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| 1 | Akt Inhibitor Perifosine Prevents Epileptogenesis in a Rat Model of Temporal Lobe Epilepsy显示文摘Accumulating data have revealed that abnormal activity of the mTOR(mammalian target of rapamycin)pathway plays an important role in epileptogenesis triggered by various factors. We previously reported that pretreatment with perifosine, an inhibitor of Akt(also called protein kinase B), abolishes the rapamycin-induced paradoxical increase of S6 phosphorylation in a rat model induced by kainic acid(KA). Since Akt is an upstream target in the mTOR signaling pathway, we set out to determine whether perifosine has a preventive effect on epileptogenesis. Here, we explored the effect of perifosine on the model of temporal epilepsy induced by KA in rats and found that pretreatment with perifosine had no effect on the severity or duration of the KA-induced status epilepticus. However, perifosine almost completely inhibited the activation of p-Akt and p-S6 both acutely and chronically following the KA-induced status epilepticus.Perifosine pretreatment suppressed the KA-induced neuronal death and mossy fiber sprouting. The frequency of spontaneous seizures was markedly decreased in rats pretreated with perifosine. Accordingly, rats pretreated with perifosine showed mild impairment in cognitive functions. Collectively, this study provides novel evidence in a KA seizure model that perifosine may be a potential drug for use in anti-epileptogenic therapy. | Feng Zhu Jiejing Kai Linglin Chen Meiling Wu Jingyin Dong Qingmei Wang Ling-Hui Zeng | 2018 | Neuroscience Bulletin2018，34，2： | 8 |
| 2 | Anisotropic corrosion behavior of sintered(Ce_(0.15)Nd_(0.85))_(30)Fe_(bal)B permanent magnets显示文摘In this work, the corrosion behavior of the surface parallel to the oriented c-axis(c‖) and perpendicular to c-axis(c⊥)in the(Ce_(0.15)Nd_(0.85))_(30)Fe_(bal)B dual main phase magnet was studied. With the addition of Ce,the volume fraction of RE-rich phase shown in the backscattered electron(BSE) images is basically approximate on the two surfaces. The free corrosion potential(E_(corr)) of the c‖ surface is more negative,which shows the worse corrosion resistance from the perspective of thermodynamics. While the reaction kinetics parameters with the smaller free corrosion current(i_(corr)) and the larger transfer resistance(R_(ct)) react the opposite conclusion in 3.5 wt% NaCl solution. Moreover, the c‖ surface performs smaller ions concentration of corrosion product and less damaged corrosion morphology compared to c⊥ surface after the free corrosion. The inconformity is not affected by the RE-rich phase, but by the anisotropy of the grains that the c‖ surface has larger density of the atoms and the lower ratio of(Nd, Ce)/Fe. | Xiaoning Shi Minggang Zhu Dong Zhou Zheng Jing Meiling Zhang Wei Li | 2019 | Journal of Rare Earths2019，37，3： | 5 |
| 3 | Pt/WO_3/C nanocomposite with parallel WO_3 nanorods as cathode catalyst for proton exchange membrane fuel cells显示文摘Pt/WO3/C nanocomposites with parallel WO3 nanorods were synthesized and applied as the cathode catalyst for proton exchange membrane fuel cells(PEMFCs). Electrochemical results and single cell tests show that an enhanced activity for the oxygen reduction reaction(ORR) is obtained for the Pt/WO3/C catalyst compared with Pt/C. The higher catalytic activity might be ascribed to the improved Pt dispersion with smaller particle sizes. The Pt/WO3/C catalyst also exhibits a good electrochemical stability under potential cycling. Thus, the Pt/WO3/C catalyst can be used as a potential PEMFC cathode catalyst. | Meiling Dou Ming Hou Zhilin Li Feng Wang Dong Liang Zhigang Shao Baolian Yi | 2015 | Journal of Energy Chemistry2015，24，1： | 4 |
| 4 | Vacuum carburization of 12Cr2Ni4A low carbon alloy steel with lanthanum and cerium ion implantation显示文摘As bearing parts, 12 Cr2 Ni4 A is expected to have high hardness and excellent fatigue strength, so carburizing is employed to improve the inherit properties of 12 Cr2 Ni4 A. However, the traditional carburizing is limited by poor microstructure distribution and low rate of carburizing. The rare earth ion implantation is known to help improving the properties of tribology, corrosion resistance and oxidation resistance of metal. In this article, the RE implantation is employed to assist the carburizing. Lanthanum and cerium ion implantations are initially used to assist 12 Cr2 Ni4 A low pressure vacuum carburization.The microstructure, content of retained austenite, hardness, thickness of layer and carbon diffusion were analyzed by optical microscopy(OM), scanning electron microscopy(SEM), X-ray diffraction(XRD) and Rockwell/Vickers hardness tester, respectively. It was shown that lanthanum and cerium implantations can improve structure of the vacuum carburizing layer, and enhance the uniformity of carbon element distribution on the carburized surface. Meanwhile the RE implantation plays a positive role in promoting the surface hardness and carburized rate. The lanthanum element has more significant effect on surface hardness and content of retained austenite than cerium element. The surface hardness of lanthanum element implanted layer was 62.9 HRC with 9.6% content of retained austenite, while the carburizing rate of cerium implanted layer increased by 12.4%. | Meiling Dong Xiufang Cui Yuhui Zhang Guo Jin Caiwen Yue Xin Zhao Zhaobing Cai Binshi Xu | 2017 | Journal of Rare Earths2017，35，11： | 3 |
| 5 | Petrogenesis of Kejie Granite in the Northern Changning-Menglian Zone, Western Yunnan: Constraints from Zircon U-Pb Geochronology, Geochemistry and Hf Isotope显示文摘The Kejie pluton is located in the north of the Changning-Menglian suture zone. The rock types are mainly biotite-granite. Zircon LA-ICP-MS U-Pb dating indicates that the Kejie pluton emplaced at about 80–77 Ma, Late Cretaceous. The Kejie pluton samples are characterized by high SiO2(71.68%–72.47%), K2O(4.73%–5.54%), total alkali(K2O + Na2O = 8.21%–8.53%), K2O/Na2O ratios(1.36–1.94) and low P2O5(0.13%–0.17%), with A/CNK of 1.025–1.055; enriched in U, Th, and K, depleted in Ba, Nb, Sr, Ti, P and Eu. They are highly fractionated, slightly peraluminous I-type granite. The two samples of the Kejie pluton give a large variation of εHf(t) values(-5.04 to 1.96) and Hf isotope crustal model ages of 1.16–1.5 Ga. Zircon Hf isotopes and zircon saturation temperatures of whole-rock(801°C–823°C) show that the mantle-derived materials maybe have played a vital role in the generation of the Kejie pluton. The Kejie pluton was most likely generated in a setting associated with the eastward subduction of the neo-Tethys ocean, where intrusion of mantle wedge basaltic magmas in the crust caused the anatexis of the latter, forming hybrid melts, which subsequently experienced high-degree fractional crystallization. | NIE Fei DONG Guochen MO Xuanxue WANG Xia FAN Wenyu DONG Meiling ZHU Huaping | 2014 | Acta Geologica Sinica(English Edition)2014，88，3： | 3 |
| 6 | Spatial-temporal patterns and driving factors for industrial wastewater emission in China显示文摘 | Yong Geng Meiling Wang Joseph Sarkis Bing Xue Lin Zhang Tsuyoshi Fujita Xiaoman Yu Wanxia Ren Liming Zhang Huijuan Dong | 2014 | Journal of Cleaner Production2014，，： | 1 |
| 7 | Monolithic gra- phene fibers for solid -phase microextraction 显示文摘 | FAN Jing DONG Zelin QI Meiling | 2013 | J Chro- matogr Y A2013，1320，： | 1 |
| 8 | TOX deficiency facilitates the differentiation of IL-17A-producingγδT cells to drive autoimmune hepatitis显示文摘The specification of theαβ/γδlineage and the maturation of medullary thymic epithelial cells(mTECs)coordinate central tolerance to self-antigens.However,the mechanisms underlying this biological process remain poorly clarified.Here,we report that dual-stage loss of TOX in thymocytes hierarchically impaired mTEC maturation,promoted thymic IL-17A-producingγδT-cell(Tγδ17)lineage commitment,and led to the development of fatal autoimmune hepatitis(AIH)via different mechanisms.Transfer ofγδT cells from TOX-deficient mice reproduced AIH.TOX interacted with and stabilized the TCF1 protein to maintain the balance ofγδT-cell development in thymic progenitors,and overexpression of TCF1 normalizedαβ/γδlineage specification and activation.In addition,TOX expression was downregulated inγδT cells from AIH patients and was inversely correlated with the AIH diagnostic score.Our findings suggest multifaceted roles of TOX in autoimmune control involving mTEC and Tγδ17 development and provide a potential diagnostic marker for AIH. | Qifeng He Yijun Lu Wenfang Tian Runqiu Jiang Weiwei Yu Yong Liu Meiling Sun Fei Wang Haitian Zhang Ning Wu Zhongjun Dong Beicheng Sun | 2022 | Cellular & Molecular Immunology2022，19，10： | 1 |
| 9 | Behavior of a unit proton exchange membrane fuel cell in a stack under fuel starvation显示文摘 | Dong Liang Meiling Dou Ming Hou Qiang Shen Zhigang Shao Baolian Yi | 2011 | Journal of Power Sources2011，，13： | 1 |
| 10 | Behaviors of proton exchange membrane fuel cells under oxidant starvation显示文摘 | Meiling Dou Ming Hou Dong Liang Qiang Shen Huabing Zhang Wangting Lu Zhigang Shao Baolian Yi | 2010 | Journal of Power Sources2010，，5： | 1 |
| 11 | Genes 'waiting' for recruitment by the adaptive immune system: the insights from amphioxus 显示文摘 | Yu Cuiling Dong Meiling Wu Xiaokun | 2005 | J Immunol2005，174，6： | 1 |
| 12 | Improved refractory wound healing with administration of acidic fibroblast growth factor in diabetic rats显示文摘 | Liyun Xie Meiling Zhang Baijun Dong Mimi Guan Meifei Lu Zhifeng Huang Hongchang Gao Xiaokun Li | 2011 | Diabetes Research and Clinical Practice2011，，： | 1 |
| 13 | Cx43 reverses the resistance of A549 lung adenocarcinoma cells to cisplatinby inhibiting EMT显示文摘 | Meiling Yu Cuiling Zhang Li Li Shuying Dong Naiju Zhang Xuhui Tong | 2014 | Oncology Reports2014，，6： | 1 |
| 14 | High coercivity Nd-Ce-Fe-B nanostructured ribbons prepared from melt spinning technique显示文摘The Ce-substituted(Nd1-xCex)12.2 Fe81.6 B6.2(x=0.0, 0.2, 0.4, 0.6) nanocrystalline ribbons were prepared by annealing amorphous ribbons from melt spinning. It is found that all ribbons are in a multiphase state consisting of a-Fe phase, Nd(Ce)-rich phases and RE2 Fe14 B(RE = Nd, Ce) phases. However, the coercivity of all annealed ribbons can reach a considerably high value without doping any heavy rare earth or other coercivity enhanced elements. A strong intergranular exchange coupling appears in these nanocrystalline ribbons. The Nd12.2 Fe81.6 B6.2 ribbons with multiphase have a coercivity of about 11.3 k Oe, and the coercivity decreases slightly with increasing Ce content. A coercivity of 7.5 kOe can be obtained when60 at% of Nd is replaced by Ce(x = 0.6) due to the grain refinement and the strong intergranular exchange coupling. This provides a practical approach of fabricating high coercivity Ce-substituted Nd-Fe-B materials. | Liang Zha Zhou Liu Hao Chen Mingzhu Xue Guanyi Qiao Shilei Ding Xin Wen Meiling Zhang Youfang Lai Wenyun Yang Jingzhi Han Dong Zhou Chenyao Zhu Jinbo Yang | 2019 | Journal of Rare Earths2019，37，10： | 1 |
| 15 | Superhydrophobic Light Alloy Materials with Corrosion-Resistant Surfaces显示文摘Metals and their alloys are irreplaceable engineered materials showing great importance in our society.Light alloy materials(i.e.,Mg,Al,Ti,and their alloys)have tremendous application potential in the aerospace,automotive industries,and biomedical fields for they are lighter and have excellent mechanical properties.The corrosion of light alloys is ubiquitous and greatly restricts their utilization.Inspired by the natural anti-water systems,many new designs and conceptions have recently emerged to create artificial superhydrophobic surfaces with great potential for corrosion resistant of light alloy.This review firstly introduces the concept of superhydrophobicity and strategies of producing superhydrophobic surfaces to inhibit the corrosion of light alloys.In addition,we elaborate the durability of superhydrophobic light alloy materials for commercial and industrial applications,and present their anticorrosion mechanism in the corrosive media. | Xiaowei XUN Rili ZHU Jiaojiao DONG Ting PAN Meiling ZHONG Richao ZHANG Dongmian ZANG | 2020 | Research and Application of Materials Science2020，2，1： | 1 |
| 16 | Improved refractory wound healing with administration of acidic fi- broblast growth factor in diabetic rats 显示文摘 | Xie Liyun Zhang Meiling Dong Baijun | 2011 | Diabetes Res Clin Pract2011，93，3： | 1 |
| 17 | Role of gap junction intercellular communication in testicular leydigcell apoptosis induced by oxaliplatin via the mitochondrial pathway显示文摘 | Xuhui Tong Xi Han Binbin Yu Meiling Yu Guojun Jiang Jie Ji Shuying Dong | 2015 | Oncology Reports2015，，1： | 1 |
| 18 | In-situ Mg_(77)Cu_(12)Zn_5Y_6 bulk metallic glass matrix composite with extraordinary plasticity显示文摘We report experimental evidence of in-situ Mg77Cu12Zn5Y6 bulk metallic glass (BMG) ma- trix composite with extraordinary plastic strain of 18.5% and specific strength of 4.31×105 N·m·kg?1, which are the highest plasticity and specific strength in Mg base BMG alloys reported to date. The excel- lent mechanical properties are attributed to the for- mation of the composite structure which is composed of amorphous matrix and hexagonal-close-packed (hcp) Mg solid solution needle phase with a width less than 500 nm. As plastic phase, the Mg needles not only possess the capability of deformation but also have work hardening phenomenon effect. They give rise to multiple shear bands, and hinder the propagation of local shear band in amorphous matrix. | HUI Xidong DONG Wei WANG Meiling LIU Xiongjun YU Jialing CHEN Guoliang | 2006 | Chinese Science Bulletin2006，51，2： | 1 |
| 19 | Liver Computed To mographic Perfusion in the Assessment of Microvascular Inva sion in Patients With Small Hepatocellular Carcinoma显示文摘 | Dong Wu Ming Tan Meiling Zhou | 2015 | Inves- tigative Radiology2015，50，4： | 1 |
| 20 | Improved refractory wound healing with administration of acidic fibroblast growth factor in diabetic rats显示文摘 | Liyun Xie Meiling Zhang Baijun Dong | | 0，，03： | 1 |
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