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| 1 | 铽(Ⅲ)与人血清脱铁转铁蛋白结合的荧光光谱研究显示文摘在pH7.40.1mol/LHepes及室温条件下,使用荧光光谱进行了Tb3+对人血清脱铁转铁蛋白的滴定.结果表明Tb3+与人血清脱铁转铁蛋白结合后,其549nm处的荧光强度增强约105倍.在549nm处Tb3+-脱铁转铁蛋白络合物的摩尔荧光强度是(9.65±0.05)×104mol-1L,Tb3+可占据脱铁转铁蛋白的两个金属离子结合部位,优先占据脱铁转铁蛋白的C端结合部位,条件平衡常数是lgKC=9.96±0.20,lgKN=6.37±0.16.Tb3+与R3+E(RE=Nd、Sm。 | 杨斌盛 HARR.,WR | 1999 | 中国生物化学与分子生物学报1999，15，3： | 10 |
| 2 | 外科手术核对清单可全球范围内降低手术并发症发生率和手术死亡率(续前)显示文摘背景外科手术已经成为全球卫生保健构成整体所必需的一部分,估计每年实施的手术有2亿3千4百万次之多,手术并发症常见,并常常是可以预防的。我们设想,通过实施一份19项外科手术安全核对清单,以改善手术团队交流和治疗一致性,将会降低手术并发症发生率和手术死亡率。方法于2007年10月至2008年9月间,从8座城市(加拿大的多伦多、印度的新德里、约旦的安曼、新西兰的奥克兰、菲律宾的马尼拉、坦桑尼亚的伊法卡拉、英国的伦敦、华盛顿州的西雅图市)各选取1所医院共计8所医院参加世界卫生组织的'安全手术拯救生命项目',前瞻性地在临床治疗过程中和治疗结束时收集资料,共有3733例年龄16岁或16岁以上的进行非心脏手术的患者入选,随后在引入'外科手术安全核对清单'后收集了连续入选的3955名患者,主要终点事件为手术后30d内的并发症(包括死亡)发生率。结果在引入核对清单前死亡率为1.5%,手术并发症发生率为11.0%,而引入后死亡率和手术并发症发生率分别下降到0.8%(P=0.003)和7.0%(P<0.001)。结论实施外科手术核对清单可以降低不同医院16岁及16岁以上非心脏手术患者的死亡率和并发症发生率。结果在基线资料收集阶段我们入选了3733名患者,实施核对清单后入选3955名患者。表4罗列了这些患者的情况和医院分布,这两个阶段的患者情况没有明显差别。 | Haynes AB Weiser TG Berry WR 丁一妹 孙永华 高建川 | 2009 | 中华损伤与修复杂志(电子版)2009，4，3： | 9 |
| 3 | 用于透皮给药系统的渗透促进剂显示文摘理论上应用于透皮给药系统中的药物应具备以下物理化学特点:1.分子量<400Da;2.每日剂量<20mg;3.低熔点;4.低极性。然而,实际上约90%以上的药物不具备这些特性,因而处方中需加入一定量的促进剂,才能制成理想的透皮给药系统。促进剂分类凡能帮助药物穿过角质层和表皮扩散的物质即为透皮促进剂及吸收促进剂,总称促进剂。其促进药物经皮吸收的程度主要取决于药物本身的物理化学性质和分子性质。大多数药物的透皮吸收为被动扩散过程,其扩散行为符合Fick’s第一扩散定律。 | Pfister WR 章丽华 | 1991 | 国外医药(合成药.生化药.制剂分册)1991，12，3： | 7 |
| 4 | 老年心脏肿瘤临床病理学研究显示文摘目的:研究老年心脏肿瘤的病理形态及其临床意义。方法:对32例老年心脏肿瘤(29例心粘液瘤)进行临床分析和光镜、电镜观察。结果:心脏粘液瘤是老年人最主要的原发心脏肿瘤(占90%以上),多见于女性(87.5%)的左心房(86.6%);老年心脏肿瘤常伴随高血压和冠心病;超声心动图有诊断价值;栓塞是老年心脏粘液瘤的主要伴发症和死因,与其松脆的海棉状组织结构有关。 | Ande.,WR 张鹏飞 | 1998 | 福建医药杂志1998，20，5： | 6 |
| 5 | 非房室和房室模型分析在临床药动学的比较显示文摘为纠正对非房室药动学范围和能力的不适当评价,综述了非房室药动学的理论,提供方法和实例。比较了两种方法的优缺点,并表达了作者对各法最适作用和优点的意见。 | Gillespie WR 汤仲明 | 1992 | 国外医学(药学分册)1992，19，1： | 4 |
| 6 | Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery. | Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen | 2008 | World Journal of Gastroenterology2008，14，45： | 4 |
| 7 | Coeliac disease in Dutch patients with Hashimoto’s thyroiditis and vice versa显示文摘AIM: To define the association between Hashimoto’s thyroiditis and coeliac disease in Dutch patients. METHODS: A total of 104 consecutive patients with Hashimoto’s thyroiditis underwent coeliac serological tests (antigliadins, transglutaminase and endomysium antibodies) and HLA-DQ typing. Small intestinal biopsy was performed when any of coeliac serological tests was positive. On the other hand, 184 patients with coeliac disease were subjected to thyroid biochemical (thyroid stimulating hormone and free thyroxine) and thyroid serological tests (thyroglobulin and thyroid peroxidase antibodies). RESULTS: Of 104 patients with Hashimoto’s thyroiditis, sixteen (15%) were positive for coeliac serology and five patients with documented villous atrophy were diagnosed with coeliac disease (4.8%; 95% CI 0.7-8.9). HLA-DQ2 (and/or -DQ8) was present in all the five and 53 patients with Hashimoto’s thyroiditis (50%; 95% CI 43-62). Of 184 patients with coeliac disease, 39 (21%) were positive for thyroid serology. Based on thyroid biochemistry, the 39 patients were subclassified into euthyroidism in ten (5%; 95% CI 2-9), subclinicalhypothyroidism in seven (3.8%; 95% CI 1.8-7.6), and overt hypothyroidism (Hashimoto’s thyroiditis) in 22 (12%; 95% CI 8-16). Moreover, four patients with coeliac disease had Graves’ disease (2%; 95% CI 0.8-5) and one patient had post-partum thyroiditis. CONCLUSION: The data from a Dutch population confirm the association between Hashimoto’s thyroiditis and coeliac disease. Screening patients with Hashimoto’s thyroiditis for coeliac disease and vice versa is recom- mended. | Muhammed Hadithi Hans de Boer Jos WR Meijer Frans Willekens Jo A Kerckhaert Roel Heijmans Amado Salvador Pea Coen DA Stehouwer Chris JJ Mulder | 2007 | World Journal of Gastroenterology2007，13，11： | 4 |
| 8 | 大量输血的并发症及输血反应显示文摘围手术期输血问题是极端复杂的问题。对于应何时输血的新观点是针对病毒传播及输血的免疫效应两方面而产生的。为保护患者免于不必要输血的危险,应考虑患者的整体情况连同外科手术方式以及进一步失血可能性的大小,以便有助于指导决定若要输,输什么血液制品。过去那种“血细胞比容低于30%就应该输血”的所谓格言现已不再被人接受了。特别重要的问题是需要大量输血(估计为患者血容量的1.5倍以上)的病人,输入如此大量的血可以预计有一系列围手术期的凝血障碍、代谢性和免疫方面的并发症。 | Marco AP Furman WR 陈鲳 | 1993 | 国外医学(输血及血液学分册)1993，16，5： | 3 |
| 9 | Tumor angiogenesis and metastasis correlation in invasive breast carcinoma显示文摘 | Weidner N Semphe JP Welch WR | | 0，，： | 3 |
| 10 | Immunological aspects of liver cell transplantation显示文摘Within the field of regenerative medicine, the liver is of major interest for adoption of regenerative strategies due to its well-known and unique regenerative capacity. Whereas therapeutic strategies such as liver resection and orthotopic liver transplantation(OLT) can be considered standards of care for the treatment of a variety of liver diseases, the concept of liver cell transplantation(LCTx) still awaits clinical breakthrough. Success of LCTx is hampered by insufficient engraftment/long-term acceptance of cellular allografts mainly due to rejection of transplanted cells. This is in contrast to the results achieved for OLT where longterm graft survival is observed on a regular basis and, hence, the liver has been deemed an immuneprivileged organ. Immune responses induced by isolated hepatocytes apparently differ considerably from those observed following transplantation of solid organs and, thus, LCTx requires refined immunological strategies to improve its clinical outcome. In addition, clinical usage of LCTx but also related basic research efforts are hindered by the limited availability of high quality liver cells, strongly emphasizing the need for alternative cell sources. This review focuses on the various immunological aspects of LCTx summarizing data available not only for hepatocyte transplantation but also for transplantation of non-parenchymal liver cells and liver stem cells. | Felix Oldhafer Michael Bock Christine S Falk Florian WR Vondran | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 11 | Posterior capsule opacification in pseudophakic eyes显示文摘 | Mcdonnell PJ Iarbin MA Green WR | 1983 | Ophthalmology1983，90，： | 2 |
| 12 | Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma显示文摘 | Weidner N Semple JP Welch WR | 1991 | N Engl J Med1991，324，1： | 2 |
| 13 | Coronary endothelial function in hyperhomocysteinemia: Improvement after treatment with folic acid and cobalamin in patients with coronary artery disease显示文摘 | Willems FF Aengevaeren WR Boers GH | 2002 | J Am Coll Cardiol2002，40，4： | 2 |
| 14 | 中国和英国普通小麦制作中国白面条和碱水面条的品质特性[J]显示文摘 | 黄思棣 莫里森WR | 1988 | 中国粮油学报1988，32，3： | 2 |
| 15 | Neuroprotec tive effect of granulocyte colony- stimulating factor after focal cerebral ischemia显示文摘 | Scabiz WR Kollmar R Schwaninger M | 2003 | Stroke2003，34，3： | 2 |
| 16 | Brompheniramine maleate: a double-blind-controlled comparison with terfenadine for symptomsof allergic rhinitis显示文摘 | Thoden WR Druced HM Furey SA | 1998 | Am J Rhinol1998，12，4： | 2 |
| 17 | 向光色素Phototropin 1的细胞和亚细胞定位显示文摘 | Sakamoto K Briggs WR 童哲 | 2002 | 植物学通报2002，19，5： | 2 |
| 18 | 异步电机噪声产生的原因及处理方法显示文摘 | 芬雷,WR 刘生 | 1994 | 起重冶金电机1994，，1： | 2 |
| 19 | Expression of adhesion molecules on CD34+ cells: CD34+ L-Selectin +cells predict a rapid platelet recovery after peripheral blood cell transplantation 显示文摘 | Dercksen MW Gerritsen WR Rodenhuis S | 1995 | Blood1995，11，： | 2 |
| 20 | Oxidative stress hypothesis in Alzheimer's disease显示文摘 | Markesbery WR | 1997 | Free Radic Biol Med1997，23，： | 2 |
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