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| 1 | PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast,and prostate cancer显示文摘 | Li J Yen C Liaw D Podsypanina K Bose S Wang S I Puc J Miliaresis C Rodgers L McCombie R | 1997 | Science1997，275，： | 1 |
| 2 | PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer 显示文摘 | Li J Yen C Liaw D Podsypanina K Bose S Wang SI Puc J Miliaresis C Rodgers L McCombie R Bigner SH Giovanella BC Ittmann l Tycko B Hibshoosh H Wigler MH Parsons R | 1997 | Science1997，275，： | 1 |
| 3 | A new method for the deoxygenation of secondary alcohols显示文摘 | Barton D H R McCombie S W | | 0，，16： | 1 |
| 4 | Utility of the photo- plethysmogram in circulatory monitoring 显示文摘 | Reisner A Shaltis PA McCombie D | 2008 | Anesthesiology2008，108，5： | 1 |
| 5 | Utility of the photopl- ethysmogram in circulatory monitoring显示文摘 | Reisner A Shaltis PA McCombie D | 2008 | Anesthesiology2008，108，5： | 1 |
| 6 | Spatial and spectral correlations in M-ALDI mass spectrometry images by clustering and multivariate analysis显示文摘 | McCombie G Staab D Stoeckli M | 2005 | Anal Chem2005，77，19： | 1 |
| 7 | Expressed sequence tag analysis in Cycas, the most primitive living seed plant显示文摘 | Brenner E D Stevenson D W McCombie R W Katari M S Rudd S A Mayer K F Palenchar P M Runko S J Twigg R W Dai G W Martienssen R A Benfey P N Coruzzi G M | 2003 | Genome Biology2003，4，： | 1 |
| 8 | A New Method for the Deoxygenation of Secondary Alcohols 显示文摘 | BARTON D H R MCCOMBIE S W | 1975 | Journal of the Chemical Society Perkin Transactions 11975，，16： | 1 |
| 9 | Multilocus sequence typing of historical Burkholderia pseudomallei isolates collected in southeast Asia from 1964 to 1967 provides insight into the epidemiology of melioidosis显示文摘 | McCombie R L Finkelstein R A Woods D E | 2006 | Journal of Clinical Microbiology2006，44，8： | 1 |
| 10 | Complementary DNA sequencing: expressed sequence tags and human genome project显示文摘 | ADAMS M D KELLEY J M GOCAYNE J D DUBNICK M POLYMEROPOULOS M H XIAO H MERRIL C R WU A OLDE B MORENO R F KERLAVAGE A R MCCOMBIE W R VENTER ] C | 1991 | Science1991，252，5013： | 1 |
| 11 | Toluene degradation by Pseudomonas putida : genetic organization of the ted operon 显示文摘 | Zylstza G J McCombie W R Gibson D T et cd | 1988 | Applied and Environmental Microbiology1988，54，6： | 1 |
| 12 | PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer 显示文摘 | Li J Yen C Liaw D Podsypanina K Bose S Wang SI Puc J Miliaresis C Rodgers L McCombie R Bigner SH Giovanella BC Ittmann M Tycko B Hibshoosh H Wigler MH Parsons R | 1997 | Science1997，275，5308： | 1 |
| 13 | Tumour evolution inferred by single-cell sequencing显示文摘 | Navin N Kendall J Troge J Andrews P Rodgers L McIndoo J Cook K Stepansky A Levy D Esposito D Muthuswamy L Krasnitz A McCombie WR Hicks J Wigler M | | 0，，7341： | 1 |
| 14 | The tomato genome sequence provides insights into fleshy fruit evolution 显示文摘 | Sato S Tabata S Hirakawa H Asamizu E Shlrasawa K Isobe S Kaneko T Nakamura Y Shibata D Aoki K Egholm M Knight J Bogden R Li C Shuang Y Xu X Pan S Cheng S Liu X Ren Y Wang J Albiero A Dal Pero F Todesco S Van Eck J Buels R M Bombarely A Gosselin J R Huang M Leto J A Menda N Strickler S Mao L Gao S Tecle I Y York T Zheng Y Vrebalov JT Lee J Zhong S Mueller L A Stiekema W J Ribeca P Alioto T Yang W Huang S Du Y Zhang Z Gao J Guo Y Wang X Li Y He J Li C Cheng Z Zuo J Ren J Zhao J Yan L Jiang H Wang B Li H Li Z Fu F Chen B Feng Q Fan D Wang Y Ling H Xue Y Ware D McCombie W R Lippman Z B Chia J M Jiang K Pasternak S Gelley L Kramer M Anderson L K Chang S B Royer S M Shearer L A Stack S M Rose J K Xu Y Eannetta N Matas A J McQuinn R Tanksley S D Camara F Guiga R Rombauts S Fawcett J Van de Peer Y Zamir D Liang C Spannagl M Gundlach H Bruggmann R Mayer K Jia Z Zhang J Ye Z Bishop G J Butcher S Lopez-Cobollo R Buchan D Filippis I Abbott J Dixit R Singh M Singh A Pal J K Pandit A Singh P K Mahato A K Gaikwad V D Sharma R R Mohapatra T Singh N K Causse M Rothan C Schiex T Noirot C Bellec A Klopp C Delalande C Berges H Mariette J Frasse P Vautrin S Zouine M Latch6 A Rousseau C Regad F Pech J C Philippot M Bouzayen M Pericard P Osorio S Fernandez del Carmen A Monforte A Granell A Fernandez-Mufioz R Conte M Lichtenstein G Carrari F De Bellis G Fuligni F Peano C Grandillo S Termolino P Pietrella M Fantini E Falcone G Fiore A Giuliano G Lopez L Facella P Perotta G Daddiego L Bryan G Orozco M Pastor X Torrents D van Schriek M G Feron R M van Oeveren J de Heer P daPonte L Jacobs-Oomen S Cariaso M Prins M van Eijk M J Janssen A van Haaren M J Jungeun Kim S H Kwon S Y Kim S Koo D H Lee S Hur C G Clouser C Rico A Hallab A Gebhardt C Klee K Jocker A Warfsmann J Gobel U Kawamura S Yano K Sherman J D Fukuoka H Negoro S Bhutty S Chowdhury P Chattopadhyay D Datema E Smit S Schijlen E G van de Belt J van Haarst J C Peters S A van Staveren M A Henkens M H Mooyman P J Hesselink T van Ham R C Jiang G Droege M Choi D Kang B C Kim B D Park M Kim S Yeom SI Lee YH Choi Y D Li G Gao J Liu Y Huang S Fernandez-Pedrosa V Collado C Zufiiga S Wang G Cade R Dietrich R A Rogers J Knapp S Fei Z White R A Thannhauser T W Giovannoni J J Botella M A Gilbert L Gonzalez R Goieoechea J L Yu Y Kudrna D Collura K Wissotski M Wing R Meyers BC Gurazada AB Green P J Vyas S M Solanke A U Kumar R Gupta V Sharma A K Khurana P Khurana J P Tyagi A K Dalmay T Mohorianu 1 Waits B Chamala S Barbazuk W B Li J Guo H Lee T H Wang Y Zhang D Paterson A H Wang X Tang H Barone A Chiusano M L Ereolano M R D' Agostino N Di Filippo M Traini A Sanseverino W Frusciante L Seymour G B Elharam M Fu Y Hua A Kenton S Lewis J Lin S Najar F Lai H Qin B Qu C Shi R White D White J Xing Y Yang K Yi J Yao Z Zhou L Roe B A Vezzi A D' Angelo M Zimbello R Sehiavon R Caniato E Rigobello C Campagna D Vitulo N Valle G Nelson D R De Paoli E Szinay D de Jong H H Bai Y Visser R G Klein R Beasley H McLaren K Nicholson C Riddle C Gianese G | 2012 | Nature2012，485，7400： | 1 |
| 15 | Utility of the photoplet- hysmogram in circulatory monitoring显示文摘 | Reisner A Shahis P McCombie D | 2008 | Anesthesiology2008，108，5： | 1 |
| 16 | Utility ofthe photoplethysmogram in circulatory monitoring 显示文摘 | Reisner A Shaltis PA McCombie D | 2008 | Anesthesiology2008，108，5： | 1 |
| 17 | A matter off at: An introduction to lipidomic profiling methods (Review)显示文摘 | Roberts L D McCombie G Titman C M | 2008 | J Chromatogr B Analyt Technol Biomed Life Sci2008，871，2： | 1 |
| 18 | Impact of preoperative antibiotics and other variables on integrated microbiome-host transcriptomic data generated from colorectal cancer resections显示文摘BACKGROUND Integrative multi-omic approaches have been increasingly applied to discovery and functional studies of complex human diseases.Short-term preoperative antibiotics have been adopted to reduce site infections in colorectal cancer(CRC)resections.We hypothesize that the antibiotics will impact analysis of multi-omic datasets generated from resection samples to investigate biological CRC risk factors.AIM To assess the impact of preoperative antibiotics and other variables on integrated microbiome and human transcriptomic data generated from archived CRC resection samples.METHODS Genomic DNA(gDNA)and RNA were extracted from prospectively collected 51 pairs of frozen sporadic CRC tumor and adjacent non-tumor mucosal samples from 50 CRC patients archived at a single medical center from 2010-2020.The 16S rRNA gene sequencing(V3V4 region,paired end,300 bp)and confirmatory quantitative polymerase chain reaction(qPCR)assays were conducted on gDNA.RNA sequencing(IPE,125 bp)was performed on parallel tumor and non-tumor RNA samples with RNA Integrity Numbers scores≥6.RESULTS PERMANOVA detected significant effects of tumor vs nontumor histology(P=0.002)and antibiotics(P=0.001)on microbialβ-diversity,but CRC tumor location(left vs right),diabetes mellitus vs not diabetic and Black/African Ancestry(AA)vs not Black/AA,did not reach significance.Linear mixed models detected significant tumor vs nontumor histology*antibiotics interaction terms for 14 genus level taxa.QPCR confirmed increased Fusobacterium abundance in tumor vs nontumor groups,and detected significantly reduced bacterial load in the(+)antibiotics group.Principal coordinate analysis of the transcriptomic data showed a clear separation between tumor and nontumor samples.Differentially expressed genes obtained from separate analyses of tumor and nontumor samples,are presented for the antibiotics,CRC location,diabetes and Black/AA race groups.CONCLUSION Recent adoption of additional preoperative antibiotics as standard of care,has a measurable impact on-omics analysis of resected specimens.This study still confirmed increased Fusobacterium nucleatum in tumor. | Sarah A Malik Chencan Zhu Jinyu Li Joseph F LaComb Paula I Denoya Igor Kravets Joshua D Miller Jie Yang Melissa Kramer W Richard McCombie Charles E Robertson Daniel N Frank Ellen Li | 2021 | World Journal of Gastroenterology2021，27，14： | 0 |
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