing pharmacological approaches aimed at activating the intrinsic protective systems in patients undergoing liver surgery. | Elisa Alchera Caterina Dal Ponte Chiara Imarisio Emanuele Albano Rita Carini | 2010 | World Journal of Gastroenterology2010，16，48： | 3 |
| 2 | VHL and HIF-1α: gene variations and prognosis in early-stage clear cell renal cell carcinoma显示文摘 | Francesca Lessi Chiara Maria Mazzanti Sara Tomei Claudio Cristofano Andrea Minervini Michele Menicagli Alessandro Apollo Lorenzo Masieri Paola Collecchi Riccardo Minervini Marco Carini Generoso Bevilacqua | 2014 | Medical Oncology2014，，3： | 2 |
| 3 | Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation显示文摘 | G. Vistoli D. De Maddis A. Cipak N. Zarkovic M. Carini G. Aldini | 2013 | Free Radical Research2013，，1： | 2 |
| 4 | Adenosine A2a receptor-mediated,normoxic induction of HIF-1 through PKC and PI-3K-dependent pathways in macrophages 显示文摘 | Deponti C Carini R Alchera E | 2007 | J Leukoc Biol2007，82，2： | 1 |
| 5 | Comparative evaluation of the antioxidant activity of alpha-tocopherol, alpha-tocopherol polyethylene glycol 1000 succinate and alpha tocopherol succiiaate in isolated hepatocytes and liver microsomal suspensions显示文摘 | Carini R Poli G Dianzaai M U | 1990 | Biochem Pharmacol1990，39，10： | 1 |
| 6 | Burning mouth syndrome:an evaluation of in vivo microcirculation显示文摘 | Scardina Giuseppe Alessandro Pisano Teresa Carini Francesco | 2008 | Journal of the American Dental Association(1939)2008，139，7： | 1 |
| 7 | Left ventricular mass and cardiovascular morbidity in essential hypertension: The MAVI Study显示文摘 | Carini G Circo A | 2001 | J Am Coll Cardiol2001，38，： | 1 |
| 8 | Nonpeptide angiotensin Ⅱ receptor antagonists: the discovery of a series of N-( biphenylmethyl)imidazoles as potent,orally active antihypertensives显示文摘 | Carini DJ Duncia JV Aldrich PE | 1991 | J Med Chem1991，34，8： | 1 |
| 9 | Diet enriched with proanthocyanidin enhances antioxidant activity and reduces myocardial post -is-caemic damage in rats显示文摘 | Facino R M Carini M Aidini G | 1999 | Life Sci1999，64，8： | 1 |
| 10 | Signal pathway involved in the development of hypoxic preconditioning in rat hepatocytes显示文摘 | Carini R De Cesaris MG Splendore R | 2001 | Hepatology2001，33，1： | 1 |
| 11 | Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrume显示文摘 | Cremon C Carini G Wang B | 2011 | Am J Gastroenterol2011，106，7： | 1 |
| 12 | Detection of IgG subclasses with anti-IgE activity in patients with atopic diseases显示文摘 | Carini C Fratazzi C | | 0，，03： | 1 |
| 13 | Cesium-134 and strontium-85 in strawberry plants following wet aerial deposition显示文摘 | Carini F Brambilla M Mitchell N | 2003 | Journal of Environmental Quality2003，32，6： | 1 |
| 14 | Left ventricular mass and cardiovascular morbidity in essential hypertension:the MAVI study显示文摘 | VERDECCHIA P CARINI G CIRCO A | 2001 | J Am Coll Cardio2001，38，7： | 1 |
| 15 | Signal pathway involved in the development of hypoxic preconditioning in rat hepatocytes显示文摘 | De Cesaris M G Splendore R | 2001 | Hepatology2001，33，1： | 1 |
| 16 | Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-( biphenylylmethyl ) imidazoles as potent, orally active antihypertensives 显示文摘 | Carini D J Duncia J V Aldrich P E | 1991 | J Med Chem1991，34，8： | 1 |
| 17 | LC coupled to ion trap MSfor the rapid screening and detection of polyphenol antioxidantsfrom Helichrysum stoechas 显示文摘 | Carini M Aldini G Furlanetto S | 2001 | BiomedAnal2001，24，： | 1 |
| 18 | Detection of microvariability for BL Lacertae objects显示文摘 | Carini M T Goodrich B D | 1989 | Nature1989，337，： | 1 |
| 19 | Purinergic P2Y2 receptors promote hepato cyte resistance to hypoxia显示文摘 | Carini R Alchera E De Cesaris M G Splendore R Piranda D Baldanzi G | 2006 | J Hepatol2006，45，： | 1 |
| 20 | Signal pathway involved in the development of hypoxic preconditioning in rat hepatocytes显示文摘 | Carini R De CesarisMG Splendore R | 2001 | Hepatology2001，33，： | 1 |
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