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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Access block: it's all about available beds 显示文摘 | Fatovich DM Hughes G Mccarthy SM | 2009 | Med J Aust2009，190，7： | 1 |
| 3 | Osteoponfin regulates multiple functions contributing to human colon cancer development and progression 显示文摘 | Irby RB McCarthy SM Yeatman TJ | 2004 | Clin Exp Metastasis2004，21，6： | 1 |
| 4 | Central overweight and obesity in British youth aged 11-16 years:cross sectional surveys of waist circumference显示文摘 | Mccarthy HD Ellis SM Cole TJ | | 0，，7390： | 1 |
| 5 | Detection of renal masses: sensitivities and specificities of excretory urography/linear tomography, US and CT 显示文摘 | WARSHAUER DM MCCARTHY SM STREET L | 1988 | Radiology1988，169，2： | 1 |
| 6 | Obstetrical Magnetic Resonance Imaging:Fetal Anatomy显示文摘 | McCarthy SM Filly RA Stark DD | 1985 | Radiology1985，154，2： | 1 |
| 7 | Osteopontin regulates multiple functions contributing to human colon cancer development and progression显示文摘 | Irby RB Mccarthy SM Yeatman TJ | 2004 | Clin Exp Metastasis2004，21，6： | 1 |
| 8 | Case 77:aggressive angiomyxoma显示文摘 | Stewart ST McCarthy SM | 2004 | Radiology2004，233，3： | 1 |
| 9 | Mullerian duct anomalies: imaging and clinical issues显示文摘 | Troiano RN McCarthy SM | 2004 | Radiology2004，233，： | 1 |
| 10 | Development of a High-speed NMR Technique for Sensing Maturity of Avocados显示文摘 | Chen P McCarthy MJ Kim SM | 1996 | Transactions of the American Society of Agricultural Engineers1996，39，6： | 1 |
| 11 | Diagnosis of uterine anomalies:relative accuracy of MR imaging,endovaginal sonography,and hysterosalpingography显示文摘 | Pellerito JS McCarthy SM Doyle MB | 1992 | Radiology1992，183，3： | 1 |
| 12 | Fruit Internal Quality Evaluation Using Online Nuclear Magnetic Resonance Sensors显示文摘 | Kim SM Chen P McCarthy MJ | 1999 | Journal of Agricultural Engineering Research1999，74，： | 1 |
| 13 | Mtillerian duct anomalies: imaging and clinical issues 显示文摘 | Troiano RN McCarthy SM | 2004 | Radiology2004，233，1： | 1 |
| 14 | Obstetrical magnetic resonance imaging:fetal anatomy显示文摘 | McCarthy SM Filly RA Stark DD | 1985 | Radiology1985，89，1： | 1 |
| 15 | Detection of recurrent rectosigmoid carcinoma:prospective evaluation of CT and clinical factors显示文摘 | McCarthy SM Baynes D Deveney K | 1985 | AJR1985，144，： | 1 |
| 16 | Osteopontin regulates multiple functions contributing to human colon cancer development and progression显示文摘 | Irby RB McCarthy SM Yeatman TJ | 2004 | Clin Exp Metastasis2004，21，6： | 1 |
| 17 | Prediction of peptides observable by mass spectrometry applied at the experimental set level显示文摘 | Sanders WS Bridges SM McCarthy FM | | 0，，： | 1 |
| 18 | Osteopontin regulates multiple functions contributing to human colon cancer devel - opment and progression 显示文摘 | Irby RB McCarthy SM Yeat man TJ | 2004 | Clin Exp Metastasis2004，21，6： | 1 |
| 19 | A prospective ran domized study of the copper 7, Multiload Cu 250 and copper 220C IUDS in Singapore 显示文摘 | McCarthy TG Lirn LS Karim SM | 1986 | Singapore Med J1986，27，3： | 1 |
| 20 | A double blind, randomised placebo controlled trial of topical 2% viscous lidocaine in improving oral intake in children with painful infectious mouth conditions 显示文摘 | Hopper SM Babl FE McCarthy M | 2011 | BMC Pediatr2011，11，： | 1 |
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