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| 1 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 2 | Macrophage Infection via Selective Capture of HIV-1-Infected CD4 + T Cells显示文摘 | Amy E. Baxter Rebecca A. Russell Christopher J.A. Duncan Michael D. Moore Christian B. Willberg Jose L. Pablos Andrés Finzi Daniel E. Kaufmann Christina Ochsenbauer John C. Kappes Fedde Groot Quentin J. Sattentau | 2014 | Cell Host & Microbe2014，，： | 1 |
| 3 | What Can Account for Fluctuations in the Terms of Trade? 显示文摘 | Baxter Marianne Kouparitsas Michael A | 2006 | International Fi- nance2006，9，1： | 1 |
| 4 | ESPEN Guidelines on Parenteral Nutrition: Home Parenteral Nutrition (HPN) in adult patients显示文摘 | Michael Staun Loris Pironi Federico Bozzetti Janet Baxter Alastair Forbes Francesca Joly Palle Jeppesen Jose Moreno Xavier Hébuterne Marek Pertkiewicz Stefan Mühlebach Alan Shenkin André Van Gossum | 2009 | Clinical Nutrition2009，，4： | 1 |
| 5 | Determination of Clinically Relevant Cutoffs for HIV-1 Phenotypic Resistance Estimates Through a Combined Analysis of Clinical Trial and Cohort Data显示文摘 | Bart Winters Julio Montaner P Richard Harrigan Brian Gazzard Anton Pozniak Michael D Miller Sean Emery Frank van Leth Patrick Robinson John D Baxter Marie Perez-Elias Delivette Castor Scott Hammer Alex Rinehart Hans Vermeiren Elke Van Craenenbroeck Lee Ba | 2008 | JAIDS Journal of Acquired Immune Deficiency Syndromes2008，，1： | 1 |
| 6 | What Can Account for Fluctuations in the Terms of Trade显示文摘 | Baxter Marianne and Kouparitsas Michael A | 2006 | International Finance2006，9，1： | 1 |
| 7 | Determi- nants of Business Cycle Comovement: A Robust A- nalysis显示文摘 | Baxter Marianne Kouparitsas Michael A | 2005 | Journal of Monetary Economics2005，52，1： | 1 |
| 8 | Determinent of Business Cycle Comovement: a Robust Analysis 显示文摘 | Marianne Baxter Michael Kouparitsas | 2005 | Journal of Monetary Economics2005，52，： | 1 |
| 9 | What Can Account for Fluctuations in the Terms of Trade显示文摘 | Baxter Marianne and Kouparitsas Michael A | 2006 | International Finance2006，9，1： | 1 |
| 10 | A Stable Isotope Breath Test With a Standard Meal for Abnormal Gastric Emptying of Solids in the Clinic and in Research显示文摘 | Lawrence A. Szarka Michael Camilleri Adrian Vella Duane Burton Kari Baxter Julie Simonson Alan R. Zinsmeister | 2008 | Clinical Gastroenterology and Hepatology2008，，： | 1 |
| 11 | Impact of stopping smoking on metabolic parameters in diabetes mellitus:A scoping review显示文摘The purpose of this scoping review is to create a single narrative that describes the impact of smoking cessation on metabolic parameters in people with diabetes.It is generally well accepted that smoking enhances the harmful effects of elevated blood glucose levels,accelerating the vascular damage seen in patients with diabetes.Smoking cessation has clear benefits in terms of reducing cardiovascular morbidity and mortality.However,there is less evidence for the impact of smoking cessation on other diabetes-related complications.Studies in people with diabetes have shown improvement as well as temporary deterioration in glycemic control after ceasing smoking.Only a few studies have described the effect of quitting smoking on insulin resistance and lipid parameters,however,their results have been inconclusive.In this situation,healthcare professionals should not assume that cessation of smoking will improve metabolic parameters in patients with diabetes.It seems they should, first of all, emphasize the prevention of weight gain that may be associatedwith quitting smoking. The lack of data regarding the metabolic effects of smoking and smokingcessation in diabetes is very disappointing and this area needs to be addressed. | Magdalena Walicka Cristina Russo Michael Baxter Isaac John Grazia Caci Riccardo Polosa | 2022 | World Journal of Diabetes2022，13，6： | 0 |
| 12 | 无砟轨道与桥梁结构的配合显示文摘新规范与标准的制订有助于无缝线路长大桥梁上最终取消钢轨伸缩接头,使高速铁路采用无砟轨道更加经济。 | David Rhodes D R Squared Michael Baxter | 2017 | 西铁科技2017，0，1： | 0 |
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