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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Low incidence of hepatitis C virus among prisoners in S cotland显示文摘 | Avril Taylor Alison Munro Elizabeth Allen Karen Dunleavy Sheila Cameron Laura Miller Matthew Hickman | 2013 | Addiction2013，，7： | 2 |
| 3 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 4 | Trace organic compounds in landfill gas at seven UK waste disposal sites 显示文摘 | Matthew R Allen Braithwaite A Hills C C | 1997 | Environmental Science & Technology1997，31，4： | 1 |
| 5 | Enzymatic properties of the ferredoxin-dependent nitrite reductase from Chlamydomonas reinhardtii. Evidence for hydroxylamine as a late intermediate in ammonia production显示文摘 | Masakazu Hirasawa Jatindra N. Tripathy Frederik Sommer Ramasamy Somasundaram Jung-Sung Chung Matthew Nestander Mahima Kruthiventi Masoud Zabet-Moghaddam Michael K. Johnson Sabeeha S. Merchant James P. Allen David B. Knaff | 2010 | Photosynthesis Research2010，，2： | 1 |
| 6 | Interleukin-6-defi- cient mice develop hepatic inflammation and systemic insulin resistance显示文摘 | Matthews VB Allen TL Risis S | 2010 | Diabetologia2010，53，11： | 1 |
| 7 | Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resist ance显示文摘 | Matthews VB Allen TL Risis S | | 0，，11： | 1 |
| 8 | Rapid evolution of animal mitochondrial DNA显示文摘 | Wesley M B Matthew G JR Allen C W | 1979 | Proc Natl Acad Sci USA1979，76，4： | 1 |
| 9 | Activation of waste MDF sawdust charcoal and its reactive dye adsorption characteristics显示文摘 | GAN Q ALLEN S J MATTHEWS R | 2004 | Waste Management2004，24，8： | 1 |
| 10 | 2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults显示文摘 | Philip Greenland Joseph S. Alpert George A. Beller Emelia J. Benjamin Matthew J. Budoff Zahi A. Fayad Elyse Foster Mark A. Hlatky John McB. Hodgson Frederick G. Kushner Michael S. Lauer Leslee J. Shaw Sidney C. Smith Allen J. Taylor William S. Weintraub N | 2010 | Journal of the American College of Cardiology2010，，25： | 1 |
| 11 | Periodontitis and type 2 diabetes: is oxidative stress the mechanistic link 显示文摘 | Allen EM Matthews JB O'Connor R | 2009 | Scott Med J2009，54，2： | 1 |
| 12 | Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance显示文摘 | Matthews VB Allen TL Risis S | 2010 | Diabetologia2010，53，11： | 1 |
| 13 | Honeycomb carbon: a review ofgraphene显示文摘 | Allen Matthew J Tung Vincent C Kaner Richard B | 2009 | Chemical Reviews2009，1101，： | 1 |
| 14 | Kinetic modeling of theadsorption of basic dyes by kudzu 显示文摘 | Allen S J Gan Q Matthews R | 2005 | Journal of Colloid andInterface Science2005，286，1： | 1 |
| 15 | Transient modeling of high- altitude rocket-stage separation 显示文摘 | Allen E Jason C Matthew B | 2008 | Journal of Spacecraft and Rockets2008，45，4： | 1 |
| 16 | Kinetic modeling of the adsorption of basic dyes by kudzu显示文摘 | Allen S J Gan Q Matthews R | | 0，，： | 1 |
| 17 | Advances in modifying and understanding whey protein functionality 显示文摘 | Allen E Jack P Davis Matthew K | 2002 | Trends in Food Science and Technology2002，13，： | 1 |
| 18 | High-throughput solution processing of large-scale graphene显示文摘 | Tung Vincent C Allen Matthew J Yang Yang | 2009 | Nature Nanotechnology2009，41，： | 1 |
| 19 | Control of Invasive Weeds with Prescribed Burning 显示文摘 | Ditomaso Joseph M Brooks Matthew L Allen Edith B | 2006 | Weed Technology2006，20，2： | 1 |
| 20 | High-throughput solution processing of large-scale graphene显示文摘 | Vincent C Tung Matthew J Allen | 2009 | Nature Nanotechn2009，4，1： | 1 |
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