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| 1 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 2 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 3 | Neuropathology of fragile X - associated tremor/ataxia syndrome (FXTAS) 显示文摘 | Greco CM Berman RF Martin RM | 2006 | Brain2006，129，1： | 1 |
| 4 | Hypertonic Saline Solution Reduces Mesenteric Microcirculatory Dysfunctions and Bacterial Translocation in a Rat Model of Strangulated Small Bowel Obstruction显示文摘 | Fernando Luiz Zanoni José Walber Miranda Costa Cruz Joilson Oliveira Martins Simon Benabou Karin Vicente Greco Ana Carolina Ramos Moreno Marina Baquerizo Martinez Franco Ferraro Calderaro Mauricio Rocha e Silva Paulina Sannomiya | 2013 | Shock2013，，1： | 1 |
| 5 | Direct comparison of umbilical cord blood versus bone marrow-derived endothelial precursor ceils in mediating neovascularization in response to vascular ischemia显示文摘 | Finney MR Greco NG Martin GN | 2006 | Biol Blood Marrow Transplant2006，12，5： | 1 |
| 6 | Tumor Control Outcomes After Hypofractionated and Single-Dose Stereotactic Image-Guided Intensity-Modulated Radiotherapy for Extracranial Metastases From Renal Cell Carcinoma显示文摘 | Michael J. Zelefsky Carlo Greco Robert Motzer Juan Martin Magsanoc Xin Pei Michael Lovelock Jim Mechalakos Joan Zatcky Zvi Fuks Yoshiya Yamada | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，5： | 1 |
| 7 | Thiol synthesis显示文摘 | Martin D J Greco C C | 1968 | J Org Chem1968，33，3： | 1 |
| 8 | Function search in a large transcription factOr gene family in Arabidopsis: assessing the potential of reverse genetics to identify insertional mutations in R2R3 MYB genes 显示文摘 | MEISSNER R C JIN H L COMINELLI E DENEKAMP M FUERTES A GRECO R KRANZ H D PENFIELD S PETRONI K URZAINQUI A MARTIN C PAZ-ARES J SMEEKENS S TONELLI C WEISSHAAR B BAUMANN E KLIMYUK V MARILLONNET S PATEL K SPEULMAN E TISSIER A F BOUCHEZ D JONES J J D PEREIRA A WISMAN E BEVAN M | 1999 | Plant Cell1999，11，： | 1 |
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