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| 1 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 2 | Mechanical modelling of micro-scale abrasion in superfinish belt grinding显示文摘 | Maxence Bigerelle Benjamin Hagege Mohamed El Mansori | | 0，，11： | 1 |
| 3 | Mechanical thrombectomy in patients with deep venous thrombosis显示文摘 | Maxence Delomez Jean-Paul Beregi M.D. Serge Willoteaux Jean-Jacques Bauchart Bertrand Janne d’Othée Philippe Asseman Nessim Perez Claude Théry | 2001 | Cardiovascular and Interventional Radiology2001，，1： | 1 |
| 4 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 5 | The perennial organelle: assembly and disassembly of the primary cilium显示文摘 | Seeley ES Maxence V Nachury | 2010 | Jounal of cell science2010，，4： | 1 |
| 6 | Influence of individual tree characteristics,spatial structure and logging history on tree-related microhabitat occurrence in North American hardwood forests显示文摘Background:Tree-related microhabitats(hereafter,'TreMs')are key components of forest biodiversity but they are still poorly known in North American hardwood forests.The spatial patterns of living trees bearing TreMs(hereafter,'TreM-trees')also remain to be determined.As logging practices can lead to a loss of TreM-trees and of their associated biodiversity,it is essential to identify the factors explaining TreM occurrence to better integrate them into forest management.We therefore inventoried TreMs in 40.5-ha survey strips in northern hardwood forests in Quebec,Canada,while recording the spatial location of each tree.Two strips were located in unmanaged oldgrowth forests,and 2 were in forests managed under selection cutting.All 4 stands were dominated by sugar maple(Acer saccharum Marsh.)and American beech(Fagus grandifolia Ehrn.).Beech bark disease,an exotic pathology,was observed in all the strips.Results:Large diameter at breast height and low tree vigor were the main characteristics explaining the presence of TreMs at the tree scale.TreM-trees presented slight spatial aggregation patterns.These aggregates,however,were not well-defined and were generally constituted by a large number of trees bearing few different types of TreMs.Two TreM classes(broken branch or top and woodpecker lodge)also presented a spatial aggregation.Logging practices had no significant effect on TreM occurrence.Beech bark disease increased the frequency of senescent beeches.The impact of this pathology on TreMs was however mitigated by the small size of infected trees and probably by the short time elapsed since its appearance.Conclusion:The factors explaining the presence and abundance of TreMs on trees has so far been little studied in North American hardwood forests.Our results highlight that TreM-tree characteristics in the surveyed forests are consistent with those of previous studies conducted in other forest types and regions(e.g.,Europe or Northwestern America).To our knowledge,this study is also the first to identify a spatial aggregation of TreM-trees and of specific TreM classes.It will be nevertheless necessary to determine whether the small impact of logging activities we observed results from current or past management practices. | Maxence Martin Patricia Raymond Yan Boucher | 2021 | Forest Ecosystems2021，8，2： | 0 |
| 7 | HIV-induced membraneless organelles orchestrate post-nuclear entry steps显示文摘HIV integration occurs in chromatin sites that favor the release of high levels of viral progeny;alternatively, the virus is alsoable to discreetly coexist with the host. The viral infection perturbs the cellular environment inducing the remodelling of thenuclear landscape. Indeed, HIV-1 triggers the nuclear clustering of the host factor CPSF6, but the underlying mechanism ispoorly understood. Our data indicate that HIV usurps a recently discovered biological phenomenon, called liquid–liquid phaseseparation, to hijack the host cell. We observed CPSF6 clusters as part of HIV-induced membraneless organelles (HIV-1 MLOs) inmacrophages, one of the main HIV target cell types. We describe that HIV-1 MLOs follow phase-separation rules and representfunctional biomolecular condensates. We highlight HIV-1 MLOs as hubs of nuclear reverse transcription, while the double-strandedviral DNA, once formed, rapidly migrates outside these structures. Transcription-competent proviruses localize outside but nearHIV-1 MLOs in LEDGF-abundant regions, known to be active chromatin sites. Therefore, HIV-1 MLOs orchestrate viral events priorto the integration step and create a favorable environment for the viral replication. This study uncovers single functional host–viralcomplexes in their nuclear landscape, which is markedly restructured by HIV-1. | Viviana Scoca Renaud Morin Maxence Collard Jean-Yves Tinevez Francesca Di Nunzio | 2022 | Journal of Molecular Cell Biology2022，14，11： | 0 |
| 8 | Chemical reproductive traits of diploid Bombus terrestris males: Consequences on bumblebee conservation显示文摘当前的土蜂衰落导致在促进突变而产生之遗传的差异和双男生产的损失的人口使近交。因为双男性是能活的,他们的后代是无菌的,土蜂人口能快速掉在扑灭的一个旋涡里。在这篇文章,我们第一次通过能阻止具单雄蕊的处女女王与双男性一起交配的一个主要化学繁殖特点(男头部的唇音腺分泌物) 调查潜在的 premating 机制。我们在头部的唇音腺分泌物上集中我们的学习双并且 Bombus terrestris (L.) 的 haploid 男性。与起始的期望相反,我们的结果不显示出头部的唇音腺分泌物在之间的任何重要区别双并且 haploid 标本。女王们因此似乎不能避免基于他们头部的唇音腺分泌物的作文与双男性一起交配。这建议双男性的扑灭的旋涡不能基于头部的唇音腺分泌物通过 premating 回避被停止,但是另外的机制能避免在双男性和女王之间交配。 | Thomas Lecocq Maxence Gerard Kevin Maebe Nicolas Brasero Lauren Dehon Guy Smagghe Irena Valterova Thibaut De Meulemeester Pierre Rasmont Denis Michez | 2017 | Insect Science2017，24，4： | 0 |
| 9 | Heat inactivation of monkeypox virus显示文摘Different kinds of media spiked with monkeypox virus(MPXV)were subjected to heat inactivation at different temperatures for various periods of time.The results showed that MPXV was inactivated in less than 5 min at 70℃and less than 15 min at 60℃,with no difference between viruses from the West African and Central African clades.The present findings could help laboratory workers to manipulate MPXV in optimal biosafety conditions and improve their protocols. | Christophe Batéjat Quentin Grassin Maxence Feher Damien Hoinard Jessica Vanhomwegen Jean-Claude Manuguerra India Leclercq | 2022 | Journal of Biosafety and Biosecurity2022，4，2： | 0 |
| 10 | 客户体验的未来显示文摘未来的客户体验系统将具备全面性、可预测性和精确性,并且与业务成果明确挂钩。近年来,中国领先银行已经基于客户旅程和触点,打造了数字化客户体验监测系统,可实时监测客户反馈,进行结构化分析展示,并以此建立起数据分析和应用管理闭环。 | Mike Thompson David Malfara Kevin Neher Maxence Vancauwenberghe Rachel Diebner 周宁人 张允宜 | 2021 | 销售与管理2021，，22： | 0 |
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