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| 1 | Hemobilia as the initial manifestation of cholangiocarcinoma in a hemophilia B patient显示文摘Hemobilia is a rare manifestation of hemophilia and is usually iatrogenic following liver biopsy. There are only few reports of spontaneous hemobilia in hemophilia patients. Cholangiocarcinoma is a well-established cause of hemobilia. We describe a case of a 70-year-old male, with known haemophilia B and a past history of papillotomy, who presented with classical symptoms of hemobilia. The initial diagnostic work-up failed to demonstrate a potential cause of bleeding other than the coagulopathy. Three months later, he was readmitted to our hospital with a second episode of hemobilia. During the second work-up, a cholangiocarcinoma was diagnosed both by imaging studies and by a significant elevation of cancer antigen 19-9. Although hemobilia could be attributed to hemophilia, especially in a patient with previous papillotomy, an underlying malignancy of the biliary tree should be suspected. | Anastassios C Manolakis Andreas N Kapsoritakis Antonis D Tsikouras Fotis D Tsiopoulos Athanassios K Psychos Spyros P Potamianos | 2008 | World Journal of Gastroenterology2008，14，26： | 5 |
| 2 | Malakoplakia of the colon associated with colonic adenocarcinoma diagnosed in colonic biopsies显示文摘Malakoplakia, typically involving the urinary tract, is an uncommon form of chronic in? ammation caused by chronic infections and characterized by accumulation of macrophages. It has also been found in many other sites such as the gastrointestinal tract, pancreas, liver, lymph nodes, skin, respiratory tract, adrenal gland, vagina and brain. We present a case of a 64-year-old man referred to our hospital with cachexia and radiologic evidence of metastatic tumor of the liver. Colonoscopy revealed a large malignant - appearing polypoid mass of the ascending colon and multiple distinct polyps throughout the rest of the colon. Biopsies of the ascending colon mass confirmed the diagnosis of adenocarcinoma. Histological examination of two of the other polyps revealed malakoplakia which was characterized by aggregates of granular histiocytes with Michaelis - Gutmann bodies and histochemically confirmed with periodic acid-Schiff and von Kossa stains. This is a rare case diagnosed on endoscopic samples. The majority of reported cases were found in surgical specimens. In addition, the endoscopic appearance of multiple polyps is unusual in malakoplakia. | F Karasavvidou SP Potamianos S Barbanis E Stathakis A Psychos AN Kapsoritakis G Koukoulis | 2007 | World Journal of Gastroenterology2007，13，45： | 2 |
| 3 | Melena:A rare complication of duodenal metastases from primary carcinoma of the lung显示文摘Small bowel metastases from primary carcinoma of the lung are very uncommon and occur usually in patients with terminal stage disease. These metastases are usually asymptomatic, but may present as perforation, obstruction, malabsorption, or hemorrhage. Hemorrhage as a first presentation of small bowel metastases is extremely rare and is related to very poor patient survival. We describe a case of a 61- year old patient with primary adenocarcinoma of the lung, presenting with melena as the first manifestation of small bowel metastasis. Both primary tumor and metastatic lesions were diagnosed almost simultaneously. Upper gastrointestinal endoscopy performed with a colonoscope revealed active bleeding from a metastatic tumor involving the duodenum and the proximal jejunum. Histological examination and immunohistochemical staining of the biopsy specimen strongly supported the diagnosis of metastatic lung adenocarcinoma, suggesting that small bowel metastases from primary carcinoma of the lung occur usually in patients with terminal disease and rarely produce symptoms. Gastrointestinal bleeding from metastatic small intestinal lesions should be included in the differential diagnosis of gastrointestinal blood loss in a patient with a known bronchogenic tumor. | Chrysoula Kostakou Lubna Khaldi Andrew Flossos Andreas N Kapsoritakis Spiros P Potamianos | 2007 | World Journal of Gastroenterology2007，13，8： | 2 |
| 4 | Mean platelet volume: a useful marker of inflammatory bowel disease activity显示文摘 | Andreas N Kapsoritakis Michael I Koukourakis Aekaterini Sfiridaki Spiros P Potamianos Maria G Kosmadaki Ioannis E Koutroubakis Elias A Kouroumalis | 2001 | The American Journal of Gastroenterology2001，，3： | 2 |
| 5 | Laparoendoscopic Rendezvous Versus Preoperative ERCP and Laparoscopic Cholecystectomy for the Management of Cholecysto-Choledocholithiasis: Interim Analysis of a Controlled Randomized Trial显示文摘 | George Tzovaras Ioannis Baloyiannis Eleni Zachari Dimitris Symeonidis Dimitris Zacharoulis Andreas Kapsoritakis George Paroutoglou Spyros Potamianos | 2012 | Annals of Surgery2012，，3： | 2 |
| 6 | Role of autophagy in gastric carcinogenesis显示文摘Gastric cancer represents a common and highly fatal malignancy,and thus a pathophysiology-based reconsideration is necessary,given the absence of efficient therapeutic regimens.In this regard,emerging data reveal a significant role of autophagy in gastric oncogenesis,progression,metastasis and chemoresistance.Although autophagy comprises a normal primordial process,ensuring cellular homeostasis under energy depletion and stress conditions,alterations at any stage of the complex regulatory system could stimulate a tumorigenic and promoting cascade.Among others,Helicobacter pylori infection induces a variety of signaling molecules modifying autophagy,during acute infection or after chronic autophagy degeneration.Subsequently,defective autophagy allows malignant transformation and upon cancer establishment,an overactive autophagy is stimulated.This overexpressed autophagy provides energy supplies and resistance mechanisms to gastric cancer cells against hosts defenses and anticancer treatment.This review interprets the implicated autophagic pathways in normal cells and in gastric cancer to illuminate the potential preventive,therapeutic and prognostic benefits of understanding and intervening autophagy. | Apostolis Papaefthymiou Gregory Christodoulidis Apostolos Koffas Michael Doulberis Stergios A Polyzos Anastasios Manolakis Spyros Potamianos Andreas Kapsoritakis Jannis Kountouras | 2021 | World Journal of Gastrointestinal Oncology2021，13，10： | 2 |
| 7 | Mean platelet volume : a useful maker of inflammatory bowel disease activity 显示文摘 | Kapsoritakis AN Koukourakis MI Sfiridaki A | 2001 | Am J Gastroentero12001，96，： | 1 |
| 8 | Laparoendoscopic rendezvous:An effective alternative to a failed preoperative ERCP in patients with cholecystocholedocholithiasis显示文摘 | Tzovaras G Baloyiannis I Kapsoritakis A | | 0，，10： | 1 |
| 9 | An epidemiological study of acute upper gastrointestinal bleeding in Crete,Greece显示文摘 | Paspatis GA Matrella E Kapsoritakis A | 2000 | Eur J Gastroenterol Hepatol2000，12，11： | 1 |
| 10 | Mean platelet volume a useful marker of inflammatory bowel disease activity显示文摘 | Kapsoritakis AN Koukourakis MI Sfiridaki A | 2001 | Am J Gastroe tevo12001，96，3： | 1 |
| 11 | Increased fetuin A levels in Helicobacter pylori infection: a missing link between H. pylori and insulin resistance?显示文摘 | A. C. Manolakis E. K. Tiaka A. N. Kapsoritakis P. Georgoulias F. Tsiopoulos V. Valotassiou S. P. Potamianos | 2011 | Diabetologia2011，，2： | 1 |
| 12 | Mean platelet volume:a useful marker of iuflammatory bowel disease activity显示文摘 | Kapsoritakis AN Koukourakis MI Sfiridaki A | | 0，，03： | 1 |
| 13 | Mean platelet volume: a useful marker of inflammatory bowel disease activity显示文摘 | Kapsoritakis AN Koukourakis MI Sfiridaki A | 2001 | Am J Gastroenterol2001，96，3： | 1 |
| 14 | α2-Heremans-schmid glycoprotein(fetuin A)downregulation and its utility in inflammatory bowel disease显示文摘AIM To investigate the impact of inflammatory bowel disease (IBD) on α2-Heremans-Schmid Glycoprotein(AHSG/fetuin A) and potential associations with disease and patient characteristics.METHODS AHSG serum levels were determined in treatment-na?ve newly-diagnosed patients, 96 with ulcerative colitis(UC), 84 with Crohn's disease (CD), 62 with diarrheapredominant or mixed irritable bowel syndrome (IBS, D- and M- types) and 180 healthy controls (HC), by an enzyme linked immunosorbent assay (ELISA).All patients were followed for a minimum period of 3 years at the Gastroenterology Department of the University Hospital of Larissa, Greece. C-reactive protein(CRP), anti-glycan antibodies, anti-Saccharomyces cerevisiae mannan antibodies Ig G, anti-mannobioside carbohydrate antibodies Ig G, anti-laminariobioside carbohydrate antibodies Ig G and anti-chitobioside carbohydrate antibodies Ig A were also determined via immunonephelometry and ELISA, respectively.RESULTS The mean ± SE of serum AHSG, following adjustment for confounders, was 0.32 ± 0.02 g/L in IBD, 0.32 ± 0.03 g/L in CD and 0.34 ± 0.03 g/L in UC patients, significantly lower than in IBS patients(0.7 ± 0.018 g/L) and HC (0.71 ± 0.02 g/L) (P < 0.0001, in all cases). AHSG levels were comparable between the CD and UC groups. Based on AHSG levels IBD patients could be distinguished from HC with about 90% sensitivity and specificity. Further adjusted analysis verified the inverse association between AHSG and penetrating, as well as stricturing CD (partial correlation coefficient: -0.45 and -0.33, respectively) (P < 0.05). After adjusting for confounding factors, inverse correlations between AHSG and CRP and the need for anti-TNFα therapy or surgery, were found (partial correlation coefficients:-0.31,-0.33,-0.41, respectively, P < 0.05, in all cases). Finally, IBD individuals who were seropositive, for at least one marker, had AHSG levels falling within the two lower quartiles (OR = 2.86, 95%CI: 1.5-5.44, P < 0.001) while those with at least two serological markers positive exhibited AHSG concentrations within the lowest quartile (OR = 5.03, 95%CI: 2.07-12.21, P < 0.001), after adjusting for age, sex and smoking.CONCLUSION AHSG can be used to distinguish between IBD and IBS patients or HC while at the same time 'predicting' complicated disease behavior, need for therapy escalation and surgery. Moreover, AHSG may offer new insights into the pathogenesis of IBD, since it is involved in key processes. | Anastassios C Manolakis Gregory Christodoulidis Andreas N Kapsoritakis Panagiotis Georgoulias Elisavet K Tiaka Kostas Oikonomou Varvara J Spyros P Potamianos | 2017 | World Journal of Gastroenterology2017，23，3： | 1 |
| 15 | Mean platelet volume: a useful marker of inflammatory bowel disease activity 显示文摘 | Kapsoritakis AN Koukourakis MI Sfiridaki A | 2001 | Am J Gastroenterol2001，96，3： | 1 |
| 16 | Readressing the Role of Toll - Like Receptor - 4 Alleles in Inflammatory Bowel Disease: Colitis, Smoking, and Seroreactivity显示文摘 | Anastassios C. Manolakis Andreas N. Kapsoritakis Anastasia Kapsoritaki Elisavet K. Tiaka Konstantinos A. Oikonomou Vassilis Lotis Dimitra Vamvakopoulou Ioanna Davidi Nikolaos Vamvakopoulos Spyros P. Potamianos | 2013 | Digestive Diseases and Sciences2013，，2： | 1 |
| 17 | Mean platelet volume: a useful marker of inflammatory bowel disease activity显示文摘 | Kapsoritakis AN Koukourakis MI Sfiridaki A | 2001 | Am J Gastroenterol2001，96，3： | 1 |
| 18 | Moder- ate performance of serum S100A12, in distinguishing inflammatory bowel disease from irritable bowel syndrome 显示文摘 | Manolakis AC Kapsoritakis AN Georgoulias P | 2010 | BMC Gastroenterology2010，10，： | 1 |
| 19 | Moderate performance of serum S100A12,in distinguishing inflammatory bowel disease from irritable bowel syndrome显示文摘 | Manolakis AC Kapsoritakis AN Georgoulias P | 2010 | BMC Gastroenterol2010，10，： | 1 |
| 20 | Mean platelet volume: a useful marker of inflammatory bowel disease activity显示文摘 | Kapsoritakis AN Koukourakis MI Sfiridaki A | 2001 | Am J Gastroenterol2001，96，： | 1 |
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