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| 1 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013，23，7： | 19 |
| 2 | Acute Kidney Injury:Global Health Alert显示文摘Acute kidney injury(AKI) is increasingly prevalent in developing and developed countries and is associated with severe morbidity and mortality.Most etiologies of AKI can be prevented by interventions at the individual,community,regional and in-hospital levels.Effective measures must include community-wide efforts to increase an awareness of the devastating effects of AKI and provide guidance on preventive strategies,as well as early recognition and management.Efforts should be focused on minimizing causes of AKI,increasing awareness of the importance of serial measurements of serum creatinine in high risk patients,and documenting urine volume in acutely ill people to achieve early diagnosis;there is as yet no definitive role for alternative biomarkers.Protocols need to be developed to systematically manage prerenal conditions and specific infections.More accurate data about the true incidence and clinical impact of AKI will help to raise the importance of the disease in the community,increase awareness of AKI by governments,the public,general and family physicians and other health care professionals to help prevent the disease.Prevention is the key to avoid the heavy burden of mortality and morbidity associated with AKI. | Philip Kam Tao Li Emmanuel A Burdmann Ravindra L Mehta | 2013 | 肾脏病与透析肾移植杂志2013，22，1： | 14 |
| 3 | Mitochondrial Autophagy and NLRP3 Inflammasome in Pulmonary Tissues from Severe Combined Immunodeficient Mice after Cardiac Arrest and Cardiopulmonary Resuscitation显示文摘 | Jing-Jun Lyu Jawahar L Mehta Yi Li Lu Ye Sheng-Nan Sun Hong-Shuang Sun Jia-Chang Li Dong-Mei Zhang Jie Wei | 2018 | Chinese Medical Journal2018，，10： | 12 |
| 4 | 血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂的使用与2019冠状病毒疾病检测阳性之间的关系显示文摘血管紧张素转换酶抑制剂(angiotensin-converting enzyme inhibitor,ACEI)和血管紧张素受体拮抗剂(angiotensin receptor blocker,ARB)在2019新型冠状病毒疾病(coronavirus disease 2019,COVID-19)全球大流行背景下的作用备受争议。此类药物是治疗一些慢性病的必须药物,有建议停止使用这些药物. | Mehta N KalraA Nowacki AS Anjewierden S Han Z Bhat p Rubio AEC Jacob M Procop GW Harrington S Milinovich A Svensson LG Jehi L Young JB Chung MK 周卫(译) 叶鹏(校) | 2020 | 中华高血压杂志2020，28，5： | 9 |
| 5 | Aspirin resistance: Fact or fiction? A point of view显示文摘Aspirin is a wonder drug that has been used for well over 100 years for its analgesic and antipyretic effects. For the past three decades, it has increasingly been used for the prevention of primary and secondary cardiovascular events. Lately, it has been suggested that a significant number of individuals taking aspirin have become resistant to this drug. The phenomenon of 'aspirin resistance' is based on the observation of clinical events in some patients taking aspirin, and/or a diminished platelet aggregation inhibitory response to aspirin therapy. Unfortunately, laboratory assays used to monitor the efficacy of aspirin are far from accurate and the results are not reproducible. Furthermore, results of different platelet function tests are often not congruent. In addition, platelet aggregation studies show marked interindividual and intra-individual variability. Patients with coronary heart disease take many drugs that interfere with the effect of aspirin on platelet aggregation. Besides inhibiting formation of thromboxane A2 from arachidonic acid, aspirin has a host of platelet-independent effects that complement its platelet inhibitory effects. Laboratory assays designed to measure platelet function do not take into account these pleiotropic effects of aspirin. In our view, use of the term 'aspirin resistance' based on inadequate knowledge of imperfect laboratory tests does a disservice to physicians and patients. | Jawahar L Mehta Bhavna Mohandas | 2010 | World Journal of Cardiology2010，2，9： | 7 |
| 6 | Effects of linagliptin and liraglutide on glucose- and angiotensin Ⅱ-induced collagen formation and cytoskeleton degradation in cardiac fibroblasts in vitro显示文摘瞄准:象 Glucagon 一样 peptide-1 (GLP-1 ) 收缩筋和 dipeptidyl peptidase-4 (DPP-4 ) 禁止者不能仅仅降低血葡萄糖层次,而且减轻在心肌的局部缺血和高血压以后的心脏的改变。在现在的学习,我们在葡萄糖上调查了一个 DPP-4 禁止者(linagliptin ) 和 GLP-1 使活跃之物(liraglutide ) 的效果 -- 并且血管收缩素 II (Ang II ) 在 vitro 在心脏的成纤维细胞导致了骨胶原形成和细胞骨架重组,并且阐明相关 mechanisms.Methods:心脏的成纤维细胞从 6-week-old C57BL/6 老鼠的心被孤立,然后为 24 h 暴露了到葡萄糖或 Ang II 的不同集中。fibrotic 的表达式发信号(象 ERK1/2 和 NF-κ 一样的 fibronectin, collagen-1, -3 和 -4), ;在成纤维细胞的 B-p65 用西方的弄污被检验试金。F 肌动朊降级在在成纤维细胞的共焦的显微镜与玫瑰精 phalloidin.Results 染色了的转换激光下面被检测:葡萄糖(1-40 mmol/L ) 和 Ang II (10 −8-10−5 mol/L ) dose-dependently 增加了 fibronectin,骨胶原, phospho-ERK1/2 和 phospho-NF-κ 的表示;在心脏的成纤维细胞的 B-p65。葡萄糖的高集中(≥ 40 mmol/L ) 并且 Ang II (≥ 10 −6 mol/L ) 引起了 F 肌动朊(更少的集会 F 肌动朊纤维和更多拆卸纤维) 的重要降级。ERK1/2 禁止者 U0126 (10 μ mol/L ) 并且 NF-κ B 禁止者 JSH-23 (10 μ mol/L ) 两个显著地压制了葡萄糖 -- 并且血管收缩素在心脏的成纤维细胞的导致 II 的 fibronectin 和骨胶原表情。而且,有 liraglutide (10-100 nmol/L ) 的预告的处理或 linagliptin (3 和 30 nmol/L ) 显著地减少了葡萄糖 -- 并且 fibrotic 信号, phospho-ERK1/2 和 phospho-NF-κ 的 Ang 导致 II 的表示;在心脏的成纤维细胞的 B-p65。而且,然而,有 liraglutide (30 nmol/L ) 的预告的处理或 liraglutide (100 nmol/L ) 显著地禁止了导致葡萄糖的 F 肌动朊降级仅仅 liraglutide 禁止的 Ang 导致 II 的 F 肌动朊 degradation.Conclusion:Linagliptin 和 liraglutide 禁止葡萄糖 -- 并且在经由 ERK/NF-κ 的激活的心脏的成纤维细胞的 Ang 导致 II 的骨胶原形成; B/pathway。Linagliptin 和 liraglutide 显著地也在心脏的成纤维细胞,而是仅仅 liraglutide 禁止导致葡萄糖的 F 肌动朊降级禁止 Ang 导致 II 的 F 肌动朊降级。 | Xian-wei WANG Fen-xi ZHANG Fen YANG Zu-feng DING Nidhi AGARWAL Zhi-kun GUO Jawahar L MEHTA | 2016 | Acta Pharmacologica Sinica2016，37，10： | 3 |
| 7 | Brain metastases: pathobiology and emerging targeted therapies显示文摘 | Matthias Preusser David Capper Aysegül Ilhan-Mutlu Anna Sophie Berghoff Peter Birner Rupert Bartsch Christine Marosi Christoph Zielinski Minesh P. Mehta Frank Winkler Wolfgang Wick Andreas Deimling | 2012 | Acta Neuropathologica2012，，2： | 2 |
| 8 | Postoperative pain expe rience: results from a national survery suggest postoperative pain continues to be undermanaged 显示文摘 | Apfelbaum J L Chert C Mehta SS | 2003 | Anesth Analg2003，97，2： | 1 |
| 9 | Upregulation of endothelial receptor for oxidized cells LDL and implications in apoptosis of human coronaiy artery endothelial cells : evidence from use of antisense LOX-1 mRNA and chemical inhibitors 显示文摘 | Li D Mehta J L | 2000 | Arterioscler Thromb Vasc Biol2000，20，4： | 1 |
| 10 | Permeability and selectivity analysis for uhrafiltration membranes 显示文摘 | Mehta A Zydney A L | 2005 | Journal of Membrane Science2005，249，12： | 1 |
| 11 | Association of bleeding and in - hospital mortality in black and white patients with ST - Seg- ment- Elevation myocardial infarction receiving reperfusion 显示文摘 | Mehta RH Parsons L Rao SV | 2012 | Circulation2012，125，14： | 1 |
| 12 | Canadian survey of the use of sedatives,analgesics,and neuromuscular blocking agents in critically ill patients显示文摘 | Mehta S Burry L Fischer S | 2006 | Crit Care Med2006，34，2： | 1 |
| 13 | The Human Hematopoietic Progenitor Cell Antigen (CD34) in Vascular Neoplasia显示文摘 | Traweek S T Kandalaft P L Mehta P | 1991 | Am J Clin Pathol1991，96，1： | 1 |
| 14 | Evidence for the presence of L-Arginine/Nitric oxide pathway in human red blood cells: Relevance in the effects of red blood cells on platelet function显示文摘 | Chen L Y Mehta J L | 1998 | Cardiovasc Pharmac1998，32，： | 1 |
| 15 | Some trigonometric identities encountered by McCoy and Orrick显示文摘 | Gervois A Mehta M L | 1995 | Journal of Mathematical Physics1995，36，： | 1 |
| 16 | The multi-ob- jective equilibrium network design problem revisited: a simulated annealing approach显示文摘 | Friesz T L Mehta N J Nam K | 1993 | European Journal of Operational Research1993，65，1： | 1 |
| 17 | Current sedation praetiees :lessons learned from international surveys 显示文摘 | Mehta S MeCullagh I Burry L | 2009 | Crit Care Clin2009，25，3： | 1 |
| 18 | Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for With a Sedation Protocol:A Randomized Controlled Trial显示文摘 | Mehta S Burry L Cook D | 2012 | JAMA2012，308，19： | 1 |
| 19 | Congenital syphilis and fluorescent treponemal antibody test reactivity after the age of 1 year显示文摘 | Rawstron SA Mehta S Marcellino L | 2001 | Sex Transm Dis2001，28，7： | 1 |
| 20 | Prospective evaluation of radiosurgery for hemangioblastomas in von HippelLindau disease显示文摘 | Asthagiri A R Mehta G U Zach L | 2010 | Neuro Oncol2010，12，1： | 1 |
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