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| 1 | Promoter hypermethylation of CDH1, FHIT, MTAP and PLAGL1 in gastric adenocarcinoma in individuals from Northern Brazil显示文摘AIM: To evaluate the methylation status of CDH1, FHIT, MTAP and PLAGL1 promoters and the association of these findings with clinico-pathological characteristics. METHODS: Methylation-specific PCR (MSP) assay was performed in 13 nonneoplastic gastric adenocarcinoma, 30 intestinal-type gastric adenocarcinoma and 35 diffuse- type gastric adenocarcinoma samples from individuals in Northern Brazil. Statistical analyses were performed using the chi-square or Fisher’s exact test to assess associations between methylation status and clinico- pathological characteristics. RESULTS: Hypermethylation frequencies of CDH1, FHIT, MTAP and PLAGL1 promoter were 98.7%, 53.9%, 23.1% and 29.5%, respectively. Hypermethylation of three or four genes revealed a significant association with diffuse-type gastric cancer compared with nonneoplastic cancer. A higher hypermethylation frequency wassignificantly associated with H pylori infection in gastric cancers, especially with diffuse-type. Cancer samples without lymph node metastasis showed a higher FHIT hypermethylation frequency. MTAP hypermethylation was associated with H pylori in gastric cancer samples, as well as with diffuse-type compared with intestinal-type. In diffuse-type, MTAP hypermethylation was associated with female gender. CONCLUSION: Our findings show differential gene methylation in tumoral tissue, which allows us to conclude that hypermethylation is associated with gastric carcinogenesis. MTAP promoter hypermethylation can be characterized as a marker of diffuse-type gastric cancer, especially in women and may help in diagnosis, prognosis and therapies. The H pylori infectious agent was present in 44.9% of the samples. This infection may be correlated with the carcinogenic process through the gene promoter hypermethylation, especially the MTAP promoter in diffuse-type. A higher H pylori infection in diffuse-type may be due to greater genetic predisposition. | Mariana Ferreira Leal Eleonidas Moura Lima Patrícia Natália Oliveira Silva Paulo Pimentel Assumpo Danielle Queiroz Calcagno Spencer Luiz Marques Payo Rommel Rodríguez Burbano Marília de Arruda Cardoso Smith | 2007 | World Journal of Gastroenterology2007，13，18： | 24 |
| 2 | 再生建筑废料铺筑沥青路面结构层力学性能现场试验显示文摘近年来,建筑与拆除废料在许多工程领域得到再生利用,公路与城市道路路面工程只需较少投入就能促进其大量应用,研究前景广阔。该文先简要综述已有相关室内外试验研究现状,着重介绍巴西2003年用再生集料铺筑基层、底基层的某沥青路面试验段,尤其是采用多种现场试验对该路面使用情况进行了8年多跟踪监测及分析评价。研究表明:再生集料能提供天然粒料相同水平的测试参数,类似于普通集料铺筑的路面,其性能可达到满意要求,建议在不同类型路面中更多地研究与应用。 | 杨敏 杨和平 肖杰 童超 Lilian Ribeiro de Rezende Michelle de Oliveira Marques Joo Carlos de Oliveira | 2017 | 中外公路2017，37，3： | 5 |
| 3 | Rapid and sensitive methodology for determination of ethyl carbamate in fortified wines using microextraction by packed sorbent and gas chromatography with mass spectrometric detection显示文摘 | Jo?o M. Le?a Vanda Pereira Ana C. Pereira José C. Marques | 2013 | Analytica Chimica Acta2013，，： | 2 |
| 4 | The 200th horizontal openhole gravel-packing operation in Campos Basin: a milestone in the history of petrohras completion practices in ultradeep waters显示文摘 | Marques L C C Paixao L C A Martions M O | 2007 | SPE1063642007，，： | 1 |
| 5 | Extraction of the soluble material from the shells of the bacuri fruit (Platonia insignis Mart) with pressurized CO2 and other solvents 显示文摘 | Monteiro A R Meireles M A Marques M O M | 1997 | J Supercrit Fluids1997，11，： | 1 |
| 6 | Simple and rapid method determination for metformin in human plasma using high performance liquid chromatography tandem mass spectrometry: application to pharmacokinetic studies 显示文摘 | S'lpoli Marques M A Soares A S Pinto O W | 2007 | Chromatography B2007，852，： | 1 |
| 7 | Extraction of ginger (Zingiber officinale Roscoe) oleoresin with CO2 and co-solvents: A study of the antioxidant action of the extracts 显示文摘 | Zancan K C Marques M O M Petenate A J | 2002 | J Supercrit Fluids2002，24，1： | 1 |
| 8 | Carbon solubility in nanostructured copper显示文摘 | Marques M T Correia J B Conde O | 2004 | Scripta Materialia2004，50，： | 1 |
| 9 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 10 | Extraction of ginger (Zingiber officinale Roscoe) oleo- resin with CO2 and co-solvents: a study of the antioxidant action of the extracts 显示文摘 | Zancan Kelly C Marques Marcia O M Petenate Ademir J | 2002 | The Journal of Supercritical Fluids2002，24，1： | 1 |
| 11 | Remediation ofheavy metal contaminated soils:an overview of site remediation techniques显示文摘 | MARQUES A P RANGEL A O CASTRO P M | 2011 | Critical Reviews in Environmental Science & Technology2011，41，912： | 1 |
| 12 | Neural Network Approach to Background Modeling for Video Object Segmentation显示文摘 | CULIBRK D MARQUES O SOCKE D | 2007 | IEEE Transactions on Neural Networks2007，18，11： | 1 |
| 13 | Topography as a major factor in the development of arcuate thrust belts:insiights from sandbox experiments显示文摘 | MARQUES F O COBBOLD P R | 2002 | Tectonophysics2002，348，2： | 1 |
| 14 | Composite compressibility model for municipal solid waste显示文摘 | MARQUES A C M FILZ G M VILAR O M | 2003 | Journal of Geoteehnieal and Geoenvironmental Engineering ASCE2003，129，4： | 1 |
| 15 | Mixed H2/H∞ control of discrete-time Markovian jump linear systems显示文摘 | Costa O L V Marques R P | 1998 | IEEE Trans Automat Contr1998，43，： | 1 |
| 16 | Theoretical and experimental analysis of axisymmetrical deep drawing显示文摘 | BARATA MARQUES M J M BAPTISTA R M S O | 1990 | Journal of Materials Processing Technology1990，24，： | 1 |
| 17 | Supercritical CO2 extraction of essential oil and oleoresin from chamomile (Chamomilla recutita Rauschert)显示文摘 | POVH N P MARQUES M O M MEIREL ES M A A | 2001 | J Supercrit Fluids2001，21，： | 1 |
| 18 | Influence of microstructure on the electrical properties of NASICON materials 显示文摘 | Fuentes R O FIGUEIREDO F M MARQUES F M FRANCO J I | 2001 | Solid State Ionics2001，140，： | 1 |
| 19 | Neural Network Approach to Background Modeling for Video Object Segmentation显示文摘 | Culibrk D Marques O Socek D | 2007 | IEEE Transactions on Neural Networks2007，18，6： | 1 |
| 20 | An Attention-Driven Model for Grouping Similar Ima- ges with Image Retrieval Applications 显示文摘 | Marques O Mayron L M Borba G B | 2007 | EUR- ASIP Journal on Advances in Signal Processing2007，，1： | 1 |
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