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| 1 | Intestinal lymphangiectasia in adults显示文摘Intestinal lymphangiectasia in the adult may be characterized as a disorder with dilated intestinal lacteals causing loss of lymph into the lumen of the small intestine and resultant hypoproteinemia, hypogamma-globulinemia, hypoalbuminemia and reduced number of circulating lymphocytes or lymphopenia. Most often, intestinal lymphangiectasia has been recorded in children, often in neonates, usually with other congenital abnormalities but initial def inition in adults including the elderly has become increasingly more common. Shared clinical features with the pediatric population such as bilateral lower limb edema, sometimes with lymphedema, pleural effusion and chylous ascites may occur but these reflect the severe end of the clinical spectrum. In some, diarrhea occurs with steatorrhea along with increased fecal loss of protein, reflected in increased fe- cal alpha-1-antitrypsin levels, while others may present with iron def iciency anemia, sometimes associated with occult small intestinal bleeding. Most lymphangiectasia in adults detected in recent years, however, appears to have few or no clinical features of malabsorption. Diagnosis remains dependent on endoscopic changes confirmed by small bowel biopsy showing histological evidence of intestinal lymphangiectasia. In some, video capsule endoscopy and enteroscopy have revealed moreextensive changes along the length of the small intes- tine. A critical diagnostic element in adults with lym- phangiectasia is the exclusion of entities (e.g. malignancies including lymphoma) that might lead to obstruction of the lymphatic system and 'secondary' changes in the small bowel biopsy. In addition, occult infectious (e.g. Whipple's disease from Tropheryma whipplei) or in? am- matory disorders (e.g. Crohn's disease) may also present with profound changes in intestinal permeability and protein-losing enteropathy that also require exclusion. Conversely, rare B-cell type lymphomas have also been described even decades following initial diagnosis of intestinal lymphangiectasia. Treatment has been historically def ined to include a low fat diet with medium-chain triglyceride supplementation that leads to portal venous rather than lacteal uptake. A number of other pharma- cological measures have been reported or proposed but these are largely anecdotal. Finally, rare reports of localized surgical resection of involved areas of small intestine have been described but follow-up in these cases is often limited. 2011 Baishideng. All rights reserved. | Hugh James Freeman Michael Nimmo | 2011 | World Journal of Gastrointestinal Oncology2011，3，2： | 13 |
| 2 | Risk factors for post-ERCP pancreatitis: A prospective, multicenter study显示文摘 | Martin L. Freeman James A. DiSario Douglas B. Nelson M.Brian Fennerty John G. Lee David J. Bjorkman Carol S. Overby Johannes Aas Michael E. Ryan Gary S. Bochna Michael J. Shaw Harry W. Snady Robert V. Erickson Joseph P. Moore Joseph P. Roel | 2001 | Gastrointestinal Endoscopy2001，，4： | 5 |
| 3 | Recent advances in small bowel diseases:Part Ⅰ显示文摘As is the case in all parts of gastroenterology and hepatology,there have been many advances in our knowledge and understanding of small intestinal diseases.Over 1000 publications were reviewed for 2008 and 2009,and the important advances in basic science as well as clinical applications were considered.In Part Ⅰ of this Editorial Review,seven topics are considered:intestinal development;proliferation and repair;intestinal permeability;microbiotica,infectious diarrhea and probiotics;diarrhea;salt and water absorption;necrotizing enterocolitis;and immunology/allergy.These topics were chosen because of their importance to the practicing physician. | Alan BR Thomson Angeli Chopra Michael Tom Clandinin Hugh Freeman | 2012 | World Journal of Gastroenterology2012，18，26： | 5 |
| 4 | Recent advances in celiac disease显示文摘Celiac disease now affects about one person in a hundred in Europe and North America. In this review, we consider a number of important and exciting recent developments, such as clinical associations, HLA-DQ2 and HLA-DQ8 predispositions, the concept of potential celiac disease, the use of new imaging/endoscopy techniques, and the development of refractory disease. This review will be of use to all internists, pediatricians and gastroenterologists. | Hugh James Freeman Angeli Chopra Michael Tom Clandinin Alan BR Thomson | 2011 | World Journal of Gastroenterology2011，17，18： | 3 |
| 5 | Mechanical Initiation of Intervertebral Disc Degeneration显示文摘 | Michael A. Adams Brian J. C. Freeman Helen P. Morrison Ian W. Nelson Patricia Dolan | 2000 | Spine2000，，13： | 2 |
| 6 | Risk factors for post-ERCP pancreatitis: A prospective, multicenter study显示文摘 | Martin L. Freeman James A. DiSario Douglas B. Nelson M.Brian Fennerty John G. Lee David J. Bjorkman Carol S. Overby Johannes Aas Michael E. Ryan Gary S. Bochna Michael J. Shaw Harry W. Snady Robert V. Erickson Joseph P. Moore Joseph P. Roel | 2001 | Gastrointestinal Endoscopy2001，，4： | 2 |
| 7 | Brain Volume and Neurobehavior in Newborns with Complex Congenital Heart Defects显示文摘 | Mallory Owen Michael Shevell Mary Donofrio Annette Majnemer Robert McCarter Gilbert Vezina Marine Bouyssi-Kobar Iordanis Evangelou Dena Freeman Neil Weisenfeld Catherine Limperopoulos | 2013 | The Journal of Pediatrics2013，，： | 1 |
| 8 | Friction,wear,and lubrication of hydrogels as synthetic articular cartilage显示文摘 | Mark E Freeman a Michael J | 2000 | Wear2000，241，： | 1 |
| 9 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
| 10 | Friction,wear,and lubrication of hydrogels as synthetic articular cartilage显示文摘 | Mark E Freeman Michael J Furey Brian J Love | 2000 | Wear2000，241，： | 1 |
| 11 | Droxidopa for neurogenic orthostatic hypotension: A randomized, placebo-controlled, phase 3 trial显示文摘 | Horacio Kaufmann Roy Freeman Italo Biaggioni Phillip Low Simon Pedder L. Arthur Hewitt Joe Mauney Michael Feirtag Christopher J. Mathias | 2014 | Neurology2014，，4： | 1 |
| 12 | The Population Ecology of Organizations显示文摘 | Hanna Michael T & John Freeman | | American Journal of Sociology0，82，： | 1 |
| 13 | Specific pattens of electrophile adduction trigger Keapl ubiq- uitination and Nrf2 activation 显示文摘 | FEI HONG KONJETI R SEKHAR MICHAEL L FREEMAN etal | 2005 | J Biol Chem2005，280，31： | 1 |
| 14 | The Popula- tion Ecology of Organizations显示文摘 | HANNAN MICHAEL T FREEMAN JOHN | 1977 | American Journal of So- ciology1977，82，5： | 1 |
| 15 | Summary report of a national conference: Evolving concepts in liver allocation in the MELD and PELD era显示文摘 | Kim M. Olthoff Robert S. Brown Francis L. Delmonico Richard B. Freeman Sue V. McDiarmid Robert M. Merion J. Michael Millis John P. Roberts Abraham Shaked Russell H. Wiesner Michael R. Lucey | 2004 | Liver Transpl . 2004 (S10)2004，，10： | 1 |
| 16 | The Population ecology of organizations显示文摘 | Hannan Michael T and Freeman John | 1977 | American Journal of Sociology1977，82，5： | 1 |
| 17 | Public attitudes towards marine aquaculture: A comparative analysis of Germany and Israel显示文摘 | Shirra Freeman Eran Vigoda-Gadot Horst Sterr Michael Schultz Irina Korchenkov Peter Krost Dror Angel | 2012 | Environmental Science and Policy2012，，： | 1 |
| 18 | Motivational bases of affective organizational commitment: a partial test of an integrative theoretical model 显示文摘 | Eby Lillian T Deena M Freeman Michael C Rush and Charles E Lance | 1999 | Journal of Occupational and Organizational Psychology1999，72，4： | 1 |
| 19 | Preparation and characterization of Au colloid monolayers显示文摘 | Grabar Katherine Freeman R Griffith Hommer Michael B | | 0，，： | 1 |
| 20 | Does prophylactic administration of corticosteroid reduce the risk and severity of post-ERCP pancreatitis: A randomized, prospective, multicenter study显示文摘 | Stuart Sherman Urszula Blaut James L. Watkins Jeffrey Barnett Martin Freeman Joseph Geenen Michael Ryan Harrison Parker James T. Frakes Evan L. Fogel William B. Silverman Kulwinder S. Dua Giuseppe Aliperti Paul Yakshe Michael Uzer Whitney Jones John Goff | 2003 | Gastrointestinal Endoscopy2003，，1： | 1 |
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