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| 1 | Developmental pathways associated with cancer metastasis:Notch,Wnt,and Hedgehog显示文摘Master developmental pathways, such as Notch, Wnt, and Hedgehog, are signaling systems that control proliferation, cell death,motility, migration, and stemness. These systems are not only commonly activated in many solid tumors, where they drive or contribute to cancer initiation, but also in primary and metastatic tumor development. The reactivation of developmental pathways in cancer stroma favors the development of cancer stem cells and allows their maintenance, indicating these signaling pathways as particularly attractive targets for efficient anticancer therapies, especially in advanced primary tumors and metastatic cancers. Metastasis is the worst feature of cancer development. This feature results from a cascade of events emerging from the hijacking of epithelial-mesenchymal transition, angiogenesis, migration, and invasion by transforming cells and is associated with poor survival, drug resistance, and tumor relapse. In the present review, we summarize and discuss experimental data suggesting pivotal roles for developmental pathways in cancer development and metastasis, considering the therapeutic potential. Emerging targeted antimetastatic therapies based on Notch, Wnt, and Hedgehog pathways are also discussed. | Armel Herve Nwabo Kamdje Paul Takam Kamga Richard Tagne Simo Lorella Vecchio Paul Faustin Seke Etet Jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera | 2017 | Cancer Biology & Medicine2017，14，2： | 10 |
| 2 | Mesenchymal stromal cells' role in tumor microenvironment:involvement of signaling pathways显示文摘Mesenchymal stromal cells(MSCs) are adult multipotent stem cells residing as pericytes in various tissues and organs where they can differentiate into specialized cells to replace dying cells and damaged tissues. These cells are commonly found at injury sites and in tumors that are known to behave like 'wounds that do not heal.' In this article, we discuss the mechanisms of MSCs in migrating, homing, and repairing injured tissues. We also review a number of reports showing that tumor microenvironment triggers plasticity mechanisms in MSCs to induce malignant neoplastic tissue formation, maintenance, and chemoresistance, as well as tumor growth. The antitumor properties and therapeutic potential of MSCs are also discussed. | Armel Herve Nwabo Kamdje Paul Takam Kamga Richard Tagne Simo Lorella Vecchio Paul Faustin Seke Etet Jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera | 2017 | Cancer Biology & Medicine2017，14，2： | 4 |
| 3 | Long-Term Follow-Up After Fractional Flow Reserve–Guided Treatment Strategy in Patients With an Isolated Proximal Left Anterior Descending Coronary Artery Stenosis显示文摘 | Olivier Muller Fabio Mangiacapra Argyrios Ntalianis Katia M.C. Verhamme Catalina Trana Michalis Hamilos Jozef Bartunek Marc Vanderheyden Eric Wyffels Guy R. Heyndrickx Frank J.A. van Rooij Jacqueline C.M. Witteman Albert Hofman William Wijns Emanuele Barb | 2011 | JACC: Cardiovascular Interventions2011，，11： | 2 |
| 4 | Sequential bone healing of immediately loaded mini-implants显示文摘 | Glaucio Serra Liliane S. Morais Carlos Nelson Elias Marc A. Meyers Leonardo Andrade Carlos Muller Marcelo Muller | 2008 | American Journal of Orthodontics & Dentofacial Orthopedics2008，，1： | 2 |
| 5 | Long-Term Clinical Outcome After Fractional Flow Reserve–Guided Treatment in Patients With Angiographically Equivocal Left Main Coronary Artery Stenosis显示文摘 | Michalis Hamilos Olivier Muller Thomas Cuisset Argyrios Ntalianis Gregory Chlouverakis Giovanna Sarno Olivier Nelis Jozef Bartunek Marc Vanderheyden Eric Wyffels Emanuele Barbato Guy R. Heyndrickx William Wijns Bernard De Bruyne | 2009 | Circulation2009，，15： | 1 |
| 6 | Severity of Coronary Arterial Stenoses Responsible for Acute Coronary Syndromes显示文摘 | Ganesh Manoharan Argyrios Ntalianis Olivier Muller Michailis Hamilos Giovanna Sarno Narbeh Melikian Marc Vanderheyden Guy R. Heyndrickx Eric Wyffels William Wijns Bernard De Bruyne | 2009 | The American Journal of Cardiology2009，，9： | 1 |
| 7 | Long-Term Clinical Outcome After Fractional Flow Reserve–Guided Treatment in Patients With Angiographically Equivocal Left Main Coronary Artery Stenosis显示文摘 | Michalis Hamilos Olivier Muller Thomas Cuisset Argyrios Ntalianis Gregory Chlouverakis Giovanna Sarno Olivier Nelis Jozef Bartunek Marc Vanderheyden Eric Wyffels Emanuele Barbato Guy R. Heyndrickx William Wijns Bernard De Bruyne | 2009 | Circulation2009，，15： | 1 |
| 8 | Comparison of 600 Versus 300-mg Clopidogrel Loading Dose in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Coronary Angioplasty显示文摘 | Fabio Mangiacapra Olivier Muller Argyrios Ntalianis Catalina Trana Guy R. Heyndrickx Jozef Bartunek Marc Vanderheyden William Wijns Bernard De Bruyne Emanuele Barbato | 2010 | The American Journal of Cardiology2010，，9： | 1 |
| 9 | Barcelona clinic liver cancer nomogram and others staging/scoring systems in a French hepatocellular carcinoma cohort显示文摘AIM To compare the performances of the Barcelona clinic liver cancer(BCLC) nomogram and others systems(BCLC, HKLC, CLIP, NIACE) for survival prediction in a large hepatocellular carcinoma(HCC) French cohort.METHODS Data were collected retrospectively from 01/2007 to 12/2013 in five French centers. Newly diagnosed HCC patients were analyzed. The discriminatory ability, homogeneity ability, prognostic stratification ability Akaike information criterion(AIC) and C-index were compared among scoring systems. RESULTS The cohort included 1102 patients, mostly men, median age 68 [60-74] years with cirrhosis(81%), child-Pugh A(73%), alcohol-related(41%), HCV-related(27%). HCC were multinodular(59%) and vascular invasion was present in 41% of cases. At time of HCC diagnosis BCLC stages were A(17%), B(16%), C(60%) and D(7%). First line HCC treatment was curative in 23.5%, palliative in 59.5%, BSC in 17% of our population. Median OS was 10.8 mo [4.9-28.0]. Each system distinguished different survival prognosis groups(P < 0.0001). The nomogram had the highest discriminatory ability, the highest C-index value. NIACE score had the lowest AIC value. The nomogram distinguished sixteen different prognosis groups. By classifying unifocal large HCC into tumor burden 1, the nomogram was less powerful. CONCLUSION In this French cohort, the BCLC nomogram and the NIACE score provided the best prognostic information, but the NIACE could even help treatment strategies. | Xavier Adhoute Guillaume Pénaranda Jean Luc Raoul Julien Edeline Jean-Frédéric Blanc Bernard Pol Manuela Campanile HervéPerrierO livier Bayle Olivier Monnet Patrick Beaurain Cyril Muller Paul Castellani Yves Patrice Le Treut Jean Pierre Bronowicki Marc Bourlière | 2017 | World Journal of Gastroenterology2017，23，14： | 1 |
| 10 | Self-organized Nanocrystallinity in MgO-AI,03-SiO, Glasses with zrO, as Nucleating Agent显示文摘 | Marc Dittmer Muller Matthias | 2010 | Materials Chemistry and Physics2010，124，23： | 1 |
| 11 | Expression of MyoD in cultured primary myotubes is dependention contractile activity:correlation with phenotype-specific expression of a sarcoplasmic reticulum Ca2+-ATPase isoform显示文摘 | Alice Muller Marc H M Thelen Marian J | 1996 | Biochem Biophys Res Commun1996，229，： | 1 |
| 12 | Wall stress modulates brain natriuretic peptide production in pressure overload cardiomyopathy显示文摘 | Marc Vanderheyden Marc Goethals Sofie Verstreken Bernard De Bruyne Kristin Muller Eddy Van Schuerbeeck Jozef Bartunek | 2004 | Journal of the American College of Cardiology2004，，12： | 1 |
| 13 | Newcastle disease virus in West Africa: new virulent strains identified in non-commercial farms显示文摘 | Chantal J. Snoeck Mariette F. Ducatez Ademola A. Owoade Olufemi O. Faleke Bello R. Alkali Marc C. Tahita Zekiba Tarnagda Jean-Bosco Ouedraogo Issoufou Maikano Patrick Okwen Mbah Jacques R. Kremer Claude P. Muller | 2009 | Archives of Virology2009，，1： | 1 |
| 14 | Self-or- ganized nanocrystallinity in MgO-AI~O3-SiO2 glasses with ZrO2 as nucleating agent 显示文摘 | Marc Dittmer Matthias MUller Christian Riissel | 2010 | Materials Chemistry and Physics2010，24，： | 1 |
| 15 | CT-based delineation of lymph node levels and related CTVs in the node-negative neck: DAHANCA, EORTC, GORTEC, NCIC,RTOG consensus guidelines显示文摘 | Vincent Grégoire Peter Levendag Kian K. Ang Jacques Bernier Marijel Braaksma Volker Budach Cliff Chao Emmanuel Coche Jay S. Cooper Guy Cosnard Avraham Eisbruch Samy El-Sayed Bahman Emami Cai Grau Marc Hamoir Nancy Lee Philippe Maingon Karin Muller Hervé R | 2003 | Radiotherapy and Oncology2003，，3： | 1 |
| 16 | Arsenic removal from groundwater using iron electrocoagulation: Effect of charge dosage rate显示文摘 | Susan Amrose Ashok Gadgil Venkat Srinivasan Kristin Kowolik Marc Muller Jessica Huang Robert Kostecki | 2013 | Journal of Environmental Science and Health Part A2013，，9： | 1 |
| 17 | Osteomodulin downregulation is associated with osteoarthritis development显示文摘Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis(OA), and osteomodulin(OMD), a proteoglycan involved in extracellular matrix mineralization, is associated with the sclerotic phenotype. However, the functions of OMD remain poorly understood, specifically in vivo. We used Omd knockout and overexpressing male mice and mutant zebrafish to study its roles in bone and cartilage metabolism and in the development of OA. The expression of Omd is deeply correlated with bone and cartilage microarchitectures affecting the bone volume and the onset of subchondral bone sclerosis and spontaneous cartilage lesions. Mechanistically, OMD binds to RANKL and inhibits osteoclastogenesis, thus controlling the balance of bone remodeling. In conclusion, OMD is a key factor in subchondral bone sclerosis associated with OA. It participates in bone and cartilage homeostasis by acting on the regulation of osteoclastogenesis. Targeting OMD may be a promising new and personalized approach for OA. | Jérémie Zappia Qiao Tong Renée Van der Cruyssen Frederique MFCornelis Cécile Lambert Tiago Pinto Coelho Juliane Grisart Erika Kague Rik JLories Marc Muller Dirk Elewaut Chrissy LHammond Christelle Sanchez Yves Henrotin | 2023 | Bone Research2023，11，4： | 0 |
| 18 | Allogeneic stem cell transplantation-A curative treatment for paroxysmal nocturnal hemoglobinuria with PIGT mutation:A case report显示文摘BACKGROUND Patients with paroxysmal nocturnal hemoglobinuria(PNH)have a clonal population of blood cells deficient in glycosylphosphatidylinositol-anchored(GPIanchored)proteins,most of the time resulting from a mutation in the X-linked gene PIGA.We report a patient with PNH resulting from a rare biallelic PIGT mutation on chromosome 20.CASE SUMMARY A 47-year-old man was referred to our hospital for febrile pancytopenia.The patient reported a history of recurrent urticaria and arthralgia and he presented during 3 mo recurrent acute dermo-hypodermitis and aseptic meningitidis.Based on clinical cases published with PIGT-PNH,with clinically typical PNH and autoinflammatory symptoms,we treated our patients with repeated infusions of eculizumab to decrease autoinflammatory symptoms and then we performed an allogeneic stem cell transplantation(allo-SCT)with a mismatched unrelated donor.Our patient experienced no acute Graft vs Host disease(GvHD)and a moderate chronic GvHD and is now considered cured at 24 mo after allo-SCT.CONCLUSION This case report suggests that allo-SCT should be considered to cure PIGT-PNH patients. | Laurence Schenone Anne-Béatrice Notarantonio Véronique Latger-Cannard Veronique Fremeaux-Bacchi Marcelo De Carvalho-Bittencourt Marie-Thérèse Rubio Marc Muller Maud D'Aveni | 2022 | World Journal of Clinical Cases2022，10，17： | 0 |
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