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| 1 | Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development显示文摘Chronic obstructive pulmonary disease(COPD) significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork(COSYCONET) study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA(miRNA) profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance(two-tailed unpaired t-test adjusted for multiple testing P < 0.05), including members of the miR-320 family. The identified mi RNAs regulate different cancer-related pathways including the MAPK pathway(P = 2.3 x 10^(-5)). We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer. | Andreas Keller Tobias Fehlmann Nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline Diener Frank Biertz Christian Herr Rudolf A. Jorres Hans-Peter Lenhof Eckart Meese Robert Bals | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 9 |
| 2 | Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin-1, claudin-3, claudin-4, and β-catenin显示文摘 | S. T. Mees R. Mennigen T. Spieker E. Rijcken N. Senninger J. Haier M. Bruewer | 2009 | International Journal of Colorectal Disease2009，，： | 2 |
| 3 | Multivariate miRNA signatures as biomarkers for non-ischaemic systolic heart failure显示文摘 | Britta Vogel Andreas Keller Karen S. Frese Petra Leidinger Farbod Sedaghat-Hamedani Elham Kayvanpour Wanda Kloos Christina Backe Ann Thanaraj Thomas Brefort Markus Beier Stefan Hardt Eckart Meese Hugo A. Katus Benjamin Meder | 2013 | European Heart Journal2013，，： | 2 |
| 4 | Machine Learning to Detect Alzheimer’s Disease from Circulating Non-coding RNAs显示文摘Blood-borne small non-coding(snc RNAs)are among the prominent candidates for blood-based diagnostic tests.Often,high-throughput approaches are applied to discover biomarker signatures.These have to be validated in larger cohorts and evaluated by adequate statistical learning approaches.Previously,we published high-throughput sequencing based microRNA(miRNA)signatures in Alzheimer’s disease(AD)patients in the United States(US)and Germany.Here,we determined abundance levels of 21 known circulating miRNAs in 465 individuals encompassing AD patients and controls by RT-qPCR.We computed models to assess the relation between miRNA expression and phenotypes,gender,age,or disease severity(Mini-Mental State Examination;MMSE).Of the 21 miRNAs,expression levels of 20 miRNAs were consistently de-regulated in the US and German cohorts.18 miRNAs were significantly correlated with neurodegeneration(Benjamini-Hochberg adjusted P<0.05)with highest significance for miR-532-5 p(BenjaminiHochberg adjusted P=4.8×10^-30).Machine learning models reached an area under the curve(AUC)value of 87.6%in differentiating AD patients from controls.Further,ten miRNAs were significantly correlated with MMSE,in particular miR-26a/26b-5p(adjusted P=0.0002).Interestingly,the miRNAs with lower abundance in AD were enriched in monocytes and T-helper cells,while those up-regulated in AD were enriched in serum,exosomes,cytotoxic t-cells,and B-cells.Our study represents the next important step in translational research for a miRNA-based AD test. | Nicole Ludwig Tobias Fehlmann Fabian Kern Manfred Gogol Walter Maetzler Stephanie Deutscher Simone Gurlit Claudia Schulte Anna-Katharina von Thaler Christian Deuschle Florian Metzger Daniela Berg Ulrike Suenkel Verena Keller Christina Backes Hans-Peter Lenhof Eckart Meese Andreas Keller | 2019 | Genomics, Proteomics & Bioinformatics2019，17，4： | 2 |
| 5 | A prospective, clinical study evaluating arthroseopie ACL reconstruction using the semitendinosus and iliotibial band: 2 to 5 year follow up显示文摘 | BILLOTFI J D MEESE M A ALBERTA F | 1997 | Orthopaedics1997，20，2： | 1 |
| 6 | A prospective, clinical study evaluating arthroscopic ACL reconstruction using the semitendinosus and iliotibial band :2-to 5-year follow up 显示文摘 | Billotti JD Meese MA Alberta F | 1997 | Orthopaedics1997，20，2： | 1 |
| 7 | Molecular cloning and characterization of the human E-cadherin cDNA显示文摘 | M. J. G. Bussemakers A. Bokhoven S. G. M. Mees R. Kemler J. A. Schalken | 1993 | Molecular Biology Reports1993，，2： | 1 |
| 8 | Empirical exchange rate models of the sevent ies:Do they fit out of sample显示文摘 | Rogoff K | 1983 | Journal of International Economics1983，14，： | 1 |
| 9 | Calcium antagonists for aneurysmal subarachnoid haemorrhage显示文摘 | Dorhout Mees SM Rinkel GJ Feigin VL | | 0，，03： | 1 |
| 10 | Neuromagnetic evoked responses to complex motions are greatest for expansion显示文摘 | Holliday IE Meese TS | | 0，，： | 1 |
| 11 | Nature of basal debris in the GISP2 and Byrd ice cores and its relevance to bed processes显示文摘 | Gow A J and Meese D A | 1996 | Annals of Glaciology1996，22，： | 1 |
| 12 | Profiling of regulatery microR- NA transcriptomes in various biological processes: a review 显示文摘 | Shah AA Meese E Blin N | 2010 | J Appl Genet2010，51，： | 1 |
| 13 | Empirical Exchange Rate Models of the Seventies显示文摘 | Meese R Rogoff K | 1983 | Journal of International Economics1983，14，1： | 1 |
| 14 | Effect of acceleratedcrucible rotation on the segregation of impurities in verticalBridgman growth of multi-crystalline silicon显示文摘 | Bellmann M P Meese E A Arnberg L | | Journal ofCrystal Growth0，，： | 1 |
| 15 | Effect of steady crucible rotationon the segregation of impurities in vertical Bridgman growthof multi-crystalline silicon显示文摘 | Bellmann M P Meese E A | 2011 | Journal of Crystal Growth2011，333，1： | 1 |
| 16 | The Supreme Court of the United States: Bulwark of a Limited Constitution 显示文摘 | Meese | 1986 | Yale Law Review1986，，27： | 1 |
| 17 | Next-generation sequencing identifies altered whole blood microRNAs in neuromyelitis optica spectrum disorder which may permit discrimination from multiple sclerosis显示文摘 | Keller A Leidinger P Meese E | 2015 | Journal of neuro- inflammation2015，12，1： | 1 |
| 18 | Effect of flow pattern on thesegregation of impurities in vertical Bridgman growth ofmulti-crystalline silicon显示文摘 | Bellmann M P Meese E A | | Journal of Crystal Growth0，，： | 1 |
| 19 | Impurity segregationin directional solidified multi-crystalline silicon显示文摘 | Bellmann M P Meese E A Arnberg L | 2010 | Journalof Crystal Growth2010，312，21： | 1 |
| 20 | Empirical exchange rate models of the seventies: Do they fit out of sample? 显示文摘 | Meese R Rogoff K | 1983 | Journal of International Economics1983，14，： | 1 |
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