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| 1 | Review of biosensing with whispering-gallery mode lasers显示文摘Lasers are the pillars of modern optics and sensing.Microlasers based on whispering-gallery modes(WGMs)are miniature in size and have excellent lasing characteristics suitable for biosensing.WGM lasers have been used for labelfree detection of single virus particles,detection of molecular electrostatic changes at biointerfaces,and barcode-type live-cell tagging and tracking.The most recent advances in biosensing with WGM microlasers are described in this review.We cover the basic concepts of WGM resonators,the integration of gain media into various active WGM sensors and devices,and the cutting-edge advances in photonic devices for micro-and nanoprobing of biological samples that can be integrated with WGM lasers. | Nikita Toropov Gema Cabello Mariana P.Serrano Rithvik R.Gutha Matias Rafti Frank Vollmer | 2021 | Light(Science & Applications)2021，10，3： | 12 |
| 2 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 3 | Morphological and functional evaluation of chronic pancreatitis with magnetic resonance imaging显示文摘Magnetic resonance imaging(MRI)techniques for assessment of morphology and function of the pancreas have been improved dramatically the recent years and MRI is very often used in diagnosing and follow-up of chronic pancreatitis(CP)patients.Standard MRI including fat-suppressed T1-weighted and T2-weighted imaging techniques reveal decreased signal and glandular atrophy of the pancreas in CP.In contrast-enhanced MRI of the pancreas in CP the pancreatic signal is usually reduced and delayed due to decreased perfusion as a result of chronic inflammation and fibrosis.Thus,morphological changes of the ductal system can be assessed by magnetic resonance cholangiopancreatography(MRCP).Furthermore,secretin-stimulated MRCP is a valuable technique to evaluate side branch pathology and the exocrine function of the pancreas and diffusion weighted imaging can be used to quantify both parenchymal fibrotic changes and the exocrine function of the pancreas.These standard and advanced MRI techniques are supplementary techniques to reveal morphological and functional changes of the pancreas in CP.Recently,spectroscopy has been used for assessment of metabolite concentrations in-vivo in different tissues and may have the potential to offer better tissue characterization of the pancreas.Hence,the purpose of the present review is to provide an update on standard and advanced MRI techniques of the pancreas in CP. | Tine Maria Hansen Matias Nilsson Mikkel Gram Jens Brφndum Frφkjr | 2013 | World Journal of Gastroenterology2013，19，42： | 7 |
| 4 | Light Perception:A Matter of Time显示文摘Optimizing the perception of external cues and regulating physiology accordingly help plants to cope with the constantly changing environmental conditions to which they are exposed.An array of photoreceptors and intricate signaling pathways allow plants to convey the surrounding light information and synchronize an endogenous timekeeping system known as the circadian clock.This biological clock integrates multiple cues to modulate a myriad of downstream responses,timing them to occur at the best moment of the day and the year.Notably,the mechanism underlying entrainment of the light-mediated clock is not clear.This review addresses known interactions between the light-signaling and circadian-clock networks,focusing on the role of light in clock entrainment and known molecular players in this process. | Sabrina E.Sanchez Matias L.Rugnone Steve A.Kay | 2020 | Molecular Plant2020，13，3： | 5 |
| 5 | 发芽糙米对高脂血症大鼠抗氧化的影响显示文摘为探讨发芽糙米对大鼠非酒精性脂肪肝内抗氧化活力以及肝脏组织的保护作用,30只SD大鼠随机分为5组,A组和B组分别饲喂普通日粮、高脂饲料8周;C、D、E组饲喂高脂饲料4周后,分别在高脂饲料中添加12.5%,25.0%,50.0%的发芽糙米,自由采食4周后观察结果。结果显示,与B组相比添加发芽糙米的3组大鼠都可以在一定程度上提高大鼠肝脏组织匀浆中T-AOC、T-SOD酶的活力,减少MDA的生成,降低血清中AST、ALT、TC的含量从而保护肝脏组织,而且差异显著(P<0.05),同时血清中TG水平也有下降趋势。这表明发芽糙米具有抗氧化的生物活性,能改善机体脂质代谢,保护肝脏。 | 文琼 Froilan Bernard Matias 文利新 李荣芳 屠迪 黄海滨 邬静 | 2014 | 中国兽医学报2014，34，8： | 3 |
| 6 | 将算法几何进行到底显示文摘与王振飞的相识是在2010年徐卫国老师举办的“数字现实”国际会议上,当时的华汇北京(HHDFUN)才刚成立不久,不同于其他刚起步的青年建造师,他更多的是把工作重心放在了展览设计上,并做了好几个艺术装置。 | 王振飞 袁烽 Matias del Campo | 2014 | 城市环境设计2014，0，11： | 3 |
| 7 | Non-operative management of pancreatic trauma in adults显示文摘To the Editor:Pancreatic trauma accounts for 0.4%-2.0%of all trauma-related injuries worldwide[1-3].The American Association for the Surgery of Trauma(AAST)categorizes pancreatic injury according to the severity[4].Pancreatic injury involving transection of the gland(grades III to V)typically requires surgical management[4].However,pancreatic trauma,especially in children and young adults,can be managed without surgery[5].This study reports the outcome of a policy of preferential non-operative management of pancreatic trauma in adults. | Nadia Matias a Santhalingam Jegatheeswaran a Vinotha Nadarajah Aali J.Sheen Saurabh Jamdar Ajith K.Siriwardena | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，6： | 3 |
| 8 | Large gangliocytic paraganglioma of the duodenum:A rare entity显示文摘Gangliocytic paragangliomas are rare tumors that almost exclusively occur within the second portion of the duodenum. Although these tumors generally have a benign clinical course, they have the potential to recur or metastasize to regional lymph nodes. The case report presented here describes a 57-year-old female patient with melena, progressive asthenia, anemia, and a mass in the second-third portion of the duodenum that was treated by local excision. The patient was diagnosed with a friable bleeding tumor. The histologic analysis showed that the tumor was a 4 cm gangliocytic paraganglioma without a malignant cell pattern. In the absence of local invasion or distant metastasis, endoscopic resection represents a feasible, curative therapy. Although endoscopic polypectomy is currently considered the treatment of choice, it is not recommended if the size of the tumor is > 3 cm and/or there is active or recent bleeding. Patients diagnosed with a gangliocytic paraganglioma should be closely followed-up for possible local recurrence. | Alejandra Gordillo Hernández Eduardo Dominguez-Adame Lanuza Auxiliadora Cano Matias Rosario Perez Huertas Katherine Maria Gallardo Rodriguez Purificacion Gallinato Perez Fernando Oliva Mompean | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 2 |
| 9 | Evidence for a Role of Second Pathophysiological Stress in Prevention of Delayed Neuronal Death in the Hippocampal CA1 Region显示文摘 | Jozef Burda Milina Matia?ová Miroslav Gottlieb Viera Danielisová Miroslava Némethová Lidia Garcia Matilde Salinas Rastislav Burda | 2005 | Neurochemical Research2005，，11： | 2 |
| 10 | Management of the primary tumor in patients with metastatic pancreatic neuroendocrine tumor: a contemporary single-institution review显示文摘 | Matias Bruzoni Purvi Parikh Rolando Celis Chandrakanth Are Quan P. Ly Jane L. Meza Aaron R. Sasson | 2009 | The American Journal of Surgery2009，，3： | 2 |
| 11 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 12 | Farm-scale evaluation of the impact of CrylAb Bt maize on canopy nontarget arthropods: a 3-year study显示文摘 | Maria Arias-Martin Matias Garcia Pedro Castanera Felix Ortego Gema P. Farinos | 2018 | Insect Science2018，25，1： | 2 |
| 13 | Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences显示文摘Pre-mRNA splicing is an essential step in the process of gene expression in eukaryotes and consists of the removal ofintrons and the linking of exons to generate mature mRNAs. This is a highly regulated mechanism that allows the alternative usage of exons, the retention ofintronic sequences and the generation of exonic sequences of variable length. Most human genes undergo splicing events, and disruptions of this process have been associated with a variety of diseases, including cancer. Hepatocellular carcinoma (HCC) is a molecularly heterogeneous type of tumor that usually develops in a cirrhotic liver. Alterations in pre-mRNA splicing of some genes have been observed in liver cancer, and although still scarce, the available data suggest that splicing defects may have a role in hepatocarcinogenesis. Here we briefly review the general mechanisms that regulatepre-mRNA splicing, and discuss some examples that illustrate how this process is impaired in liver tumorigenesis, and may contribute to HCC development. We believe that a more thorough examination of pre-mRNA splicing is still needed to accurately draw the molecular portrait of liver cancer. This will surely contribute to a better understanding of the disease and to the development of new effective therapies. | Carmen Berasain Saioa Gońi Josefa Castillo Maria Ujue Latasa Jesús Prieto Matias A Avila | 2010 | World Journal of Gastroenterology2010，16，25： | 2 |
| 14 | Spatial shift-share analysis versus spatial filtering: an application to Spanish employment data 显示文摘 | Matias Mayor Ana Jesus Lopez | 2008 | Empirical Economics2008，，34： | 1 |
| 15 | Building geometric fealure based maps for indoor service robots 显示文摘 | RODRIGUEZ L D MATIA F GALAN R | 2006 | Robotics and Autonomous Systems2006，54，7： | 1 |
| 16 | Proteinase activity of pseudomonas fluorescens grown in cold milk supplemented with nitrogenand carbon sources显示文摘 | JASPE A PALACIOS P MATIAS P | 1994 | J Dairy Sci1994，77，： | 1 |
| 17 | Simultaneous measurement of strain and temperature using a fiber Bragg grating and a thermochromic material显示文摘 | Fernandez-Valdivielso C Matias I R Arregui F J | 2002 | Sensors and Actuators A: Physical2002，101，12： | 1 |
| 18 | P450 enzyme expression patterns in the NCI human tumor cell line panel显示文摘 | Yu LJ Matias J Scudiero DA | 2001 | Drug Metab Dispos2001，29，3： | 1 |
| 19 | Wavelet-based histograms for selectivity estimation 显示文摘 | Matias Y Vitter J S Wang M | 1998 | ACM SIGMOD Record1998，27，2： | 1 |
| 20 | Brazilian and African passive margins of the Central Segment of the South Atlantic Ocean: Kinematic constraints显示文摘 | Daniel Aslanian Maryline Moulin Jean-Louis Olivet Patrick Unternehr Luis Matias Fran?ois Bache Marina Rabineau Hervé Nouzé Frauke Klingelheofer Isabelle Contrucci Cinthia Labails | 2008 | Tectonophysics2008，，1： | 1 |
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