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| 1 | Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria显示文摘BACKGROUND Surgical resection and radiofrequency ablation(RFA)represent two possible strategy in treatment of hepatocellular carcinoma(HCC)in Milan criteria.AIM To evaluate short-and long-term outcome in elderly patients(>70 years)with HCC in Milan criteria,which underwent liver resection(LR)or RFA.METHODS The study included 594 patients with HCC in Milan criteria(429 in LR group and 165 in RFA group)managed in 10 European centers.Statistical analysis was performed using the Kaplan-Meier method before and after propensity score matching(PSM)and Cox regression.RESULTS After PSM,we compared 136 patients in the LR group with 136 patients in the RFA group.Overall survival at 1,3,and 5 years was 91%,80%,and 76%in the LR group and 97%,67%,and 41%in the RFA group respectively(P=0.001).Diseasefree survival at 1,3,and 5 years was 84%,60%and 44%for the LR group,and 63%,36%,and 25%for the RFA group(P=0.001).Postoperative Clavien-Dindo IIIIV complications were lower in the RFA group(1%vs 11%,P=0.001)in association with a shorter length of stay(2 d vs 7 d,P=0.001).In multivariate analysis,Model for End-stage Liver Disease(MELD)score(>10)[odds ratio(OR)=1.89],increased value of international normalized ratio(>1.3)(OR=1.60),treatment with radiofrequency(OR=1.46),and multiple nodules(OR=1.19)were independent predictors of a poor overall survival while a high MELD score(>10)(OR=1.51)and radiofrequency(OR=1.37)were independent factors associated with a higher recurrence rate.CONCLUSION Despite a longer length of stay and a higher rate of severe postoperative complications,surgery provided better results in long-term oncological outcomes as compared to ablation in elderly patients(>70 years)with HCC in Milan criteria. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Letizia Laera Francesca Ratti Maximiliano Gelli Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño AntonioRampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 2 | Interpatient heterogeneity in hepatic microvascular blood flow during vascular inflow occlusion (Pringle manoeuvre)显示文摘Hepatic inflow occlusion(Pringle manoeuvre),is a widely used technique,consisting in temporary intermittent or continuous clamping of the hepatic pedicle.This technique was described in 1908 by Pringle to minimize blood loss during emergency surgery for liver trauma.Therefore,in hepatobiliary surgery,the Pringle manoeuvre assumes a primary role especially in complex liver resections where an intraoperative blood loss could be significant.Afterwards. | Eric Felli Edoardo Maria Muttillo Emanuele Felli | 2021 | Hepatobiliary Surgery and Nutrition2021，10，3： | 2 |
| 3 | Experimental analysis of the flow field around a propeller-rudder configuration显示文摘 | FELLI M ROBERTO C | 2009 | Exp Fluids2009，46，： | 1 |
| 4 | CEA versus CAS: short-term and mid-term results显示文摘 | FELLI MM ALUNNO A CASTIGLIONE A | 2012 | Int Angiol2012，31，5： | 1 |
| 5 | Perturbation results of critical elliptic equations of CaffareUi-Kohn-Niren- berg type显示文摘 | VERONICA FELLI MATTHIAS SCHNEIDER | 2003 | Journal of Differential Equations2003，191，1： | 1 |
| 6 | Low dose of acyclovlr may be an effective treatment against pityriasls rosea: a random investiga- tor-blind clinical trial on 64 patients 显示文摘 | Rassai S Felly A Sina N etal | 2011 | J Eur Aead Dermatol Venereol2011，25，1： | 1 |
| 7 | CEA versus CAS: short-term and mid-term results显示文摘 | Felli MM Alunno A Castiglione A | 2012 | Int Angiol2012，31，： | 1 |
| 8 | The inhibitory effect of Hypericum perforatum ex- tract on morphine withdrawal syndrome in rat and comparison with elonidine显示文摘 | Felly A Abbasi N | 2009 | Phytother Res2009，23，11： | 1 |
| 9 | Nursing Workers' Exposure to Chemical Products at a Public Universitary Hospital in Sao Paulo City显示文摘 | Costa T F Felli V E | 2005 | Rev Lat Am Enfermagem2005，13，4： | 1 |
| 10 | Study of Work Accidents Related to Human Body Fluids Exposure among Health Workers at a University Hospital显示文摘 | Balsamo A C Felli V E | 2006 | Rev Lat Am Enfermagem2006，14，3： | 1 |
| 11 | Incomplete written contracts: Undescribable States of nature显示文摘 | Anderlini L Felli L | 1994 | The Quarterly Journal of Economics1994，109，4： | 1 |
| 12 | Should courts always enforce what contracting parties write? 显示文摘 | Anderlini L Felli L Postlewaite A | 2011 | Review of Law Economics2011，7，1： | 1 |
| 13 | On Schrodinger operators with multipolar inverse-square potentials显示文摘 | E MARCHINI TERRACINI S | 2007 | Journal of Functional Analysis2007，250，： | 1 |
| 14 | Costly bargaining and renegotiation显示文摘 | Anderlini L Felli L | 2001 | Econometrica2001，69，2： | 1 |
| 15 | Mechanisms of evolution of the propeller wake in the transition and far fields显示文摘 | FELLI M CAMUSSI R DI FELICE F | 2011 | Journal of Fluid Mechanics2011，682，3： | 1 |
| 16 | Costly bargaining and renegotiation显示文摘 | Anderlini L Felli L | 2001 | Econometrica2001，69，2： | 1 |
| 17 | Notch3 and pre-TCR interaction unveils distinct NF-kappatB pathways in T-cell development and leukemia 显示文摘 | Vacca A Felli MP Palermo R | 2006 | EMBO J2006，25，5： | 1 |
| 18 | Production of aluminumcoated ferritic stainless steel by co-rolling and annealing 显示文摘 | PILONE D FELLI F BERNABA1 U | 2006 | LaMetallurgia Italiana2006，98，78： | 1 |
| 19 | Metabolic hormones regulate insulin-like growth factor binding protein-1 mRNA levels in primary cultured salmon hepatocytes:lack of inhibition by insulin显示文摘 | Pierce A L Shimizu M Felli L | 2006 | J Endocrinol2006，191，2： | 1 |
| 20 | Improving the self- confidence level of medical undergraduates during emer- gencies using high fidelity simulation显示文摘 | Muniandy R K Nyein K K Felly M | 2015 | Med J Malay- sia2015，70，5： | 1 |
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