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| 1 | Disturbance of hepatic and intestinal microcirculation in experimental liver cirrhosis显示文摘AIM: To analyze hepatic, mesenteric and mucosal microcirculation and leukocyte-endothelium interaction (LEI) in a rat model with liver cirrhosis.METHODS: Hepatic cirrhosis was induced in Wistar rats by gavage with carbon tetrachloride, and intravital videomicroscopy was performed in liver, mesentery and small intestine mucosa. Special emphasis is given on microcirculatory and morphometric changes during cirrhotic portal hypertension.RESULTS: LEI was influenced significantly in the cirrhotic liver but not in the gut. Blood flow measurement showed significant differences among liver, main mesenteric vessels and the mucosa. The results of our study indicate that liver cirrhosis leads to alterations in hepatic and mesenteric blood flow but not in mucosal blood flow.CONCLUSION: The enhanced inflammatory response in hepatic microvessels may be caused by a decrease of antithrombin Ⅲ levels and could be responsible for disturbances of organ pathology. | Sasa-Marcel Maksan Eduard Ryschich Zilfi (U|¨)lger Martha Maria Gebhard Jan Schmidt | 2005 | World Journal of Gastroenterology2005，11，6： | 11 |
| 2 | Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection显示文摘 | Nezam Afdhal Stefan Zeuzem Paul Kwo Mario Chojkier Norman Gitlin Massimo Puoti Manuel Romero-Gomez Jean-Pierre Zarski Kosh Agarwal Peter Buggisch Graham R. Foster Norbert Br?u Maria Buti Ira M. Jacobson G. Mani Subramanian Xiao Ding Hongmei Mo Jenny C. Ya | 2014 | The New England Journal of Medicine2014，，： | 6 |
| 3 | Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy显示文摘AIM: To evaluate the impact of hepatitis C virus (HCV) infection with genotype 1 or 3 and the presence or absence of liver cirrhosis (LC) in the early viral kinetics response to treatment. METHODS: Naive patients (n = 46) treated with interferon-α (IFN-α) and ribavirin and followed up with frequent early HCV-RNA determinations were analysed. Patients were infected with genotype 1 (n = 28, 7 with LC) or 3 (n = 18, 5 with LC). RESULTS: The fi rst phase decline was larger in geno- type 3 patients than in genotype 1 patients (1.72 vs 0.95 log IU/mL, P < 0.001). The second phase slope decline was also larger in genotype 3 patients than in genotype 1 patients (0.87 vs 0.15 log/wk, P < 0.001). Differences were found in both cirrhotic and non-cirrhotic patients. Genotype 1 cirrhotic patients had a slower 2nd phase slope than non-cirrhotic patients (0.06 vs 0.18 log/wk, P < 0.02). None of genotype 1 cirrhotic patients had a 1st phase decline larger than 1 log (non-cirrhotic patients: 55%, P < 0.02). A similar trend toward a slower 2nd phase slope was observed in genotype 3 cirrhotic pa- tients but the 1st phase slope decline was not different. Sustained viral response was higher in genotype 3 pa- tients than in genotype 1 patients (72% vs 14%, P < 0.001) and in genotype 1 non-cirrhotic patients than in genotype 1 cirrhotic patients (19% vs 0%). A secondphase decline slower than 0.3 log/wk was predictive of non-response in all groups. CONCLUSION: Genotype 3 has faster early viral decline than genotype 1. Cirrhosis correlates with a slower 2nd phase decline and possibly with a lower 1st phase slope decline in genotype 1 patients. | José Eymard Medeiros-Filho Isabel Maria Vicente Guedes de Carvalho Mello Joo Renato Rebello Pinho Avidan U Neumann Fernanda de Mello Malta Luiz Caetano da Silva Flair José Carrilho | 2006 | World Journal of Gastroenterology2006，12，45： | 3 |
| 4 | Evolution of plasma parameters in an Ar-N2/He inductive plasma source with magnetic pole enhancement显示文摘Magnetic pole enhanced inductively coupled plasmas(MaPE-ICPs) are a promising source for plasma-based etching and have a wide range of material processing appUcations.In the present study Langmuir probe and optical emission spectroscopy were used to monitor the evolution of plasma parameters in a MaPE-ICP Ar-N_2/He mixture plasma.Electron density(n_e) and temperature(T_e),excitation temperature(T_(exc)),plasma potential(V_p),skin depth(δ) and the evolution of the electron energy probability function(EEPF) are reported as a function of radiofrequency(RF) power,pressure and argon concentration in the mixture.It is observed that n_e increases while T_e decreases with increase in RF power and argon concentration in the mixture.The emission intensity of the argon line at 750.4 nm is also used to monitor the variation of the 'high-energy tail' of the EEPF with RF power and gas pressure.The EEPF has a'bi-Maxwellian' distribution at low RF powers and higher pressure in a pure N_2 discharge.However,it evolves into a 'Maxwellian' distribution at RF powers greater than 70 W for pure N_2,and at 50 W for higher argon concentrations in the mixture.The effect of argon concentration on the temperatures of two electron groups in the 'bi-Maxwellian' EEPF is examined.The temperature of the low-energy electron group T_L shows a decreasing trend with argon addition until the 'thermalization' of the two temperatures occurs,while the temperature of high-energy electrons T_H decreases continuously. | Maria YOUNUS N U REHMAN M SHAFIQ M NAEEM M ZAKA-UL-ISLAM M ZAKAULLAH | 2017 | Plasma Science and Technology2017，19，2： | 2 |
| 5 | Screening and identification of neuroprotective compounds relevant to Alzheimer?s disease from medicinal plants of S. Tomé e Príncipe显示文摘 | Antonio Currais Chandramouli Chiruta Marie Goujon-Svrzic Gustavo Costa Tania Santos Maria Teresa Batista Jorge Paiva Maria do Céu Madureira Pamela Maher | 2014 | Journal of Ethnopharmacology2014，，： | 2 |
| 6 | Alzueta, Angela Millera, Experimental study of the influence of the operating variables on natural gas reburning efficiency显示文摘 | Rofael Bilbao Maria U | 1995 | American Chemical Society1995，34，： | 1 |
| 7 | Simplified kinetic model of the chemistry in the reburning zone using natural gas显示文摘 | Bilbao Rafael Alzueta Maria U Millera Angela | 1995 | Ind Eng Chem Res1995，34，： | 1 |
| 8 | Comparative antioxidant and cytotoxic effects of lignins from different sources 显示文摘 | Vanessa U Montserrat M Maria P V | 2008 | Bioresource Technology2008，99，14： | 1 |
| 9 | Environment,tourism and land use planning-Riachinho Basin,Brazil显示文摘 | Maria G P Leila N M V Alexandre U | 2001 | Environmental Management and Health2001，12，1： | 1 |
| 10 | Severe obesity in haemo dialysis: the utility of bioimpedance vector analysis显示文摘 | Maria F Giorgio M Michele U | 2001 | Nephrol Dial Transplant2001，16，： | 1 |
| 11 | Sulfite residues on litchi fruit treated with sulfur dioxide显示文摘 | Robert E Paull Maria Eloisa Q Reyes Marcelino U Reyes | 1998 | Postharvest Biology and Technology1998，14，： | 1 |
| 12 | Geographic distribution of vacA allelic types of Helicobacter pylori显示文摘 | Leen–Jan Van Doorn Céu Figueiredo Francis Mégraud Salvador Pena Peter Midolo Dulciene Maria De Magalh?es Queiroz Fátima Carneiro Bart Vanderborght Maria Da Glória F. Pegado Ricardo Sanna Wink De Boer Peter M. Schneeberger Pelayo Correa Enders K.W. Ng John | 1999 | Gastroenterology1999，，4： | 1 |
| 13 | Use of plasma spraying in the manufacture of continuously graded and layered/graded molybdenum disilicide/alumina composites 显示文摘 | Vaidya Rajendra U Castro Richard G Peters Maria I | 2002 | Journal of Thermal Spray Technology2002，11，3： | 1 |
| 14 | Presentation and outcome of hepatocellular carcinoma in HIV-infected patients: A U.S.–Canadian multicenter study显示文摘 | Norbert Br?u Rena K. Fox Peiying Xiao Kristen Marks Zeenat Naqvi Lynn E. Taylor Anita Trikha Morris Sherman Mark S. Sulkowski Douglas T. Dieterich Michael O. Rigsby Teresa L. Wright Maria D. Hernandez Mamta K. Jain Gajendra K. Khatri Richard K. Sterling M | 2007 | Journal of Hepatology2007，，4： | 1 |
| 15 | E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions显示文摘 | Patrícia Carneiro Maria Sofia Fernandes Joana Figueiredo Joana Caldeira Joana Carvalho Hugo Pinheiro Marina Leite Soraia Melo Patrícia Oliveira Joana Sim?es-Correia Maria José Oliveira Fátima Carneiro Céu Figueiredo Joana Paredes Carla Oliveira Raquel Ser | 2012 | FEBS Letters2012，，18： | 1 |
| 16 | Pendular, funi- cular, and capillary bridges: results for two dimen- sions显示文摘 | Maria E D U Chris J L Michael J A | 1999 | Journal of Colloid and Interface Science1999，220，： | 1 |
| 17 | A two dimen- sional study of the rupture of funicular liquid bridges 显示文摘 | Maria E D U Chris J L Michael J A | 2002 | Chemical Engineering Science2002，57，： | 1 |
| 18 | High pressure phase equilibrium and PVT-data of the water-oxygen system including water-air to 673 K and 250 MPa显示文摘 | Japas Maria L Franck E U | 1985 | Berichte der Bunsengesellschaft für Physikalische Chemie1985，89，12： | 1 |
| 19 | Low temperature interactions between hydrocarbons and nitric oxide: an experimental study显示文摘 | MARIA U ALZUETA PETER GLARBORG KIM DAM JOHANSEN | 1997 | Combustion and Flame1997，109，1： | 1 |
| 20 | Asymmetric reduction of (4R)-(-)-carvone catalyzed by baker's yeast in aqueous mono- and biphasic systems显示文摘 | VANESSA D S BORIS U S MARIA DA G N | 2012 | J Mol Catal B Enzym2012，77，： | 1 |
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