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| 1 | 故障一点通显示文摘通用 行驶时SIR(辅助充气式气囊保护)警告灯点亮 对1999款以及更老的通用客车以及装有SDM安全气囊控制系统的轻型卡车来说,气囊警告灯点亮是驾驶员判别SIR系统出现故障的关键。当警告灯持续点亮或闪烁时,如果汽车仍在行驶,就可能发生下述一个或多个故障现象:①撞车时安全气囊不发生作用;②没发生撞车时安全气囊发生作用;③撞车时安全气囊不能如正常情况下完全起作用。如果车主发现安全气囊警告灯点亮或闪烁,应立即对车辆进行维修。 | John A Meir 学书 | 2002 | 汽车维修与保养2002，，1： | 10 |
| 2 | 以色列突发大规模伤亡事件应急体系对我国西部应急医疗体系建设的启示显示文摘以色列突发大规模伤亡事件的应急体系,具有合理的组织构架、训练有素的团队成员、和谐的医护警配合、充足的应急物资储备、强大的通讯设施、丰富的实战及演练经验。针对中国西部(以青海省,新疆、西藏自治区为例)的应急医疗体系中存在的问题,可借鉴以色列应急体系,构建区域特色的医疗卫生应急体系,进一步确保人民生命安全。 | 张宏伟 王芳 景曜 Meir Oren 彭心宇 | 2014 | 中华灾害救援医学2014，2，10： | 10 |
| 3 | The polyketide synthase OsPKS2 is essential for pollen exine and Ubisch body patterning in rice显示文摘Lipid and phenolic metabolism are important for pollen exine formation. In Arabidopsis, polyketide synthases(PKSs) are essential for both sporopollenin biosynthesis and exine formation. Here, we characterized the role of a polyketide synthase(OsPKS2) in male reproduction of rice(Oryza sativa). Recombinant OsPKS2 catalyzed the condensation of fatty acyl-CoA with malonyl-CoA to generate triketide and tetraketide α-pyrones, the main components of pollen exine. Indeed, the ospks2 mutant had defective exine patterning and was male sterile. However, the mutant showed no significant reduction in sporopollenin accumulation. Compared with the WT(wild type), ospks2 displayed unconfined and amorphous tectum and nexine layers in the exine, and less organized Ubisch bodies. Like the pksb/lap5 mutant of the Arabidopsis ortholog, ospks2 showed broad alterations in the profiles of anther-related phenolic compounds.However, unlike pksb/lap5, in which most detected phenolics were substantially decreased, ospks2 accumulated higher levels of phenolics. Based on these results and our observation that OsPKS2 is unable to fully restore the exine defects in the pksb/lap5, we propose that PKS proteins have functionally diversified during evolution.Collectively, our results suggest that PKSs represent a conserved and diversified biochemical pathway for anther and pollen development in higher plants. | Xiaolei Zhu Jing Yu Jianxin Shi Takayuki Tohge Alisdair R.Fernie Sagit Meir Asaph Aharoni Dawei Xu Dabing Zhang Wanqi Liang | 2017 | Journal of Integrative Plant Biology2017，59，9： | 9 |
| 4 | Modulators affecting the immune dialogue between human immune and colon cancer cells显示文摘The link between chronic inflammation and colorectal cancer has been well established. The events proceeding along tumorigenesis are complicated and involve cells activated at the cancer microenvironment, tumor infiltrating polymorphonuclears, immune cells including lymphocyte subtypes and peripheral blood mononuclear cells(PBMC), as well as tumor-associated macrophages. The immune cells generate inflammatory cytokines, several of them playing a crucial role in tumorigenesis. Additional factors, such as gene expression regulated by cytokines, assembling of tumor growth- and transforming factors, accelerated angiogenesis, delayed apoptosis, contribute all to initiation, development and migration of tumor cells. Oxygen radical species originating from the inflammatory area promote cell mutation and cancer proliferation. Tumor cells may over-express pro-inflammatory mediators that in turn activate immune cells for inflammatory cytokines production. Consequently, an immune dialogue emerges between immune and cancer cells orchestrated through a number of activated molecular pathways. Cytokines, encompassing migration inhibitory factor, transforming growth factor beta 1, tumor necrosisfactor-α, Interleukin(IL)-6, IL-10, IL-12, IL-17, IL-23 have been reported to be involved in human cancer development. Some cytokines, namely IL-5, IL-6, IL-10, IL-22 and growth factors promote tumor development and metastasis, and inhibit apoptosis via activation of signal transducer activator transcription-3 transcription factor. Colon cancer environment comprises mesenchymal, endothelial and immune cells. Assessment of the interaction between components in the tumor environment and malignant cells requires a reconsideration of a few topics elucidating the role of chronic inflammation in carcinogenesis, the function of the immune cells expressed by inflammatory cytokine production, the immunomodulation of cancer cells and the existence of a cross-talk between immune and malignant cells leading to a balance in cytokine production. It is conceivable that the prevalence of anti-inflammatory cytokine production by PBMC in the affected colonic mucosa will contribute to the delay, or even to halt down malignant expansion. Targeting the interplay between immune and cancer cells by mediators capable to alter cytokine secretion toward increased anti-inflammatory cytokine release by PBMC and tumor associated macrophages, may serve as an additional strategy for treatment of malignant diseases. This review will focus on the inflammatory events preceding tumorigenesis in general, and on a number of modulators capable to affect colon cancer cell-induced production of inflammatory cytokines by PBMC through alteration of the immune crosstalk between PBMC and cancer cells. | Meir Djaldetti Hanna Bessler | 2014 | World Journal of Gastrointestinal Oncology2014，6，5： | 7 |
| 5 | 湿帘风机系统温室夏季蒸腾与微气候试验显示文摘在2种通风率和湿帘开、关状况下对温室内部气候相关参数进行了检测和对比分析,并重点对蒸腾速率进行了模拟计算和测量。试验结果表明:蒸腾速率与通风率、湿帘工作状况相关,在相对干燥的环境下(不开启湿帘),提高通风率可使植物获得更大的蒸腾量,从而可使温室内部温度不超过室外温度。在湿帘不工作的情况下,由于蒸腾的作用植物叶面温度低于周围的环境空气温度;而在湿帘工作情况下,室内湿度较高,蒸腾受到抑制,叶面温度高于周围环境空气温度。 | 赵云 沈剑英 Meir Teitel | 2008 | 农业机械学报2008，39，8： | 7 |
| 6 | Gastric stimulation for weight loss显示文摘The prevalence of obesity is growing to epidemic proportions,and there is clearly a need for minimally invasive therapies with few adverse effects that allow for sustained weight loss.Behavior and lifestyle therapy are safe treatments for obesity in the short term,but the durability of the weight loss is limited.Although promising obesity drugs are in development,the currently available drugs lack efficacy or have unacceptable side effects.Surgery leads to long-term weight loss,but it is associated with morbidity and mortality.Gastric electrical stimulation(GES) has received increasing attention as a potential tool for treating obesity and gastrointestinal dysmotility disorders.GES is a promising,minimally invasive,safe,and effective method for treating obesity.External gastric pacing is aimed at alteration of the motility of the gastrointestinal tract in a way that will alter absorption due to alteration of transit time.In addition,data from animal models and preliminary data from human trials suggest a role for the gut-brain axis in the mechanism of GES.This may involve alteration of secretion of hormones associated with hunger or satiety.Patient selection for gastric stimulation therapy seems to be an important determinant of the treatment's outcome.Here,we review the current status,potential mechanisms of action,and possible future applications of gastric stimulation for obesity. | Meir Mizrahi Ami Ben Ya'acov Yaron Ilan | 2012 | World Journal of Gastroenterology2012，18，19： | 4 |
| 7 | Perioperative topical ascorbic acid for the prevention of phacoemulsification-related corneal endothelial damage:Two case reports and review of literature显示文摘BACKGROUND The current case report describes successful phacoemulsification with the aid of perioperative topical ascorbic acid(AA) in two patients with corneal endothelial disorders to prevent postoperative corneal endothelial decompensation.CASE SUMMARY Two eyes of two patients underwent phacoemulsification with pre-existing corneal endothelial disorders including Fuchs corneal endothelial dystrophy(Patient 1) and endotheliitis(Patient 2). Topical AA was applied to both patients at least one month before and after with a frequency of four times per day. After the surgery, both eyes improved best-corrected visual acuity(BCVA) and there was limited human corneal endothelial cell loss without signs of corneal endothelial decompensation, such as deteriorated BCVA or persistent corneal edema during the follow-up of at least two years.CONCLUSION Perioperative administration of topical AA may be an alternative therapy to the triple procedure in patients expecting to undergo cataract surgery. | Chia-Yi Lee Hung-Ta Chen Yi-Jen Hsueh Hung-Chi Chen Chieh-Cheng Huang Yaa-Jyuhn James Meir Chao-Min Cheng Wei-Chi Wu | 2019 | World Journal of Clinical Cases2019，7，5： | 4 |
| 8 | Unreliability of aortic size index to predict risk of aortic dissection in a patient with Turner syndrome显示文摘Aortic size index(ASI) has been proposed as a reliable criterion to predict risk for aortic dissection in Turner syndrome with significant thresholds of 20-25 mm/m2. We report a case of aortic arch dissection in a patient with Turner syndrome who, from the ASI thresholds proposed, was deemed to be at low risk of aortic dis-section or rupture and was not eligible for prophylactic surgery. This case report strongly supports careful monitoring and surgical evaluation even when the ASI is < 20 mm/m2 if other significant risk factors are present. | Jan Nijs Sandro Gelsomino Fabiana Lucà Orlando Parise Jos G Maessen Mark La Meir | 2014 | World Journal of Cardiology2014，6，5： | 3 |
| 9 | Plasma Concentration of C-Reactive Protein and Risk of Developing Peripheral Vascular Disease显示文摘 | Paul M. Ridker Mary Cushman Meir J. Stampfer Russell P. Tracy Charles H. Hennekens | 1998 | Circulation1998，，5： | 3 |
| 10 | MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors显示文摘 | Liu Xi Sempere Lorenzo F Ouyang Haoxu Memoli Vincent A Andrew Angeline S Luo Yue Demidenko Eugene Korc Murray Shi Wei Preis Meir Dragnev Konstantin H Li Hua DiRenzo James Bak Mads Freemantle Sarah J Kauppinen Sakari Dmitrovsky Ethan | 2010 | Journal of Clinical Investigation2010，，4： | 3 |
| 11 | Prospective Study of Sudden Cardiac Death Among Women in the United States显示文摘 | Christine M. Albert Claudia U. Chae Francine Grodstein Lynda M. Rose Kathryn M. Rexrode Jeremy N. Ruskin Meir J. Stampfer JoAnn E. Manson | 2003 | Circulation: Journal of the American Heart Association2003，，16： | 3 |
| 12 | Azathioprine-induced fever in autoimmune hepatitis显示文摘Underdiagnosis of drug-induced fever leads to extensive investigation and prolongation of hospitalization, and may lead to multiple unnecessary invasive procedures and a wrong diagnosis. Azathioprine is a widely used immunosuppressive drug. We report a case of a 53-year-old female patient diagnosed with autoimmune hepatitis treated with azathioprine, who presented to the emergency room with a 6-wk history of fever and chills without other associated symptoms. Since the patient's fever was of unknown origin, she was hospitalized. All treatment was stopped and an extensive workup to explore the source of fever and chills was performed. Results of chest X-ray, viral, urine, and blood cultures, autoimmune serology, transthoracic and transesophageal echocardiography, and abdominal ultrasound revealed no source of infection. A rechallenge test of azathioprine was performed and the fever and chills returned within a few hours. Azathioprine was established as the definite cause following rechallenge. Fever as an adverse drug reaction is often unrecognized. Azathioprine has been reported to cause druginduced fever in patients with inflammatory bowel disease, rheumatoid arthritis, and sarcoidosis. To the bestof our knowledge there have been no previous reports documenting azathioprine-induced fever in patients with autoimmune hepatitis. The occurrence of fever following the readministration of azathioprine suggests the diagnosis of drug-induced fever, particularly after the exclusion of other causes. A careful rechallenge is recommended to confirm the diagnosis. | Tawfik Khoury Jacob E Ollech Shmuel Chen Meir Mizrahi Meir Shalit | 2013 | World Journal of Gastroenterology2013，19，25： | 3 |
| 13 | 基于变频驱动的温室变风量通风节能效果试验显示文摘基于变频调速驱动技术的温室变风量通风(VAV)方法,可以实现温室夏季通风节能。在一个装备机械通风系统的连栋温室中对设置由变频驱动(VFD)控制的通风系统和常规的开关通风系统进行对比试验。变频控制系统由输入参数为室外环境太阳辐射热流密度和温室内外部温度的控制算法实现变风量通风(VAV),两部分温室的内部气候参数和耗电量得到连续检测并进行对比。连续试验结果表明:在保证两个温室气候参数一致的条件下,变频驱动控制方式比非变频驱动控制方式具有36%(湿帘不工作)和46%(湿帘工作)的节能效果。 | 赵云 Meir Teitel | 2006 | 农业机械学报2006，37，5： | 3 |
| 14 | Glycosylation of N-hydroxy-pipecolic acid equilibrates between systemic acquired resistance response and plant growth显示文摘N-hydroxy-pipecolic acid(NHP)activates plant systemic acquired resistance(SAR).Enhanced defense responses are typically accompanied by deficiency in plant development and reproduction.Despite of extensive studies on SAR induction,the effects of NHPmetabolismon plant growth remain largely unclear.In this study,we discovered that NHP glycosylation is a critical factor that fine-tunes the tradeoff between SAR defense and plant growth.We demonstrated that a UDP-glycosyltransferase(UGT76B1)forming NHP glycoside(NHPG)controls the NHP to NHPG ratio.Consistently,the ugt76b1 mutant exhibits enhanced SAR response and an inhibitory effect on plant growth,while UGT76B1 overexpression attenuates SAR response,promotes growth,and delays senescence,indicating that NHP levels are dependent on UGT76B1 function in the course of SAR.Furthermore,our results suggested that,upon pathogen attack,UGT76B1-mediated NHP glycosylation forms a‘‘hand brake’’on NHP accumulation by attenuating the positive regulation of NHP biosynthetic pathway genes,highlighting the complexity of SAR-associated networks.In addition,we showed that UGT76B1-mediated NHP glycosylation in the local site is important for fine-tuning SAR response.Our results implicate that engineering plant immunity through manipulating the NHP/NHPG ratio is a promising method to balance growth and defense response in crops. | Jianghua Cai Adam Jozwiak Lara Holoidovsky Michael MMeijler Sagit Meir Ilana Rogachev Asaph Aharoni | 2021 | Molecular Plant2021，14，3： | 2 |
| 15 | Adalimumab-induced Autoimmune Hepatitis显示文摘 | Tomer Adar Meir Mizrahi Orit Pappo Anat Scheiman-Elazary Oren Shibolet | 2010 | Journal of Clinical Gastroenterology2010，，1： | 2 |
| 16 | 缺氧对HRE-TK/GCV系统杀伤骨肉瘤细胞的增强作用显示文摘目的:探讨缺氧条件下,缺氧反应元件启动子-胸苷激酶/丙氧鸟苷(HRE-TK/GCV)系统对骨肉瘤细胞系MG63靶向性杀伤作用。方法:构建由HRE启动子驱动的含潮霉素磷酸转移酶-单纯疱疹病毒胸腺嘧啶激酶(Hygromycinphosphotransferase-thymidinekinase,HyTK)融合基因的真核表达质粒pBI-HRE-HyTK,并将其转染入骨肉瘤细胞系MG63。应用PCR和RT-PCR方法检测TK基因的整合及表达;用MTT法和混合共培养实验分别检测转基因细胞在缺氧或不缺氧状态下对GCV的敏感性以及HRE-TK/GCV系统的“旁观者效应”;流式细胞仪检测细胞周期改变及电镜观察细胞超微结构变化探讨其作用机制。结果:成功构建了真核表达质粒pBI-HRE-HyTK,得到转基因细胞系MG63TK。检测到MG63TK细胞内TK基因的DNA和mRNA。MG63TK细胞在不缺氧状态下对GCV不敏感,当GCV浓度达50μg/ml时,仅30%左右细胞被杀死;而缺氧状态下,GCV浓度1μg/ml时,50%左右细胞被杀死,GCV浓度50μg/ml时,90%以上细胞被杀死。混合共培养实验中,缺氧状态下,HRE-TK/GCV系统旁观者效应明显增强,MG63细胞存活率显著低于不缺氧状态下。缺氧和GCV共同作用使转基因细胞DNA合成抑制,细胞周期阻滞于G0G1期,细胞发生凋亡和坏死。结论:缺氧可以增强HRE-TK/GCV系统对体外培养骨肉瘤细胞系选择性的杀伤作用? | 王燕 丘钜世 乔慧 汪睿 彭挺生 李扬 EG Van Meir | 2005 | 中国肿瘤临床2005，32，2： | 2 |
| 17 | Hyperglycemia, Insulin Resistance, Impaired Pancreatic β-Cell Function, and Risk of Pancreatic Cancer显示文摘 | Brian M. Wolpin Ying Bao Zhi Rong Qian Chen Wu Peter Kraft Shuji Ogino Meir J. Stampfer Kaori Sato Jing Ma Julie E. Buring Howard D. Sesso I-Min Lee John Michael Gaziano Anne McTiernan Lawrence S. Phillips Barbara B. Cochrane Michael N. Pollak JoAnn E. Ma | 2013 | JNCI Journal of the National Cancer Institute2013，，14： | 2 |
| 18 | The Tomato Hybrid Proline-rich Protein regulates the abscission zone competence to respond to ethylene signals显示文摘The Tomato Hybrid Proline-rich Protein(THyPRP)gene was specifically expressed in the tomato(Solanum lycopersicum)flower abscission zone(FAZ),and its stable antisense silencing under the control of an abscission zone(AZ)-specific promoter,Tomato Abscission Polygalacturonase4,significantly inhibited tomato pedicel abscission following flower removal.For understanding the THyPRP role in regulating pedicel abscission,a transcriptomic analysis of the FAZ of THyPRP-silenced plants was performed,using a newly developed AZ-specific tomato microarray chip.Decreased expression of THyPRP in the silenced plants was already observed before abscission induction,resulting in FAZ-specific altered gene expression of transcription factors,epigenetic modifiers,post-translational regulators,and transporters.Our data demonstrate that the effect of THyPRP silencing on pedicel abscission was not mediated by its effect on auxin balance,but by decreased ethylene biosynthesis and response.Additionally,THyPRP silencing revealed new players,which were demonstrated for the first time to be involved in regulating pedicel abscission processes.These include:gibberellin perception,Ca2+-Calmodulin signaling,Serpins and Small Ubiquitin-related Modifier proteins involved in post-translational modifications,Synthaxin and SNARE-like proteins,which participate in exocytosis,a process necessary for cell separation.These changes,occurring in the silenced plants early after flower removal,inhibited and/or delayed the acquisition of the competence of the FAZ cells to respond to ethylene signaling.Our results suggest that THyPRP acts as a master regulator of flower abscission in tomato,predominantly by playing a role in the regulation of the FAZ cell competence to respond to ethylene signals. | Srivignesh Sundaresan Sonia Philosoph-Hadas Chao Ma Cai-Zhong Jiang Joseph Riov Raja Mugasimangalam Betina Kochanek Shoshana Salim Michael SReid Shimon Meir | 2018 | Horticulture Research2018，5，1： | 2 |
| 19 | 计算机辅助外科在创伤骨科中的目前观念显示文摘计算机辅助外科(computer assisted surger,CAS)技术已经开始对创伤骨科的临床实际操作产生了重要的影响。虽然计算机已广泛应用于患者的术前检查中,尤其是在影像学上的应用,但事实上将计算机辅助设备引入创伤骨科手术室始于20世纪90年代末。 | 王簕(译校) Yoram A. Weil Amal Khoury David L Helfet Meir Liebergall | 2008 | 中华创伤骨科杂志2008，10，3： | 2 |
| 20 | Budesonide foam versus budesonide enema in active ulcerative proctitis and proctosigmoiditis显示文摘 | V.GROSS S.BAR‐MEIR A.LAVY O.MICKISCH Z.TULASSAY L.PRONAI L.KUPCINSKAS G.KIUDELIS J.POKROTNIEKS á.KOVáCS M.FASZCZYK A.RAZBADAUSKAS B.MARGUS M.STOLTE R.MüLLER R.GREINWALD | 2005 | Alimentary Pharmacology & Therapeutics2005，，2： | 2 |
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