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| 1 | Pathogenesis and clinical management of Helicobacter pylori gastric infection显示文摘Helicobacter pylori(H.pylori)is a gram-negative bacterium that infects approximately 4.4 billion individuals worldwide.However,its prevalence varies among different geographic areas,and is influenced by several factors.The infection can be acquired by means of oral-oral or fecal-oral transmission,and the pathogen possesses various mechanisms that improve its capacity of mobility,adherence and manipulation of the gastric microenvironment,making possible the colonization of an organ with a highly acidic lumen.In addition,H.pylori presents a large variety of virulence factors that improve its pathogenicity,of which we highlight cytotoxin associated antigen A,vacuolating cytotoxin,duodenal ulcer promoting gene A protein,outer inflammatory protein and gamma-glutamyl transpeptidase.The host immune system,mainly by means of a Th1-polarized response,also plays a crucial role in the infection course.Although most H.pylori-positive individuals remain asymptomatic,the infection predisposes the development of various clinical conditions as peptic ulcers,gastric adenocarcinomas and mucosa-associated lymphoid tissue lymphomas.Invasive and non-invasive diagnostic methods,each of them with their related advantages and limitations,have been applied in H.pylori detection.Moreover,bacterial resistance to antimicrobial therapy is a major challenge in the treatment of this infection,and new therapy alternatives are being tested to improve H.pylori eradication.Last but not least,the development of effective vaccines against H.pylori infection have been the aim of several research studies. | Breno Bittencourt de Brito Filipe Ant?nio Fran?a da Silva Aline Silva Soares Vinícius Afonso Pereira Maria Luísa Cordeiro Santos Mariana Miranda Sampaio Pedro Henrique Moreira Neves Fabrício Freire de Melo | 2019 | World Journal of Gastroenterology2019，25，37： | 84 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Nephrotoxicity in cancer treatment:An overview显示文摘Anticancer drug nephrotoxicity is an important and increasing adverse drug event that limits the efficacy of cancer treatment.The kidney is an important elimination pathway for many antineoplastic drugs and their metabolites,which occurs by glomerular filtration and tubular secretion.Chemotherapeutic agents,both conventional cytotoxic agents and molecularly targeted agents,can affect any segment of the nephron including its microvasculature,leading to many clinical manifestations such as proteinuria,hypertension,electrolyte disturbances,glomerulopathy,acute and chronic interstitial nephritis,acute kidney injury and at times chronic kidney disease.The clinician should be alert to recognize several factors that may maximize renal dysfunction and contribute to the increased incidence of nephrotoxicity associated with these drugs,such as intravascular volume depletion,the associated use of nonchemotherapeutic nephrotoxic drugs(analgesics,antibiotics,proton pump inhibitors,and bonetargeted therapies),radiographic ionic contrast media or radiation therapy,urinary tract obstruction,and intrinsic renal disease.Identification of patients at higher risk for nephrotoxicity may allow the prevention or at least reduction in the development and severity of this adverse effect.Therefore,the aim of this brief review is to provide currently available evidences on oncologic drug-related nephrotoxicity. | Maria Luísa Cordeiro Santos Breno Bittencourt de Brito Filipe Antonio FranÇa da Silva Anelise Costa dos Santos Botelho Fabrício Freire de Melo | 2020 | World Journal of Clinical Oncology2020，11，4： | 4 |
| 4 | Analysis of foundation sliding of an arch dam considering the hydromechanical behavior显示文摘This paper presents the application of a methodology which can be used to assess arch dam foundation stability,using the discrete element method(DEM)and the code 3DEC.A global three-dimensional model of a dam foundation was developed,in which some discontinuities were simulated and both the grout and drainage curtains were represented.The model,calibrated taking into account recorded data,was used to carry out nonlinear mechanical analysis.The same model was employed to perform a hydraulic analysis,based on equivalent continuum concepts,which allowed the water pressure pattern within the foundation to be obtained.These water pressures were applied on discontinuities involved in the possible sliding mechanism along the dam/foundation interface,and the safety of the dam/foundation system was evaluated using a process of reduction of strength characteristics,with the aim of calculating the minimum safety factors that ensure stability.Results were compared with those obtained with the usual bi-linear uplift pressure distribution at the base of the dam,commonly used in concrete dam design.The relevance of carrying out hydraulic analysis in arch dam foundation failure studies is highlighted. | Maria Luísa Braga FARINHA JoséVieira de LEMOS Emanuel MARANHA DAS NEVES | 2012 | Frontiers of Structural and Civil Engineering2012，6，1： | 4 |
| 5 | Immunotherapy – new perspective in lung cancer显示文摘Lung carcinoma is associated with a high mortality worldwide,being the leading cause of cancer death.It is mainly classified into squamous non-small cell lung cancer(NSCLC),non-squamous NSCLC,and small cell lung cancer.However,such malignancy has been increasingly subdivided into histological and molecular subtypes to guide treatment.Therapies can be used in adjuvant and palliative settings.Regarding immunotherapy,it has been widely tested in both first or subsequent palliative lines.In this sense,drugs such as pembrolizumab,nivolumab,atezolizumab,ipilimumab,avelumab,and durvalumab have been assessed in large studies.Some of these trials have also studied these medicines in adjuvant and in maintenance therapy.In recent years,advances in immunotherapy have raised the hope that the unfavorable prognosis observed in several affected individuals can be changed.Immunotherapy has increased the overall survival in squamous NSCLC,non-squamous NSCLC,and small cell lung cancer.However,it has added to the oncology practice some side effects that are unusual in standard chemotherapy and require special clinical support.In order to show how immunotherapy is being applied in the treatment of lung carcinoma,we reviewed the main studies in adjuvant and palliative scenarios.What is the better scheme?What is the better combination?What is the better dose?When should we use immunotherapy?Does programmed cell death ligand 1 expression significantly interfere in immunotherapy efficiency?Some of these questions have already been answered,while others require more investigations. | Fillipe Dantas Pinheiro Adriano Fernandes Teixeira Breno Bittencourt de Brito Filipe Antonio Franca da Silva Maria Luísa Cordeiro Santos Fabrício Freire de Melo | 2020 | World Journal of Clinical Oncology2020，11，5： | 3 |
| 6 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 7 | Helicobacter pylori infection:How does age influence the inflammatory pattern?显示文摘The inflammatory pattern during Helicobacter pylori(H.pylori)infection is changeable and complex.During childhood,it is possible to observe a predominantly regulatory response,evidenced by high concentrations of key cytokines for the maintenance of Treg responses such as TGF-β1 and IL-10,in addition to high expression of the transcription factor FOXP3.On the other hand,there is a predominance of cytokines associated with the Th1 and Th17 responses among H.pylori-positive adults.In the last few years,the participation of the Th17 response in the gastric inflammation against H.pylori infection has been highlighted due to the high levels of TGF-β1 and IL-17 found in this infectious scenario,and growing evidence has supported a close relationship between this immune response profile and unfavorable outcomes related to the infection.Moreover,this cytokine profile might play a pivotal role in the effectiveness of anti-H.pylori vaccines.It is evident that age is one of the main factors influencing the gastric inflammatory pattern during the infection with H.pylori,and understanding the immune response against the bacterium can assist in the development of alternative prophylactic and therapeutic strategies against the infection as well as in the comprehension of the pathogenesis of the outcomes related to that microorganism. | Glauber Rocha Lima Araújo Hanna Santos Marques Maria Luísa Cordeiro Santos Filipe Antônio França daSilva Breno Bittencourt da Brito Gabriel Lima Correa Santos Fabrício Freire de Melo | 2022 | World Journal of Gastroenterology2022，28，4： | 2 |
| 8 | High-precision geochronology of Mesozoic magmatism in Macao,Southeast China:Evidence for multistage granite emplacement显示文摘Six new high precision U-Pb zircon ID-TIMS ages plus thirteen in situ high spatial resolution U-Pb zircon LA-MC-ICPMS ages are reported from Jurassic plutonic(metaluminous to weakly peraluminous biotite granites)and Jurassic to Cretaceous hypabyssal(dacites)rocks from Macao.Despite its relatively small area(~30 km^2),the new ages tightly constrain the Macao granitic magmatism to two periods ranging from 164.5±0.6 Ma to 162.9±0.7 Ma and 156.6±0.2 Ma to 155.5±0.8 Ma,separated by ca.6 Ma.Inherited zircons point to the existence of a basement with ages up to Paleo-Proterozoic and late Archean in the region.In addition,younger dacitic rocks were dated at 150.6±0.6 Ma and<120 Ma.U-Pb zircon ages and whole-rock REE data of Macao granites indicate that the first pulse is also represented in Hong Kong and Southeast(SE)China,while magmatism with the chemical characteristics of the second pulse seems to not be represented outside Macao.The two granitic magmatic pulses have distinct mineralogical and geochemical features that support their discrete nature rather than a continuum of comagmatic activity and suggest that the Macao granitic suite was incrementally assembled during a period of ca.9 Ma,a hypothesis also extendable to the neighboring Hong Kong region for a time lapse of ca.24 Ma.In Macao,the transition from granitic magmatism(Middle to Upper Jurassic)to the younger dacite dykes(Upper Jurassic to Lower Cretaceous)most likely corresponds to a change in the regional tectonic setting,from an extensional regime related with foundering of the subducting paleoPacific plate during the Early Yanshanian period to the reestablishment of a normal subduction system in SE China during the Late Yanshanian period. | Pedro Quelhas Agata Alveirinho Dias Joao Mata Donald Wayne Davis Maria Luísa Ribeiro | 2020 | Geoscience Frontiers2020，11，1： | 2 |
| 9 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 10 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 11 | S-adenosyl-methionine decreases ethanol-induced apoptosis in primary hepatocyte cultures by a c-Jun N-terminal kinase activity-independent mechanism显示文摘AIM:To determine the role of c-Jun N-terminal kinase(JNK)activity in ethanol-induced apoptosis and themodulation of this signaling cascade by S-Adenosyl-methionine(AdoMet).METHODS:Primary hepatocyte cultures werepretreated with 100 μmol/L SP600125,a selective JNKinhibitor,1 mL/L DMSO or 4 mmol/L AdoMet and thenexposed to 100 mmo/L ethanol.Hepatocyte apoptosiswas determined by the TUNEL and DNA ladder assays.JNK activity and its inhibition by SP600125 and AdoMetwere determined by Western blot analysis of c-junphosphorylation and Bid fragmentation.SP600125 andAdoMet effects on the apoptotic signaling pathway weredetermined by Western blot analysis of cytochrome crelease and pro-caspase 3 fragmentation.The AdoMeteffect on glutathione levels was measured by Ellman'smethod and reactive oxygen species(ROS)generationby cell cytometry.RESULTS:The exposure of hepatocytes to ethanolinduced JNK activation,c-jun phosphorylation,Bidfragmentation,cytochrome c release and pro-caspase 3cleavage;these effects were diminished by SP600125,and caused a significant decrease in ethanol-inducedapoptosis(P<0.05).AdoMet exerted an antioxidanteffect maintaining glutathione levels and decreasing ROSgeneration,without a significant effect on JNK activity,and prevented cytochrome c release and pro-caspase 3cleavage. CONCLUSION:The JNK signaling cascade is a keycomponent of the proapoptotic signaling pathwayinduced by ethanol.JNK activation may be independentfrom ROS generation,since AdoMet which exertedantioxidant properties did not have a significant effect onJNK activity.JNK pathway modulator agents and AdoMetmay be components of promising therapies for alcoholicliver disease(ALD)treatment. | Maria del Pilar Cabrales-Romero Lucrecia Márquez-Rosado Samia FatteI-Fazenda Cristina Trejo-Solis Evelia Arce-Popoca Leticia Alemán-Lazarini Saúl Villa-Trevineo | 2006 | World Journal of Gastroenterology2006，12，12： | 2 |
| 12 | Donepezil: An Important Prototype to the Design of New Drug Candidates for Alzheimerμs Disease显示文摘 | Maria Cecilia Rodrigues Simoes Flavia Pereira Dias Viegas Marcella Soares Moreira Matheus de Freitas Silva Mariana Maximo Riquiel Patricia Mattos da Rosa Maísa Rosa Castelli Marcelo Henrique dos Santos Marisi Gomes Soares Claudio Viegas | 2014 | Mini-Reviews in Medicinal Chemistry2014，，1： | 1 |
| 13 | Synthesis of polyhydroxyalkanoates from different short-chain fatty acids by mixed cultures submitted to aerobic dynamic feeding显示文摘 | Paulo C. Lemos Luísa S. Serafim Maria A.M. Reis | 2005 | Journal of Biotechnology2005，，2： | 1 |
| 14 | Immune response to Helicobacter pylori infection and gastric cancer development显示文摘Gastric adenocarcinoma is a global health concern,and Helicobacter pylori(H.pylori)infection is the main risk factor for its occurrence.Of note,the immune response against the pathogen seems to be a determining factor for gastric oncogenesis,and increasing evidence have emphasized several host and bacterium factors that probably influence in this setting.The development of an inflammatory process against H.pylori involves a wide range of mechanisms such as the activation of pattern recognition receptors and intracellular pathways resulting in the production of proinflammatory cytokines by gastric epithelial cells.This process culminates in the establishment of distinct immune response profiles that result from the cytokine-induced differentiation of T naïve cells into specific T helper cells.Cytokines released from each type of T helper cell orchestrate the immune system and interfere in the development of gastric cancer in idiosyncratic ways.Moreover,variants in genes such as single nucleotide polymorphisms have been associated with variable predispositions for the occurrence of gastric malignancy because they influence both the intensity of gene expression and the affinity of the resultant molecule with its receptor.In addition,various repercussions related to some H.pylori virulence factors seem to substantially influence the host immune response against the infection,and many of them have been associated with gastric tumorigenesis. | Breno Bittencourt de Brito Fabian Fellipe Bueno Lemos Caroline da Mota Carneiro Andressa Santos Viana Nilo Manoel Pereira Vieira Barreto Gabriela Alves de Souza Assis Barbara Dicarlo Costa Braga Maria Luísa Cordeiro Santos Filipe Antônio França da Silva Hanna Santos Marques Natália Oliveira e Silva Fabrício Freire de Melo | 2021 | World Journal of Meta-Analysis2021，9，3： | 1 |
| 15 | Fibrosis and heart failure 显示文摘 | Maria SA Frazier OH Maximilian BL | 2014 | Heart Fail Rev2014，19，2： | 1 |
| 16 | Effect of the adhesive application mode and fiber post translucency on the push-- out bond strength to dentin 显示文摘 | Luis A Sa D Maria G etal | 2007 | J Endodont2007，33，9： | 1 |
| 17 | Optimum Zinc supplementation level in Nile tilapia Oreochromis niloticus juveniles diets 显示文摘 | Marcelo Viniciuss do Carmoe Sa Luiz Edivaldo Pezzato Margarida Maria Barros Ferreira Lima | 2004 | Aquaculture2004，238，： | 1 |
| 18 | Molecular identification of nontuberculous mycobacteria isolates in a Brazilian mycobacteria reference laboratory显示文摘 | Ana Roberta Fusco da Costa Maria Luiza Lopes Ismari Perini Furlaneto Maísa Silva de Sousa Karla Valéria Batista Lima | 2010 | Diagnostic Microbiology & Infectious Disease2010，，4： | 1 |
| 19 | The prevalence of peripheral arterial disease in a racially diverse population显示文摘 | Tracie C Nance J Maria SA | 2003 | Arch Intern Med2003，163，12： | 1 |
| 20 | Calorimetric study of the interactions between small-molecule surfactants and sodium caseinate with reference to the foaming ability of their binary mixtures 显示文摘 | Michael M Maria SA Anokhina MG | 2005 | Food Hydrocolloids2005，19，： | 1 |
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