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| 1 | Generation of human haploid embryonic stem cells from parthenogenetic embryos obtained by microsurgical removal of male pronucleus显示文摘 | Cuiqing Zhong Meiling Zhang Qi Yin Han Zhao Yang Wang Sexin Huang Wenrong Tao Keliang Wu Zi-Jiang Chen Jinsong Li | 2016 | Cell Research2016，26，6： | 16 |
| 2 | Highly efficient base editing in human tripronuclear zygotes显示文摘 | Changyang Zhou Meiling Zhang Yu Wei Yidi Sun Yun Sun Hong Pan Ning Yao Wanxia Zhong Yixue Li Weiping Li3 Hui Yang Zi-jiang Chen | 2017 | Protein & Cell2017，8，10： | 6 |
| 3 | Transmission identification of Escherichia coli aerosol in chicken houses to their environments using ERIC-PCR显示文摘In order to study E. coli aerosol spreading from chicken houses to their surrounding air, air samples, including indoor and outdoor air (upwind 10 and 50 m as well as downwind 10, 50, 100, 200 and 400 m away) of 5 chicken houses were collected using six-stage Andersen microbial samplers and Reuter-Centrifugal samplers (RCS). E. coli concentrations (CFU/m3 air) collected from different sampling sites were calculated. E. coli strains from chicken feces samples were also isolated. Furthermore, the enterobacterial repetitive intergenic consensus (ERIC)-PCR method was applied to amplify the isolated E. coli strain DNA samples. Through the genetic similarity analyses of the E. coli obtained from different sampling sites, the spreading of bioaerosol from animal houses to the ambient air was characterized. The results showed that the isolated E. coli concentrations in indoor air (9―63 CFU/m3) in 5 chicken houses were higher than those in upwind and downwind air, but there were no significant differences between the indoor and downwind sites 10 m away from all the 5 houses (P>0.05). The phylogenetic tree indicated that a part of the E. coli (34.1%) isolated from indoor air had 100% similarity with those isolated from feces, and that most of E. coli isolated (54.5%) from downwind at 10, 50, 100 or even 200 m had 100% similarity with those isolated from indoor air or feces too. But those isolated from upwind air had a lower similarity (73%―92%) with corresponding strains isolated from indoor air or feces. Our results suggested that some strains isolated from downwind air and indoor air originated in the chicken feces, but most of isolates obtained from upwind air samples did not come from the chicken feces or indoor air. Effective hygienic measures should be taken in animal farms to prevent or minimize downwind spreading of microorganism aerosol. | DUAN HuiYong CHAI TongJie CAI YuMei ZHONG ZhaoBing YAO MeiLing ZHANG XingXiao | 2008 | Science China(Life Sciences)2008，51，2： | 5 |
| 4 | 紫杉醇脂质体与紫杉醇联合铂类同步放化疗治疗宫颈癌的随机对照研究(英文)显示文摘Objective:The aim of the study was to compare the efficacy,side effect and influence on the survival rate of two chemotherapy regimens,paclitaxel liposome combined with platinum and paclitaxel combined with platinum,in concurrent chemoradiotherapy for cervical carcinoma.Methods:The 162 cases with primary cervical carcinoma diagnosed between January 2008 and November 2009 in Jiangxi Maternal and Child Health Hospital(China) were enrolled in this randomized controlled trial.Seventy-one cases were included in paclitaxel group and 91 in paclitaxel liposome group.And the chemotherapy doses were as follows:paclitaxel liposome and paclitaxel 135 mg/m2;cisplatin 80 mg/m2 or carboplatin AUC 4-6;then repeated every 21 days for two or three times.Radical radiotherapy was given to both groups at the same time.Efficacy was evaluated according to the tumor regression six months later and follow-up was done consistently.Results:The overall response rates of paclitaxel group and paclitaxel liposome group were 90.1% and 89 % respectively(P > 0.05).The one year cumulative survival was 91.4% for paclitaxel group and 89.2% for paclitaxel liposome group(P > 0.05).The incidence rates of adverse effects such as rash,gastrointestinal toxicity,bone marrow suppression and muscle/joint pain in paclitaxel liposome group were much lower than those in paclitaxel group(P < 0.05),while there was no difference regarding hair loss,hepatic function damage,peripheral neuritis and other aspects(P > 0.05).Conclusion:Paclitaxel liposome plus platinum is a safe and effective method for staging IIa-IV cervical carcinomas.While the long-term efficacy should be further observed. | Siyuan Zeng Ling Li Meiling Zhong Wei Jiang Yun Xiao | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，2： | 3 |
| 5 | Wet-spinning fabrication of shear-patterned alginate hydrogel microfibers and the guidance of cell alignment显示文摘Native tissue is naturally comprised of highly-ordered cell-matrix assemblies in a multi-hierarchical way,and the nano/submicron alignment of fibrous matrix is found to be significant in supporting cellular functionalization.In this study,a self-designed wet-spinning device appended with a rotary receiving pool was used to continuously produce shear-patterned hydrogel microfibers with aligned submicron topography.The process that the flow-induced shear force reshapes the surface of hydrogel fiber into aligned submicron topography was systematically analysed.Afterwards,the effect of fiber topography on cellular longitudinal spread and elongation was investigated by culturing rat neuron-like PC12 cells and human osteosarcoma MG63 cells with the spun hydrogel microfibers,respectively.The results suggested that the stronger shear flow force would lead to more distinct aligned submicron topography on fiber surface,which could induce cell orientation along with fiber axis and therefore form the cell-matrix dual-alignment.Finally,a multi-hierarchical tissue-like structure constructed by dual-oriented cell-matrix assemblies was fabricated based on this wet-spinning method.This work is believed to be a potentially novel biofabrication scheme for bottom-up constructing of engineered linear tissue,such as nerve bundle,cortical bone,muscle and hepatic cord. | You Yang Jing Sun Xiaolu Liu Zhenzhen Guo Yunhu He Dan Wei Meiling Zhong Likun Guo Hongsong Fan Xingdong Zhang | 2017 | Regenerative Biomaterials2017，4，5： | 2 |
| 6 | An insight into aggregation kinetics of polystyrene nanoplastics interaction with metal cations显示文摘Once inevitably released into the aquatic environment,polystyrene nanoplastics(PS-NPs)will present complicated environmental behaviors,of which the aggregation is a key process determining their environmental fate and impact.In this study,the aggregation kinetics of different sizes(30 nm and 100 nm)of PS-NPs with metal cations(Na^(+),K^(+),Ca^(2+),Mg^(2+)and Pb^(2+))at different solution pH(3,6 and 8)were investigated.The results showed that the aggregation of PS-NPs increased with cation concentration.Taking Pb^(2+)as an example,the adsorption behavior of cations onto PS-NPs was determined by transmission electron microscopy(TEM)and energy dispersive X-ray(EDX)spectroscopy,which demonstrated Pb^(2+)could be adhered onto the surface of PS-NPs with the effect of charge neutralization.The critical coagulation concentrations(CCC)of smaller PS-NPs were higher than that of larger PS-NPs for monovalent cations,whereas a different pattern is observed for divalent cations.It was suggested that there were other factors that DLVO theory does not consider affect the stability of NPs with different particle sizes.In addition,it should be noted that PS-NPs had the capacity of adsorbing large amounts of heavy metal cations and carried them transport to a long distance,and the corresponding ecological risks need to further elucidate. | Yucheng Zhang Xiaotong Su Nora FYTam Xiaolan Lao Meiling Zhong Qihang Wu Huifang Lei Zihui Chen Zhang Li Jie Fu | 2022 | Chinese Chemical Letters2022，33，12： | 1 |
| 7 | Superhydrophobic Light Alloy Materials with Corrosion-Resistant Surfaces显示文摘Metals and their alloys are irreplaceable engineered materials showing great importance in our society.Light alloy materials(i.e.,Mg,Al,Ti,and their alloys)have tremendous application potential in the aerospace,automotive industries,and biomedical fields for they are lighter and have excellent mechanical properties.The corrosion of light alloys is ubiquitous and greatly restricts their utilization.Inspired by the natural anti-water systems,many new designs and conceptions have recently emerged to create artificial superhydrophobic surfaces with great potential for corrosion resistant of light alloy.This review firstly introduces the concept of superhydrophobicity and strategies of producing superhydrophobic surfaces to inhibit the corrosion of light alloys.In addition,we elaborate the durability of superhydrophobic light alloy materials for commercial and industrial applications,and present their anticorrosion mechanism in the corrosive media. | Xiaowei XUN Rili ZHU Jiaojiao DONG Ting PAN Meiling ZHONG Richao ZHANG Dongmian ZANG | 2020 | Research and Application of Materials Science2020，2，1： | 1 |
| 8 | Differences in olfactory functional connectivity in early-onset depression and late-onset depression显示文摘Background:Late-onset depression(LOD)and early-onset depression(EOD)exhibit different pathological mechanisms and clinical phenotypes,including different extents of olfactory dysfunction.However,the brain abnormalities underlying the differences in ol-factory dysfunction between EOD and LOD remain unclear.Objective:The aim of this study was to compare the functional connectivity(FC)patterns of olfactory regions between EOD patients and LOD patients and examine their relationship with cognitive function.Methods:One hundred and five patients with EOD,101 patients with LOD and 160 normal controls(NCs)were recruited for the present study.Participants underwent clinical assessment,olfactory testing,cognitive assessments,and magnetic resonance imaging.Eight regions of the primary and secondary olfactory regions were selected to investigate olfactory FC.Results:Patients with LOD exhibited decreased odor identification(OI)compared with patients with EOD and NCs.The LOD group exhibited decreased FC compared with the EOD and NC groups when primary and secondary olfactory regions were selected as the regions of interest(the piriform cortex,lateral entorhinal cortex,and orbital-frontal cortex).Additionally,these abnormal olfactory FCs were associated with decreased cognitive function scores and OI,and the FC between the left orbital-frontal cortex and left amygdala was a partial mediator of the relationship between global cognitive scores and OI.Conclusion:Overall,patients with LOD exhibited decreased FC in both the primary and secondary olfactory cortices compared with patients with EOD,and abnormal olfactory FC was associated with OI dysfunction and cognitive impairment.The FC between the orbital-frontal cortex and amygdala mediated the relationship between global cognitive function and OI. | Ben Chen Mingfeng Yang Meiling Liu Qiang Wang Huarong Zhou Min Zhang Le Hou Zhangying Wu Si Zhang Gaohong Lin Xiaomei Zhong Yuping Ning | 2023 | Psychoradiology2023，3，1： | 0 |
| 9 | Extended State Observer based Attitude Control of a Bird-like Flapping-wing Flying Robot显示文摘The attitude control system of a flapping-wing flying robot plays an important role in the precise orientation and tracking of the robot.In this paper,the modeling of a bird-like micro flapping-wing system is introduced,and the design of a sliding mode controller based on an Extended State Observer(ESO)is described.The main design difficulties are the control law and the adaptive law for the attitude control system.To address this problem,a sliding mode adaptive extended state observer algorithm is proposed.Firstly,a new extended state approximation method is used to estimate the final output as a disturbance state.Then,a sliding mode observer with good robustness to the model approximation error and external disturbance is used to estimate the system state.Compared with traditional algorithms,this method is not only suitable for more general cases,but also effectively reduces the influence of the approximation error and interference.Next,the simulation and experiment example is given to illustrate the implementation process.The results show that the algorithm can effectively estimate the state of the attitude control system of the flapping-wing flying robot,and further guarantee the robustness of the model regarding error and external disturbance. | Keqiang Bai YunZhi Luo Zhihong Dan Song Zhang Meiling Wang Qiumeng Qian Jun Zhong | 2020 | Journal of Bionic Engineering2020，17，4： | 0 |
| 10 | Tild-CRISPR可在小鼠和人类细胞中实现高效、精确的基因敲入显示文摘文章简介研究团队基于CRISPR/Cas9系统,设计了一种新的靶向整合策略Tild-CRISPR,通过PCR扩增或者精确酶切,获得含有800bp同源臂的转基因供体与Cas9 mRNA以及single-guide RNA一起注射到小鼠受精卵中。 | 姚璇 Meiling Zhang Xing Wang Wenqin Ying Xinde Hu Pengfei Dai Feilong Meng Linyu Shi Yun Sun Ning Yao Wanxia Zhong Yun Li Keliang Wu 李卫平 陈子江 杨辉 | 2019 | 科学新闻2019，0，2： | 0 |
| 11 | An engineered xCas12i with high activity,high specificity,and broad PAM range显示文摘Dear Editor,The clustered regularly interspaced short palindromic repeats-Cas(CRISPR-Cas)systems,including type II Cas9 and type V Cas12 systems,which serve in the adaptive immunity of prokaryotes against viruses,have been developed into genome-editing tools(Anzalone et al.,2020;Doudna,2020).Compared with type II systems,the type V systems including V-A to V-K showed more functional diversity(Yan et al.,2019).Amongst them,Cas12i has a relatively smaller size(1,033-1,093 aa),compared to SpCas9 and Cas12a,and has a 5'-TTN protospacer adjacent motif(PAM)preference(Yan et al.,2019). | Hainan Zhang Xiangfeng Kong Mingxing Xue Jing Hu Zikang Wang Yinghui Wei Haoqiang Wang Jingxing Zhou Weihong Zhang Mengqiu Xu Xiaowen Shen Fengcai Yin Zhiyuan Ai Guangyan Huang Junhui Xia Xueqiong Song Hengbin Li Yuan Yuan Jinhui Li Na Zhong Meiling Zhang Yingsi Zhou Hui Yang | 2023 | Protein & Cell2023，14，7： | 0 |
| 12 | Predicting the structure and stability of titanium oxide electrides显示文摘The search for new inorganic electrides has attracted significant attention due to their potential applications in transparent conductors,battery electrodes,electron emitters,as well as catalysts for chemical synthesis.However,only a few inorganic electrides have been successfully synthesized thus far,limiting the variety of electride examples.Here,we show the stabilization of inorganic electrides in the Ti-rich Ti–O system through first-principles calculations in conjunction with swarm-intelligence-based CALYPSO method for structure prediction.Besides the known Ti-rich stoichiometries of Ti_(2)O,Ti_(3)O,and Ti_(6)O,two hitherto unknown Ti_(4)O and Ti_(5)O stoichiometries are predicted to be thermodynamically stable at certain pressure conditions.We found that these Tirich Ti–O compounds are primarily zero-dimensional electrides with excess electrons confined in the atom-sized lattice voids or between the cationic layers playing the role as anions.The underlying mechanism behind the stabilization of electrides has been rationalized in terms of the excess electrons provided by Ti atoms and their accommodation of excess electrons by multiple cavities and layered atomic packings.The present results provide a viable direction for searching for practical electrides in the technically important Ti–O system. | Xin Zhong Meiling Xu Lili Yang Xin Qu Lihua Yang Miao Zhang Hanyu Liu Yanming Ma | 2018 | npj Computational Materials2018，，1： | 0 |
| 13 | Effects of multi-sequence combination forces on creep characteristics of bales during wheat harvesting显示文摘During the baling operation,the wheat stalks are subjected to various mechanisms in the baler and the main form is compression.After the wheat stem is forced by a combination of the threshing cylinder,it needs to be formed under the action of straw baler and meet transport requirements.This paper mainly studies the properties of wheat stalks when baling,and proposes the application of the creep after-effect theory during the baling process.The tension-compression tester was used to perform a 50 mm stalk mechanical test,50 mm stalk static pressure test,35 mm×40 mm×50 mm stalk module static pressure test and bale static pressure test.The measured elastic modulus of the stem sample was 7.59 MPa,and the elastic modulus of the inner core of the stem was 8.24 MPa.The return curve of the single stalk and the bale is consistent with the initial creep and steady-state creep in the creep after-effect theory.A logarithmic function was used for fitting of the first stage with coefficient of determination R2=0.8364,and a linear function was used for fitting of the second stage with coefficient of determination R2=0.9921.The high water content static pressure test suggests that the load in the loading direction is the coupled load of the working load of the hydraulic cylinder and the internal stress of the bale.When harvesting wheat stalks with high moisture content,the density parameter of the bale can be appropriately increased while the load parameter of the hydraulic cylinder can be considered unchanged or even reduced.The adjustment of density and load can still ensure the forming quality of the bale. | Zhong Tang Yaquan Liang Ben Zhang Meiling Wang Hao Zhang Yaoming Li | 2021 | International Journal of Agricultural and Biological Engineering2021，14，5： | 0 |
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