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| 1 | Excretion of biliary compounds during intrauterine life显示文摘In adults,the hepatobiliary system,together with the kidney,constitute the main routes for the elimination of several endogenous and xenobiotic compounds into bile and urine,respectively.However,during intrauterine life the biliary route of excretion for cholephilic compounds,such as bile acids and biliary pigments,is very poor.Although very early in pregnancy the fetal liver produces bile acids,bilirubin and biliverdin,these compounds cannot be efficiently eliminated by the fetal hepatobiliary system,owing to the immaturity of the excretory machinery in the fetal liver.Therefore,the potentially harmful accumulation of cholephilic compounds in the fetus is prevented by their elimination across the placenta.Owing to the presence of detoxifying enzymes and specifi c transport systems at different locations of the placental barrier,such as the endothe-lial cells of chorionic vessels and trophoblast cells,this organ plays an important role in the hepatobiliary-like function during intrauterine life.The relevance of this excretory function in normal fetal physiology is evident in situations where high concentrations of biliary compounds are accumulated in the mother.This may result in oxidative stress and apoptosis,mainly in the placenta and fetal liver,which might affect normal fetal development and challenge the fate of the pregnancy.The present article reviews current knowledge of the mechanisms underlying the hepatobiliary function of the fetal-placental unit and the repercussions of several pathological conditions on this tandem. | Rocio IR Macias Jose JG Marin Maria A Serrano | 2009 | World Journal of Gastroenterology2009，15，7： | 6 |
| 2 | The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy显示文摘 | Jose JG MARIN Maria J MONTE Alba G BLAZQUEZ Rocio IR MACIAS Maria A SERRANO Oscar BRIZ | 2014 | Acta Pharmacologica Sinica2014，35，1： | 4 |
| 3 | Prophylaxis of post-ERCP pancreatitis: a practice survey显示文摘 | Jean-Marc Dumonceau Johanne Rigaux Michel Kahaleh Carlos Macias Gomez Alain Vandermeeren Jacques Devière | 2010 | Gastrointestinal Endoscopy2010，，6： | 3 |
| 4 | Type 2 diabetes in a Senegalese rural area显示文摘AIM To estimate the prevalence of diabetes in the rural population of Tessekere(Senegal) and investigate associated risk factors. METHODS Data from a 2015 survey of 500 individuals age 20 and over representative of the population of the municipality of Tessekere were used. Sociodemographic characteristics, health related variables, capillary whole blood glucose, and weight and height measurements of individuals were collected during face-to-face interviews. Statistical analyses used were bivariate tests and binary logistic regressions.RESULTS The percentage of individuals having impaired fasting glucose(IFG) is 6.6%. Those with fasting blood glucose(FBG) levels ≥ 126 mg/dL and/or currently being treated for diabetes is 4.2%. Only mean body mass index(BMI) is significantly higher among diabetic individuals and among those having FBG levels ≥ 110 mg/dL. After adjustment for sex, age, educational level, BMI and hypertension, only BMIis associated with diabetes. CONCLUSION Prevalence of diabetes and IFG in our study correspond to the high range of rural sub-Saharan Africa prevalence. Diabetes is thus becoming a pressing public health concern, even in rural areas. But the risk factors identified in Tessekere suggest that the diabetes epidemic is still in the early stages, such that concerted action would make it possible to contain the devastating impact of this chronic condition. | Priscilla Duboz Gilles Boetsch Lamine Gueye Enguerran Macia | 2017 | World Journal of Diabetes2017，8，7： | 2 |
| 5 | Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways显示文摘 | Claudio Alarcón Alexia-Ileana Zaromytidou Qiaoran Xi Sheng Gao Jianzhong Yu Sho Fujisawa Afsar Barlas Alexandria N. Miller Katia Manova-Todorova Maria J. Macias Gopal Sapkota Duojia Pan Joan Massagué | 2009 | Cell2009，，4： | 2 |
| 6 | Size-resolved measurements of light scattering by ambient particles in the southwestern U S显示文摘 | White W H Macias E S Ninenger R C | 1994 | Atmos Environ1994，28，： | 1 |
| 7 | Subacute Presentation of Propionic Acidemia显示文摘 | De18ado C Macias C Maria S | 2007 | J of child neurol2007，22，12： | 1 |
| 8 | Survival in a rat model of lethal hemorrhagic shock is prolonged following resuscitation with a small volume of a solution containing a drag-reducing polymer derived from aloe vera显示文摘 | Macias CA Kameneva MV Tenhunen JJ | 2004 | Shock2004，22，2： | 1 |
| 9 | Prevention of gastrointestinal infection using immunobiological methods with milk fermented with Lactobacillus casei and Lactobacillus acidophillus显示文摘 | Perdigon G Macias M Alvarez S | 1990 | J Dairy Res1990，57，2： | 1 |
| 10 | Diabetes insipidus and adipsic hypermatremia in a patient with a craniopharyngioma显示文摘 | Macias Batista A Martinez Martin F J de Pablos Velasco PL | 1999 | An Med Interna1999，16，2： | 1 |
| 11 | Lesion of the subthalamic nucleus in Parkinson's disease:long term follow-up显示文摘 | Alvarez Gonzalez L Macias R Guridi J | 1999 | Ann Neurol1999，46，： | 1 |
| 12 | Effect of maternal cholestasis on bile acid transfer across the rat placenta-maternal liver tandem 显示文摘 | MACIAS R I PASCUAL M J BRAVO A | 2000 | Hepatology2000，31，4： | 1 |
| 13 | Enhanced malignant tumorigenesis in CDK4 transgenic mice 显示文摘 | MILIANI de MARVAL P L MACIAS E CONTI C J | 2004 | Oneogene2004，23，10： | 1 |
| 14 | Impact of genetic polyrnorphisms on tacrolirnus pharmacokinetics and the clinical outcome of renal transplantation显示文摘 | Gervasini G Garcia M Macias RM | 2012 | Transpl Int2012，25，4： | 1 |
| 15 | Efficacy of a sclerostin antibody compared to a low dose of PTH on metaphyseal bone healing显示文摘 | Agholme F Macias B Hamang M | 2014 | Orthop Res2014，32，3： | 1 |
| 16 | Survival in a rat model of lethal hemorrhagic shock is prolonged following resuscitation with a small volume of a solution containing a drag-reducing polymer derived from aloe vera显示文摘 | Macias CA Kameneva MV Tenhunen JJ | 2004 | SHOCK2004，22，： | 1 |
| 17 | Chemical composition of fumarolic gases and spring discharges from EI Chichon volcano,Mexico:Causes and implications of the changes detected over the period 1998-2000显示文摘 | Tassi F vaselli O Capaccioni B Macias J Ⅰ Nencetti A | 2003 | Journal of Volcanology and Geothermal Resesrch2003，，123： | 1 |
| 18 | Excretion of foetal bilirubin by the rat placenta-maternal liver tandem 显示文摘 | Briz O Macias RI Serrano MA | 2003 | Placenta2003，24，5： | 1 |
| 19 | Caleincurin impo ses T cell unresponsiveness through targeted proteolysis of signaling proteins显示文摘 | Heissmeyer V Macia'n F Im SH | 2004 | Nat Immunol2004，5，： | 1 |
| 20 | Dorsal subthalamotomy for Parkinson's disease显示文摘 | Alvarez L Macias R Guridi J | 2001 | Mov Disord2001，16，1： | 1 |
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