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| 1 | Hydrocarbon sources and stages of reservoir formation in Kuqa depression, Tarim Basin显示文摘Kuqa depression bears not only plenty ofnatural gas, but also a large amount of condensate and smallquantity of crude oil. Based on the geochemical correlationbetween the Jurassic and Triassic terrestrial hydrocarbonsource rock, this paper confirms that the natural gas in Kuqadepression belongs to coal-type gas and the main gas sourcerock is attributed to the middle to lower Jurassic coal seriesformation, while the main oil source rock is the upper Tri-assic lacustrine mudstone. The authors indicated that Kuqadepression was slowly subsided in Mesozoic, but rapidlywent down in Late Tertiary, which made the Jurassic andTriassic source rock suddenly deep-buried and rapidlyevolved to high and over-mature phase since 5 Ma. TheTriassic source rock is postponed to the Early Miocene dur-ing 23-12 Ma when entering the oil-generating peak, whilethe Jurassic is suspended to the latest 5 Ma, especially since2.5 Ma to the dry gas-generating period, which is one of thecharacteristics of the source rock thermal evolution in Kuqadepression. This paper presents a two-stage trapping andlate gas trapping model in Kuqa depression whose charac-teristics are: The main oil and gas reservoirs have differentsources. The oil reservoir is formed early while the gas res-ervoir is formed lately. During the early stage, it, mainly asoil, takes long distance lateral migration, while in the laterstage, it, mainly as gas, takes the vertical migration and alsohas lateral migration. The trap formed in different time onthe south and north sides of the depression and evolved intoa distributional pattern with oil in the south part and gas inthe north, also oil on the outer ring and gas on the inner ring.This paper points out that the late trapping of the naturalgas in Kuqa depression is favorable for the preservation oflarge gas fields. | LIANG Digang ZHANG Shuichang ZHAO Mengjun WANG Feiyu | 2002 | Chinese Science Bulletin2002，47，S1： | 34 |
| 2 | Coalbed methane genesis, occurrence and accumulation in China显示文摘Coalbed methane (CBM) is an important type of unconventional gas. Commercial development of CBM in America has been very successful since the 1980s. The CBM industry in Australia and Canada has developed rapidly during the last decade. Commercial development of CBM in China started in the 1990s, and has made great progress. The geological theory of CBM in China has achieved great advancement in genesis, occurrence and accumulation. On the aspect of CBM genesis, five CBM genetic types (primary biogenic gas, secondary biogenic gas, thermal degradation gas, pyrolysis gas and mixed gas) are identified by studying the geochemical characteristics of CBM, and a tracing indicator system is established. The discovery of secondary biogenic gas in medium-high rank coal reservoirs has widened the potential of CBM resources. On the aspect of CBM occurrence, the gas adsorption regulation under combined action of temperature and pressure is revealed by conducting adsorption experiments of different coal ranks under varying temperature and pressure conditions. Besides, by applying the adsorption potential theory in CBM research, the adsorption model under combined action of temperature and pressure is established. The new model can predict CBM resources accurately, and overcome the limitation of the traditional Langmuir model which uses just a single factor to describe the adsorption characteristics of deep buried coal. On the aspect of CBM accumulation, it is proposed that there are three evolutionary stages during CBM accumulation, including gas generation and adsorption, unsaturated gas adsorption, gas desorption-diffusion and preservation. Controlled by tectonic evolution, hydrodynamics and sealing conditions, CBM tends to be regionally enriched in synclines. Advances in geological theory of CBM in China can not only improve understanding of natural gas, but also provide new ideas for further exploration of CBM. | Song Yan Liu Shaobo Zhang Qun Tao Mingxin Zhao Mengjun Hong Feng | 2012 | Petroleum Science2012，9，3： | 29 |
| 3 | Geochemical features and genesis of the natural gas and bitumen in paleo-oil reservoirs of Nanpanjiang Basin, China显示文摘Bitumen from the Nanpanjiang Basin occurs mainly in the Middle Devonian and Upper Permian reef limestone paleo-oil reservoirs and reserves primarily in holes and fractures and secondarily in minor matrix pores and bio-cavities. N2 is the main component of the natural gas and is often associated with pyrobitumen in paleo-oil reservoirs. The present study shows that the bitumen in paleo-oil reservoirs was sourced from the Middle Devonian argillaceous source rock and belongs to pyrobitumen by crude oil cracking under high temperature and pressure. But the natural gas with high content of N2 is neither an oil-cracked gas nor a coal-formed gas generated from the Upper Permian Longtan Formation source rock, instead it is a kerogen-cracked gas generated at the late stage from the Middle Devonian argilla- ceous source rock. The crude oil in paleo-oil reservoirs completely cracked into pyrobitumen and methane gas by the agency of hugely thick Triassic deposits. After that, the abnormal high pressure of methane gas reservoirs was completely destroyed due to the erosion of 2000--4500-m-thick Triassic strata. But the kerogen-cracked gas with normal pressure was preserved under the relatively sealed condition and became the main body of the gas shows. | ZHAO MengJun ZHANG ShuiChang ZHAO Lin DA Jiang | 2007 | Science China Earth Sciences2007，50，5： | 11 |
| 4 | Accumulation process and model for the Ordovician buried hill reservoir in the western Lunnan area,the Tarim Basin显示文摘The Ordovician buried hill reservoir in the western Lunnan area, a type of dissolved fracture and cavernous reservoir, is mainly composed of heavy oil. The oil is the mixture sourcing from the Middle-Lower Cambrian and Middle-Lower Ordovician, with three stages of pool forming process: (1) the destruction and parallel migration/accumulation during the late Caledonian to early Hercynian; (2) the oil and gas accumulation during the late Hercynian characterized by adjustment upward along faults and parallel migration/accumulation; (3) the formation of heavy oil during the latest Hercynian. The Ordovician buried hill reservoir is affected by the diffusion of light oil and gas but had no hydrocarbon charging during the late Yanshan period to Himalayan period, but in this period, formed the association of heavy oil and dissolved gas cracked from crude oil with dry coefficient of 0.91-0.96. The study on accumulation process of the Ordovician buried hill reservoir has important implications for the exploration potential of early oil and gas accumulation in the cratonic area of the Tarim Basin. | ZHAO MengJun PAN WenQing HAN JianFa LIU ShaoBo QIN ShengFei ZHANG BaoMin | 2007 | Chinese Science Bulletin2007，52，A01： | 6 |
| 5 | Privacy-preserving Distributed Location Proof Generating System显示文摘The rapid development of location-based service(LBS) drives one special kind of LBS, in which the service provider verifies user location before providing services. In distributed location proof generating schemes, preventing users from colluding with each other to create fake location proofs and protecting user's location privacy at the same time, are the main technical challenges to bring this kind of LBS into practical. Existing solutions tackle these challenges with low collusion-detecting efficiency and defected collusion-detecting method. We proposed two novel location proof generating schemes, which inversely utilized a secure secret-sharing scheme and a pseudonym scheme to settle these shortcomings. Our proposed solution resists and detects user collusion attacks in a more efficient and correct way. Meanwhile, we achieve a higher level of location privacy than that of previous work. The correctness and efficiency of our proposed solution is testified by intensive security analysis, performance analysis, as well as experiments and simulation results. | LIU Mengjun LIU Shubo ZHANG Rui Li Yongkai WANG Jun CAO Hui | 2016 | China Communications2016，13，3： | 3 |
| 6 | AFF3-DNA methylation interplay in maintaining the mono-allelic expression pattern of XIST in terminally differentiated cells显示文摘X chromosome inactivation and genomic imprinting are two classic epigenetic regulatory processes that cause mono-allelic gene expression.In female mammals,mono-allelic expression of the long non-coding RNA gene X-inactive specific transcript(XIST)is essential for initiation of X chromosome inactivation upon differentiation.We have previously demonstrated that the central factor of super elongation complex-like 3(SEC-L3),AFF3,is enriched at gamete differentially methylated regions(DMRs)of the imprinted loci and regulates the imprinted gene expression.Here,we found that AFF3 can also bind to the DMR downstream of the XIST promoter.Knockdown of AFF3 leads to de-repression of the inactive allele of X IST in terminally differentiated cells.In addition,the binding of AFF3 to the XIST DMR relies on DNA methylation and also regulates DNA methylation level at DMR region.However,the KAP1-H3K9 methylation machineries,which regulate the imprinted loci,might not play major roles in maintaining the mono-aUelic expression pattern of XIST in these cells.Thus,our results suggest that the differential mechanisms involved in the X IST DMR and gDMR regulation,which both require AFF3 and DNA methylation. | Yue Zhang Chao Wang Xiaoxu Liu Qian Yang Hongliang Ji Mengjun Yang Manman Xu Yunyan Zhou Wei Xie Zhuojuan Luo Chengqi Lin | 2019 | Journal of Molecular Cell Biology2019，11，9： | 3 |
| 7 | Life Prediction Based on Transient Dynamics Analysis of Van Semi-trailer with Air Suspension System显示文摘The early fatigue damage in the van-body of the semi-trailer is often caused by the unique mechanical characteristics and the dynamic impact of the loads.The traditional finite element method with static strength analysis cannot support the fatigue design of van-body;thus,the dynamics analysis should be adopted for the endurance performance.The accurate dynamics model to describe the transient impacts of all kinds of uneven road and the proper system transfer functions to calculate the load transfer effects from tire to van-body are two critical factors for transient dynamics analysis.In order to evaluate the dynamic performance,the dynamics model of the trailer with the air suspension is brought forward.Then the analysis method of the power spectral density (PSD) is set up to study the transient responses of the road dynamic impacts.The transient responses transferred from axles to van-body are calculated,such as dynamic stress,dynamic RMS acceleration,and dynamic load factors.Based on the above dynamic responses,the fatigue life of van-body is predicted with the finite element analysis (FEA) method.Applying the test parameters of the trailer with air suspension,the simulation system with Matlab/Simulink is constructed to describe the dynamic responses of the impacts of the tested PSD of the vehicle axles,and then the fatigue life is predicted with FEA method.The simulated results show that the vibration level of the van-body with air suspension is reduced and the fatigue life is improved.The real vehicle tests on different roads are carried out,and the test results validate the accuracy of the simulation system.The proposed fatigue life prediction method is effective for the virtual design of auto-body. | LI Liang SONG Jian HE Lin ZHANG Mengjun LI Hongzhi | 2011 | Chinese Journal of Mechanical Engineering2011，24，3： | 3 |
| 8 | The regulatory pathways of distinct flowering characteristics in Chinese jujube显示文摘Flowering is the most important event in higher plants.Compared to most fruit tree species,Chinese jujube(Ziziphus jujuba Mill.),the most important member of the large,diverse Rhamnaceae family and a leading dry fruit-producing species,has unique characteristics that include a short juvenile phase and extremely fast flower bud differentiation.However,the distinct mechanism of flowering regulation in Chinese jujube is still unclear.The morphological and cytological development period of jujube flowering was first investigated,and the crucial developmental stages were defined.Flower bud differentiation in Chinese jujube took only approximately 11–13 days,which is a distinct characteristic of perennial fruit trees.Afterward,44 genes related to six flowering pathways were identified in the jujube genome and were found to be randomly distributed among 11 of the 12 chromosomes.Tissue-specific and spatiotemporal expression patterns showed that all these genes were expressed in the flowers.Overall,photoperiodrelated genes were highly expressed during flower bud differentiation.These genes were also positively responsive to photoperiod regulation and phase change processes,indicating that photoperiod-related genes play crucial roles in jujube flower bud differentiation.Under protected cultivation,ZjPIF4,a temperature-related gene,was expressed in the early stages of flowering and responded to increasing temperatures.Moreover,STRING analysis and yeast two-hybrid screening indicated that photoperiod-related(ZjCO)and temperature-related(ZjPIF4)proteins could interact with ZjFT,the key protein involved in the determination of flowering time,indicating crosstalk between photoperiodrelated pathways and ambient temperature-related pathways in jujube.This study is the first report to comprehensively analyze the flowering pathways in Chinese jujube and revealed that photoperiod-related and ambient temperature-related pathways are the main mechanisms regulating the distinct flowering process and that members of the ZjPHY family(ZjPIF4,ZjFT,and ZjCO5)are the key factors involved in the regulatory network.These results will increase our understanding of the molecular and genetic mechanisms of flowering in Chinese jujube and provide meaningful clues for the flowering regulation of other fruit tree species. | Xianwei Meng Ying Li Ye Yuan Yao Zhang Hongtai Li Jin Zhao Mengjun Liu | 2020 | Horticulture Research2020，7，1： | 3 |
| 9 | Features of the type Ill-like source rock and its generated natural gas显示文摘The mother matter of Ordovician source are mainly sapropelic and generate oil in mature stage, since the high plants did not appear in Ordovician period, which is well known by internal and external scholars. Now we find a kind of Orodovician source rock generating mainly light oil and gas in mature stage during appraising source rocks in the Tarim Basin. The organic matters of this source rock are chiefly constructed by benthic brown algae in organisms (showing as macro algae), and are similar to humic source in hydrocarbon generation. The natural gas generated by this kind of source matters is obviously different from the sapropelic gas. | ZHAO Mengjun, ZHANG Baomin, BIAN Lizeng, XIAO Zhongyao, LI Mei, PENG Yan & QIN Shengfei1. Research Center of Exploration of TPEDB, CNPC, Korla 841000, China 2. Research Institute of Petroleum Exploration & Development, CNPC, Beijing 100083, China 3. Department of Earth Science, Nanjing University, Nanjing 210002, China | 2000 | Chinese Science Bulletin2000，45，9： | 2 |
| 10 | Applying generalized hydrophobicity scale of amino acids to quantitative prediction of human leukocyte antigen-A~*0201-restricted cytotoxic T lymphocyte epitope显示文摘Derived from 149 hydrophobic factors of 20 natural amino acids, a novel amino acid descriptor termed as generalized hydrophobicity scale (GH-scale) was proposed by principal component analysis (PCA). Via genetic algorithm-partial least square (GPLS) method, quantitative structure-activity relationship (QSAR) model was constructed by GH-scale for 152 human leukocyte antigen (HLA)-A*0201-restricted cytotoxic T lymphocyte (CTL) epitopes with the model estimated and cross-validated correlative coefficients of R2 = 0.813 and Q2 = 0.725, respectively. It was in- dicated that hydrophobic interaction played an im- portant role in HLA-A*0201-CTL interaction, promi- nently at anchor residues. | ZHOU Peng TIAN Feifei ZHANG Mengjun LI Zhiliang | 2006 | Chinese Science Bulletin2006，51，12： | 2 |
| 11 | A novel vector of topological and structural information for amino acids and its QSAR applications for peptides and analogues显示文摘A new descriptor, called vector of topological and structural information for coded and noncoded amino acids (VTSA), was derived by principal component analysis (PCA) from a matrix of 66 topological and structural variables of 134 amino acids. The VTSA vector was then applied into two sets of peptide quantitative structure-activity relationships or quantitative sequence-activity modelings (QSARs/ QSAMs). Molded by genetic partial least squares (GPLS), support vector machine (SVM), and immune neural network (INN), good results were obtained. For the datasets of 58 angiotensin converting en-zyme inhibitors (ACEI) and 89 elastase substrate catalyzed kinetics (ESCK) , the R2, cross-validation R2, and root mean square error of estimation (RMSEE) were as follows: ACEI, R2cu≥0.82, Q2cu≥0.77, Ermse≤0.44 (GPLS+SVM); ESCK, R2cu≥0.84, Q2cu≥0.82, Ermse≤0.20 (GPLS+INN), respectively. | LI ZhiLiang LI GenRong SHU Mao SUN JiaYing YANG ShanBin MEI Hu ZHANG MengJun ZHOU Ping WU ShiRong CHEN GuoHua LU FengLin LU TingTing | 2008 | Science China Chemistry2008，51，10： | 2 |
| 12 | Glutamate synthase 1 is involved in iron-deficiency response and long-distance transportation in Arabidopsis显示文摘Iron is an essential microelement for plant growth.After uptake from the soil,iron is chelated by ligands and translocated from roots to shoots for sub-sequent utilization.However,the number of ligands in-volved in iron chelation is unclear.In this study,we identified and demonstrated that GLU1,which encodes a ferredoxin-dependent glutamate synthase,was involved in iron homeostasis.First,the expression of GLU1 was strongly induced by iron deficiency condition.Second,lesion of GLU1 results in reduced transcription of many iron-deficiency-responsive genes in roots and shoots.The mutant plants revealed a decreased iron concentration in the shoots,and displayed severe leaf chlorosis under the condition of Fe limitation,compared to wild-type.Third,the product of GLU1,glutamate,could chelate iron in vivo and promote iron transportation.Last,we also found that supplementation of glutamate in the medium can alleviate cadmium toxicity in plants.Overall,our results provide evidence that GLU1 is involved in iron homeo-stasis through affecting glutamate synthesis under iron deficiency conditions in Arabidopsis. | Man Cui Mengjun Gu Yaru Lu Yue Zhang Chunlin Chen Hong‐Qing Ling Huilan Wu | 2020 | Journal of Integrative Plant Biology2020，62，12： | 2 |
| 13 | Design and heat transfer analysis of a compound multi-layer insulations for use in high temperature cylinder thermal protection systems显示文摘Thermal protection systems are very essential for high temperature thermal conductivity measurement system to reduce the heat loss to environment at the range of 600–1800 K. A compound multi-layer insulations structure which composed of inner carbon fibrous materials and outer alternately arranged alumina fibrous materials and high reflectivity foils is proposed for use in high temperature cylinder thermal protection systems. A coupled conductive and radiation governing equations is presented for heat transfer analysis of the structure. The finite volume method and the discrete ordinate method are used to solve the governing equations. The optimization structure of the compound multi-layer insulations is investigated by considering the pressure of the gas, the density of the carbon fibrous materials, the density of the alumina fibrous materials, the number of reflective foil layers and the emissivity of reflective foils. The results show that the compound structure has the best thermal insulation performance when the pressure of the gas is below 0.01 k Pa, the density of carbon fibrous materials is 180 kg m^(-3), the density of alumina fibrous materials is 256 kg m^(-3) and the number of reflective foil layers is 39. In addition, the thermal insulation performance is much better when the emissivity of reflective foils is lower. | CHEN MengJun ZHANG Ping LI Qiang | 2018 | Science China(Technological Sciences)2018，61，7： | 2 |
| 14 | Synthesis and biological evaluation of ^(18)F-FB-NGA as a hepatic asialoglycoprotein receptor PET imaging agent显示文摘Asialoglycoprotein receptor(ASGP-R)is a hepatic membrane receptor that uniquely exists on the surface of mammalian hepatocytes,and has been used as target of liver functional imaging agents for many years.We labeled the Galactosyl-neoglycoalbumin(NGA)with 18F to get a PET molecular probe 18F-FB-NGA and evaluated its ability as a liver functional PET imaging agent.The 18F-FB-NGA was prepared with NGA by conjugation with Nsuccinimidyl-4-18F-fluorobenzoate(18F-SFB)and purified with PD-10 desalting column.The radiolabeling yield and radiochemical purity of 18F-FB-NGA were determined by radio-HPLC.Starting with 18F-F–,the total time for 18F-FB-NGA was about 120±10 min.The decay-corrected radiochemical yield is about 25–30%.The radiochemical purity of purified 18F-FB-NGA was more than 98%.Labeled with 185–1850 MBq 18F-SFB,the specific activity of 18F-FBNGA was estimated to be 7.83–78.3 TBq/mmol.Biodistribution of 18F-FB-NGA in normal mice was investigated after injection through the tail vein.The results showed that the liver accumulated 39.47±3.42 and 12.12±6.11%ID/g at 10 and 30 min after injection,respectively.Dynamic MicroPET images in mice were acquired with and without block after injection of the radiotracer,respectively.High liver activity accumulation was observed at 5 min after injection in normal group.On the contrary,the liver accumulation was significantly lower after block,indicating the specific binding to ASGP-R.18F-FB-NGA is probably a potential PET liver imaging agent. | GU Xiaobo CAI Gangming JIANG Mengjun ZHOU Yaoyuan ZHANG Rongjun | 2013 | Nuclear Science and Techniques2013，24，6： | 2 |
| 15 | Characteristics,origin and controlling effects on hydrocarbon accumulation of overpressure in foreland thrust belt of southern margin of Junggar Basin,NW China显示文摘Aiming at the differential distribution of overpressure in vertical and lateral directions in the foreland thrust belt in the southern margin of Junggar Basin,the study on overpressure origin identification and overpressure evolution simulation is carried out.Based on the measured formation pressure,drilling fluid density and well logging data,overpressure origin identification and overpressure evolution simulation techniques are used to analyze the vertical and lateral distribution patterns of overpressure,genetic mechanisms of overpressure in different structural belts and causes of the differential distribution of overpressure,and the controlling effects of overpressure development and evolution on the formation and distribution of oil and gas reservoirs.The research shows that overpressure occurs in multiple formations vertically in the southern Junggar foreland thrust belt,the deeper the formation,the bigger the scale of the overpressure is.Laterally,overpressure is least developed in the mountain front belt,most developed in the fold anticline belt,and relatively developed in the slope belt.The differential distribution of overpressure is mainly controlled by the differences in disequilibrium compaction and tectonic compression strengths of different belts.The vertical overpressure transmission caused by faults connecting the deep overpressured system has an important contribution to the further increase of the overpressure strength in this area.The controlling effect of overpressure development and evolution on hydrocarbon accumulation and distribution shows in the following aspects:When the strong overpressure was formed before reservoir becoming tight overpressure maintains the physical properties of deep reservoirs to some extent,expanding the exploration depth of deep reservoirs;reservoirs below the overpressured mudstone cap rocks of the Paleogene Anjihaihe Formation and Lower Cretaceous Tugulu Group are main sites for oil and gas accumulation;under the background of overall overpressure,both overpressure strength too high or too low are not conducive to hydrocarbon enrichment and preservation,and the pressure coefficient between 1.6 and 2.1 is the best. | LU Xuesong ZHAO Mengjun ZHANG Fengqi GUI Lili LIU Gang ZHUO Qingong CHEN Zhuxin | 2022 | Petroleum Exploration and Development2022，49，5： | 2 |
| 16 | Super-absorbent swellable polymer as grouting material for treatment of karst water inrush显示文摘Grouting is the most commonly used method to control water inrush in underground engineering.Traditional cement-based materials are easy to dilute and hard to coagulate under the influence of large flow and high-velocity water inrush.To address these deficiencies,a new type of polymer grouting material with an excellent expansion ratio was synthesised.The material quickly absorbs water and has an expansion ratio of 1:300.The material is composed of a superabsorbent polymer(SAP),glycerol,and ethanol.The effects of water quality on the expansion ratio and expansion rate of the material were examined,and the best solid–liquid ratio for the slurry was determined by fluidity measurements.A karst specially designed pipeline water inrush test device showed that 800 g of SAP can achieve 0.6 m/s water flow blockage in the smooth pipeline,demonstrating that the ability of the SAP slurry to block water inrush is superior to those of other materials.This study provides a reference for water inrush plugging,and has important implications for the reduction and control of karst pipeline-type water inrush disasters,ensuring the safety of construction sites and preventing loss of life and damage to property. | Shucai Li Chenyang Ma Rentai Liu Mengjun Chen Jia Yan Zhenjun Wang Shaolong Duan Huasheng Zhang | 2021 | International Journal of Mining Science and Technology2021，31，5： | 2 |
| 17 | The regulation of cell wall lignification and lignin biosynthesis during pigmentation of winter jujube显示文摘Fruit lignification is due to lignin deposition in the cell wall during cell development.However,there are few studies on the regulation of cell wall lignification and lignin biosynthesis during fruit pigmentation.In this study,we investigated the regulation of cell wall lignification and lignin biosynthesis during pigmentation of winter jujube.The cellulose content decreased,while the lignin content increased in the winter jujube pericarp during pigmentation.Safranin O-fast green staining showed that the cellulose content was higher in the cell wall of winter jujube prior to pigmentation,whereas the lignin in the cell wall increased after pigmentation.The thickness of the epidermal cells decreased with pericarp pigmentation.A combined metabolomics and transcriptomics analysis showed that guaiacyl-syringyl(G-S)lignin was the main lignin type in the pericarp of winter jujube,and F5H(LOC107424406)and CCR(LOC107420974)were preliminarily identified as the key genes modulating lignin biosynthesis in winter jujube.Seventeen MYB and six NAC transcription factors(TFs)with potential regulation of lignin biosynthesis were screened out based on phylogenetic analysis.Three MYB and two NAC TFs were selected as candidate genes and further studied in detail.Arabidopsis ectopic expression and winter jujube pericarp injection of the candidate genes indicated that the MYB activator(LOC107425254)and the MYB repressor(LOC107415078)control lignin biosynthesis by regulating CCR and F5H,while the NAC(LOC107435239)TF promotes F5H expression and positively regulates lignin biosynthesis.These findings revealed the lignin biosynthetic pathway and associated genes during pigmentation of winter jujube pericarp and provide a basis for further research on lignin regulation. | Qiong Zhang Lihu Wang Zhongtang Wang Rentang Zhang Ping Liu Mengjun Liu Zhiguo Liu Zhihui Zhao Lili Wang Xin Chen Haifeng Xu | 2021 | Horticulture Research2021，8，1： | 2 |
| 18 | Enhanced weathering input from South Asia to the Indian Ocean since the late Eocene显示文摘nhanced silicate weathering induced by the uplift of the Himalayan-Tibetan Plateau(HTP)has been considered as the major cause of pCO_(2) decline and Cenozoic cooling.However,this hypothesis remains to be validated,largely due to the lack of a reliable reconstruction of the HTP weathering flux.Here,we present a 37-million-year record of the difference in the seawater radiogenic neodymium isotopic composition(△ε_(Nd))of Ocean Drilling Program(ODP)sites and Fe-Mn crusts between the northern and central Indian Ocean,which indicates the contribution of regional weathering input from the South Asian continent to the Indian Ocean.The results show a long-term increase in △ε_(Nd) and thus provide the first critical evidence of enhanced South Asian weathering input since the late Eocene.The evolution coincided well with major pulses of surface uplift in the HTP and global climatic transitions.Our foraminiferal eNd record suggests that tectonic uplift and silicate weathering in South Asia,especially in the Himalayas,might have played a significant role in the late Cenozoic cooling. | Zehua Song Shiming Wan Christophe Colin Christian France-Lanord Zhaojie Yu Arnaud Dapoigny Hualong Jin Mengjun Li Jin Zhang Debo Zhao Xuefa Shi Anchun Li | 2023 | Science Bulletin2023，，3： | 2 |
| 19 | Calculation of Hardness Scale for Elements on Density Functional Theory (DFT) with Generalized Local Density Approximation (LDA) and Modif ied Slater Transition2State (MST)显示文摘 | QIN Renhui UANG Ying | 2005 | Journal of Southwest China Normal University (Natural Science)2005，30，： | 1 |
| 20 | An altered CD8^(+) T cell epitope of insulin prevents type 1 diabetes in humanized NOD mice显示文摘Autoreactive CD8^(+)T cells,which play an indispensable role inβcell destruction,represent an emerging target for the prevention of type 1 diabetes(T1D).Altered peptide ligands(APLs)can efficiently induce antigen-specific T cells anergy,apoptosis or shifts in the immune response.Here,we found that HLA-A*0201-restricted CD8^(+)T cell responses against a primaryβ-cell autoantigen insulin epitope InsB15–14 were present in both NOD.β2m null.HHD NOD mice and T1D patients.We generated several APL candidates for InsB15–14 by residue substitution at the p6 position.Only H6F exhibited an inhibitory effect on mInsB1_(5–14)-specific CD8^(+)T cell responses in vitro.H6F treatment significantly reduced the T1D incidence,which was accompanied by diminished autoreactive CD8^(+)T cell responses to mInsB15-14,inhibited infiltration of CD8^(+)and CD4^(+)T cells in the pancreas and reduced pro-inflammatory cytokine production in pancreatic and splenic T cells in NOD.β2m^(null).HHD mice.Mechanistically,H6F treatment significantly augmented a tiny portion of CD8^(+)CD25^(+)Foxp3^(+)T cells in the spleen and especially in the pancreas.This subset exhibited typical Treg phenotypes and required peptide-specific restimulation to exert immunosuppressive activity.Therefore,this APL H6F may be a promising candidate with potential clinical application value for antigen-specific prevention of T1D. | Mengjun Zhang Shufeng Wang Binbin Guo Gang Meng Chi Shu Wenli Mai Qian Zheng Xiaoling Chen Yuzhang Wu Li Wang | 2019 | Cellular & Molecular Immunology2019，16，6： | 1 |
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