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| 1 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 2 | Use of shear wave elastography for the diagnosis and follow-up of biliary atresia: A meta-analysis显示文摘BACKGROUND Timely differentiation of biliary atresia(BA)from other infantile cholestatic diseases can impact patient outcomes.Additionally,non-invasive staging of fibrosis after Kasai hepatoportoenterostomy has not been widely standardized.Shear wave elastography is an ultrasound modality that detects changes in tissue stiffness.The authors propose that the utility of elastography in BA can be elucidated through meta-analysis of existing studies.AIM To assess the utility of elastography in:(1)BA diagnosis,and(2)post-Kasai fibrosis surveillance.METHODS A literature search identified articles that evaluated elastography for BA diagnosis and for post-Kasai follow-up.Twenty studies met criteria for meta-analysis:Eleven for diagnosis and nine for follow-up post-Kasai.Estimated diagnostic odds ratio(DOR),sensitivity,and specificity of elastography were calculated through a random-effects model using Meta-DiSc software.RESULTS Mean liver stiffness in BA infants at diagnosis was significantly higher than in non-BA,with overall DOR 24.61,sensitivity 83%,and specificity 79%.Post-Kasai,mean liver stiffness was significantly higher in BA patients with varices than in patients without,with DOR 16.36,sensitivity 85%,and specificity 76%.Elastography differentiated stage F4 fibrosis from F0-F3 with DOR of 70.03,sensitivity 96%,and specificity 89%.Elastography also differentiated F3-F4 fibrosis from F0-F2 with DOR of 24.68,sensitivity 85%,and specificity 81%.CONCLUSION Elastography has potential as a non-invasive modality for BA diagnosis and surveillance post-Kasai.This paper’s limitations include inter-study method heterogeneity and small sample sizes.Future,standardized,multi-center studies are recommended. | Ellen S Wagner Hussien Ahmed H Abdelgawad Meghan Landry Belal Asfour Mark B Slidell Ruba Azzam | 2022 | World Journal of Gastroenterology2022，28，32： | 5 |
| 3 | 1423 Pancreaticoduodenectomies for Pancreatic Cancer: A Single-Institution Experience显示文摘 | Jordan M. Winter John L. Cameron Kurtis A. Campbell Meghan A. Arnold David C. Chang JoAnn Coleman Mary B. Hodgin Patricia K. Sauter Ralph H. Hruban Taylor S. Riall Richard D. Schulick Michael A. Choti Keith D. Lillemoe Charles J. Yeo | 2006 | Journal of Gastrointestinal Surgery2006，，9： | 5 |
| 4 | Systematic review of periprosthetic tibia fracture after total knee arthroplasties显示文摘AIM: To investigate the known incidences, treatment options, and related outcomes of periprosthetic tibia fractures after total knee arthroplasty(TKA).METHODS: A literature search was done to identify studies that fit the inclusion criteria. The database search yielded 185 results, which were further reduced by the exclusion criteria to 13 papers, totaling 157 patients that met these criteria. Incidence rates of the different types of periprosthetic tibia fractures were determined and their treatments were subsequently analyzed based on the fracture's subclass, with patient outcomes being overall favorable.RESULTS: Of the 144 documented patients, 54(37.5%) had a subclass C fracture, which are frequently seen in revision arthroplasties or when using cement intraoperatively. The fractures of subclasses A and B occur postoperatively. There were 90 subclass A and B fractures with incidences of 18.75% and 43.75% respectively. When broken down by type, 62(55.36%) were type 1, 24(21.4%) were type 2, 24(21.4%) were type 3, and 2(1.8%) were type 4. Furthermore, from the studies that included origin of injury, the types were further classified as having non-traumatic or traumatic origins. Type 1 had 78%(40/51) non-traumatic origin and 22%(11/51) traumatic origin. Fifteen fractures were type 2, but 5 were falls and 1 through a motor vehicle accident, giving a trauma causation of 40%(6/15). Of the 24 type 3 fractures, 12 were falls and 2 vehicular accidents, leading to a trauma causation of 58%(14/24).CONCLUSION: Type 1 fractures were the most common. Subclass A was treated with locking plates, B required a revision TKA, and C was treated intraoperatively or nonoperatively. | Nabil A Ebraheim Joseph R Ray Meghan E Wandtke Grant S Buchanan Chris G Sanford Jiayong LiuZ | 2015 | World Journal of Orthopedics2015，6，8： | 4 |
| 5 | A Dominant Allele of Arabidopsis Pectin-Binding Wall-Associated Kinase Induces a Stress Response Suppressed by MPK6 but Not MPK3 Mutations显示文摘植物房间墙由纤维素纤维,灵活果胶聚合物,和一连串的分类糖类和蛋白质的一个矩阵组成。Arabidopsis 的像受体的联系墙的 Kinases (WAK ) 在墙中绑果胶,并且在开发期间并且为对病原体的回答为房间扩大两个都是必要的并且伤害。Mitogen 激活蛋白质 Kinases (MPK ) 在优核质形成在房间表面受体和 transcriptional 和酶规定之间的一个主要发信号连接,并且 Arabidopsis MPK6 和 MPK3 确实在到应力和病原体的开发和反应有重要角色。WAK2 的主导的等位基因要求 kinase 活动并且激活包括增加的 ROS 累积和涉及病原体抵抗的众多的基因的起来规定的压力回答,伤害,并且房间墙生物的续生说。这主导的等位基因要求功能的果胶绑定和 kinase 领域,显示它从事表明小径的 WAK。主要血浆膜生产 ROS 酶建筑群的空异种, rbohd/f 不压制导致 WAK2cTAP 的显型。mpk6,然而并非 mpk3,空等位基因能压制这个主导的 WAK2 变化,因此区分的 MPK3 和 MPK6 的效果,其活动以前被认为冗余。基因表示的果胶激活被消除在一 wak2 空,但是由导致的 WAK 主导的等位基因的 tempered 被提高基础压力相关的抄本层次。结果建议细胞墙的变化能在细胞的回答和帮助在导致一个大变化解释病原体和伤害的罐头怎么在生长上有一般效果的机制。 | Bruce D. Kohorn Susan L. Kohorn Tanya Todorova Gillian Baptiste Kevin Stansky Meghan McCullough | 2012 | Molecular Plant2012，5，4： | 4 |
| 6 | Highly Fluorescent Dye-Doped Silica Nanoparticles Increase Flow Cytometry Sensitivity for Cancer Cell Monitoring显示文摘Early and accurate diagnosis and treatment of cancer depend on rapid,sensitive,and selective detection of tumor cells.Current diagnosis of cancers,especially leukemia,relies on histology and fl ow cytometry using single dye-labeled antibodies.However,this combination may not lead to high signal output,which can hinder detection,especially when the probes have relatively weak affi nities or when the receptor is expressed in a low concentration on the target cell surface.To solve these problems,we have developed a novel method for sensitive and rapid detection of cancer cells using dye-doped silica nanoparticles(NPs)which increases detection sensitivity in fl ow cytometry analyses between 10-and 100-fold compared to standard methods.Our NPs are~60 nm in size and can encapsulate thousands of individual dye molecules within their matrix.We have extensively investigated surface modifi cation strategies in order to make the NPs suitable for selective detection of cancer cells using fl ow cytometry.The NPs are functionalized with polyethylene glycol(PEG)to prevent nonspecifi c interactions and with neutravidin to allow universal binding with biotinylated molecules.By virtue of their reliable and selective detection of target cancer cells,these NPs have demonstrated their promising usefulness in conventional fl ow cytometry.Moreover,they have shown low background signal,high signal enhancement,and effi cient functionalization,either with antibody-or aptamer-targeting moieties. | M.-Carmen Estévez Meghan B.OʼDonoghue Xiaolan Chen Weihong Tan | 2009 | Nano Research2009，2，6： | 3 |
| 7 | The amazing potential of fungi:50 ways we can exploit fungi industrially显示文摘Fungi are an understudied,biotechnologically valuable group of organisms.Due to the immense range of habitats that fungi inhabit,and the consequent need to compete against a diverse array of other fungi,bacteria,and animals,fungi have developed numerous survival mechanisms.The unique attributes of fungi thus herald great promise for their application in biotechnology and industry.Moreover,fungi can be grown with relative ease,making production at scale viable.The search for fungal biodiversity,and the construction of a living fungi collection,both have incredible economic potential in locating organisms with novel industrial uses that will lead to novel products.This manuscript reviews fifty ways in which fungi can potentially be utilized as biotechnology.We provide notes and examples for each potential exploitation and give examples from our own work and the work of other notable researchers.We also provide a flow chart that can be used to convince funding bodies of the importance of fungi for biotechnological research and as potential products.Fungi have provided the world with penicillin,lovastatin,and other globally significant medicines,and they remain an untapped resource with enormous industrial potential. | Kevin D.Hyde Jianchu Xu Sylvie Rapior Rajesh Jeewon Saisamorn Lumyong Allen Grace T.Niego Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahamanage Siraprapa Brooks Amornrat Chaiyasen K.W.Thilini Chethana Putarak Chomnunti Clara Chepkirui Boontiya Chuankid Nimali I.de Silva Mingkwan Doilom Craig Faulds Eleni Gentekaki Venkat Gopalan Pattana Kakumyan Dulanjalee Harishchandra Hridya Hemachandran Sinang Hongsanan Anuruddha Karunarathna Samantha C.Karunarathna Sehroon Khan Jaturong Kumla Ruvishika S.Jayawardena Jian-Kui Liu Ningguo Liu Thatsanee Luangharn Allan Patrick G.Macabeo Diana S.Marasinghe Dan Meeks Peter E.Mortimer Peter Mueller Sadia Nadir Karaba N.Nataraja Sureeporn Nontachaiyapoom Meghan O’Brien Watsana Penkhrue Chayanard Phukhamsakda Uma Shaanker Ramanan Achala R.Rathnayaka Resurreccion B.Sadaba Birthe Sandargo Binu C.Samarakoon Danushka S.Tennakoon Ramamoorthy Siva Wasan Sriprom T.S.Suryanarayanan Kanaporn Sujarit Nakarin Suwannarach Thitipone Suwunwong Benjarong Thongbai Naritsada Thongklang Deping Wei S.Nuwanthika Wijesinghe Jake Winiski Jiye Yan Erandi Yasanthika Marc Stadler | 2019 | Fungal Diversity2019，，4： | 3 |
| 8 | High school sports programs differentially impact participation by sex显示文摘背景:研究表明,参加体育活动可降低儿童和青少年肥胖的风险。学校是促进儿童和青少年参加体育活动的理想环境,但目前尚不清楚体育活动的'获得'和'选择'如何影响学生的参与度,也不清楚学校体育课的特点对学生参与体育的影响是否存在性别差异。本研究旨在评价高中体育运动项目的特点,并确定这些体育课程对男女生参与运动队的影响程度。方法:用电话采访的方式纵向调查了1,244名新罕布什尔州和佛蒙特州的学生。学生自述他们小学至高中阶段参与运动队的情况。通过调查高中职员了解体育机会。在本研究中,'体育机会'是指每100名学生所对应的学校提供的体育项目种类《选择)和学校提供的体育种类中不限制参加人数的体育项目的比例(获得)。结果:约70%的儿童参加了至少一个体育运动队,男生为73%,女生为66%。研究发现在性别和两个体育机会变量之间存在显著交互影响。控制小学生参与体育活动和其他协变量后,发现如果学校不限制最受欢迎的体育项目的参与人数,男生会参加更多的体育运动队(RR=1.12,p<0.01)。相反,如果学校提供广泛的体育项目,女生会参加更多的体育运动队(RR=1 47,p<0.001)。结论:前人研究表明,参加体育活动能带来许多健康效益。对公共卫生工作包括预防肥胖而言,学校体育课可能是一个重要而有效但未被充分利用的对象。要使青少年参加更多的体育活动,就应综合考虑学校体育项目的获得和选择。学校可运用不同策略,促使男生和女生更多地参加体育活动。 | Keith M. Drake Meghan R. Longacre Todd MacKenzie Linda J. Titus Michael L. Beach Andrew G. Rundle Madeline A. Dalton | 2015 | Journal of Sport and Health Science2015，4，3： | 3 |
| 9 | Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease显示文摘 | Acloque Hervé Adams Meghan S Fishwick Katherine Bronner-Fraser Marianne Nieto M Angela | 2009 | Journal of Clinical Investigation2009，，6： | 2 |
| 10 | 1423 pancreaticoduodenectomies for pancreatic cancer: A single-institution experience显示文摘 | Jordan M. Winter M.D. John L. Cameron M.D. Kurtis A. Campbell M.D. Meghan A. Arnold M.D. David C. Chang Ph.D. M.B.A. M.P.H. JoAnn Coleman C.R.N.P. Mary B. Hodgin C.M.S.R.N. Patricia K. Sauter C.R.N.P. Ralph H. Hruban M.D. Taylor S. Riall M.D. Richard D. | 2006 | Journal of Gastrointestinal Surgery2006，，9： | 2 |
| 11 | Computational Modeling of Pancreatic Cancer Reveals Kinetics of Metastasis Suggesting Optimum Treatment Strategies显示文摘 | Hiroshi Haeno Mithat Gonen Meghan B. Davis Joseph M. Herman Christine A. Iacobuzio-Donahue Franziska Michor | 2012 | Cell2012，，1： | 2 |
| 12 | Bone marrow stromal cells as replacement cells for Parkinson’s disease: generation of an anatomical but not functional neuronal phenotype显示文摘 | Meghan G. Thomas Leah Stone Lauren Evill Syerna Ong Mel Ziman Livia Hool | 2011 | Translational Research2011，，2： | 2 |
| 13 | Home Tonometry for Management of Pediatric Glaucoma显示文摘 | Meghan S. Flemmons Ya-Chuan Hsiao Jacqueline Dzau Sanjay Asrani Sarah Jones Sharon F. Freedman | 2011 | American Journal of Ophthalmology2011，，3： | 2 |
| 14 | Efficacy of Entecavir With or Without Tenofovir Disoproxil Fumarate for Nucleos(t)ide-Na?ve Patients With Chronic Hepatitis B显示文摘 | Anna S. Lok Huy Trinh Giampiero Carosi Ulus S. Akarca Adrian Gadano Fran?ois Habersetzer William Sievert David Wong Meghan Lovegren David Cohen Cyril Llamoso | 2012 | Gastroenterology2012，，3： | 2 |
| 15 | Humanized mice are susceptible to Salmonella typhi infection显示文摘Salmonella enterica serovar Typhi is a pathogen that only infects humans.Currently,there is no animal model for studying this pathogen.Recently,alymphoid RAG2^(-/-)/γc^(-/-) mice engrafted with human leukocytes,known as humanized mice,have been successfully utilized to develop experimental models for several human-specific viral infections,including HIV,human-like dengue fever and hepatitis C virus.Little is known about the usefulness and feasibility of the humanized mouse model for the study of human-specific bacterial pathogens,such as S.typhi.The aim of this study was to determine if Salmonella enterica serovar Typhi could establish productive infection in humanized mice.Here we report that intravenous inoculation of S.typhi into humanized mice,but not controls,established S.typhi infections.High bacterial loads were found in the liver,spleen,blood and bone marrow of mice reconstituted with human leukocytes,but not in the unreconstituted control mice.Importantly,S.typhi-infected humanized mice lost significant body weight,and some of the infected mice displayed neurological symptoms.Our data suggest,for the first time,that humanized mice are susceptible to S.typhi challenge and that this model can be utilized to study the pathogenesis of S.typhito develop novel therapeutic strategies. | M Firoz Mian Elisabeth A Pek Meghan J Chenoweth Ali A Ashkar | 2011 | Cellular & Molecular Immunology2011，8，1： | 2 |
| 16 | Geodynamics of oceanic plateau and plume head accretion and their role in Phanerozoic orogenic systems of China显示文摘We present three 3D numerical models of deep subduction where buoyant material from an oceanic plateau and a plume interact with the overriding plate to assess the influence on subduction dynamics,trench geometry,and mechanisms for plateau accretion and continental growth.Transient instabilities of the convergent margin are produced,resulting in:contorted trench geometry;trench migration parallel with the plate margin;folding of the subducting slab and orocline development at the convergent margin;and transfer of the plateau to the overriding plate.The presence of plume material beneath the oceanic plateau causes flat subduction above the plume,resulting in a 'bowed' shaped subducting slab.In plateau-only models,plateau accretion at the edge of the overriding plate results in trench migration around the edge of the plateau before subduction is re-established directly behind the trailing edge of the plateau.The plateau shortens and some plateau material subducts.The presence of buoyant plume material beneath the oceanic plateau has a profound influence on the behaviour of the convergent margin.In the plateau + plume model,plateau accretion causes rapid trench advance.Plate convergence is accommodated by shearing at the base of the plateau and shortening in the overriding plate.The trench migrates around the edge of the plateau and subduction is re-established well behind the trailing edge of the plateau,effectively embedding the plateau into the overriding plate.A slab window forms beneath the accreted plateau and plume material is transferred from the subducting plate to the overriding plate through the window.In all of the models,the subduction zone maintains a relatively stable configuration away from the buoyancy anomalies within the downgoing plate.The models provide a dynamic context for plateau and plume accretion in Phanerozoic accretionary orogenic systems such as the East China Orogen and the Central Asian Orogen(Altiads),which are characterised by accreted ophiolite complexes with diverse geochemical affinities,and a protracted evolution of accretion of exotic terranes including oceanic plateau and terranes with plume origins. | Peter G.Betts Louis Moresi Meghan S.Miller David Willis | 2015 | Geoscience Frontiers2015，6，1： | 2 |
| 17 | An assessment of interspecific competition between two introduced parasitoids of Diaphorina citri (Hemiptera: Liviidae)on caged citrus plants显示文摘Two parasitoids attacking nymphs of Asian citrus psyllid,Diaphorina citri Kuwayama (Hemiptera:Liviidae),Tamarixia radiata (Waterston)(Hymenoptera:Eulophi- dae)and Diaphoreneyrtus aligarhensis (Shafee,Alam &Agarwal)(Hymenoptera:Encyrtidae)are being released in California,USA in a classical biological control program. To evaluate the effect of multiple parasitoid species on D.citri mortality,we conducted mesocosm experiments under controlled conditions using a complete block design with 6 treatments (D.cirri nymphs exposed to:no parasitoids;D.aligarhensis or T.radiata alone;D.aligarhensis or T.radiata released first (by 48 h);and both species released simultaneously).Parasitism of D.citri nymphs by T.radiata exceeded 60%and was unchanged when D.aligarhensis were present.Parasitism by D.aligarhensis was greatest when T. radiata was absent (-28%)and was reduced in all treatments with T.radiata present (<3%).D.cirri mortality and parasitoid-related mortality olD.citri was consistent across parasitoid treatments.Laboratory results suggest that competition between D.aligarhensis and T.radiata is asymmetric and favors T.radiata.It may be difficult for D.aligarhensis to contribute significantly to D.cirri biological control where T.radiata is present.However, results reported here suggest that competition between T.radiata and D.aligarhensis is not likely to reduce parasitism by T.radiata or reduce parasitoid-induced mortality of D.citri. | Meghan A.Vankosky Mark S.Hoddle | 2019 | Insect Science2019，26，1： | 2 |
| 18 | Inhibition of the Hedgehog Pathway Targets the Tumor-Associated Stroma in Pancreatic Cancer显示文摘 | Rosa F. Hwang Todd T. Moore Maureen Mertens Hattersley Meghan Scarpitti Bin Yang Erik Devereaux Vijaya Ramachandran Thiruvengadam Arumugam Baoan Ji Craig D. Logsdon Jeffrey L. Brown Robert Godin | 2012 | Molecular Cancer Research2012，，9： | 2 |
| 19 | Laser treatment of pediatric vascular lesions: Port wine stains and hemangiomas显示文摘 | Meghan F. Stier Sharon A. Glick Ranella J. Hirsch | 2008 | Journal of the American Academy of Dermatology2008，，2： | 1 |
| 20 | Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids显示文摘 | Meghan Cundall Yongchang Sun Christina Miranda John B. Trudeau Stephen Barnes Sally E. Wenzel | 2003 | The Journal of Allergy and Clinical Immunology2003，，6： | 1 |
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