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| 1 | Hydroxytryptamine transporter gene-linked polymorphic region(5HTTLPR)is associated with delusions in Alzheimer’s disease显示文摘Background:Serotoninergic pathways underlying delusion symptoms in Alzheimer’s disease(AD)have not been fully clarified.5-Hydroxytryptamine transporter gene-linked polymorphic region(5-HTTLPR)is a variable number tandem repeats in the promoter region of serotonin transporter encoding-gene affecting transcription.Methods:We investigated the association of 5-HTTLPR with delusions in a total of 257 consecutive patients clinically diagnosed as AD according to the National Institute on Aging-Alzheimer’s Association criteria.All participants underwent a comprehensive evaluation with a standardized comprehensive geriatric assessment and Neuropsychiatric Inventory.Results:Delusion symptoms were observed in 171 patients(66.54%).In respect to AD patients without delusions,AD patients with delusions showed a low prevalence of S-plus carriers(5-HTTLPR-L/S+5-HTTLPR-S/S genotypes)[p<0.001;odds ratio(OR)=0.240,95% confidence interval(CI)=0.121–0.471].Logistic regression analysis adjusted for the apolipoprotein E polymorphism showed that in AD patients with delusions the presence of an 5-HTTLPR-S allele may reduce disease duration(p=0.005;OR=0.680,95% CI=0.522–0.886)and increase aberrant motor activity(p=0.013;OR=2.257,95% CI=1.195–4.260).The present findings suggested that 5-HTTLPR might be associated with delusions in AD.S-plus carriers might be associated with protective effect against delusions in AD.Conclusions:More studies on wider samples of high selected demented patients are needed to confirm our results.However,the present findings suggested that a genetic factor related to serotonin metabolism might exert a protective role on the clinical expression of neuropsychiatric clusters in AD with important implications regarding mechanisms underlying delusions and their possible treatment across the AD and dementia spectrum. | Grazia D’Onofrio Francesco Panza Daniele Sancarlo Michele Lauriola Mariangela P.Dagostino Giulia Paroni Madia Lozupone Antonio Mangiacotti Paola Bisceglia Carolina Gravina Maria Urbano Filomena Addante Francesco Paris Leandro Cascavilla Antonio Greco Davide Seripa | 2019 | Translational Neurodegeneration2019，8，1： | 2 |
| 2 | A New Look at Framing Effects: Distribution of Effect Sizes, Individual Differences, and Independence of Types of Effects显示文摘 | Irwin P. Levin Gary J. Gaeth Judy Schreiber Marco Lauriola | 2002 | Organizational Behavior and Human Decision Processes2002，，1： | 2 |
| 3 | Increased cy- clooxygenase - 2 ( COX - 2 ) expression is associated withchemotherapy resistance and outcome in ovarian cancer pa- tients显示文摘 | Ferrandina G Lauriola L Zannoni GF | 2002 | Ann Onco12002，13，8： | 1 |
| 4 | Increased cyelooxygenase-2 expression is associated with chemotherapy resistance and poor survival in cervical cancer patients显示文摘 | Ferrandina G Lauriola L Distefano MG | | 0，，： | 1 |
| 5 | Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling显示文摘 | Pradeep C R Kstler W J Lauriola M | 2012 | Oncogene2012，31，7： | 1 |
| 6 | Increased cyclooxygenase-2(COX-2) expression is associated with chemotherapy resistance and outcome in ovarian cancer patients显示文摘 | Ferrandina G Lauriola L Zannoni GF | 2002 | Ann Oncol2002，13，8： | 1 |
| 7 | Endovascular treatment of inlracranial arterio-venous malformations with Onyx embolizarion: preliminary experience显示文摘 | Florio F Lauriola W Nardella M | 2003 | Radiol Med (Torino)2003，106，56： | 1 |
| 8 | Thymus changes in anti- MuSK-positive and -negative myasthenia gravis 显示文摘 | Lauriola L Ranelletti F Maggiano N | 2005 | Neurology2005，64，3： | 1 |
| 9 | Effect of different growth hormone dosages on the growth velocity in children born small for gestational age显示文摘 | Bozzola E Lauriola S Messina MF | 2004 | Horm Res2004，61，2： | 1 |
| 10 | Spinal epidural angiolipoma complicated by an intratumoral abscess显示文摘 | Petrella G Tamburrini G Lauriola L | 2005 | J Neurosurg2005，103，2： | 1 |
| 11 | Silicon in hair loss:a preliminary SEM microanalysis study显示文摘 | Strumia R Lauriola MM | 2007 | J Eur Acad Dermatol Venereol2007，21，8： | 1 |
| 12 | Sweet’s Syndrome:A Retrospective Clinical,Histopathological and Immunohistochemical Analysis of11Cases显示文摘 | Corazza M Lauriola MM Borghi A | 2008 | Acta Derm Venereol2008，88，6： | 1 |
| 13 | Increased cyclooxygenase-2 expression is associated with chemotherapy resistance and poor survival in cervical cancer patients 显示文摘 | Fetrandina G Lauriola L Distefano MG | 2002 | J Clin Oncol2002，20，： | 1 |
| 14 | The role of personality in positively and negatively framed risky health decisions显示文摘 | Lauriola M Russo P.M Lucidi F Violani C & Levin I.P | | 0，，： | 1 |
| 15 | A new look at framing effects:Distribution of effect sizes,individual differences,and independ ence of types of framing显示文摘 | Levin I P Gaeth G J S chneider S L Lauriola M | 2002 | Organizational Behavior and Human Decision Processes2002，，88： | 1 |
| 16 | Incresed cyclooxygenase-2 expression is associated with chemotherapy resistance and poor survival in cervical cancer patients显示文摘 | Ferrandian G Lauriola L Distefano MG | 2002 | J Clin Oncol2002，20，4： | 1 |
| 17 | Cyclooxygenase-2 expression in lymph node metastasis of cervical and vulvar cancer显示文摘 | Ferrandina G Ranelletti FO Lauriola L | 2003 | Oncol Rep2003，10，6： | 1 |
| 18 | Personality traits and risky decision-making in a controlled experimental task:An exploratory study显示文摘 | Lauriola M Levin I.P | | 0，，： | 1 |
| 19 | A New Look at Framing Effects:Distribution of Effect Sizes Individual Differences and Independence of Types of Effects显示文摘 | Levin I.P Gaeth G.J Schreiber J Lauriola M | | 0，，： | 1 |
| 20 | Neuroendocrine differentiation is a common feature of thymic carcinoma显示文摘 | Lauriola L Erlandson RA Rosai J | 1998 | Am J Surg Pathol1998，22，9： | 1 |
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