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您的检索式：作者名="Maxence Martin"
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| 1 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 2 | Influence of individual tree characteristics,spatial structure and logging history on tree-related microhabitat occurrence in North American hardwood forests显示文摘Background:Tree-related microhabitats(hereafter,'TreMs')are key components of forest biodiversity but they are still poorly known in North American hardwood forests.The spatial patterns of living trees bearing TreMs(hereafter,'TreM-trees')also remain to be determined.As logging practices can lead to a loss of TreM-trees and of their associated biodiversity,it is essential to identify the factors explaining TreM occurrence to better integrate them into forest management.We therefore inventoried TreMs in 40.5-ha survey strips in northern hardwood forests in Quebec,Canada,while recording the spatial location of each tree.Two strips were located in unmanaged oldgrowth forests,and 2 were in forests managed under selection cutting.All 4 stands were dominated by sugar maple(Acer saccharum Marsh.)and American beech(Fagus grandifolia Ehrn.).Beech bark disease,an exotic pathology,was observed in all the strips.Results:Large diameter at breast height and low tree vigor were the main characteristics explaining the presence of TreMs at the tree scale.TreM-trees presented slight spatial aggregation patterns.These aggregates,however,were not well-defined and were generally constituted by a large number of trees bearing few different types of TreMs.Two TreM classes(broken branch or top and woodpecker lodge)also presented a spatial aggregation.Logging practices had no significant effect on TreM occurrence.Beech bark disease increased the frequency of senescent beeches.The impact of this pathology on TreMs was however mitigated by the small size of infected trees and probably by the short time elapsed since its appearance.Conclusion:The factors explaining the presence and abundance of TreMs on trees has so far been little studied in North American hardwood forests.Our results highlight that TreM-tree characteristics in the surveyed forests are consistent with those of previous studies conducted in other forest types and regions(e.g.,Europe or Northwestern America).To our knowledge,this study is also the first to identify a spatial aggregation of TreM-trees and of specific TreM classes.It will be nevertheless necessary to determine whether the small impact of logging activities we observed results from current or past management practices. | Maxence Martin Patricia Raymond Yan Boucher | 2021 | Forest Ecosystems2021，8，2： | 0 |
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