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| 1 | 眼前节内眼手术应用5%吡咯烷酮碘两种不同用法的前瞻性随机化比较研究显示文摘目的:确定5%吡咯烷酮碘采用两种不同的方法(结膜囊滴两滴和10ml溶液穹窿结膜冲洗)对降低结膜囊菌群的功效。方法:在这项前瞻性对照实验中。将行眼前节手术的200只眼随机分为对照组和研究组。两组病例术前均给予氧氟沙星滴眼液局部点眼和5%吡咯烷酮碘眶周区域皮肤擦洗消毒。术前对照组眼结膜囊内给予2滴5%吡咯烷酮碘溶液,研究组眼用5%吡咯烷酮碘溶液冲洗穹窿结膜。分别于术前和术后4个时间点行结膜细菌培养。结果:研究组78只眼中20只眼(26%)术前结膜细菌培养阳性:对照组94只眼中40只眼(43%)为阳性(P=0.02)。手术结束时。研究组78只眼中14只眼(18%)、对照组94只眼中30只眼(32%)结膜细菌培养阳性(PP=0.05)。结论:手术时应用5%吡咯烷酮碘溶液冲洗穹窿结膜与结膜囊仅点入两滴相比。前者显著降低了结膜细菌培养阳性率。 | Herminia Mino de Kaspar Robert T. Chang Kuldev Singh Peter R. Egbert Mark S. Blumenkranz Christopher N. Ta 董白霞(译) 马景学(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，3： | 6 |
| 2 | Human adenovirus(HAdV)infection in children with acute respiratory tract infections in Guangzhou,China,2010–2021:a molecular epidemiology study显示文摘Background Human adenovirus(HAdV)infection can cause a variety of diseases.It is a major pathogen of pediatric acute respiratory tract infections(ARIs)and can be life-threatening in younger children.We described the epidemiology and subtypes shifting of HAdV among children with ARI in Guangzhou,China.Methods We conducted a retrospective study of 161,079 children diagnosed with acute respiratory illness at the Guangzhou Women and Children’s Medical Center between 2010 and 2021.HAdV specimens were detected by real-time PCR and the hexon gene was used for phylogenetic analysis.Results Before the COVID-19 outbreak in Guangzhou,the annual frequency of adenovirus infection detected during this period ranged from 3.92%to 13.58%,with an epidemic peak every four to fve years.HAdV demonstrated a clear seasonal distribution,with the lowest positivity in March and peaking during summer(July or August)every year.A signifcant increase in HAdV cases was recorded for 2018 and 2019,which coincided with a shift in the dominant HAdV subtype from HAdV-3 to HAdV-7.The latter was associated with a more severe disease compared to HAdV-3.The average mortality proportion for children infected with HAdV from 2016 to 2019 was 0.38%but increased to 20%in severe cases.After COVID-19 emerged,HAdV cases dropped to 2.68%,suggesting that non-pharmaceutical interventions probably reduced the transmission of HAdV in the community.Conclusion Our study provides the foundation for the understanding of the epidemiology of HAdV and its associated risks in children in Southern China. | Yi Chen Tao Lin Chang‑Bing Wang Wan‑Li Liang Guang‑Wan Lian Mark Zanin Sook‑San Wong Xin‑Gui Tian Jia‑Yu Zhong Ying‑Ying Zhang Jia‑Hui Xie Ling‑Ling Zheng Fei‑Yan Chen Run Dang Ming‑Qi Zhao Yi‑Yu Yang Rong Zhou Bing Zhu | 2022 | World Journal of Pediatrics2022，18，8： | 5 |
| 3 | Morbidity and Mortality Analysis of 200 Treatments With Cytoreductive Surgery and Hyperthermic Intraoperative Intraperitoneal Chemotherapy Using the Coliseum Technique显示文摘 | Arvil D. Stephens MD Robert Alderman PA-C David Chang MD Gary D. Edwards PA-C Jesus Esquivel MD Gilbert Sebbag MD Mark A. Steves MD Paul H. Sugarbaker MD | 1999 | Annals of Surgical Oncology1999，，8： | 5 |
| 4 | Source apportionment of atmospheric particulate carbon in Las Vegas,Nevada,USA显示文摘研究被进行确定到在在拉斯维加斯山谷的四个城市的地点的碳的 PM2.5 的来源类型的冬贡献,在西南的美国的最快成长的城市的区域之一。24 个小时平均的周围的样品为质量,离子,元素,器官的碳(OC ) ,元素的碳(EC ) ,和踪迹被收集器官的标记分析。另外的大小被做决定日报在轻吸收的黑碳(BC ) 的模式作为为燃烧来源的一个标记。在道路上汽油车辆,在道路上柴油机车辆,和越野的柴油机引擎的碳的下午来源与他们的化学侧面,以及基于燃料的排放因素被描绘,用一个在里面羽毛采样系统。有效变化化学集体平衡(EV-CMB ) 来源分配模型被用于收集的周围的样品,用在象从另外的相关研究的侧面一样的这研究开发的来源侧面。四主要来源在拉斯维加斯山谷以内贡献了 PM2.5 碳:(1 ) 铺了道路灰尘,(2 ) 在道路上汽油车辆,(3 ) 居住木头燃烧,并且(4 ) 在道路上柴油机车辆。CMB 估计在道路上混合了舰队汽油车辆根本是为 OC 和 EC 的最大的来源这些地点。到 OC 和 EC 的铺的道路灰尘的贡献在四个地点是 510% 。在道路上柴油机车辆在城市中心附近在一个地点贡献 22% OC 和 34% EC,它被定位一条主要马路立即顺风。居住木头燃烧比为二个居住邻居地点的在道路上柴油机车辆是更重要的来源。这些结果与我们的概念的模型一致,并且研究方法论可以被用于学习另外的城市的区域。 | Mark C.Green Judith C.Chow M.-C.Oliver Chang L.-W.Antony Chen Hampden D.Kuhns Vicken R.Etyemezian John G.Watson | 2013 | Particuology2013，11，1： | 5 |
| 5 | 159例腹腔镜根治性前列腺癌切除术的疗效评估显示文摘目的探讨腹腔镜根治性前列腺切除术的疗效.方法回顾性分析2000年3月至2003年8月159例腹腔镜根治性前列腺切除术患者资料.平均年龄58岁(42~74岁),同时行双侧盆腔淋巴结清扫术57例(35.9%).术前159例患者前列腺活检均确诊为前列腺癌.Gleason肿瘤分级:3+3:129例(81.1%),3+4:23例(14.5%),4+3:4例(2.5%),4+4:3例(1.9%).TNM肿瘤分期:T1c126例(79.3%),T2a 33例(20.7%).结果 159例患者平均手术时间298 min(165~660min).术中估计失血量平均293 ml(50~2500 ml),发生严重并发症15例(9.4%),其中中转开放手术6例(3.8%),无死亡病例.术后病理确诊为前列腺癌158例,1例诊断为良性前列腺增生伴急性前列腺炎.标本切缘阳性34例(21.5%).术后1年53例患者获得随访,术前31例(58.5%)有阴茎勃起功能的患者根据国际阴茎勃起功能指数(ⅡEF-5)评分分组进行术后变化评估.术后ⅡEF-5评分显著下降,各评分组间的差异无统计学意义.36例(67.9%)可通过使用Viagra等药物进行性生活,6例(11.3%)有尿失禁.结论腹腔镜根治性前列腺切除术是一种相对安全、微创、并发症低、术后康复快,同时又能达到肿瘤治疗效果的手术方法.但长期疗效尚待进一步观察. | 李爱华 Demetrius H.Bagley Edouard Trabulsi Deborah T.Glassman Stephen Strup Mark Chang Dolores Shupp-Byrne Leonard G.Gomella | 2005 | 中华泌尿外科杂志2005，26，12： | 4 |
| 6 | Conventional laparoscopic versus single-incision laparoscopic right hemicolectomy: a case cohort comparison of short-term outcomes in 144 consecutive cases显示文摘 | Min-Hoe Chew Mei-Huan Chang Wah-Siew Tan Mark Te-Ching Wong Choong-Leong Tang | 2013 | Surgical Endoscopy2013，，2： | 4 |
| 7 | Endoscopic submucosal dissection vs endoscopic mucosal resection for colorectal polyps:A meta-analysis and metaregression with single arm analysis显示文摘BACKGROUND Endoscopic submucosal dissection(ESD)has shown to be effective in management of colorectal neoplasm in the Asian countries,while its implementation in Western countries where endoscopic mucosal resection(EMR)is preferred is still debatable.AIM To compare the surgical,histological,and oncological outcomes between ESD and EMR in the treatment of colorectal polyps,with subgroup analysis comparing the efficacy of ESD and EMR between Japan and the rest of the world.METHODS Embase and Medline databases were searched from inception to October 2020 in accordance with PRISMA guidelines for studies comparing en bloc,complete resection,margin involvement,resection time,need for additional surgery,complications,and recurrence rate of ESD with EMR.RESULTS Of 281344 colorectal polyps from 21 studies were included.When compared to EMR,the pooled analysis revealed ESD was associated with higher en bloc and complete resection rate,and lower lateral margin involvement and recurrence.ESD led to increased procedural time,need for additional surgery,and perforation risk.No significant difference in bleeding risk was found between the two groups.Meta-regression analysis suggested only right colonic polyps correlated with an increased perforation risk in ESD.Confounders including polyp size and invasion depth did not significantly influence the en bloc and complete resection rate,bleeding risk and recurrence.In subgroup analysis,Japan performed better than the rest of the world in both ESD and EMR with perforation risk of 4%and 0.0002%,respectively,as compared to perforation risk of 8%and 1%,respectively,in reports coming from rest of the world.CONCLUSION ESD resulted in better resection outcomes and lower recurrence compared to EMR.With appropriate training,ESD is preferred over EMR as the first-line therapy for resection of colorectal polyps,without restricting to lesions greater than 20 mm and those with high suspicion of submucosal invasion. | Xiong Chang Lim Kameswara Rishi Yeshayahu Nistala Cheng Han Ng Snow Yunni Lin Darren Jun Hao Tan Khek-Yu Ho Choon-Seng Chong Mark Muthiah | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 8 | ICC density predicts bacterial overgrowth in a rat model of post-infectious IBS显示文摘AIM:To investigate the interstitial cells of Cajal(ICC) number using a new rat model.METHODS:Sprague-Dawley rats were assigned to two groups.The first group received gavage with Campylobacter jejuni(C.jejuni) 81-176.The second group was gavaged with placebo.Three months after clearance of Campylobacter from the stool,precise segments of duodenum,jejunum,and ileum were ligated in self-contained loops of bowel that were preserved in anaerobic bags.Deep muscular plexus ICC(DMP-ICC) were quantified by two blinded readers assessing the tissue in a random,coded order.The number of ICC per villus was compared among controls,Campylobacter recovered rats without small intestinal bacterial overgrowth(SIBO),and Campylobacter recovered rats with SIBO.RESULTS:Three months after recovery,27% of rats gavaged with C.jejuni had SIBO.The rats with SIBO had a lower number of DMP-ICC than controls in the jejunum and ileum.Additionally there appeared to be a density threshold of 0.12 DMP-ICC/villus that was associated with SIBO.If ileal density of DMP-ICC was < 0.12 ICC/villus,54% of rats had SIBO compared to 9% among ileal sections with > 0.12(P<0.05).If the density of ICC was < 0.12 DMP-ICC/villus in more than one location of the bowel,88% of these had SIBO compared to 6% in those who did not(P<0.001).CONCLUSION:In this post-infectious rat model,the development of SIBO appears to be associated with a reduction in DMP-ICC.Further study of this rat model might help understand the pathophysiology of postinfectious irritable bowel syndrome. | Sam-Ryong Jee Walter Morales Kimberly Low Christopher Chang Amy Zhu Venkata Pokkunuri Soumya Chatterjee Edy Soffer Jeffrey L Conklin Mark Pimentel | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 9 | The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism显示文摘小 GTPase Rap1 经由一条在内外面发信号的小径导致 integrin 激活由交往 Rap1 adaptormolecule (RIAM ) 调停了。堵住这条小径可以压制与活动过度的 integrins.However 有关的肿瘤转移和其它疾病,由 Rap1 的 RIAM 的特定的识别的分子的基础仍然保持大部分未知。此处我们在场在有地岬协会(RA ) 的建筑群的 Rap1 的一个活跃、 GTP 固定的 GTPase 领域的 crystalstructure pleckstrin 相同(PH ) 在 1.65 点的 RIAM 的结构的模块 ? 。结构表明由 Rap1 的 RIAM 的识别被 side-chaininteractions 管理。几方面链在决定这识别的特性是批评的,特别地相对地在另外的地岬 GTPases 与 Glu31/Asp31 残余相比被控告的 Lys31 residuein Rap1。Lys31 形成盐桥 withRIAM 残余 Glu212,使它成为相互作用的关键特性决定因素。我们也在 Rap1 的减小显示出这些 interactionsresults 的那混乱: RIAM 协会,导致共同聚类和房间粘附的损失。我们的调查结果 elucidatethe RIAM 由调停的分子的机制导致 Rap1 的 integrin 激活。水晶结构也由他们的小 GTPasepartners 为 RAPH 包含模块的受动器蛋白质的特定的招募为新 insightinto 提供结构的基础。 | Hao Zhang Yu-Chung Chang Mark L. Brennan Jinhua Wu | 2014 | Journal of Molecular Cell Biology2014，8，2： | 3 |
| 10 | Pretreatment Assessment of Resectable and Borderline Resectable Pancreatic Cancer: Expert Consensus Statement显示文摘 | Mark P. Callery MD Kenneth J. Chang MD Elliot K. Fishman MD Mark S. Talamonti MD L. William Traverso MD David C. Linehan MD | 2009 | Annals of Surgical Oncology2009，，7： | 3 |
| 11 | Immune modulation of effector CD4+ and regulatory T cell function by sorafenib in patients with hepatocellular carcinoma显示文摘 | Roniel Cabrera Miguel Ararat Yiling Xu Todd Brusko Clive Wasserfall Mark A. Atkinson Lung Ji Chang Chen Liu David R. Nelson | 2013 | Cancer Immunology Immunotherapy2013，，4： | 3 |
| 12 | 手助式腹腔镜肾切除术围手术期并发症的处理显示文摘目的探讨手助式腹腔镜肾切除术围手术期并发症的处理方法。方法回顾性分析1998-2004年377例手助式腹腔镜肾切除术患者资料,其中根治性肾切除术206例,单纯性肾切除术91例,根治性肾、输尿管切除术49例,肾部分切除术31例,对围手术期并发症类型、发生率及处理方法进行统计分析。结果377例患者术中估计失血量平均315.6 ml(30~7000 m1)。术中发生脾脏损伤、难以控制的出血、肠道损伤、肾蒂血管损伤、胰腺损伤等并发症14例(3.7%)。中转开放手术13例(3.4%)。术后发生肠梗阻、肺炎、切口疝、继发性出血、冠心病发作、血管栓塞、低钠血症等并发症48例(12.7%)。死亡2例(0.5%)。有腹腔或腹膜后手术史者围手术期并发症和术式中转率高于无手术史者。结论手助式腹腔镜。肾切除术仍会出现一些严重的围手术期并发症。局部粘连、肿瘤体积过大会增加并发症的发生。术中一旦出现严重出血、器官损伤等难以控制的并发症时应及时中转开放手术。充分的术前准备、正确熟练的手术操作可降低并发症的发生率。 | 李爱华 Leonard G.Gomella Ramsay Kuo Dolores Shupp-Byrne Mark Chang Stephen Strup Demetrias H.Bagley | 2006 | 中华泌尿外科杂志2006，27，10： | 2 |
| 13 | Crystal structure of Lamellipodin implicates diverse functions in actin polymerization and Ras signaling显示文摘The adapter protein Lamellipodin(Lpd)plays an important role in cell migration.In particular,Lpd mediates lamellipodia formation by regulating actin dynamics via interacting with Ena/VASP proteins.Its RA-PH tandem domain confi guration suggests that like its paralog RIAM,Lpd may also mediate particular Ras GTPase signaling.We determined the crystal structures of the Lpd RA-PH domains alone and with an N-terminal coiled-coil region(cc-RA-PH).These structures reveal that apart from the anticipated coiled-coil interaction,Lpd may also oligomerize through a second intermolecular contact site.We then validated both oligomerization interfaces in solution by mutagenesis.A fluorescence-polarization study demon-strated that Lpd binds phosphoinositol with low affinity.Based on our crystallographic and biochemical data,we propose that Lpd and RIAM serve diverse functions:Lpd plays a predominant role in regulating actin polymerization,and its function in mediating Ras GTPase signaling is largely suppressed compared to RIAM. | Yu-Chung Chang Hao Zhang Mark LBrennan Jinhua Wu | 2013 | Protein & Cell2013，4，3： | 2 |
| 14 | Management of the Open Abdomen: From Initial Operation to Definitive Closure显示文摘 | Vargo Daniel Richardson J David Campbell Andre Chang Michael Fabian Timothy Franz Michael Kaplan Mark Moore Frederick Reed R Lawrence Scott Bradford Silverman Ronald | 2009 | The American Surgeon2009，，11： | 2 |
| 15 | Understanding pancreatic cancer genomes显示文摘 | Mark J. Cowley David K. Chang Marina Pajic Amber L. Johns Nicola Waddell Sean M. Grimmond Andrew V. Biankin | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，6： | 2 |
| 16 | Interleukin-22: Implications for Liver Ischemia-Reperfusion Injury显示文摘 | Paul J. Chestovich Yoichiro Uchida William Chang Mark Ajalat Charles Lassman Robert Sabat Ronald W. Busuttil Jerzy W. Kupiec-Weglinski | 2012 | Transplantation2012，，5： | 2 |
| 17 | Pretreatment Assessment of Resectable and Borderline Resectable Pancreatic Cancer: Expert Consensus Statement显示文摘 | Mark P. Callery MD Kenneth J. Chang MD Elliot K. Fishman MD Mark S. Talamonti MD L. William Traverso MD David C. Linehan MD | 2009 | Annals of Surgical Oncology2009，，7： | 2 |
| 18 | Sex-related differences in IBS patients: central processing of visceral stimuli显示文摘 | Bruce D Naliboff Steve Berman Lin Chang Stuart W.G Derbyshire Brandall Suyenobu Brent A Vogt Mark Mandelkern Emeran A Mayer | 2003 | Gastroenterology2003，，7： | 1 |
| 19 | MiR-122,a mammalian liver-specific microRNA,is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1显示文摘 | Chang J Nicolas E Marks D | 2004 | RNA Biol2004，1，2： | 1 |
| 20 | Multimodality treatment of giant intracranial arteriovenous malformations 显示文摘 | Chang SD Marcellus ML Marks MP | 2003 | Neurosurg2003，53，1： | 1 |
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