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| 1 | Cerebral ischemia and neuroregeneration显示文摘Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke(a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics(i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies again st stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies(i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia. | Reggie H.C.Lee Michelle H.H.Lee Celeste Y.C.Wu Alexandre Couto e Silva Harlee E.Possoit Tsung-Han Hsieh Alireza Minagar Hung Wen Lin | 2018 | Neural Regeneration Research2018，13，3： | 30 |
| 2 | Toward a unified model of Altaids geodynamics:Insight from the Palaeozoic polycyclic evolution of West Junggar(NW China)显示文摘The Altaid tectonic collage extends over Central Asia, exposing numerous accretionary orogens that can account for the Palaeozoic continental crust growth. A pluridisciplinary approach, using geochronological, geochemical, structural and palaeomagnetic tools was carried out to unravel the architecture and the evolution of West Junggar(Northwestern China), a segment of the Altaid Collage. A polycyclic geodynamic evolution is inferred and includes:(1) an Early Palaeozoic cycle, characterized by the closure of two oceanic basins bounded by island-arc systems;(2) an Early Devonian subduction jamming resulting in a minor-scale collision documented by thrusting, syntectonic sedimentation and subsequent crutal thinning associated with alkaline magmatism;(3) a Late Palaeozoic cycle, driven by the evolution of two opposite subduction zones developed upon the Early Palaeozoic basement. Detailed structural analysis and paleomagnetic data provide constraints for the late evolution of Junggar in the frame of the development of the Late Palaeozoic Kazakh orocline, which led to oblique subduction and transpression in the West Junggar accretionary complex. Progressive buckling of the Kazakh orocline further resulted in Late Carboniferous to Permian wrench tectonics, and lateral displacement of lithotectonic units. Block rotations that continued after the Late Triassic are due to diachronous intraplate reactivation. This scenario mirrors the Palaeozoic geodynamics of the Altaid Collage. Multiple Early Palaeozoic collisions of intra-oceanic arcs and micro continents have contributed to the formation of the Kazakhstan Microcontinent. Since the Late Palaeozoic, subductions formed around this microcontinent and the final oblique closure of oceanic domains resulted in the transcurrent collage of Tarim and Siberia cratons. Palaeozoic strike-slip faults were later reactivated during Mesozoic intracontinental tectonics. | Flavien CHOULET Michel FAURE Dominique CLUZEL CHEN Yan LIN Wei WANG Bo XU Bei | 2016 | Science China Earth Sciences2016，59，1： | 6 |
| 3 | Cerebral aneurysm treatment: modern neurovascular techniques显示文摘Endovascular treatment of cerebral aneurysm continues to evolve with the development of new technologies.This review provides an overview of the recent major innovations in the neurointerventional space in recent years. | Bowen Jiang Michelle Paff Geoffrey P Colby Alexander L Coon Li-Mei Lin | 2016 | Stroke & Vascular Neurology2016，1，3： | 6 |
| 4 | Ultra-flat dispersion in an integrated waveguide with five and six zero-dispersion wavelengths for mid-infrared photonics显示文摘We propose a new type of dispersion flattening technology, which can generate an ultra-flat group velocity dispersion profile with five and six zero-dispersion wavelengths(ZDWs). The dispersion value varies from-0.15 to 0.35 ps/(nm·km) from 4 to 8 μm, which to the best of our knowledge is the flattest one reported so far, and the dispersion flatness is improved by more than an order of magnitude. We explain the principle of producing six ZDWs. Mode distribution in this waveguide is made stable over a wide bandwidth. General guidelines to systematically control the dispersion value, sign, and slope are provided, and one can achieve the desired dispersion by properly adjusting the structural parameters. Fabrication tolerance of this waveguide is also examined. | Yuhao Guo Zeinab Jafari Lijuan Xu Changjing Bao Peicheng Liao Guifang Li Anuradha M.Agarwal Lionel C.Kimerling Jurgen Michel Alan E.Willner Lin Zhang | 2019 | Photonics Research2019，7，11： | 3 |
| 5 | Cloning, expression and localization of a trypsin-like serine protease in the spruce budworm, Choristoneura fumiferana显示文摘像胰岛素的脱毛相关的丝氨酸朊酶 cDNA (CfMRSP ) 从云杉芽虫被克隆, Choristoneura fumiferana。全身的 CfMRSP 互补 DNA (cDNA ) 编码了包含了像胰岛素的丝氨酸朊酶的 43 kDa 蛋白质催化领域,而是没有片断领域。C 终端延期包含了五 cystein 残余,它可以允许蛋白质形成通过更暗淡的一个人内部锁住二硫化物契约并且调整 CfMRSP 的活动。种系发生的树分析证明 CfMRSP 与象丝氨酸朊酶 1 Lonomia obliqua 那样的鳞翅类的相当或相同事物聚类,血淋巴朊酶 20 (HP20 ) ,模式识别丝氨酸朊酶先锋(ProHP14 ) 和 Manduca 祷告的像胰岛素的蛋白质一。CfMRSP 的发展表示的北污点分析显示它的抄本首先在外皮被发现并且测试视距在所有期间被生产,从第 4 中间形态幼虫到蛹,但是增加了抄本总是在每根脱毛以后被发现的 CfMRSP 的层次。蛋白质的高水平被免疫组织化学分析在外皮发现。总的来说这些数据建议 CfMRSP 在 molting 和变形期间在外皮起一个作用。 | Wen-Ying He Yi-Ping Zheng Lin Tang Si-Chun Zheng Catherine Beliveau Daniel Doucet Michel Cusson Qi-Li Feng | 2009 | Insect Science2009，16，6： | 3 |
| 6 | High-efficiency normal-incidence vertical p-i-n photodetectors on a germanium-on-insulator platform显示文摘In this paper, normal incidence vertical p-i-n photodetectors on a germanium-on-insulator(GOI) platform were demonstrated. The vertical p-i-n structure was realized by ion-implanting boron and arsenic at the bottom and top of the Ge layer, respectively, during the GOI fabrication. Abrupt doping profiles were verified in the transferred high-quality Ge layer. The photodetectors exhibit a dark current density of ~47 mA∕cm^2 at-1 V and an optical responsivity of 0.39 A/W at 1550 nm, which are improved compared with state-of-the-art demonstrated GOI photodetectors. An internal quantum efficiency of ~97% indicates excellent carrier collection efficiency of the device. The photodetectors with mesa diameter of 60 μm exhibit a 3 dB bandwidth of ~1 GHz, which agrees well with theoretical calculations. The bandwidth is expected to improve to ~32 GHz with mesa diameter of 10 μm. This work could be similarly extended to GOI platforms with other intermediate layers and potentially enrich the functional diversity of GOI for near-infrared sensing and communication integrated with Ge CMOS and mid-infrared photonics. | YIDING LIN KWANG HONG LEE SHUYU BAO XIN GUO HONG WANG JURGEN MICHEL CHUAN SENG TAN | 2017 | Photonics Research2017，5，6： | 2 |
| 7 | Comparison of drug abuse in Germany and China显示文摘药滥用在德国和中国有长,而且不同的历史。鸦片战争大部分在第 19 世纪影响了中国的历史;然而,中国曾经从 1950 年代作为一个没有药的国家被认出 3 十年到 1980 年代。自从 re-emerging,药滥用在 1980 年代末在中国作为一个国家问题快速传播了。登记吸毒者的数字增加了从 70 000 在 1990 到超过 100 万在 2005 底。在过去的十年,不正当的药交通国王和生产在中国打扫了大多数省,并且药滥用为滥用者和社区引起了许多问题。一个主要药相关的问题是 HIV 的传播,它在中国引起了主要社会、经济的损坏。德国,最大的发达欧洲国家,也面对这药和嗜好问题。德国有大约 150 000 个海洛因瘾君子,自从 1980 年代中, HIV/AIDS 为成为了严肃的威胁。控制药问题,德国政府在 2003 在药和 Addictionq 上采用了合同计划;中国中央政府在 2005 在反药运动同意了一条类似的规定。德国在减少药相关的伤害有经验。一种镇痛剂维护处理(MMT ) 节目竞选了超过 20 年,公众瘾君子变得更容忍。在 2003,中国为控制 HIV/AIDS 的传播开始了 MMT 节目。中国从发达国家学习在它的反药运动获得成功是必要的。在这评论,我们将温习在在德国和中国之间的药滥用的差别和类似。差别与历史,人口和经济有关,药政策上下文,药法律, HIV/hepatitis C 病毒感染, MMT 节目等等。这 2 个国家与不同历史有药滥用问题并且当前使用不同途径处理不正当的药出售和使用。为不正当的药冒犯的法律惩罚关于罪行的特别类型的严重反映这 2 个国家的社会差别。MMT 节目的特征可以也在这 2 个国家影响药滥用的模式,中国应该在欧洲,美国,和澳大利亚基于成功的模型改进 MMT 节目。我们推荐在德国和中国之间的更多的对话和合作。 | Ingo Ilja MICHELS Yu-xia FANG Dong ZHAO Li-yan ZHAO Lin LU | 2007 | Acta Pharmacologica Sinica2007，28，10： | 2 |
| 8 | Regression of Inflammation in Atherosclerosis by the LXR Agonist R211945显示文摘 | Esad Vucic Claudia Calcagno Stephen D. Dickson James H.F. Rudd Katsumi Hayashi Jan Bucerius Erin Moshier Jessica S. Mounessa Michelle Roytman Matthew J. Moon James Lin Sarayu Ramachandran Tatsuo Tanimoto Karen Brown Masakatsu Kotsuma Sotirios Tsimikas Edw | 2012 | JACC: Cardiovascular Imaging2012，，8： | 2 |
| 9 | Cooling paths of the NE China crust during the mesozoic extensional tectonics: example from the south-Liaodong penin- sula metamorphic core complex显示文摘 | WE1 Lin PATRICK M MICHEL f | 2011 | Journal of Asian Earth Sciences2011，42，： | 1 |
| 10 | Differential Contributions of C3, C5, and Decay-Accelerating Factor to Ethanol-Induced Fatty Liver in Mice显示文摘 | Michele T. Pritchard Megan R. McMullen Abram B. Stavitsky Jessica I. Cohen Feng Lin M. Edward Medof Laura E. Nagy | 2007 | Gastroenterology2007，，3： | 1 |
| 11 | Targeting β 2 -microglobulin for induction of tumor apoptosis in human hematological malignancies显示文摘 | Jing Yang Jianfei Qian Michele Wezeman Siqing Wang Pei Lin Michael Wang Shmuel Yaccoby Larry W. Kwak Bart Barlogie Qing Yi | 2006 | Cancer Cell2006，，4： | 1 |
| 12 | Rural-to-urban male migrant workers’ vulnerability to HIV infection in Chengdu, China: Qualitative findings from a mixed-method study显示文摘 | Lin Li Martha Morrow Michelle Kermode | 2010 | Work2010，，4： | 1 |
| 13 | Antiangiogenic therapy显示文摘 | Michelle I. Lin William C. Sessa | 2004 | Cancer Cell2004，，6： | 1 |
| 14 | Toxicity and Cardiac Effects of Carbaryl in Early Developing Zebrafish(Danio rerio)Embryos显示文摘 | Lin C C Michelle N Y H Cheng S H | 2007 | Toxicology and Applied Pharmacology2007，222，15： | 1 |
| 15 | Toxicity and Cardiac Effects of Carbaryl in Early Developing Zebrafish (Danio rerio) Embryos显示文摘 | LIN C C MICHELLE N Y H CHENG S H | 2007 | Toxicology and Applied Pharmacology2007，222，： | 1 |
| 16 | Transient elec- tromagnetic field couphng to long shielded cables 显示文摘 | Michel Aguet Mircea Ianovici Lin Chung-chi | 1980 | IEEE Transactions on Electromagnetic Compatibility1980，10，4： | 1 |
| 17 | Nanometer Scale Chemistry and Microstructure of CrN/AlN Multilayer Films显示文摘 | Lin Jianliang Hunter B Henderson Michele V Manuel | | 0，，： | 1 |
| 18 | Critical role of multidrug efflux pump CmeABC in bile resistance and in vivo colonization of Campylobacterjejuni显示文摘 | Lin J Sahin O Michel L O | 2003 | Infect Immun2003，71，8： | 1 |
| 19 | Transient electromagnetic field coupling to long shielded cables显示文摘 | Michel A Mircea I Lin C C | 1980 | IEEE Trans on Electromagnetic Compatibility1980，22，4： | 1 |
| 20 | Post-exposure efficacy of Oral T-705 (Favipiravir) against inhalational Ebola virus infection in a mouse model显示文摘 | Sophie J. Smither Lin S. Eastaugh Jackie A. Steward Michelle Nelson Robert P. Lenk Mark S. Lever | 2014 | Antiviral Research2014，，： | 1 |
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