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| 1 | Methionine-dependence and combination chemotherapy on human gastric cancer cells in vitro显示文摘AIM: To elucidate whether human primary gastric cancer and gastric mucosa epithelial calls in vitro can grow normally in a rnethionine (Met) depleted environment, i.e.Met-dependence, and whether Met-depleting status can enhance the killing effect of chemotherapy on gastric cancer cells.lMETHODS: Fresh human gastric cancer and mucosal tissueswere managed to form monocellular suspensions, whichwere then cultured in the Met-free but homocysteine-containing ( MetHcy+ ) medium, with differentchemotherapeutic drugs. The proliferation of the cells wasexamined by cell counter, flow cytometry (FCM) andmicrocytotoxicity assay (MTT).RESULTS: The growth of human primary gastric cancer cellsin Met Hcy+ was suppressed, manifested by the decrease oftotal cell counts [1.46±0.42 ( x 109@L-1) in Met-Hcy+ vs .64±0.44 ( x l09@L-1) in Met+ Hcy, P<0.01], the decline inthe percentage of G0G1 phase cells (0.69±0.24 in Met-Hey+vs 0.80±0.18 in Met+ Hcy, P<0.01) and the increase of Scells(0.24±0.20inMet-Hcy+ vs 0.17 ± 0.16 in Met+ Hcy-, P< 0.01); however, gastric mucusal cells grew normally. IfMet-Hcy+ medium was used in combination withchemotherapeutic drugs, the number of surviving gastriccancer cells dropped significantly.CONCLUSION: Human primary gastric cancer cells in vitroare Met-dependent; however, gastric mucosal cells have notshown the same characteristica. Met- Hcy+ environment maystrengthen the killing effect of chemotherapy on humanprimary gastric cancer cells. | Wei-Xin Cao Jing-Min Ou Xu-Feng Fei,Department of Clinical Nutrition,Shanghai Institute of Digestive Surgery,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China Zheng-Gang Zhu Hao-Ran Yin Min Yan Yan-Zhen Lin,Department of Surgery,Shanghai Institute of Digestive Surgery,Ruijin Hospital,Shanghai Second Medical University,Shangha 200025,China | 2002 | World Journal of Gastroenterology2002，8，2： | 24 |
| 2 | Association between Vitamin D Insufficiency and the Risk for Gestational Diabetes Mellitus in Pregnant Chinese Women显示文摘Objective To investigate the association between vitamin D deficiency and risk of gestational diabetes mellitus(GDM) in pregnant Chinese women.Methods A nested case-control study was conducted.Clinical and biochemical data were analyzed for 200 subjects with GDM and 200 subjects with normal glucose tolerance(NGT).Results The median(interquartile range) serum 25-hydroxyvitamin D(25OHD) levels were 22.39(17.67,29.38) and 25.86(19.09,34.88) nmol/L in the GDM and NGT groups,respectively.Rates of 25OHD deficiency or insufficiency were significantly higher in the GDM group than in the NGT group.Subjects with 25OHD levels <25 nmol/L had a 1.8-fold higher risk of GDM compared with subjects with higher vitamin D levels.In the GDM group,serum 25OHD was independently associated with HbA1c and insulin resistance after adjusting for confounding factors.In the NGT group,serum 25OHD was independently associated with fasting plasma glucose and systolic blood pressure after adjusting for maternal age and other confounding factors.Conclusion 25OHD insufficiency is very common in Chinese women.Low 25OHD status may be associated with insulin resistance and act as a risk factor for GDM. | WANG Ou NIE Min HU Ying Ying ZHANG Kui LI Wei PING Fan LIU Jun Tao CHEN Li Meng XING Xiao Ping | 2012 | Biomedical and Environmental Sciences2012，25，4： | 21 |
| 3 | Involvement of aquaporins in a mouse model of rotavirus diarrhea显示文摘Rotavirus diarrhea is a major worldwide cause of infantile gastroenteritis; however, the mechanism responsible for intestinal fluid loss remains unclear. Water transfer across the intestinal epithelial membrane seems to occur because of aquaporins(AQPs). Accumulating evidence indicates that alterations in AQPs may play an important role in pathogenesis. Here, we focus on changes in AQPs in a mouse model of rotavirus diarrhea. In the present study, 32 of 35 mice developed diarrhea and mild dehydration within 24 hours after infection with rotavirus strain SA11. Intestinal epithelial cells demonstrated cytoplasmic vacuolation, malaligned villi, and atrophy. AQP1 expression was significantly attenuated in the ileum and colon in comparison with controls; likewise, AQP4 and-8 protein expression were significantly decreased in the colon of rotavirus diarrhea-infected mice. In contrast, AQP3 protein expression was significantly increased in the colon of rotavirus-infected mice in comparison with controls. These results indicate that rotavirus diarrhea is associated with the downregulation of AQP1,-4, and-8 expression. Therefore, AQPs play an important role in rotavirus diarrhea. | Meiwan Cao Min Yang Zhiying Ou Dingyou Li Lanlan Geng Peiyu Chen Huan Chen Sitang Gong | 2014 | Virologica Sinica2014，29，4： | 13 |
| 4 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 5 | A survey on numerical simulations of drag and heat reduction mechanism in supersonic/hypersonic flows显示文摘Along with the survey on experimental investigations drawing attention to the drag and heat reduction mechanism, the authors simultaneously focus on the recent advances of numerical simulations on the schemes applied to supersonic/hypersonic vehicles. The CFD study has evolved as an irreplaceable method in scheme evaluation and aircraft optimization. Similar to our previous experimental survey, the advances in drag and heat reduction schemes are reviewed by similar kinds of mechanism in this article, namely the forward-facing cavity, the opposing jet, the aerospike, the energy deposition and their combinational configurations. This review article puts an emphatic eye on the flow conditions, numerical methods, novel schemes and analytical conclusions given in the simulations. Further, the multi-objective design optimization concept has also been illustrated due to the observable advantages of using CFD over experimental method, especially those performances conducted in drag reduction and thermal protection practice, and this would possess reference value in the design of aircraft system. | Xiwan SUN Wei HUANG Min OU Ruirui ZHANG Shibin LI | 2019 | Chinese Journal of Aeronautics2019，32，4： | 12 |
| 6 | Computed morphometric analysis and expression of alpha fetoprotein in hepatocellular carcinoma and its related lesion显示文摘INTRODUCTION Hepatocellular carcinoma(HCC)is closely relatedwith hepatitis and cirrhosis.In order to investigatethe pathogenesis and early pathologic diagnosis ofHCC,HCC and related lesions were analyzedqualitively and quantitively by automatic imageanalysor and immunohistochemical assay. | Li Juan Shen Zong Ji Zhang Yang Ming Ou Hua Xian Zhang Run Huang Yun He Min Jie Wang Guo Shu Xu | 2000 | World Journal of Gastroenterology2000，6，3： | 11 |
| 7 | Biogenic silica in intertidal marsh plants and associated sediments of the Yangtze Estuary显示文摘Biogenic silica (BSi) contents in the marsh plants (Phragmites australis, Scirpus mariqueter and Spartina alterniflora) and associated sediments in Chongming Island eastern intertidal flat of the Yangtze Estuary were determined. The BSi contents in P. australis, S. mariqueter and S. alterniflora varied from 25.78-42.74 mg/g, 5.71-19.53 mg/g and 6.71-8.92 mg/g, respectively. Over the entire growth season, P. australis and S. mariqueter were characterized by linear accumulation patterns of BSi. The aboveground biomass (leaves and culms) of the marsh plants generally contained more BSi than underground biomass (roots). BSi contents were relatively higher in dead plant tissues than in live tissues which was probably due to the decomposition and the leaching of labile components of plant tissues such as organic carbon and nitrogen. Comparing with the habitats of S. mariqueter and S. alterniflora, the highest BSi content was recorded in sediments inhabited by P. australis, with an annual average of 15.69 mg/g. Overall, the intertidal marshes in the Yangtze Estuary may act as a net sink of BSi via plant uptake and sedimentary burial. | Lijun Hou Min Liu Yi Yang Dongni Ou Xiao Lin Hui Chen | 2010 | Journal of Environmental Sciences2010，22，3： | 10 |
| 8 | Expression of Ki-67, galectin-3, fragile histidine triad, and parafibromin in malignant and benign parathyroid tumors显示文摘 | WANG Ou WANG Chun-yan SHI Jie NIE Min XIA Wei-bo LI Mei JIANG Yan GUAN Heng MENG Xun-wu XING Xiao-ping | 2012 | Chinese Medical Journal2012，，16： | 8 |
| 9 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 10 | CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6显示文摘睫是毛一般的细胞器从房间表面延长与重要感觉并且活动性功能。睫的缺点能导致作为 ciliopathies 知道的大量人的疾病。然而,控制 ciliogenesis 的分子的机制仍然保持糟糕定义。这里,我们显示出那 cylindromatosis (CYLD ) ,怀有 deubiquitinase 活动的肿瘤 suppressor 蛋白质,在多重机关在主要、能动的睫的集会起一个关键作用。CYLD 猛烈老鼠 polydactyly 展出并且各种各样的睫的缺点,例如在基础身体抛锚和基础身体和 axenomes 的组织的破坏的失败。CYLD 的睫的功能部分从 70 kDa (Cep70 ) 的 centrosomal 蛋白质被归因于它 polyubiquitin 链的 deconjugation,为 Cep70 到的一个要求与 γ 交往;导管素并且在中心体本地化。另外, histone deacetylase 的调停 CYLD 的抑制 6 (HDAC6 ) ,它支持导管素 acetylation,为 CYLD 的睫的功能组成另一机制。HDAC6 的小分子的禁止者能部分在 CYLD 猛烈老鼠救睫的缺点。这些调查结果在 ciliogenesis 的调整强调蛋白质 ubiquitination 的重要性,作为这个过程的一个关键管理者识别 CYLD,并且建议在 ciliopathies 的 CYLD 缺乏的参与。 | Yunfan Yang Jie Ran Min Liu Dengwen Li Yuanyuan Li Xingjuan Shi Dan Meng Junmin Pan Guangshuo Ou Rim Aneja Sbao-Cong Sun Jun Zhou | 2014 | Cell Research2014，24，11： | 8 |
| 11 | Distribution and accumulation of biogenic silica in the intertidal sediments of the Yangtze Estuary显示文摘沉积源於生物的硅石被知道是一个重要参数在河口和沿海的生态系统理解 biogeochemical 进程和 paleoenviromental 记录。因而,在沉积调查源於生物的硅石的累积和分发意义大。二拍子的圆舞温和酸温和的碱的抽取过程被用来沥滤源於生物的硅石和它的早 diagenetic 产品在内部 Yangtze 河口的潮汐的沉积。结果显示出那全部的源於生物的硅石( t-BSi )在内部潮汐的沉积从 237.7-419.4 亩摩尔 Si/g 变化了,当时可滤取的硅石( Si-HCl )和温和碱的可滤取的硅石( Si-Alk )在 25.1-72.9 亩摩尔 Si/g 和 208.1-350.4 亩 rnol Si/g 的范围的温和的酸, respectively.Significant 关联为沉积和不同源於生物的硅石水池的粒度分布被观察在内部潮汐的沉积。这证实粒度分发能显著地在沉积影响源於生物的硅石内容。有器官的碳和氮的源於生物的硅石的关系也是的结束发现在源於生物的硅石和有机物 biogeochemical 之间有强壮的联合在,反映那内部 Yangtze 河口的潮汐的系统。另外,在沉积的源於生物的硅石的早 diagenetic 变化在现在的学习被讨论。 | HOU Lijun LIU Min XU Shiyuana YAN Huimin OU Dongni CHENG Shubo LIN Xiao | 2008 | Journal of Environmental Sciences2008，20，5： | 7 |
| 12 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 13 | RELATIONSHIP BETWEEN CYCLIN G1 AND HUMAN PAPILLOMA VIRUS INFECTION IN CERVICAL INTRAEPITHELIAL NEOPLASIA AND CERVICAL CARCINOMA显示文摘Objective To evaluate the overexpression of cyclin G1 in cervical intraepithelial neoplasia (CIN) and cervical carcinoma, and the correlation between cyclin G1 and high-risk human papilloma virus (HPV) infection. Methods All of the specimens were obtained from the Department of Pathology of China-Japan Friendship Hospital from January 2000 to August 2004.We detected the expression of cyclin G1 with immunohistochemistry, HPV16/18 infection with in situ hybridization, and high-risk HPV infection with Hybrid capture system II (HC-II) in normal group (25 cases), CIN I (48 cases), CIN II (56 cases), CIN III (54 cases), and invasive cervical squamous-cell carcinoma (SCC, 31 cases). Results The positive rates of cyclin G1 expression in CIN(77.85%)and SCC cervical tissues (87.10%) were significantly higher than normal (8.00%, P<0.01), and the intensities of cyclin G1 expression in CIN(40.60%)and SCC cervical tissues (61.51%) were significantly higher than normal (2.72%, P<0.05). The positive rates and intensities of cyclin G1 expression increased gradually with the grade of cervical lesions. High-risk HPV infection rates were higher in CIN and SCC than normal groups (P<0.05). There was a positive correlation between cyclin G1 expression and high-risk HPV infection detected with HC-II (Kendall’s tau-b=0.316, 0.269, 0.352, and 0.474 in CIN I, CINII, CIN III, and SCC, respectively, P<0.05). Conclusions Cyclin G1 is overexpressed in CIN and SCC. Cyclin G1 may be a biomarker for detecting CIN and SCC. Cyclin G1 may play an important role in the oncogenesis of CIN and SCC by high-risk HPV infection. | Jing Liang Mei-lu Bian Qing-yun Chen Xia Liu Hua Ou Min Li Jun Liu | 2006 | Chinese Medical Sciences Journal2006，21，2： | 5 |
| 14 | Monitoring the ionosphere based on the Crustal Movement Observation Network of China显示文摘The Global Navigation Satellite System(GNSS) is becoming important for monitoring the variations in the earth's ionosphere based on the total electron content(TEC) and ionospheric electron density(IED). The Crustal Movement Observation Network of China(CMONOC), which includes GNSS stations across China's Mainland, enables the continuous monitoring of the ionosphere over China as accurately as possible. A series of approaches for GNSS-based ionospheric remote sensing and software has been proposed and developed by the Institute of Geodesy and Geophysics(IGG) in Wuhan. Related achievements include the retrieval of ionospheric observables from raw GNSS data, differential code biases estimations in satellites and receivers, models of local and regional ionospheric TEC,and algorithms of ionospheric tomography. Based on these achievements, a software for processing GNSS data to determine the variations in ionospheric TEC and IED over China has been designed and developed by IGG. This software has also been installed at the CMONOC data centers belonging to the China Earthquake Administration and China Meteorological Administration. This paper briefly introduces the related research achievements and indicates potential directions of future work. | Yuan Yunbin Li Zishen Wang Ningbo Zhang Baocheng Li Hui Li Min Huo Xingliang Ou Jikun | 2015 | Geodesy and Geodynamics2015，6，2： | 5 |
| 15 | The diffusive fluxes of inorganic nitrogen across the intertidal sediment-water interface of the Changjiang Estuary in China显示文摘Ammonium and nitrate concentrations were analyzed in near-bottom water and pore water collected from ten stations of the intertidal flat of the Changjiang Estuary during April, July, November and February. The magnitudes of the benthic exchange fluxes were determined on the basis of concentration gradients of ammonium and nitrate at the near-bottom water and interstitial water interface in combination with calculations of a modified Fick’s first law. Ammonium fluxes varied from-5.05 to 1.43 μg/(cm 2 ·d) and were greatly regulated by the production of ammonium in surface sediments, while nitrate fluxes ranged from-0.38 to 1.36 μg/(cm 2 ·d) and were dominated by nitrate concentrations in the tidal water. It was found that ammonium was mainly released from sediments into water columns at most of stations whereas nitrate was mostly diffused from overlying waters to intertidal sediments. In total, 823.75 t/a ammonium-N was passed from intertidal sediments to water while about 521.90 t/a nitrate-N was removed from overlying waters to intertidal sediments. This suggests that intertidal sediments had the significant influence on modulating inorganic nitrogen in the tidal water. | HOU Lijun LIU Min XU Shiyuan LU Jianjian OU Dongni YU Jie | 2006 | Acta Oceanologica Sinica2006，25，3： | 5 |
| 16 | Progress of quantum molecular dynamics model and its applications in heavy ion collisions显示文摘In this review article,we first briefty introduce the transport theory and quantum molecular dynamics model applied in the study of the heavy ion collisions from low to intermediate energies.The developments of improved quantum molecular dynamics model(ImQMD)and ultra-relativistic quantum molecular dynamics model(UrQMD),are reviewed.The reaction mechanism and phenomena related to the fusion,multinucleon transrer,fragmentation,collective flow and particle production are reviewed and discussed within the framework of the two models.The constraints on the isospin asymmetric muclear equation of state and in-medium nucleon nucleon cross sections by comparing the heavy ion collision data with transport models calculations in last decades are also discussed,and the uncertainties of these constraints are analyzed as well.Finally,we discuss the future direction of the development of the transport models for improving the understanding of the reaction mechanism,the descriptions of various observables,the constraint on the nuclear equation of state,as well as for the constraint on in-medium nucleon-nucleon cross sections. | Ying-Xun Zhang Ning Wang Qing-Feng Li Li Ou Jun-Long Tian Min Liu Kai Zhao Xi-Zhen Wu Zhu-Xia Li | 2020 | Frontiers of physics2020，15，5： | 5 |
| 17 | A Quantum Chemistry Study of Inhibition Properties of Imidazole and Its Derivatives on Iron Surface Corrosion显示文摘The geometries of imidazole and its derivatives were respectively optimized by using ab initio method, and the molecular orbital energy levels and the charge densities were obtained for their optimum geometries. The frontier orbital energy levels, and the net charges of N (1) atom and the imidazole ring of those molecules were obtained with ab initio and SCC-DV-Xα methods. It was found that the inhibition properties of those compounds change with the highest occupied molecular orbital energy levels, and the net charges of N(1) atom. We took four iron atoms on the crystal plane (100) of α-iron as the surface which was used to study the adsorption towards the inhibitors. The adsorption models of the inhibitor to be adsorbed on the Fe-cluster surface were optimized with SCC-DV-Xα method. It turns out that the most favorable model is that the inhibitor molecule is adsorbed on the Fe-cluster surface in an inclined state. The calculation shows that the stabilization energies of the systems are well correlated with the inhibition efficien cies. | YAN Xiao-ci, XIA Wen-bing, LIU Jie, OU YANG-li, LUO Ming-dao~(**) and YANG Feng (Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China) MIN Xin-min (National Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, P. R. China) To whom correspondence should be addressed. | 2001 | Chemical Research in Chinese Universities2001，17，3： | 4 |
| 18 | Single Beacon Cruise Positioning Algorithm in Wireless Sensor Networks显示文摘 | ZHU Darong HAN Jianghong OU Jian MIN Jie | 2013 | Chinese Journal of Electronics2013，22，3： | 4 |
| 19 | Roxadustat as treatment for a blood transfusion-dependent maintenance hemodialysis patient:A case report and review of literature显示文摘BACKGROUND Erythropoiesis-stimulating agents(ESAs)have revolutionized the therapeutic strategy for anemia in chronic kidney disease.However,some cases are resistant or hyporesponsive to ESAs.Roxadustat is an oral hypoxia-inducible factor-prolyl hydroxylase inhibitor that stimulates erythropoiesis and regulates iron metabolism.Here,we describe a hemodialysis patient with refractory anemia who did not respond to traditional treatments and depended on blood transfusion for more than 1 year.After applying Roxadustat,the patient’s anemia improved significantly.CASE SUMMARY A 44-year-old man was diagnosed with uremia accompanied by severe anemia with a hemoglobin(Hb)level ranging from 30-40 g/L.His anemia did not improve after sufficient dialysis or high doses of active ESAs;other causes of anemia were excluded.The patient required approximately 600-1000 mL of red blood cell suspension every 15-30 d for more than 1 year.After accepting Roxadustat therapy,the patient’s anemia symptoms improved significantly;his Hb level gradually increased to 50 g/L,and no further blood transfusions were administered.His Hb level reached 69 g/L by the 34th week.Although a Hb level of 60-70 g/L cannot be considered satisfactory,he no longer required blood transfusions and his quality of life was substantially improved.Roxadustat showed good efficacy and safety in this case.CONCLUSION Roxadustat represents an innovative and effective agent for the clinical treatment of renal anemia caused by multiple complex factors. | Min Fei Xiang-Qiong Wen Zhao-Lan Yu Ting Kang Wei-Hua Wu San-Tao Ou | 2021 | World Journal of Clinical Cases2021，9，15： | 4 |
| 20 | Selective removal of nitrate by using a novel macroporous acrylic anion exchange resin显示文摘阴离子交换树脂 NDP-5 成功地被准备了并且从 SO42/NO3 二进制共存系统在硝酸盐的选择移动上适用。NDP-5 的作文和形态学被英尺红外和 SEM 证实。NDP-5 树脂在硫酸盐的缺席或存在在吸附能力,运动的吸附和完成的阴离子的效果上展出完全不同的行为,与 D213 相比。并且, resultants 运动被伪 first-order 和 pseudo-second-order 模型很好适合。这些结果是很重要的与大特征开发新奇树脂。 | Hai Ou Song Yang Zhou Ai Min Li Sandra Mueller | 2012 | Chinese Chemical Letters2012，23，5： | 4 |
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