|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pharmacogenetics of the systemic treatment in advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. To date, most patients with HCC are diagnosed at an advanced tumor stage, excluding them from potentially curative therapies (i.e., resection, liver transplantation, percutaneous ablation). Treatments with palliative intent include chemoembolization and systemic therapy. Among systemic treatments, the small-molecule multikinase inhibitor sorafenib has been the only systemic treatment available for advanced HCC over 10 years. More recently, other smallmolecule multikinase inhibitors (e.g., regorafenib, lenvatinib, cabozantinib) have been approved for HCC treatment. The promising immune checkpoint inhibitors (e.g., nivolumab, pembrolizumab) are still under investigation in Europe while in the US nivolumab has already been approved by FDA in sorafenib refractory or resistant patients. Other molecules, such as the selective CDK4/6inhibitors (e.g., palbociclib, ribociclib), are in earlier stages of clinical development, and the c- MET inhibitor tivantinib did not show positive results in a phase III study. However, even if the introduction of targeted agents has led to great advances in patient response and survival with an acceptable toxicity profile, a remarkable inter-individual heterogeneity in therapy outcome persists and constitutes a significant problem in disease management. Thus, the identification of biomarkers that predict which patients will benefit from a specific intervention could significantly affect decision-making and therapy planning. Germ-line variants have been suggested to play an important role in determining outcomes of HCC systemic therapy in terms of both toxicity and treatment efficacy. Particularly, a number of studies have focused on the role of genetic polymorphisms impacting the drug metabolic pathway and membrane translocation as well as the drug mechanism of action as predictive/prognostic markers of HCC treatment. The aim of this review is to summarize and critically discuss the pharmacogenetic literature evidences, with particular attention to sorafenib and regorafenib, which have been used longer than the others in HCC treatment. | Elena De Mattia Erika Cecchin Michela Guardascione Luisa Foltran Tania Di Raimo Francesco Angelini Mario D’Andrea Giuseppe Toffoli | 2019 | World Journal of Gastroenterology2019，25，29： | 8 |
| 2 | Pharmacogenetics of ABC and SLC transporters in metastatic colorectal cancer patients receiving first-line FOLFIRI treatment显示文摘 | Elena De Mattia Giuseppe Toffoli Jerry Polesel Mario D’Andrea Giuseppe Corona Vittorina Zagonel Angela Buonadonna Eva Dreussi Erika Cecchin | 2013 | Pharmacogenetics and Genomics2013，，10： | 2 |
| 3 | Effects of antihypertensive drugs on blood pressure and proteinuria in childhood显示文摘 | Giacomo D Simonetti Mattia Rizzi Rebecca Donadini Mario G Bianchetti | 2007 | Journal of Hypertension2007，，12： | 1 |
| 4 | The abrogation of the HOXB7/PBX2 complex induces apoptosis in melanoma through the miR‐221&222‐c‐FOS pathway显示文摘 | M. Cristina Errico Federica Felicetti Lisabianca Bottero Gianfranco Mattia Alessandra Boe Nadia Felli Marina Petrini Maria Bellenghi Hardev S. Pandha Marco Calvaruso Claudio Tripodo Mario P. Colombo Richard Morgan Alessandra Carè | 2013 | Int J Cancer2013，，4： | 1 |
| 5 | Prognostic Value of Pathologic Complete Response After Neoadjuvant Therapy in Locally Advanced Rectal Cancer: Long-Term Analysis of 566 ypCR Patients显示文摘 | Carlo Capirci Vincenzo Valentini Luca Cionini Antonino De Paoli Claus Rodel Robert Glynne-Jones Claudio Coco Mario Romano Giovanna Mantello Silvia Palazzi Falchetti Osti Mattia Maria Luisa Friso Domenico Genovesi Cristiana Vidali Maria Antonietta Gambacor | 2008 | International Journal of Radiation Oncology Biology Physics2008，，1： | 1 |
| 6 | Troponin T, creatine kinase MB mass, and creatine kinase MB isoform ratio in the detection of myocardial damage during non-surgical coronary revascularization显示文摘 | Bernhard Reimers Mattia Lachin Luisa Cacciavillani Sandra Secchiero Angelo Ramondo Giambattista Isabella Armando Marzari Martina Zaninotto Mario Plebani Raffaello Chioin Francesco Maddalena Sergio Dalla-Volta | 1997 | International Journal of Cardiology1997，，： | 1 |
| 7 | The integrated manage- ment of logistic chains in the white goods industry:A field research in Italy显示文摘 | Marco Perona Roberto Cigolini Mattia Adani Roberto Bionic Guzzett Ruggero Jenna Mario Chessa Stefano Agellara | 2001 | International Journal of Production Economics2001，69，： | 1 |
| 8 | Identification by a Digital Gene Expression Displayer (DGED) and testby RT-PCR analysis of new mRNA candidate markers for colorectal cancer in peripheralblood显示文摘 | Mattia Lauriola Giampaolo Ugolini Giancarlo Rosati Simone Zanotti Isacco Montroni Alessio Manaresi Davide Zattoni Stefano Rivetti Gabriella Mattei Domenico Coppola Pierluigi Strippoli Mario Taffurelli Rossella Solmi | 2010 | International Journal of Oncology2010，，2： | 1 |
| 9 | The abrogation of the HOXB7/PBX2 complex induces apoptosis in melanoma through the miR‐221&222‐c‐FOS pathway显示文摘 | M. Cristina Errico Federica Felicetti Lisabianca Bottero Gianfranco Mattia Alessandra Boe Nadia Felli Marina Petrini Maria Bellenghi Hardev S. Pandha Marco Calvaruso Claudio Tripodo Mario P. Colombo Richard Morgan Alessandra Carè | 2013 | Int. J. Cancer2013，，4： | 1 |
| 10 | Planktonic foraminifera as bio-indicators for monitoring the climatic changes that have occurred over the past 2000 years in the southeastern Tyrrhenian Sea显示文摘A high-resolution integrated study has been performed in a super-expanded marine record(sedimentation rate spanning from 11 cm/100 years to 20 cm/100 years)from the continental shelf area of the southeastern Tyrrhenian Sea.Planktonic foraminiferal distribution illustrates 6 major environmental changes during the past 2000 years:(i)the Roman Period-Dark Age transition(from herbivorous-opportunistic to carnivorous species);(ii)the Dark Age-MCA transition(from carnivorous to herbivorous-opportunistic species);(iii)the Medieval Classic Anomaly-Little Ice Age transition(a further and definitive change from carnivorous to herbivorous-opportunistic species);(iv)the period during the Maunder event between approximately 1720 AD and 1740 AD(turnover from the carnivorous planktonic foraminifer Globigerinodes ruber to the herbivorous-opportunistic planktonic foraminifer Turborotalita quinqueloba);(v)the Industrial Period(dominance of herbivorous-opportunistic planktonic foraminifera);and(vi)the Modern Warm Period at approximately 1940 AD(the last turnover in favor of herbivorous-opportunistic planktonic foraminifers,associated with an increase in benthic foraminifera).Our studies lead us to link this latter feature to an anthropogenic impact associated with the damming of Sele River(Salerno Gulf)at 1934 AD,which induced a change in the sediment input with a strong decrease in coarse-grained fraction and a probable alteration in nutrient supply.Theδ^(18)O_(G.ruber) record of the past 2000 years shows the alternation of warm/wet and cold/dry events related to the Roman Period,the Dark Age,the Medieval Classic Anomaly,the Little Ice Age,the Industrial Period and the Modern Warm Period.The 5 evidentδ^(18)O_(G.ruber) oscillations(between approximately 1325 AD and 1940 AD)coincide with the 5 minima in the solar activity record(Wolf,Spörer,Maunder,Dalton and Damon events). | Fabrizio LIRER Mario SPROVIERI Mattia VALLEFUOCO Luciana FERRARO Nicola PELOSI Laura GIORDANO Lucilla CAPOTONDI | 2014 | Integrative Zoology2014，9，4： | 0 |
| 11 | Developing food,water and energy nexus workflows显示文摘There is a growing recognition of the interdependencies among the supply systems that rely upon food,water and energy.Billions of people lack safe and sufficient access to these systems,coupled with a rapidly growing global demand and increasing resource constraints.Modeling frameworks are considered one of the few means available to understand the complex interrelationships among the sectors,however development of nexus related frameworks has been limited.We describe three opensource models well known in their respective domains(i.e.TerrSysMP,WOFOST and SWAT)where components of each if combined could help decision-makers address the nexus issue.We propose as a first step the development of simple workflows utilizing essential variables and addressing components of the above-mentioned models which can act as building-blocks to be used ultimately in a comprehensive nexus model framework.The outputs of the workflows and the model framework are designed to address the SDGs. | Ian McCallum Carsten Montzka Bagher Bayat Stefan Kollet Andrii Kolotii Nataliia Kussul Mykola Lavreniuk Anthony Lehmann Joan Maso Paolo Mazzetti Aline Mosnier Emma Perracchione Mario Putti Mattia Santoro Ivette Serral Leonid Shumilo Daniel Spengler Steffen Fritza | 2020 | International Journal of Digital Earth2020，13，2： | 0 |
| 12 | 二十一世纪国家艺术博物馆显示文摘建筑设计概念以及城市策略:可能性领域的划分通过维持与原军队营房的索引关系,博物馆的设计提出了建筑与其所在城市文脉的问题。这绝不是对地貌混合拼凑的尝试,而是为了应对平衡场地周边的强势街区脉络,所提出的对弱城市肌理的延续。 | Zaha Hadid Patrik Schumacher Anja Simons Paolo Matteuzzi Fabio Ceci Mario Mattia Maurizio Meossi Paolo Zilli Luca Peralta Maria Velceva Matteo Grimal Ana M.Cajiao Barbara Pfenningstorff Dillon Lin Kenneth Bostock Raza Zahid Lars Teichmann Adriano De Gioannis Amin Taha Caroline Voet Gianluca Ruggeri Luca Segarelli | 2016 | 建筑创作2016，0，6： | 0 |
| 13 | Simultaneous observation of ultrafast electron and proton beams in TNSA显示文摘The interaction of ultra-intense high-power lasers with solid-state targets has been largely studied for the past 20 years as a future compact proton and ion source.Indeed,the huge potential established on the target surface by the escaping electrons provides accelerating gradients of TV/m.This process,called target normal sheath acceleration,involves a large number of phenomena and is very difficult to study because of the picosecond scale dynamics.At the SPARC LAB Test Facility,the high-power laser FLAME is employed in experiments with solid targets,aiming to study possible correlations between ballistic fast electrons and accelerated protons.In detail,we have installed in the interaction chamber two different diagnostics,each one devoted to characterizing one beam.The first relies on electro-optic sampling,and it has been adopted to completely characterize the ultrafast electron components.On the other hand,a time-of-flight detector,based on chemical-vapour-deposited diamond,has allowed us to retrieve the proton energy spectrum.In this work,we report preliminary studies about simultaneous temporal resolved measurements of both the first forerunner escaping electrons and the accelerated protons for different laser parameters. | Fabrizio Bisesto Mario Galletti Maria Pia Anania Gemma Costa Massimo Ferrario Riccardo Pompili Arie Zigler Fabrizio Consoli Mattia Cipriani Martina Salvadori Claudio Verona | 2020 | High Power Laser Science and Engineering2020，8，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员