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| 1 | Goal-directed therapy in intraoperative fluid and hemodynamic management显示文摘Intraoperative fluid management is pivotal to the outcome and success of surgery,especially in high-risk procedures.Empirical formula and invasive static monitoring have been traditionally used to guide intraoperative fluid management and assess volume status.With the awareness of the potential complications of invasive procedures and the poor reliability of these methods as indicators of volume status,we present a case scenario of a patient who underwent major abdominal surgery as an example to discuss how the use of minimally invasive dynamic monitoring may guide intraoperative fluid therapy. | Maria Cristina Gutierrez Peter G.Moore Hong Liu | 2013 | The Journal of Biomedical Research2013，27，5： | 7 |
| 2 | Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma显示文摘Objective: To examine the effect of metanol extract of Petiveria alliacea(PM) on airway inflammation in a murine model of chronic asthma. Methods: Two-month-old male BALB/c mice(n=6–8/group) were sensitized on days 0 and 14 by intraperitoneal injection of 20 μg ovalbumin(OVA). On day 25, the mice received an airway challenge with OVA(3%, w/v, in phosphate buffered saline). PM was administered orally by oral gavage to mice at doses of 100, 200 and 400 mg/kg body weight once daily from days 18 to 23. Control mice were orally administered phosphate buffered saline(PBS) to induce a model of asthma. At the end of the test, respiratory reactivity was assayed, the total cell number, interleukin-4(IL-4), IL-5, IL-13, tumor necrosis factor-alpha(TNF-α) and reactive oxygen species(ROS) in the bronchoalveolar lavage fluid(BALF) were determined and the levels of serum IgE, intercellular cell adhesion molecule 1(ICAM-1) and eotoxin were measured. In addition, lung tissue was used to qualify the IL-4, IL-5, IL-13, TNF-α and transforming growth factor beta 1(TGF-β1). Histologic examination was performed to observe inflammatory cellular infiltration. Results: The administration of PM in comparison with the OVA-only treated group significantly attenuated the infiltration of eosinophils and other inflammatory cells(P<0.01). Airway resistance(RI) in the OVA-only induced group was significantly higher than that of the PBS control group(P<0.01) when methacholine was added. TNF-α, IgE, TGF-β1 and cytokine levels IL-4, IL-5, IL-13 in the BALF decreased compared to control mice(P<0.01 or P<0.05). PM treatment also inhibited the production of chemokines, eotaxin and ICAM-1 in BALF(P<0.01), which improved lung function. Histopathological examination revealed that the sensitized treated PM groups had significant lower in inflammatory scores similar to dexamethasone treatments and the untreated group. Conclusion: Administration of PM could inhibit airway inflammation, regulate cytokines, chemokines and enhance pulmonary conditions in allergic murine model of asthma. | Rosa Martha Perez Gutierrez Jose Maria Mota Flores | 2018 | Chinese Journal of Integrative Medicine2018，24，12： | 3 |
| 3 | Influence of occult hepatitis B virus infection in chronic hepatitis C outcomes显示文摘Persistence of hepatitis B virus-DNA in the sera,peripheral blood mononuclear cells or in the liver of hepatitis B surface antigen(HBsAg) -negative patients with or without serological markers of previous exposure(antibodies to HBsAg and/or to HB-core antigen) defines the entity called occult hepatitis B infection(OBI).Co-infection with hepatitis B and hepatitis C viruses is frequent in highly endemic areas.While this co-infection increases the risk of liver disease progression,development of cirrhosis and hepatocellular carcinoma and also increases the rate of therapeutic failure to interferon-based treatments than either virus alone,a potentially negative effect of OBI on clinical outcomes and of therapeutic response to current antiviral regimes of patients with chronic hepatitis C remains inconclusive. | Conrado M Fernandez-Rodriguez Maria Luisa Gutierrez JoséLuis Lledó Maria Luisa Casas | 2011 | World Journal of Gastroenterology2011，17，12： | 3 |
| 4 | Successful treatment of psychosis induced by interferon alpha and ribavirin with paliperidone:first case reported显示文摘Several clinical studies have shown a large number of mental symptoms by immunomodulatory treatment with interferon (IFN). The most frequently described symptoms are depression, suicidal behaviour, manic symptoms, anxiety, psychosis and delirium, associated with other non-specific symptoms such as fatigue, irritability, psychomotor retardation, decreased libido, insomnia, difficulty in concentration and attention. Having a history of mental disorder contraindicates the use of IFN-alpha. These adverse effects that affect the mental state appear usually at the beginning of the treatment (most after 3 weeks of treatment). The incidence of psychotic episodes is low and the episodes usually remit when treatment is interrupted;only some cases require antipsychotic treatment. We present the case of a patient affected with hepatitis C who began to present self-referential delirious symptoms after receiving the treatment with IFN and who was successfully treated with paliperidone. This patient could be classified within the group of high-risk psychiatric patients given the family history of schizophrenia and his personal history of illegal drug consumption. The pharmacological actions of paliperidone are similar to other high potency atypical antipsychotics.丁he receptorbinding profile of paliperidone most closely resembles that of risperidone and ziprasidone. Paliperidone differs from risperidone and most other antipsychotics by its relatively low extent of enzymatic hepatic metabolism. To the best of our knowledge, this is the first case described that was successfully treated with paliperidone. | Carmen Maura Carrillo de Albornoz Calahorro Maria Isabel Navarrete Paez Margarita Guerrero Jimenez Luis Gutierrez Rojas | 2019 | General Psychiatry2019，32，4： | 2 |
| 5 | Biotransformation of ent-13-ePimanoyl,oxides difunetionalizedat C-3 and C-12 by filamentous fungi显示文摘 | Andres Garcia-Granados Antonia Fernandez Maria C Gutierrez | 2004 | Phytoehemistry2004，65，： | 1 |
| 6 | Transient elastography to rule out esophageal varices and portal hypertensive gastropathy in HIV-infected individuals with liver cirrhosis显示文摘 | Maria L. Montes Ramirez Jose F. Pascual-Pareja Matilde Sánchez-Conde Jose I. Bernardino De la Serna Francisco X. Zamora Vargas Pilar Miralles Juan M. Castro Margarita Ramírez Isabel Gutierrez Juan Gonzalez-García Juan Berenguer Jose R. Arribas López | 2012 | AIDS2012，，14： | 1 |
| 7 | Biological filters in aquaculture: Trends and research directions for freshwater and marine applications 显示文摘 | GUTIERREZ WING MARIA TERESA MALONE | 2006 | Aquacultural Engineering2006，34，3： | 1 |
| 8 | Ice-templated materials Sophisticated structures exhibiting enhanced functionalities ob tained after unidirectional freezing and ice-segregation-induced self-assembly 显示文摘 | Maria C Gutierrez Maria L F | 2008 | Chem Mater2008，20，3： | 1 |
| 9 | Reversible acetylation regulates vascular endothelial growth factor receptor-2 activity显示文摘酷氨酸 kinase 受体(VEGFR2 ) 脉管的 endothelial 生长因素受体 2 是 angiogenesis 的一个关键管理者。VEGFR2 在在 kinaseinsert 领域形成稠密的簇的四离氨酸残余两个都是在 endothelial 房间的 acetylated,在一个单身者,离氨酸在受体激活环定位的 Herewe 表演。这些修正在动态 controlof 下面是 acetyltransferase p300 和二 deacetylases HDAC5 和 HDAC6。我们实质上表明那 VEGFR2 acetylation regulatesreceptor phosphorylation。特别地, VEGFR2 acetylation 显著地改变受体 phosphorylationafter ligand 绑定的动力学,允许受体 phosphorylation 并且在在激活循环的离氨酸的那 acetylation 贡献的有模拟显示的 VEGF.Molecular 动力学的延长刺激之上的细胞内部的发信号 transitionto 一个开的活跃状态,在哪个酷氨酸 phosphorylation 被 kinase 目标残余的更好的暴露赞成。Thesefindings 显示由 acetylation 的那 translational 以后修正是直接影响 VEGFR2function 的批评机制。 | Annalisa Zecchin Lucia Pattarini Maria Ines Gutierrez Miguel Mano Antonello Mai Sergio Valente Mike P. Myers Sergio Pantano Mauro Giacca | 2014 | Journal of Molecular Cell Biology2014，8，2： | 1 |
| 10 | Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of cyclooxygenase-2 in mice显示文摘Alzheimer’s disease is a progressive brain disorder and complex mechanisms are involved in the physiopathology of Alzheimer’s disease.However,there is data suggesting that inflammation plays a role in its development and progression.Indeed,some non-steroidal antiinflammatory drugs,such as meloxicam,which act by inhibiting cyclooxygenase-2 have been used as neuroprotective agents in different neurodegenerative disease models.The purpose of this study was to investigate the effects of co-nanoencapsulated curcumin and meloxicam in lipid core nanocapsules(LCN)on cognitive impairment induced by amyloid-beta peptide injection in mice.LCN were prepared by the nanoprecipitation method.Male Swiss mice received a single intracerebroventricular injection of amyloid-beta peptide aggregates(fragment 25–35,3 nmol/3μL)or vehicle and were subsequently treated with curcumin-loaded LCN(10 mg/kg)or meloxicam-loaded LCN(5 mg/kg)or meloxicam+curcumin-co-loaded LCN(5 and 10 mg/kg,respectively).Treatments were given on alternate days for 12 days(i.e.,six doses,once every 48 hours,by intragastric gavage).Our data showed that amyloid-beta peptide infusion caused long-term memory deficits in the inhibitory avoidance and object recognition tests in mice.In the inhibitory avoidance test,both meloxicam and curcumin formulations(oil or co-loaded LCN)improved amyloid-beta-induced memory impairment in mice.However,only meloxicam and curcumin-co-loaded LCN attenuated non-aversive memory impairment in the object recognition test.Moreover,the beneficial effects of meloxicam and curcuminco-loaded LCN could be explained by the anti-inflammatory properties of these drugs through cortical cyclooxygenase-2 downregulation.Our study suggests that the neuroprotective potential of meloxicam and curcumin co-nanoencapsulation is associated with cortical cyclooxygenase-2 modulation.This study was approved by the Committee on Care and Use of Experimental Animal Resources,the Federal University of Pampa,Brazil(approval No.02-2015)on April 16,2015. | Maria Eduarda Ziani Gutierrez Anne Suély Pinto Savall Edina da Luz Abreu Kelly Ayumi Nakama Renata Bem Dos Santos Marina Costa Monteiro Guedes Daiana SilvaÁvila Cristiane Luchese Sandra Elisa Haas Caroline Brandão Quines Simone Pinton | 2021 | Neural Regeneration Research2021，16，4： | 1 |
| 11 | The chemical composition of the uropygial gland secretion of rock dove显示文摘 | Ana Maria Gutierrez Guillermo Reboredo | 2005 | Columba livia Comparative Biochemistry and Physiology2005，140，： | 1 |
| 12 | Influence of the microstructure in the collapse of a residual clayey tropical soil显示文摘 | Nelcí Helena Maia Gutierrez Maria Teresa Nóbrega Orencio Monje Vilar | 2009 | Bulletin of Engineering Geology and the Environment2009，，1： | 1 |
| 13 | Avoiding Axillary Treatment in Sentinel Lymph Node Micrometastases of Breast Cancer: A Prospective Analysis of Axillary or Distant Recurrence显示文摘 | Sonia Pernas Marta Gil Ana Benítez Maria Teresa Bajen Fina Climent Maria Jesús Pla Enrique Benito Anna Gumà Cristina Gutierrez Aleydis Pisa Ander Urruticoechea Javier Pérez Miguel Gil Gil | 2010 | Annals of Surgical Oncology2010，，： | 1 |
| 14 | Ice-templated materials: Sophisticated structures exhibiting enhanced functionalities obtained after unidirectional freezing and ice-segregation-induced self-assembly 显示文摘 | Maria C Gutierrez Maria L F | 2008 | Chemistry of Materials2008，20，： | 1 |
| 15 | Evaluation of Grid Pattern Photocoagulation for Macular Edema in Central Vein Occlusion显示文摘 | John G. Clarkson Elaine Chuang Donald Gass Maria Pedroso Tony Cubillas Erlinda S. Duria Ditte J. Hess Isabel Rams Marguerite Ball Alex Gutierrez Nayla Muniz June Thompson Michele Pall Charles J. Pappas | 1995 | Ophthalmology1995，，10： | 1 |
| 16 | Thl and Th2 lymphocytes in perennialallergic rhinitis显示文摘 | Daniel Aguilar Angeles Ernestina Serrano Miranda Maria Isabel Rojo Gutierrez | 2006 | Rev Alerg Mex2006，53，3： | 1 |
| 17 | Normal Values of Liver Shear Wave Velocity in Healthy Children Assessed by Acoustic Radiation Force Impulse Imaging Using a Convex Probe and a Linear Probe显示文摘 | Teresa Fontanilla Teresa Ca?as Araceli Macia Marta Alfageme Carolina Gutierrez Junquera Ana Malalana Maria Luz Cilleruelo Enriqueta Roman Maria Miralles | 2013 | Ultrasound in Medicine & Biology2013，，： | 1 |
| 18 | Effect of iron on the dissolution of bovine enamel powder in vitro by carbonated beverages 显示文摘 | Melissa Thiemi Kato Andrea Gutierrez Maria S'lvia Helena de Carvalho Sales-Peres | 2007 | Archives of Oral Biology2007，52，： | 1 |
| 19 | Effect of iron on the dissolution of bovine enamel powder in vitro by carbonated beverages 显示文摘 | Melissa Thiemi Kato Andrea Gutierrez Maria S'lvia Helena de Carvalho Sales - Peres | 2007 | Archives of Oral Biology2007，52，： | 1 |
| 20 | Antecedents of the difference in perceived risk between store brands and national brands显示文摘 | Gelina G M Maria D M Juan Antonio Trespalacios Gutierrez | 2006 | European Journal of Marketing2006，40，12： | 1 |
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